尹航(清華大學教授)

尹航(清華大學教授)

尹航，清華大學藥學院教授、副院長，藥學技術中心主任，中組部國家特聘專家，清華大學-北京大學生命科學聯合中心高級研究員。尹航教授2019年獲得北京市卓越青年科學家和國家自然基金委傑出青年科學基金項目資助。

基本介紹

  • 中文名：尹航
  • 民族：漢族
  • 出生地：北京
  • 畢業院校：北京大學、耶魯大學 
  • 研究領域：化學生物學、藥物化學
學術成就,代表論文,

學術成就

尹航1999年獲得北京大學套用化學學士學位；2004年獲得美國耶魯大學化學專業博士學位；2004至2007年在美國賓夕法尼亞大學醫學院從事博士後研究；加入清華大學之前於美國科羅拉多大學化學和生物化學系任終身教授。尹航教授的研究領域為交叉學科，主要涉及化學生物學、免疫藥物研發、蛋白質設計和計算機模擬、癌症篩查和診斷、自身免疫疾病等領域。尹航教授團隊在本領域一流期刊《科學》、《自然》、《科學》及《細胞》子刊，《美國國家科學院院刊》，《德國套用化學》，《美國化學學會志》等發表研究論文超過100篇 (總引用>6000) ；並多次被《自然》、《科學》、《美國國家科學院院刊》、 美國化學會會刊《C&EN》等雜誌作為科研亮點專題報導。科研成果已申請專利11項（授予美國、歐盟、日本等專利4項），有多項專利成果已經商業化。尹航教授先後獲得國家自然基金委傑出青年科學基金、美國化學學會大衛·W·羅伯特森傑出藥物化學家獎、中美化學及化學生物學教授聯合會傑出青年教授獎、美國國家科學基金會傑出青年教授獎、美國癌症研究學會格特魯德·B·埃利恩獎、美國癌症研究學會的SU2C創新研究獎、悉德尼·金梅爾學者獎、霍華德·休斯醫學研究院合作創新獎、以及美國國家衛生研究院的 NIDA 青年化學家獎等多個獎項。

代表論文

  1. Zhang, S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian, Y.; Ohto, U.; Shimizu, T.;*Yin, H.“Small Molecule Inhibition of TLR8 through Stabilization of Its Resting State”,Nat. Chem. Biol.2018,14, 58-64(cover article; featured inC&EN“Latest News”).
  2. Hu, Z.; Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia, A.; Shimizu, T.;*Yin, H.“Small Molecule TLR8 Antagonists via Structure-Based Rational Design”,Cell Chem. Biol.2018, 25,1286-1291(cover article).
  3. Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.;*Yin, H.; *Varga, J. “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”,JCI Insight2018,3, e98850 (featured in “News & Views”Nat. Rev. Rheumatol.2018,14,564-566).
  4. Zhang, L.; Shi, L.; Soars, S. M.; Kamps, J.;*Yin, H.“Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Anti-Inflammatory and Anti-Cancer Properties”,J. Med. Chem.2018,61,5881-5899.
  5. Zhang, L.; Dewan, V.;*Yin, H.“Discovery of Small Molecules as Multi-TLR Agonists with Proinflammatory and Anticancer Activities”,J. Med. Chem.2017,60,5029-5044.
  6. Smith, C. E.; Soti, S.; Jones, T. A.; Nakagawa, A.; Xue, D.;*Yin, H.“NSAIDs are Caspase Inhibitors”,Cell Chem. Biol.2017,24,281-292(featured in “Concentrates”C&EN2017,95(10), 10; NIHResearch Matters;The Sun; Daily Mail).
  7. Das, N.; Dewan, V.; Grace, P. M.; Gunn, R. J.; Tamura, R.; Tzarum, N.; Watkins, L. R.; Wilson, I. A.;*Yin, H.“HMGB-1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia”,Cell Rep.2016,17, 1128-1140.
  8. *Yin, H.; Flynn, A.D. “Drugging Membrane Protein Interactions”,Annu. Rev. Biomed. Eng.2016,18, 51-76.
  9. Wang, T.; de Jesus, A.; *Shi, Y.;*Yin, H.; “Pyridoxamine is a substrate of the energy-coupling factor transporter HmpT",Cell Discov.2015,1, 15014.
  10. Daniele, S. G.; Beraud, D.; Davenport, C.; Cheng, K.;*Yin, H.; *Maguire-Zeiss, K. A.; “Activation of MyD88-Dependent TLR1/2Signaling by Misfolded α-Synuclein, a Protein Linked to Neurodegenerative Disorders”,Sci. Signal.2015,8, ra45 (highlighted in “This Week in Science”Science2015,348, 769; Podcast:Maguire-Zeiss, K. A.; Daniele, S. G.;Yin, H.; VanHook, A. M.;Sci. Signal.2015,8, pc12; feature story by the Xinhua News Agency).
  11. Cheng, K.; Gao, M.; Godfroy, J. I. III; Brown, P. N.; Kastelowitz, N.;*Yin, H.; “Specific Activation of the TLR1-TLR2 Heterodimer by Small-molecule Agonists”,Sci. Adv.2015,1, e1400139(featured in “Science & Technology”C&EN2015,93(15), 39-40).
  12. Smith, C. E.; Wang, X. H.;*Yin, H.; “Caspases Come Together Over LPS”,Trends Immunol.2015,36, 59-61.
  13. Yang, H.; Chen, Y. Z.; Zhang, Y.; Wang, X. H.; Zhao, X.; Godfroy, J. I.; Liang, Q.; Zhang, M.; Zhang, T.; Yuan, Q.; Royal, M. A.; Driscoll, M.; Xia, N. S.;Yin, H.; Xue, D. “A Lysine-Rich Motif in the Phosphatidylserine Receptor PSR-1 Mediates Recognition and Removal of Apoptotic Cells”,Nat. Commun.2015,6, 5717.
  14. Csakai, A.; Smith, C.; Davis, E.; Martinko, A.; Coulup, S.;*Yin, H. “Saccharin Derivatives as Inhibitors of Interferon-Mediated Inflammation”,J. Med. Chem.2014,57,5348-5355(cover article).
  15. Wang, X. H.; Grace, P. M.; Pham, M. N.; Cheng, K.; Strand, K. A.; Smith, C. E.; Li, J.; Watkins, L. R.;*Yin, H.“Rifampin Inhibits Toll-like Receptor 4 Signaling by Targeting Myeloid Differentiation Protein 2 and Attenuates Neuropathic Pain”,FASEB J.2013,27,2713-2722.
  16. Wang, X. H.; Smith, C.;*Yin,H.“Targeting Toll-Like Receptors with Small Molecule Agents”,Chem. Soc. Rev.2013,42,4859-4866(cover article).
  17. Brown, P. N.;*Yin, H. “PNA-Based MicroRNA Inhibitors Elicit Anti-Inflammatory Effects in Microglia Cells”,Chem. Commun.2013, 49,4415-4417(2013 Emerging Investigatorsissue).
  18. Morton, L. A.; Saludes, J. P.; Beninson, L.; Chapman, E. R.; Fleshner, M.;*Yin, H.“MARCKS-ED Peptide as a Membrane Curvature Sensor”,ACS Chem. Biol.2013, 8,218-225.
  19. Cheng, K.; Wang, X. H.; Zhang, S.;*Yin, H.“Discovery of Small-Molecules that Inhibit the Protein Complex of Toll-Like Receptor 1 and 2”,Angew. Chem. Int. Ed.2012,51,12246-12249(cover article; featured in “Science & Technology Concentrates”C&EN2012,90(35), 33).
  20. Saludes, J. P.; Morton, L. A.; Ghosh, N.; Beninson, L.; Chapman, E. R.; Fleshner, M.;*Yin, H.“Detection of Highly Curved Membrane Surfaces Using a Cyclic Peptide Derived from Synaptotagmin-I”,ACS Chem. Biol.2012, 7,1629-1635.
  21. Wang, X. H.; Loram, L. C.; Ramos, K.; de Jesus, A.; Thomas, J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.;*Yin,H. “Morphine Activates Neuroinflammation in a Parallel Manner to Endotoxin”,Proc. Natl. Acad. Sci. U. S. A.2012,109,6325-6330(highlighted in “Research Highlights This Week”Nature2012,484, 419; “This Week in PNAS”; Sci. Signal. Editors’ Choice;featured on the website ofthe Association of American Universities; recommended by theFaculty of 1000website).
  22. Chavez, S. A.; Martinko, A. J.; Lau, C.; Pham, M. N.; Cheng, K.; Mollnes, T. E.;*Yin,H. “Development of β–Amino Alcohol Derivatives that Inhibit TLR4-Mediated Inflammatory Response as Potential Antiseptics”,J. Med. Chem.2011,54,4659-4669(headlined inGlobal Medical Discovery).
  23. Cheng, K.; Wang, X. H.;*Yin, H.“Small Molecule Inhibitors of the TLR3/dsRNA Complex”,J. Am. Chem. Soc.2011,133,3764-3767.
  24. *Yin, H. “Exogenous Agents that Target Transmembrane Domains of Proteins”,Angew. Chem. Int. Ed.2008,47,2744-2752(cover article).
  25. Yin,H.; Slusky, J. S; Berger, B. W.; Walters, R. S.; Vilaire, G.; Litvinov, R. I.; Lear, J. D.; Caputo,G. A.; Bennett, J. S.; DeGrado, W. F. “Computational Design of Peptides that Target Transmembrane Helices”,Science2007,315,1817-1822(featured in “News of the Week”C&EN2007,85, 11; “News and Views”Nat. Biotech.2007,25, 646; and “Editors’ Choice”Sci. Signal.2007,2007, tw119).

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