宋關斌

宋關斌，男，1968年5月生，重慶銅梁人，博士，重慶大學生物工程學院教授、博士生導師。

基本介紹

• 中文名：宋關斌
• 出生地：重慶銅梁
• 出生日期：1968年5月
• 畢業院校：重慶大學
• 學位/學歷：博士
• 專業方向：生物醫學工程
• 任職院校：重慶大學

人物經歷

學習簡歷

1986.06~1990.06 西南大學 生物學專業 理學學士

1990.07~1993.06 西南大學 生物化學專業 理學碩士

1999.09~2002.06 重慶大學 生物醫學工程專業 工學博士

2003.09~2005.05 重慶大學 電氣工程博士後流動站 博士後

工作簡歷

1993.07~2000.10 重慶大學 生物工程學院 助教/講師

2000.11~2004.08 重慶大學 生物工程學院 副教授/碩士生導師

2004.09~現在. 重慶大學 生物工程學院 教授/博士生導師

國外研究經歷

2004.10~2005.10 Tohoku University, Sendai, Japan. Visiting Scientist

東北大學（日本，仙台） 國家公派訪問學者

2006.08~2007.05 Tohoku University, Sendai, Japan. Japan Society for the Promotion of Science (JSPS) Fellow

東北大學（日本，仙台） 日本學術振興會外國人特別研究員

2007.06~2008.07 Nagoya University, Nagoya, Japan. JSPS Fellow

名古屋大學（日本，名古屋） 日本學術振興會外國人特別研究員

社會兼職

國家自然科學基金委員會數理科學部、生命科學部、醫學科學部通訊評審委員；重慶市生物醫學工程學會常務理事；中國力學學會第七屆生物力學專業委員會委員；中國力學學會第六、七屆青年工作委員會委員；醫用生物力學雜誌特約審稿人；中國神經再生研究（英文版）評審專家；“中國科技論文線上”評審專家；中科院力學所微重力國家重點實驗室客座研究員；國際雜誌World Journal of Stem Cells和World Journal of Biological Chemistry 執行編委。

研究領域

1.腫瘤細胞侵襲轉移的分子及細胞生物力學機理

(Molecular & cellular biomechanics mechanism of tumor cells invasion and metastasis)

2.幹細胞增殖分化的調控機理及相關規律。

(Mechanisms of stem cells proliferation and differentiation)

3.幹細胞與腫瘤細胞相互作用的力學生物學研究

(Mechanobiology of interplays between stem cells and tumor cells)

代表論著

[20] Baiyao Xu, Guanbin Song, Yang Ju, Xian Li, Yuanhui Song, Sachi Watanabe. RhoA/ROCK, cytoskeleta dynamics and focal adhesion kinase are required for mechanical stretch-induced tenogenic differentiation of human mesenchymal stem cells. Journal of Cellular Physiology, 2011 (in press, DOI 10.1002/jcp.23016).

[19] Baiyao Xu, Guanbin Song, Yang Ju. Effect of focal adhesion kinase signaling on the regulation of alignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch. Connective Tissue Research, 2011, 52(5):373-379.

[18] Chengyu Zou, Guanbin Song, Qing Luo, Lin Yuan and Li Yang. Mesenchymal stem cells require integrin β1 for directed migration induced by osteopontin in vitro. In Vitro Cellular & Developmental Biology - Animal, 2011, 47: 241-250.

[17] Guanbin Song, Lin Yuan, Qing Luo, Yisong Shi, Li Yang, Yang Ju. ERK1/2 mediates mechanical stretch-induced proliferation of bone marrow-derived mesenchymal stem cells. IFMBE Proceedings, 2010, 31(Part 4): 1125-1128.

[16] Guanbin Song, Qing Luo, Baiyao Xu, Yang Ju. Mechanical stretch-induced changes in cell morphology and mRNA expression of tendon/ligament-associated genes in rat bone-marrow mesenchymal stem cells. Molecular & Cellular Biomechanics, 2010, 7(3): 165-174.

[15] Kaifu Tang, Guanbin Song, Yisong Shi, Lin Yuan, Yonghua Li. Dicer knockdown induces fibronectin- 1expression in HEK293T cells via induction of Egr1. Biochemica et Biophysica Acta-General Subjects, 2010, 1800(3): 380-384. (IF: 4.663)

[14] Qing Luo, Guanbin Song, Yuanhui Song, Baiyao Xu, Jian Qin, Yisong Shi. Indirect coculture with tenocyte promotes the proliferation and mRNA expression of tendon/ligament related genes in mesenchymal stem cells. Cytotechnology, 2009, 61: 1-10.

[13] KF Tang, M Chen, J Xie, GB Song, YS Shi, Q Liu, ZC Mei, A Steinle, H Ren. Inhibition of hepatitis B virus replication by small interference RNA induces expression of MICA in HepG2.2.15 cells. Medical Microbiology and Immunology, 2009, 198(1): 27-32.

[12] Guanbin Song, Yang Ju, Hitoshi Soyama. Growth and proliferation of bone marrow mesenchymal stem cells affected by type I collagen, fibronectin and bFGF. Materials Science and Engineering C, 2008, 28: 1467-1471.

[11] Guanbin Song, Jian Qin, Chengguo Yao, Yang Ju. Effect of steep pulsed electric field on proliferation, viscoelasticity and adhesion of human hepatoma SMMC-7721 cells. Anticancer Research, 2008, 28(4B): 2245-2251.

[10] Kaifu Tang, Caixia He, Guili Zeng, Jinfeng Wu, Guanbin Song, Yisong Shi, Weiguang Zhang, Ailong Huang, Alexander Steinle, Hong Ren. Induction of MHC class I-related chain B (MICB) by 5- aza-2'-deoxycytidine. Biochemical and Biophysical Research Communications, 2008, 370 (4): 578-583.

[09] Guanbin Song, Yang Ju, Hitoshi Soyama, Toshiro Ohashi, Masaaki Sato. Regulation of cyclic longitudinal mechanical stretch on proliferation of human bone marrow mesenchymal stem cells. Molecular & Cellular Biomechanics, 2007, 4(4): 201-210.

[08] Guanbin Song, Yang Ju, Xiaodong Shen, Qing Luo, Yisong Shi, Jian Qin. Mechanical stretch promotes proliferation of rat bone marrow mesenchymal stem cells. Colloids and Surfaces B: Biointerface, 2007, 58: 271-277.

[07] Zesong Li, Shaoxi Cai, Kabin Rong, Guanbin Song, Yuan Li, Ruijun Guo. The first compound heterozygosity for HKaa allele and Southeast Asian deletion allele. Clinical Biochemistry, 2007, 40: 407-410.

[06] Guanbin Song, Toshiro Ohashi, Naoya Sakamoto, Masaaki Sato. Adhesive force of human hepatoma HepG2 cells to endothelial celld and expression of E-selectin. Molecular & Cellular Biomechanics, 2006, 3(2): 61-68.

[05] Guanbin Song, Qing Luo, Jian Qin, Lu Wang, Yisong Shi, Caixin Sun. Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells. Colloids and Surfaces B: Biointerface, 2006, 48: 1-5.

[04] Guanbin Song, Qing Luo, Jian Qin, Xiaodong Shen, Runbin Yan, Cai Shaoxi, Expression of integrin- bata1 and its roles on adhesion between different cyclic hepatocellular carcinoma cells(SMMC- 7721) and human umbilical vein endothelial cells. Colloids and Surfaces B: Biointerface， 2004，26 (4)：247-252.

[03] Song Guanbin, Yu Weiqun, Long Mian, Wu Zezhi, Liu Baoan, Wang Bochu, Cai Shaoxi. Investigation on the viscoelasticity of synchronous hepatocellular carcinoma cells. Colloids and Surfaces B: Biointerface, 2002, 24: 327-332.

[02] Zezhi Wu, Mian Long, Guanbin Song, Shaoxi Cai. Comparison of the viscoelastic properties of normal hepatocytes and hepatocellular carcinoma cells under cytoskeletal perturbation. Biorheology, 2000, 37: 279-290 .

[01] Xiang Wang, Zezhi Wu, Guanbin Song, Hongbing Wang, Mian Long, Shaoxi Cai. Effects of oxidative damage of membrane protein thiol groups on erythrocyte membrane viscoelasticities. Clinical Hemorheology and Microcirculation, 1999, 21: 137-146.