孫曉鷗,遼寧人,博士畢業於南開大學生命科學學院遺傳學與細胞生物學專業,2017年10月入職廣東工業大學,被聘為青年百人,主持廣東工業大學人才項目1項。
基本介紹
- 中文名:孫曉鷗
- 國籍:中國
- 畢業院校:南開大學
- 學位/學歷:博士
- 職業:教師
- 職務:博士生導師
- 職稱:副教授
教育背景,工作經歷,榮譽獎勵,科研成果,科研領域,主要論文,科研項目,
教育背景
2003.9-2007.6 南開大學生命科學學院,生物科學專業(本科)
2007.9-2012.6 南開大學生命科學學院,遺傳學與細胞生物學專業(碩博連讀)
2012.10-2013.10 美國艾默里(Emory)大學,病理學與實驗藥學專業,博士後
工作經歷
2014.10-2017.10 華南理工大學生物科學與工程學院,講師
2017.10至今 廣東工業大學副教授
榮譽獎勵
1.華南理工大學,2015年指導本科生國際遺傳工程機器大賽(iGEM)團隊獲得金獎
科研成果
科研領域
主要從事細胞生物學、分子生物學與生物化學等領域的教學與科研工作。研究領域包括:神經退行性疾病、中風和衰老等疾病的分子機制,特異性蛋白切割在神經元損傷中的作用及分子機制,細胞骨架與疾病等。
主要論文
1. Hao Zhang#, Jie Zan#, Kailun Zhong, Minyi Lu,Xiaoou Sun*,Wen Tan*. Neuroprotective Effects of Isosteviol Sodium through Increasing CYLD by the Downregulation miRNA-181b. Brain Research Bulletin. 2018.06, 140:392~401(影響因子:3.44)
2. Hao Zhang#,Xiaoou Sun#,Yanxiang Xie, Fang Tian, Wen Tan*. Isosteviol sodium inhibits astrogliosis after cerebral ischemia/reperfusion injury in rats. Bulletins of the Pharmaceutical Society of Japan. 2018 Apr;41(4) (影響因子:1.694)
3.Sun X, Yang Y, Xie Y, et al. Protective role of STVNa in myocardial ischemia reperfusion injury by inhibiting mitochondrial fission. Oncotarget. 2017 Dec 5;9(2):1898-1905. (影響因子:5.168)
4. Hao Zhang#,Xiaoou Sun#,Yanxiang Xie, Jie Zhan, Wen Tan*. Isosteviol Sodium Protects Against Permanent Cerebral Ischemia Injury in Mice via Inhibition of NF-κB-Mediated Inflammatory and Apoptotic Responses. Journal of Stroke and Cerebrovascular Diseases. 2017 Nov;26(11):2603-2614. (影響因子:1.598)
5. Hao Su#, Marco Pistolozzi, Xingjuan Shi,Xiaoou Sun*,Wen Tan*. Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy. Acta Biochim Biophys Sin. 2017 Nov 1;49(11):1022-1028. (影響因子:2.224)
6. Xingjuan Shi#*, Xiaoou Sun*. Regulation of paclitaxel activity by microtubule-associated proteins in cancer chemotherapy. Cancer Chemother Pharmacol. 2017 Nov;80(5):909-917.
7. Xingjuan Shi#*, Yujue Wang,Xiaoou Sun, Chan Wang, Peng Jiang, Yu Zhang, Qinghai Huang, Xiangdong Liu, Dengwen Li, Jun Zhou, Min Liu*. Centrosomal Protein 70 Is a Mediator of Paclitaxel Sensitivity. International Journal of Molecular Sciences. Jun 20;18(6). pii: E1267. (影響因子:2.808)
8. Hui Hu#,Xiao ou Sun, Fang Tian, Hao Zhang, Qing Liu, Wen Tan*. Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats. Oxidative Medicine and Cellular Longevity. 2016;2016:1379162. (影響因子:4.936)
9.Sun X,Shi X, Liu M, Li D, Zhang L, Liu X, Zhou J. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability. Cell Cycle. 2011 Nov 15; 10(22):3929-37.(影響因子:4.999)
10. Shi X,Sun X(Co-first author), Liu M, Li D, Aneja R, Zhou J. Cep70 interacts with gamma-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. The journal of biological chemistry. 2011 Sep 23;286(38):33401-8. Epub 2011 Jul 27.(影響因子:5.328)
11.Sun X, Shi X, Sun X (Co-first author), Luo Y, Wu X, Yao C, Yu H, Li D, Liu M, Zhou J. Dimethylenastron allosterically inhibits the mitotic kinesin Eg5 and suppresses pancreatic cancer cell migration and invasion. Acta Pharmacologica Sinica (2011)32:1543-1548.(影響因子:1.909)
12. Tala,Xiaoou Sun (Co-first author),Jie Chen, Linlin Zhang, Ningning Liu, Jun Zhou, Dengwen Li, Min Liu. Microtubule Stabilization by Mdp3 Is Attributed to Its Modulation of HDAC6 in Addition to Its Association with Tubulin and Microtubules. Plos One 2014 Mar 10;9(3):e90932. doi: 10.1371/journal.pone.0090932. eCollection 2014. (影響因子:4.092)
13. Huo L, Li D,Sun X, Shi X, Karna P, Yang W, Liu M, Qiao W, Aneja R, Zhou J. Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6. The journal of biological chemistry. 2011 Mar 18;286(11):9280-6. Epub 2011 Jan 10. (影響因子:5.328)
14. Huo L, Li D, Sun L, Liu M, Shi X,Sun X, Li J, Dong B, Dong X, Zhou J. Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes. The journal of pathology. 2011 Jan;223(1):28-36. (影響因子:6.466)
15. Sun L, Gao J, Huo L,Sun X, Shi X, Liu M, Li D, Zhang C, Zhou J. Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B. The journal of pathology. 2010 Aug;221(4):425-32. (影響因子:6.466)
16. Gao J, Huo L,Sun X, Liu X, Li D, Dong JT, Zhou J. The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration. The journal of biological chemistry. 2008 Apr 4; 283(14):8802-9. Epub 2008 Jan 24.(影響因子:5.328)
17. Tala, Songbo Xie, Xiaodong Sun,Xiaoou Sun, Jie Ran, Linlin Zhang, Dengwen Li, Min Liu, Gang Bao, Jun Zhou. Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis. Theranostics. 2014; 4(10): 1052–1061. (影響因子:8.022)
18. Hui Hu,Xiaoou Sun, Fang Tian, Hao Zhang, Qing Liu, Wen Tan. Neuroprotective effects of isosteviol sodium injection on acute focal cerebral ischemia in rats. Oxidative Medicine and Cellular Longevity.(2016, Accepted, 影響因子:3.516)
科研項目
2. 主持廣東工業大學青年百人人才項目
3. 主持華南理工大學生物科學與工程學院引進人才科研啟動費
4. 主持華南理工大學中央高校面上項目:“Stv1-Na保護心肌細胞抗缺血再灌注損傷的分子機制”
5. 參與973計畫:“上皮組織細胞分裂與細胞命運決定”
6. 參與973計畫:“調控細胞增殖與細胞凋亡的分子機制研究”
7. 參與國家自然基金重點項目:“微管結合蛋白EB1磷酸化的調控及功能研究”