宋國傑，男，英國倫敦大學 Charing Cross& Westminster醫學院心血管專業博士，美國Cincinnati大學心臟病學系博士後；中華醫學會、英國皇家醫學會、美國心臟協會、國際心臟研究學會會員。
基本介紹
- 中文名：宋國傑
- 國籍：中國
- 民族：漢族
- 職業：醫生
- 畢業院校：英國倫敦大學
- 職務： 嘉興學院醫學院院長
簡歷,教育,特長,已發表文章,已出版專業書籍,
簡歷
2006.9-至今 嘉興學院醫學院 院長
2005.8-2006.8揚州市第一人民醫院心內科副主任、中心實驗室業務指導主任、科教處副主任。
1980.9－1983.3大連醫學院心血管系碩士研究生畢業，1983.4－1987.10在天津市胸科醫院/心血管研究所心內科從事臨床工作
1987.11－1989.12英國倫敦Brompton皇家國家心肺醫院心臟科研究員
1990.1－1994.1英國倫敦大學Charing Cross & Westminster 醫學院及Westminster 醫院心臟科研究員
1994.2－1996.12美國辛辛那提大學醫學院心臟科博士後研究員
1997.1－1998.7美國辛辛那提大學醫學院心臟科高級研究員
1998.8－2005年英國倫敦大學 University College醫學院心臟科/生理系高級研究員、愛爾蘭皇家聖三一學院藥理繫心血管研究室/St Jame’s醫院心臟科高級研究員。在國外工作期間，曾經於1999-2001年協助天津胸科醫院/心血管病研究所陳樹勛教授建立天津市分子心臟病學研究中心，設計了探查MMP在心肌梗塞後心室重構中的分子機制等項目。
2002－2005年兼職任中國山東省立醫院中心實驗室主任、內科副主任、心血管中心副主任，院長特別助理，為該院建立了分子心臟病學研究室，設計開展了在細胞和分子水平研究病毒性心肌炎的科研和臨床項目。
2003－至今擔任中國人民解放軍總醫院、軍醫進修學院基礎醫學研究所分子生物學室客座研究員，合作開展了小分子熱休克蛋白HSP20基因在心臟病患者中的突變分布及其意義等項目。在國際國內學術期刊發表論文40餘篇，其中收錄SCI期刊12篇。主編《臨床分子心臟病學現代心臟病學的新領域》一書。
教育
1958.9-1964.8 天津市塘沽區明星路國小 學生
1973.9-1977.2 吉林醫學院醫療系 學生
1980.9-1983.3 大連醫學院心血管系 碩士研究生
1990.1-1994.1 英國倫敦大學Charing Cross & Westminster 醫學院心血管專業 博士研究生工作經歷
1977.3-1980.8 天津市塘沽醫院內科 住院醫師
1983.4-1987.10 天津市胸科醫院心內科 住院醫師、總住院醫師、主治醫師
1987.11-1989.12 英國倫敦Brompton醫院心臟科 研究員
1990.1-1994.1 英國倫敦大學Charing Cross & Westminster 醫學院心臟科 研究員
1994.2-1997.2 美國Cincinnati大學醫學院心臟科 博士後研究員
1997.2-1998.7 高級研究員
1998.8-2003.8 英國倫敦大學 University College醫學院內科/生理系 高級研究員
2003.9-2005.7 愛爾蘭Dublin大學TrnityCollege /St Jame’s醫院心臟科 高級研究員
2005.8-2006.8 揚州大學第二臨床醫學院心內科 副主任、中心實驗室主任、博士生導師
2006.9-至今 嘉興學院醫學院 院長
特長
1. 心血管病臨床診斷與治療
2. 心血管病基礎研究
3. 醫學心理學和臨床心理學的套用和教育
專業學會會員
1. 中華醫學會 (1985)
2. 英國皇家醫學會 (1988)
3. 美國心臟協會 (1995)
4. 國際心臟研究學會 (1995)
已發表文章
1. Continuous observing ECG PTFv1 to determine left ventricular function of patients with AMI. (心電圖PTFv1動態觀察判斷急性心肌梗塞患者左室功能的價值) 陳樹勛, 宋國傑, 梁爽霖 天津醫藥 1986;15:29
2. An echocardiographic study in AMI patients and an attempt to predict pump failure by ECHO indices (超聲心動圖預判急性心肌梗塞患者泵衰竭) 陳樹勛, 宋國傑 中華心血管病雜誌 1987;15:316
3. Using ECG Q-Tc and R wave changes to diagnose coronary artery disease (使用心電圖校正Q-T間期和R波改變診斷冠心病) 陳樹勛，宋國傑 中華心血管病雜誌 1988;16:27)
4. Left ventricular dysfunction and obstructive lung disease: an echocardiographic and angiographic study of cor pulmonale patients with decreased mitral E-F slope
Song G and Oldershaw P J International Journal of Cardiology 1989;25:47
5. Atria-ventricular interaction and the origins of "a" wave in left ventricular disease. Jones CJH, Song G ,Gibson DG British Heart Journal 1991;65(1):31
6. Myocardial ischemia in identical twins discordant for type one diabetes. Dubrey S, Song G , Akhras F, Hardman T, Noble MIM and Leslie RDG European Heart Journal 1991; (12) Supplemen:223
7. Haemodynamic and neurohumoral response in heart failure produced by rapid ventricular pacing. Travill C M, Williams T D, Pate P, Song G , Chalmers J, Lightman SL, Sutton R, Noble M I M. Cardiovascular Research 1992;26(8):783
8. Does insulin dependent diabetes (IDDM) cause myocardial ischemia: a study of 70 identical twins IDDM. Dubrey S, Akhras F, Song G , Noble M I M , et al. Clinical Science 1992;82:(3)4
9. The effects of renal denervation on the renal and humoral response to fluid load. Song G, Belcher P, Travill C M, Noble M I M , et al. European Heart Journal 1993; (14) Supplemen:1639
10. Heart failure induced by rapid ventricular pacing enhanced renin gene expression. Song G, Gao Y, Belcher P, Noble M I M, et al. European Heart Journal 1993; (14) Supplemen:413
11. Myocardial renin gene expression in heart failure induced by rapid ventricular pacing in association with renal denervation. GJ Song, Y Gao K. Kanayama, PR Belcher, S. Dubrey, M. I. M. Noble. European Heart Journal 1994; (15) Supplemen:199
12. Myocardial neuropeptide Y gene expression in heart failure induced by rapid ventricular pacing. GJ Song, Y Gao, D. Larhammar, PR Belcher, S. Dubrey, M. I. M. Noble. European Heart Journal 1994; (15) Supplemen:199
13. Exercise electrocardiography and aortic Doppler velocimetry in asymptomatic identical twins discordant for type I (insulin dependent) diabetes. Dubrey S, Akhars F, Guojie Song , Hardman T, Travill C, Hynd J, Noble MI, Lo SS, Leslie RD. British Heart Journal 1994;71(4):341
14. Depressed intracellular Ca2+ homeostasis and mechanical properties of cardiomyocytes in annexin VI transgenic mouse. Guojie Song , Ann-Marie E. Gunteski-Hamblin, Gerald W. Dorn II, Darryl L. Kirkpatrick, John R. Dedman, Richard A. Walsh. Journal of the American College of Cardiology Special Issue: 1995; 277A
15. Abnormal Na+/Ca2+ Exchanger Activity in Annexin VI Overexpression Transgenic Mice. Guojie Song , Gerald W. Dorn II, Ann-Marie E. Gunteski-Hamblin, Darryl L. Kirkpatrick, John R. Dedman, Richard A. Walsh. Journal of Molecular and Cellular Cardiology 1995; 27(6): A133
16. Unchanged intracellular Ca2+ levels and depressed mechanical properties of cardiomyocytes in myosin light chain transgenic mice. Guojie Song , Darryl L. Kirkpatrick, Gerald W. Dorn II, Joe Palermo, Jeffrey Robbins, Richard A. Walsh. Circulation 1995;92(8):I-321
17. Abnormal Na+/Ca2+ Exchanger Activity in Transgenic Mice with Cardiac Specific Overexpression of Annexin VI. Guojie Song , Darryl L. Kirkpatrick, Ann-Marie E. Gunteski-Hamblin, Gerald W. Dorn II, John R. Dedman, Richard A. Walsh. Circulation 1995;92 (8):I-697
18. Annexin VI overexpression in transgenic mouse heart alters cardiac myocyte contractile function, calcium dynamics and heart pathology. Gunteski-Hamblin AE, Guojie Song , Walsh RA, Frenzke M, Dorn II GW, Kaetzel MA, Horseman ND, Dedman JR. Am J Physiol Physiol 1996;270 (3 Pt 2):H1091-100
19. Decreased Ca2+ sensitivity: a reason for depressed mechanical properties of cardiomyocytes from myosin light chain overexpression transgenic mice. Guojie Song , Darryl L. Kirkpatrick, Gerald W. Dorn II, Jeffrey Robbins, Richard A. Walsh. Journal of the American College of Cardiology 1996;27 (2, Supplement): 277A
20. Altered protein levels of cardiac annexins in human end-stage congestive heart failure. Guojie Song , Corinn M. Pawloski-Dahm, Darryl L. Kirkpatrick, Richard A. Walsh. Circulation 1996;94 (8):I-725
21. Natriuresis caused by blood volume expansion in dogs is not mediated by the renal nerves. Drake-Holland AJ, Song G, Belcher PR, Noble MI Experiment Physiology 1996;81 (2):285
22. Down-regulated annexin VI mRNA and protein levels in guinea pigs with aortiac banding-induced heart failure. Guojie Song , Nancy Ball, John R. Dedman and Richard A. Walsh. European Heart Journal 1997; 18 (Suppl):512
23. Transcripational regulation of cardiac annexins in human end-stage congestive heart failure. Guojie Song , Begonia Campos, Lynne E. Wagoner, John R. Dedman, Richard A. Walsh. Circulation 1997;96(8):I-138
24. Altered cardiac annexin mRNA and protein levels in the left ventricle of patients with end-stage heart failure. Guojie Song , Begonia Campos, Lynne E. Wagoner, John R. Dedman, Richard A. Walsh. Journal of Molecular & Cellular Cardiology, 1998;30:443
25. Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice Pawloski-Dahm CM, Song G, Kirkpatrick DL, Palermo J, Gulick J, Dorn GW 2nd, Robbins J, Walsh RA. Circulation 1998; 97(15):150827.
26. Protein Kinase C-b2 expression and activity in non-failed and failed human hearts Nancy Bowling, Guojie Song , Richard A. Walsh, George L. King, George E Sandusky, Chris J. Vlahos. Circulation 1999;99(3):384
27. PKC translocation without changes in Gq and PLC-b protein abundance in cardiac hypertrophy and failure Jalili T, Song G , Takeishi Y, Ball NA, Howles G, Walsh RA Am J Physiol 1999 Dec;277(6 Pt 2):H2298
28. Altered mechanical properties and intracellular calcium homeostasis in cardiomy-
ocytes from mice with targeted disruption of the annexin VI Gene. Guojie Song , Sian Harding, Michael Duchen, Peter O’Gara, Tim Hawkins, Stephen Moss Circulation 1999;100(18):I762
29. Changes in Ca2+ cycling proteins underlie cardiac action potential prolongation in a pressure-overloaded guinea pig model with cardiac hypertrophy and failure. Ahmmed GU, Dong PH, Song G, Ball NA, Xu Y, Walsh RA, Chiamvimonvat N Circulation Research 2000 Mar 17;86(5):558-570
30. Increased cardiac expression of the Na+/Ca2+ exchanger may be responsible for altered myocyte intracellular Ca2+ cycling in mice with targeted disruption of the annexin-6 gene. Guojie Song , Richard E. Tunwell, Timothy E. Hawkins, Stephen E. Moss Circulation 2000;102(18): II141
31. Targeted Disruption of the Annexin 6 GeneImproves Resistanceto Hypoxia Injury in the Cardiaomyocyte. Guojie Song, Timothy E. Hawkins, Stephen E. Moss Circulation 2001;104(14): I330
32. Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. Song G, Harding SE, Duchen MR, Tunwell R, O'Gara P, Hawkins TE, Moss SE. FASEB J. 2002 Apr;16(6):622-4.
33. Increased intracellular ATP in adult mice cardiomyocytes treated with ACE inhibitor. Guojie Song , Ying Hong, John F. Martin, Jorge D. Erusalimsky Circulation 2003;Suppl 11(22): 98
34. Dynamic changes in myocardial matrix metalloproteinase activity in mice with viral myocarditis. Meng XH, Wang Y, Zhuang JX, Han XZ, Chen Y, Jin YP, Wang YL, Yu YH, Spires JP, Song GJ. Chin Med J (Engl). 2004 Aug;117(8):1195
35. Novel cardioprotective effects by the small heat shock preotein Hsp20. Fan GC, Yuan Q, Qian J, Nicolaou P, Song G, Chen G, Chu G, Kranias EG. Circulation Research, 2005, 97 (2): E18
36. Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade. Spiers JP, Kelso EJ, Siah WF, Edge G, Song G, McDermott BJ, Hennessy M. J Hypertens. 2005 Sep; 23(9):1717-24.
37. Adrenoceptor blockade alters plasma gelatinase activity in patients with heart failure and MMP-9 promoter activity in a human cell line (ECV304). Song G, Hennessy M, Zhao YL, Li Q, Han WD, Qi Y, Zhao WN, Silke B, Barry M, Doyle R, Spiers JP. Pharmacol Res. 2006 Jul;54(1):57-64.
38. Statin therapy for patients with chronic heart failure. Gong K, Song G, Zhang Z. Am J Cardiol. 2006 Sep 1;98(5):707
39. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG. Circ Res. 2006 Nov 24;99(11):1233-42.
40. Activation of immune and inflammatory systems in chronic heart failure: novel therapeutic approaches. Gong KZ, Song G, Spiers JP, Kelso EJ, Zhang ZG. Int J Clin Pract. 2007 Apr;61(4):611-21.
已出版專業書籍
宋國傑 主編：《臨床分子心臟病學¾¾現代心臟病學的新領域》
天津科技出版社出版， 2001年5月， 中國，天津
獲獎情況
1987-1988 Sino-British Scholar Fellowship (UK) 英國英中基金會學者獎
1989 Wellcome Trust Outstanding Scholar Travel Fellowship (UK)
英國 Wellcome 信託基金會學者出訪講學獎
1995 American Heart Association Research Fellowship (USA)美國心臟協會研究獎
博士論文題目
The Haemodynamic, Neurohormonal and Molecular Biological Response in Pacing-Induced Heart Failure with Renal or Cardiac Denervation
腎臟和心臟去神經時起搏誘發的心力衰竭中血液動力學、神經激素系統和分子生物學的反應性改變
