尤明:現為美國威斯康星醫學院副院長、II級教授和癌症研究中心所長。本科畢業於北京大學醫學院，在俄亥俄洲大學醫學院獲病理學博士學位。尤明教授是美國國家癌症研究所（NCI）癌症易感性及化學預防智囊團成員和化學預防藥物發展研究集團審查小組主席，美國國家衛生研究所（NIH）化療/飲食預防和化學病理學研究組成員。還擔任世界著名期刊Cancer Research和Cancer Prevention副主編，PLoS One學術主編，Carcinogenesis、Translational Oncogenomics和Application of Clinical Genetics等世界著名期刊編委。研究領域為腫瘤學，研究方向為肺癌的發病機制及其化學預防治療研究。主持評審NIH等科研課題40餘項，在Cell 等世界頂尖雜誌上發表SCI 論文280餘篇，在肺癌的化學預防研究中取得了傑出成就。
研究方向
● 個體化用藥
● 肺癌的化學預防
● 齧齒動物和人類肺癌的易感基因研究
● 肺癌的分子發病機制
發表論文
[1] Pan J, Zhang Q, Li K, Liu Q, Wang Y, You M*. Chemoprevention of lungsquamous cell carcinoma by ginseng. Cancer Prev Res (Phila). 2013Jun;6(6):530-9.
[2] Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F,Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, WangY, You M*. Exome sequencingidentifies MXRA5 as a novel cancer gene frequently mutated in non-small celllung carcinoma from Chinese patients. Carcinogenesis. 2012 Sep;33(9):1797-805.
[3] Liu P, Morrison C, Wang L, Xiong D, Vedell P,Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, AndraeJW, Tschannen MR, Jacob H,Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, PatelJ, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, StarnesS, Yang P, You M*. Identification ofsomatic mutations in non-small cell lung carcinomas using whole-exomesequencing. Carcinogenesis. 2012 Jul;33(7):1270-6.
[4] Zhang Q, Pan J, Wang Y, Lubet R, You M*. Beetroot red (betanin) inhibitsvinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis throughapoptosis. Mol Carcinog. 2013 Sep;52(9):686-91.
[5] Zhang Q, Pan J, North PE, Yang S, Lubet RA,Wang Y, You M*. Aerosolized3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicityCancer Prev Res (Phila). 2012 May;5(5):717-25.
[6] Lu Y, Govindan R, Wang L, Liu PY, Goodgame B,Wen W, Sezhiyan A, Pfeifer J, Li YF, Hua X, Wang Y, Yang P, You M*. MicroRNA profiling andprediction of recurrence/relapse-free survival in stage I lung cancer.Carcinogenesis. 2012 May;33(5):1046-54.
[7] Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, You M*. Genome-wide association andfine mapping of genetic loci predisposing to colon carcinogenesis in mice. MolCancer Res. 2012 Jan;10(1):66-74.
[8] Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E,Hu M, Lubet RA, You M*.Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemicallyinduced oral carcinogenesis. Mol Carcinog. 2013 Jan;52(1):49-56.
[9] Lu Y, Liu P, Van den Bergh F, Zellmer V, JamesM, Wen W, Grubbs CJ, Lubet RA, You M*.Modulation of gene expression and cell-cycle signaling pathways by the EGFRinhibitor gefitinib (Iressa) in rat urinary bladder cancer. Cancer Prev Res(Phila). 2012 Feb;5(2):248-59.
[10] Govindan R, Ding L, Griffith M, Subramanian J,Dees ND, Kanchi KL, Maher CA, Fulton R, Fulton L, Wallis J, Chen K, Walker J,McDonald S, Bose R, Ornitz D,Xiong D, You M, Dooling DJ, Watson M, Mardis ER, Wilson RK. Genomic landscape ofnon-small cell lung cancer in smokers and never-smokers. Cell. 2012 Sep14;150(6):1121-34.
