尹繼業

尹繼業，男，1982年5月10日出生，醫學博士，副教授，博士研究生導師，現任教於中南大學湘雅醫院臨床藥理研究所，擔任個體化醫學分子檢測實驗室主任。

基本介紹

• 中文名：尹繼業
• 學位/學歷：博士
• 職業：教師
• 專業方向：藥學
• 任職院校：中南大學

個人經歷

教育經歷

[1]2009.9-2011.12

美國印第安納大學| 藥理學

[2]2005.9-2011.12

中南大學| 藥理學| 博士學位| 博士研究生畢業

[3]2000.9-2005.6

南華大學| 臨床醫學| 學士學位| 大學本科畢業

工作經歷

[1]2012.9-至今

臨床藥理研究所| 中南大學湘雅醫院

社會兼職

• [1]Clinical Pharmacogenetics Implementation Consortium (CPIC)委員會成員兼職時間：2018/01/01 --至今
• [2]湖南省醫學會藥物基因組轉化醫學專業委員會委員兼職時間：2017/11/01 --至今
• [3]Current Pharmacogenomics & Personalized Medicine 編委兼職時間：2017/06/01 --至今
• [4]湖南省青年科技工作者協會副會長、生物與醫藥科學專業委員會主任兼職時間：2016/12/01 --至今
• [5]湖南省自然科學基金會評專家兼職時間：2016/01/01 --至今
• [6]《中國生化藥物雜誌》編委兼職時間：2016/04/01 --至今
• [7]中國藥理學會藥物基因組專業委員會委員兼職時間：2016/12/01 --至今
• [8]湖南省藥學會藥理學專業委員會委員兼職時間：2016/06/01 --至今
• [9]湖南省生理科學會理事兼職時間：2015/10/01 --至今

研究方向

藥物基因組學

學術成果

論文成果

[1] Shao WH, Wang LY, Yin JY#. Current Clinical Application and Response Prediction Biomarkers of PARP Inhibitors. [J]. Current Pharmacogenomics and Personalized Medicine, 16(2): 108-117

[2] Wang LY*, Cui JJ*, Liu JY*, Guo AX, Zhao ZY, Liu YZ, Wu JC, Li M, Hu CP, Gao Y, Zhou HH, Yin JY#. A gene-gene and gene-environment interaction data set for platinum-based chemotherapy in non-small cell lung cancer. [J]. Sci Data., 2018, 11(5): 180284

[3] Wang LY, Cui JJ, Guo AX, Yin JY#. Clinical efficacy and safety of afatinib in the treatment of non-small-cell lung cancer in Chinese patients. [J]. Onco Targets Ther, 11: 529-538

[4] Shi YX, Wang Y, Li X, Zhang W, Zhou HH, Yin JY#, Liu ZQ#. Genome-wide DNA methylation profiling reveals novel epigenetic signatures in squamous cell lung cancer [J]. BMC Genomics, 18(1): 901

[5] Yin JY#, Zhang JT, Zhang W, Zhou HH, Liu ZQ#. eIF3a: A new anticancer drug target in the eIF family [J]. Cancer Lett, 412: 81-87

[6] Cui JJ*, Wang LY*, Zhu T, Gong WJ, Zhou HH, Liu ZQ, Yin JY#. Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients. [J]. Sci Rep, 2017, 7(1): 1-8

[7] Xiong Y, Huang BY, Yin JY#. Pharmacogenomics of platinum-based chemotherapy in non-small cell lung cancer: focusing on DNA repair systems [J]. Med Oncol, 2017, 34(4): 1-16

[8] Liu JY, Qian CY, Gao YF, Chen J, Zhou HH, Yin JY#. Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients. Chin J Cancer, 2017, 36(1): 12

[9] He H*, Xu YJ*, Yin JY*, Li X, Qu J, Xu XJ, Liu ZG, Zhou F, Zhai M, Li Y, Zhou HH, Liu ZQ. Association of nitric oxide synthase 3 (NOS3) 894 G＞T polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukemia Clin Exp Pharmacol Physiol, 2014, 41(6): 400-7

[10] Qu J*, Zhou BT*, Yin JY*, Xu XJ, Zhao YC, Lei GH, Tang Q, Zhou HH, Liu ZQ. ABCC2 Polymorphisms and Haplotype are Associated with Drug Resistance in Chinese Epileptic Patients CNS Neurosci Ther, 2012, 18(8): 647-651

[11] Yang M, Huang Q*, Wu J*, Yin JY*, Sun H, Liu HL, Zhou HH, Liu ZQ. Effects of UCP2 –866 G/A and ADRB3 Trp64Arg on rosiglitazone response in Chinese patients with type 2 diabetes Br J Clin Pharmacol, 2009, 68(1): 14-22

[12] Yu M, Xu XJ*, Yin JY*, Wu J, Chen X, Gong ZC, Ren HY, Huang Q, Sheng FF, Zhou HH, Liu ZQ. KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) Polymorphisms Affect Therapeutic Efficacy of Repaglinide in Chinese Patients With Type 2 Diabetes Clin Pharmacol Ther, 2010, 87(3): 330-5

[13] Liu RY, Dong Z, Liu J, Yin JY, Zhou L, Wu X, Yang Y, Mo W, Huang W, Khoo SK, Chen J,....... Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma Oncogene, 2011, 30(48): 4814-23

[14] Yin JY, Zhang JT. Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms: from discovery to clinical application J Cent South Univ (Med Sci), 2011, 36(10): 927-38

[15] Yin JY, Dong Z, Zhang JT. EIF3A (eukaryotic translation initiation factor 3, subunit A) Atlas Genet Cytogenet Oncol Haematol, 2010,

[16] Yang Z*, Yin JY*, Gong ZC, Huang Q, Zhang W, Zhou HH, Liu ZQ. Evidence for an effect of clozapine on the regulation of fat-cell derived factors Clin Chim Acta, 2009, 408(1-2): 98-104

[17] Yin JY#, Dong Z, Zhang JT#. eIF3 Regulation of Protein Synthesis, Tumorigenesis, and Therapeutic Response Methods Mol Biol, 2017, 1507: 113-127

[18] Yin JY, Qu J, Mao CX, Li X, Mao XY, Xiao B, Xiao L, Zheng W, Zhou HH, Liu ZQ. Establishing Prediction Model of Antiepileptic Drugs Response using Data Mining Approach CNS Neurosci Ther, 2016, 22(10): 860-2

[19] Gong WJ, Zheng W, Xiao L, Tan LM, Song J, Li XP, Xiao D, Cui JJ, Li X, Zhou HH, Yin JY#, Liu ZQ#.. Circulating resistin levels and obesity-related cancer risk: a meta-analysis Oncotarget, 2016, 7(36): 57694-57704

[20] Yin JY#, Li X, Zhou HH, Liu ZQ#. Pharmacogenomics of platinum-based chemotherapy sensitivity in NSCLC: toward precision medicine Pharmacogenomics, 2016, 17(12): 1365-78

[21] Yin JY#, Li X, Li XP, Xiao L, Zheng W, Chen J, Mao CX, Fang C, Cui JJ, Guo CX, Zhang W..... Prediction models for platinum-based chemotherapy response and toxicity in advanced NSCLC patients Cancer Lett, 2016, 377(1): 65-73

[22] Xiao L, Zhou H, Li XP, Chen J, Fang C, Mao CX, Cui JJ, Zhang W, Zhou HH, Yin JY#, Liu ZQ#. MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1 Oncotarget, 2016, 7(26): 40038-40046

[23] Zhang Y, Yu JJ, Tian Y, Li ZZ, Zhang CY, Zhang SF, Cao LQ, Zhang Y, Qian CY....Yin JY#, Liu ZQ#. eIF3a improve cisplatin sensitivity in ovarian cancer by regulating XPC and p27Kip1 translation Oncotarget, 2015, 6(28): 25441-25451

[24] Wang Y, Qian CY, Li XP, Zhang Y, He H, Wang J, Chen J, Cui JJ, Liu R......Yin JY#, Liu ZQ#. Genome-scale long noncoding RNA expression pattern in squamous cell lung cancer Sci Rep, 2015, 5: 11671

[25] Yin JY #, Meng XG, Qian CY, Li XP, Chen J, Zheng Y, Liu R, Zhou HH, Liu ZQ. Association of positively selected eIF3a polymorphisms with toxicity of platinum-based chemotherapy in NSCLC patients Acta Pharmacol Sin, 2015, 36(3): 375-84

[26] Huang Q, Yang TL, Tang BS, Chen X, Huang X, Luo XH, Zhu YS, Chen XP....Yin JY#, Liu ZQ#. Two novel functional single nucleotide polymorphisms of ADRB3 are associated with Type 2 Diabetes in Chinese population J Clin Endocrinol Metab, 2013, 98(7): E1272-7

[27] Yin JY, Dong ZZ, Liu RY, Chen J, Liu ZQ, Zhang JT. Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a Carcinogenesis, 2013, 34(6): 1224-31

[28] Yin JY, Huang Q, Zhao YC, Zhou HH, Liu ZQ. Meta-Analysis on Pharmacogenetics of Platinum-Based Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Patients PLoS One, 2012, 7(6): e38150

[29] Yin JY, Han LF, Huang Q, Xu XJ, Zhou HH, Liu ZQ.. MRP1/ABCC1 polymorphism Arg723Gln (2168G＞A) is associated with lung cancer susceptibility in Chinese population. Clin Exp Pharmacol Physiol., 2011, 38(9): 632-7

[30] Yin JY, Shen J, Dong Z, Huang Q, Zhong M, Feng D, Zhou H, Zhang JT, Liu Z.. Effect of eIF3a on response of lung cancer patients to platinum-based chemotherapy by regulating DNA repair. Clin Cancer Res., 2011, 17(13): 4600-9

[31] Yin JY, Dong Z, Liu ZQ, Zhang JT.. Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments. Biosci Rep., 2010, 31(1): 1-15

[32] Yin JY, Huang Q, Yang Y, Zhang JT, Zhong MZ, Zhou HH, Liu ZQ. Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population Pharmacogenet Genomics, 2009, 19(3): 206-216

科研項目

[1]ITRS調控蒽環類抗生素耐藥的機制與臨床研究

[2]基於藥物基因組學的示範性新藥臨床評價技術平台建設

[3]細胞內部核糖體進入位點及其多態影響鉑類藥物敏感性的機制與臨床研究

[4]非小細胞肺癌鉑類化療個體化用藥模型的建立

[5]eIF3a 及其多態調控DSB DNA 修復途徑的機制和臨床研究

[6]細胞IRES多態的功能與臨床研究

[7]湖湘青年創新英才

[8]升華獵英計畫

[9]湖南省優秀博士學位論文科研項目

著作成果

[1]中國醫學科技發展報告2017

[2]藥物基因組學與個體化治療用藥決策

[3]精準醫療與藥物治療個體化實操手冊

[4]心血管遺傳藥理學

[5]METHODS IN MOLECULAR BIOLOGY

榮譽獎項

[1]基於藥物基因組學的高血壓個體化治療策略、產品與推廣套用

[2]重大慢性疾病發生與藥物反應差異的基因組學研究

[3]2型糖尿病的藥物基因組研究

[4]湖南省生理科學會2016年度優秀學術論文特等獎

[5]第十四屆湖南醫學科技獎一等獎

[6]湖南省生理科學會2015年度優秀學術論文

[7]湘雅醫院青年崗位能手

[8]湖南省生理科學會2013年度優秀學術論文

[9]湖南省優秀博士學位論文

[10]湖南省生理科學會2012年度優秀學術論文

[11]中南大學優秀博士學位論文

[12]湖南省醫學科技獎

[13]中國藥理學會施維雅青年藥理學工作者獎

[14]湖南省第十四屆自然科學優秀學術論文

[15]中國藥學會科學技術獎

[16]中南大學首批優秀畢業研究生學術獎

[17]中南大學優秀畢業生

[18]湖南省生理科學會2011年度優秀學術論文

[19]湖南省生理科學年會2011年度學術年會青年論文競賽

[20]湖南省第十三屆自然科學優秀學術論文