孫桂鴻

孫桂鴻，武漢大學基礎醫學院副教授 碩士生導師，學科專業：病毒學、分子生物學，研究方向：病毒與腫瘤。

基本介紹

• 中文名：孫桂鴻
• 國籍：中國
• 民族：漢
• 職業：碩士生導師，副教授
• 畢業院校：1990.9月至1994.7月在武漢大學生命科學學院學習
• 主要成就：進行病毒（特別是朊病毒）與腫瘤的關係研究

學習經歷

1990.9月至1994.7月在武漢大學生命科學學院學習， 獲理學學士學位。

2001.9-2006.6月在在武漢大學生命科學學院碩博連讀, 獲理學博士。

2008.10－2010.10 美國美國國立醫學院（National Institutes of Health）交流訪問學者。

工作經歷

社會兼職為為美州華人科學家協會會員、美國甲狀腺素學會會員。曾受邀請作為International Journal of Biomedical Science雜誌的編輯，《》等雜誌審稿專家。

研究領域

研究方向：主要從事以朊病毒(Prion)為主的神經退化性疾病的致病機制研究，通過對引起疾病的蛋白質的變構、聚集及毒性的分子機制的研究，尋找檢測與治療這類構象病的靶點；同時也進行病毒（特別是朊病毒）與腫瘤的關係研究。主持或參與國家自然科學基金、973子課題、湖北省衛生廳基金、湖北省自然科學基金等多項項目。

教學情況

承擔本科生和研究生《生物醫學研究方法與前沿技術》教學

代表性論文

近5年代表性論文（近5年第一作者或通訊作者）：

1) Guihong Sun, Rachel A. Heimeier, Liezhen Fu, Takashi Hasebe, Biswajit Das,Atsuko Ishizuya-Oka, and Yun-Bo Shi. Expression profiling of intestinal tissues implicates tissue-specific genes and pathways essential for thyroid hormone-induced adult stem cell development. Endocrinology. 2013 Nov;154(11):4396-407.

2) Thomas C. Miller, Guihong Sun, Takashi Hasebe, Liezhen Fu, Rachel A. Heimeier, Biswajit Das, Atsuko Ishizuya-Oka, Yun-Bo Shi. Tissue-Specific Upregulation of MDS/EVI Gene Transcripts in the Intestine by Thyroid Hormone during Xenopus Metamorphosis. PLoS One. 8(1):e55585, 2013.

3) Guihong Sun*, Yun-Bo Shi*. Thyroid hormone regulation of adult intestinal stem cell development: mechanisms and evolutionary conservations. Int J Biol Sci. 8(8):1217-24, 2012.

4) Fanghua Mei , Jin Xiang, Song Han, Yuan He, Yajing Lu, Jian Xu, Deyin Guo, Gengfu Xiao, Po Tien, Guihong Sun*.Expression, purification, and secondary structure characterization of recombinant KCTD1. Biochemistry (Mosc). 77(8):941-5, 2012.

5) Liezhen Fu, Guihong Sun, Maria Fiorentino, Yun-Bo Shi. Characterization of Xenopus Tissue Inhibitor of Metalloproteinases-2: A role in regulating matrix metalloproteinase activity during development. PLoS One. 7(5):e36707, 2012.

6) Tao Huang, Jian Xu, Jin Xiang, Yajing Lu, Rui Chen, Liqin Huang, Gengfu Xiao, Guihong Sun. PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP51-136 region containing octapeptide repeats. Biochem Biophys Res Commun. 2012 Jan 6;417(1):182-6

7) Jin Xiang, Guihong Sun, Hui Liu, Yong-xin Mu, Ying Liu, Fang Yang, Jian Xu, and Hong Ding, Ritonavir stimulates foam cell formation by activating PKC, Chem. Bio. Interact. 2011, 194: 127-133.

8) Guihong Sun, Takashi Hasebe, Kenta Fujimoto, Rosemary Lu, Liezhen Fu, Hiroki Matsuda, Mitsuko Kajita, Atsuko Ishizuya-Oka, Yun-Bo Shi. Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis. PLoS ONE. 2010 Oct 22;5(10):e13605.

9) Guihong Sun, Biswajit Das, Liezhen Fu and Yun-Bo Shi. Temporal and Spatio-Regulation of Tissue-Specific Thyroid Hormone Response Genes during Intestinal Metamorphosis in Xenopus Laevis. Endocrine Reviews, Supplement 1, June 2010, 31[3]: S1477