宋春青，河北石家莊人，博士研究生，現為西湖大學生命科學學院教師。
宋春青實驗室今後的研究方向主要包括：1）發現及鑑定新的肝癌驅動因子及其機制研究；2）運用CRISPR/Cas9基因編輯技術高效快速建立小鼠肝癌疾病模型，進而研究肝癌發病機理和鑑定潛在的藥物靶點；3）運用CRISPR/Cas9基因編輯技術糾正人體肝內的遺傳突變，進而服務人類遺傳病治療。期望本實驗室的研究能夠加速肝癌的早期標記物及藥物靶點的發現，並拓寬我們對肝癌發病機理的理解和認識。
基本介紹
- 中文名：宋春青
- 國籍：中國
- 出生地：河北石家莊
- 畢業院校：中國農業大學
- 職業：大學教師，科研工作者
- 學歷：博士研究生
個人簡介,代表論文,
個人簡介
2014年於北京生命科學研究所/中國農業大重永恥學獲得博士學位，博士期間的研究方向為線粒體蛋白組學和生物體衰老多和企講的機制研究。
2015年3月至2019年9月在麻省連悼大學醫學院漏戰道漿RNA治療研究所進行博士後研究，研究肝癌發生的分鑽店滲子機制和利用基因編輯技術糾正基因突變相關棄達鞏的遺傳病。
2019年匪糠刪10月全職加入西湖大學任特聘研究員。
代表論文
*These authors contribute equally
1.Chun-Qing Song*, Tingting Jiang*, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M Schatoffet al,“Adenine base editing in an adult mouse model of tyrosinaemia”,Nature Biomedical Engineering, 2019.
2.Chun-Qing Song, Wen Xue. “CRISPR–Cas Related Technologies in Basic and Translational Liver Research.”Nature Reviews Gastroenterology & Hepatology, 2018 May;15(5):251-252
3.Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O Connor, Qiushi Tang, Xiangrui Li, Zhiping Weng,et al. “In Vivo Genome Editing Partially Restores alpha1-Antitrypsin in a Murine Model of AAT Deficiency.”Human Gene Therapy.2018 Aug;29(8):853-860.
4.Yin Hao*,Chun-Qing Song*, Sneha Suresh, Suet-yan Kwan, and Qiongqiong Wuet al. “Partial DNA-Guided Cas9 Enables Genome Editing with Reduced off-Target Activity.”Nature Chemical Biology. 2018 Mar;14(3):311-316.
5.Chun-Qing Song*, Yingxiang Li*, Haiwei Mou, Jill Moore, Angela Park, Yotsawat Pomyen, Soren Hough,et al. “Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.”Gastroenterology2017 Apr;152(5):1161-1173.e1.
6.En-Zhi Shen*,Chun-Qing Song*, Yuan Lin*, Wen-Hong Zhang, Pei-Fang Su, Wen-Yuan Liu, Pan Zhang,et al. “Mitoflash Frequency in Early Adulthood Predicts Lifespan in Caenorhabditis elegans.”Nature2014 Apr 3;508(7494):128-32.
7.Liu, Chao*,Chun-Qing Song*, Zuo-Fei Yuan, Yan Fu, Hao Chi, Le-Heng Wang, Sheng-Bo Fan, et al. “pQuant Improves Quantitation by Keeping out Interfering Signals and Evaluating the Accuracy of Calculated Ratios.”Analytical Chemistry2014 86 (11): 5286–94.
8.Wang, Hui*, Shengcheng Han*, Wei Siao*, Chunqing Song*, Yun Xiang, Xiaorong Wu, Pengyu Cheng, et al. “Arabidopsis Synaptotagmin 2 Participates in Pollen Germination and Tube Growth and Is Delivered to Plasma Membrane via Conventional Secretion.” 2015. Molecular Plant 8 (12): 1737–50.
9.Hao Yin,Chun-Qing Song, Sneha Suresh, Qiongqiong Wu, Stephen Walsh, Luke Hyunsik Rhym, Esther Mintzer, et al. “Structure-Guided Chemical Modification of Guide RNA Enables Potent Non-Viral in Vivo Genome Editing.”Nature Biotechnology. 2017 35 (12): 1179–87.
10.Hao Yin,Chun-Qing Song, Joseph R Dorkin, Lihua J Zhu, Yingxiang Li, Qiongqiong Wu, Angela Park, et al. “Therapeutic Genome Editing by Combined Viral and Non-Viral Delivery of CRISPR System Components in Vivo.”Nature Biotechnology2016 34 (3): 328–33.
11.Wang D, Li J,Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, et al. “Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice”.Nature Biotechnology. 2018 Oct;36(9):839-842
5.Chun-Qing Song*, Yingxiang Li*, Haiwei Mou, Jill Moore, Angela Park, Yotsawat Pomyen, Soren Hough,et al. “Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.”Gastroenterology2017 Apr;152(5):1161-1173.e1.
6.En-Zhi Shen*,Chun-Qing Song*, Yuan Lin*, Wen-Hong Zhang, Pei-Fang Su, Wen-Yuan Liu, Pan Zhang,et al. “Mitoflash Frequency in Early Adulthood Predicts Lifespan in Caenorhabditis elegans.”Nature2014 Apr 3;508(7494):128-32.
7.Liu, Chao*,Chun-Qing Song*, Zuo-Fei Yuan, Yan Fu, Hao Chi, Le-Heng Wang, Sheng-Bo Fan, et al. “pQuant Improves Quantitation by Keeping out Interfering Signals and Evaluating the Accuracy of Calculated Ratios.”Analytical Chemistry2014 86 (11): 5286–94.
8.Wang, Hui*, Shengcheng Han*, Wei Siao*, Chunqing Song*, Yun Xiang, Xiaorong Wu, Pengyu Cheng, et al. “Arabidopsis Synaptotagmin 2 Participates in Pollen Germination and Tube Growth and Is Delivered to Plasma Membrane via Conventional Secretion.” 2015. Molecular Plant 8 (12): 1737–50.
9.Hao Yin,Chun-Qing Song, Sneha Suresh, Qiongqiong Wu, Stephen Walsh, Luke Hyunsik Rhym, Esther Mintzer, et al. “Structure-Guided Chemical Modification of Guide RNA Enables Potent Non-Viral in Vivo Genome Editing.”Nature Biotechnology. 2017 35 (12): 1179–87.
10.Hao Yin,Chun-Qing Song, Joseph R Dorkin, Lihua J Zhu, Yingxiang Li, Qiongqiong Wu, Angela Park, et al. “Therapeutic Genome Editing by Combined Viral and Non-Viral Delivery of CRISPR System Components in Vivo.”Nature Biotechnology2016 34 (3): 328–33.
11.Wang D, Li J,Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, et al. “Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice”.Nature Biotechnology. 2018 Oct;36(9):839-842
