孫文智，男，畢業於中國科學院神經科學研究所，現任北京腦科學與類腦研究中心研究員，主要研究方向為“利用形態、功能和代謝等多種手段研究長期壓力應激和抑鬱的神經機制，探求神經與精神疾病治療的新策略。”
基本介紹
- 中文名：孫文智
- 外文名：Wenzhi Sun
- 國籍：中國
- 畢業院校：2004年8月 中國科學院神經科學研究所神經生物學專業，博士學位、1999年6月 中國海洋大學海洋生物學專業，學士學位
- 職稱：研究員
人物經歷,研究方向,發表論文,授權專利,
人物經歷
2020年01月- ，首都醫科大學基礎醫學院，PI & 研究員
2018年12月- ，北京腦科學與類腦研究中心，PI & 研究員
2016年09月-2018年11月，上海科技大學 iHuman研究所，PI & 研究員
2012年05月-2016年09月，霍華德休斯醫學研究所（Howard Hughes Medical Institute）詹寧斯研究園（Janelia Research Campus），研究專員
2010年11月-2012年05月，傑克遜實驗室（Jackson Laboratory），研究員科學家
2004年12月-2010年10月，加州大學伯克利分校，博士後研究工作
2004年08月-2004年12月，中國科學院神經科學研究所，助理研究員
研究方向
實驗室發展和套用活體光學成像、神經調控、遺傳學標記與神經環路示蹤等多項環路功能研究的前沿技術回答情感和相關精神類疾病的重要科學問題，擁有國際領先且全面的光學成像儀器（雙光子顯微鏡、梯度折射透鏡、光纖光度測量）和技術手段。也將結合單細胞測序等前沿的分子生物學手段，深入研究以下重要的神經科學問題：應激與獎賞的神經環路機制、神經藥理的環路解析、神經與精神疾病治療的新策略。
發表論文
1. Zilong Gao*, Hanqing Wang*, Chen Lu, Sean Froudist-Walsh, Ming Chen, Xiao-Jing Wang#, Ji Hu#, Wenzhi Sun (2021) Neural Basis of the Delayed Gratification, bioRxiv doi: https://doi.org/10.1101/2021.03.10.434739
2. Juan Guo*, Mingzi Ran*, Zilong Gao, Xinxin Zhang, Dan Wang, Huiming Li, Shiyi Zhao, Wenzhi Sun, Hailong Dong#, Ji Hu# (2021) Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia, EBioMedicine 65, 103272.
3. Samuel Lundt*, Nannan Zhang, Jun-Liszt Li, Zhe Zhang, Li Zhang, Xiaowan Wang, Ruisi Bao, Feng Cai, Wenzhi Sun, Woo-Ping Ge, Shinghua Ding# (2021) Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways in vivo after neuronal deletion of NAMPT. Journal of Cerebral Blood Flow & Metabolism, 0271678X21992625.
4. Nanxiang Xiong*#, Xiaofei Gao*, Hongyang Zhao, Feng Cai, Fang-cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-ping Ge# (2020) Using arterial-venous analysis to characterize cancer metabolic consumption in patients. Nature Communications 11 (1), 1-9.
5. Gaolin Qiu*, Ying Wu, Zeyong Yang, Long Li, Xiaona Zhu, Yiqiao Wang, Wenzhi Sun, Hailong Dong, Yuanhai Li, Ji Hu# (2020), Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice. Anesthesiology 133: 377–392.
6. Xu Zhang*, Bo Lei*, Yuan Yuan*, Li Zhang, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong#, Ji Hu#, Hai Qi# (2020), Brain control of humoral immune responses amenable to behavioural modulation. Nature 581: 204–208.
7. Xiaofei Gao*, Zhaohuan Zhang, Tomoyuki Mashimo, Bo Shen, James Nyagilo, Hao Wang, Yihui Wang, Zhida Liu, Aditi Mulgaonkar, Xiao-Ling Hu, Sara GM Piccirillo, Ugur Eskiocak, Digant P Davé, Song Qin, Yongjie Yang, Xiankai Sun, Yang-Xin Fu, Hui Zong, Wenzhi Sun, Robert M Bachoo, Woo-ping Ge# (2020), Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles. Cell Reports 30: 2489-2500.
8. Xiao Y*, Luo H, Yang WZ, Zeng Y, Shen Y, Ni X, Shi Z, Zhong J, Liang Z, Fu X, Tu H, Sun W, Shen WL#, Hu J#, Yang J# (2020), A brain signaling framework for stress-induced depression and ketamine treatment elucidated by phosphoproteomics. Frontiers in Cellular Neuroscience 14: 48.
9. Fang Wang*, Juen Zhang, Yuan Yuan, Ming Chen, Zilong Gao, Shulu Zhan, Chengyu Fan, Wenzhi Sun, Ji Hu# (2020), Salience Processing by Glutamatergic Neurons in the Ventral Pallidum. Sci Bull 65:389-401.
10. Zheng-dong Zhao*, Zongming Chen*, Xinkuan Xiang*, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li#, Wei L Shen# (2019), Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting. Nature Neuroscience 22: 921-932.
11. Yuan, Yuan*; Wu, Wei*; Chen, Ming; Cai, Fang; Fan, Chengyu; Shen, Wei; Sun, Wenzhi; Hu, Ji#; (2019) Reward Inhibits Paraventricular CRH Neurons to Relieve Stress, Curr Biol, 2019, 2 9(7): 1243-1251.
12. Su XY*, Chen M*, Yuan Y, Li Y, Luo HQ, Sun W, Zhu MX, Liu MG#, Hu J#, Xu TL# (2019), Central processing of itch in the midbrain reward center. Neuron 102: 858-872
13. Zhou H*, Zhang S, LV F, Sun W, Wang L, Fan C, Li J# & Hu J# (2019), Citrate‐assisted efficient local delivery of naked oligonucleotide into live mouse brain cells. Cell proliferation 52: e12622.
14. Liang Y*, Sun W, Lu R, Chen M & Ji N# (2019), A distinct population of L6 neurons in mouse V1 mediate cross-callosal communication. bioRxiv 778019
15. Zhang S*, Lv F, Yuan Y, Fan C, Li J, Sun W, Hu J# (2019), Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons. Frontiers in Neuroscience 13: e565.
16. Richie CT*, Whitaker LR, Whitaker KW, Necarsulmer J, Baldwin HA, Zhang Y, Fortuno L, Hinkle JJ, Koivula P, Henderson MJ, Sun W, Wang K, Smith JC, Pickel J, N Ji, Hope BT, Harvey BK# (2017), Near-infrared fluorescent protein iRFP713 as a reporter protein for optogenetic vectors, a transgenic Cre-reporter rat, and other neuronal studies. Journal of Neuroscience Methods, 284, 1-14
17. Lu R*, W Sun, Liang Y, Kerlin A, Bierfeld J, Seelig J, Wilson V, Scholl B, Mohar B, Tanimoto M, Koyama M, Fitzpatrick D,Orger MB, Ji N# (2017), Video-rate volumetric functional imaging of the brain at synaptic resolution. Nature Neuroscience, 20, 620-628.
18. Sun W*, Tan Z, Mensh BD & Ji N # (2016), Thalamus provides layer 4 of primary visual cortex with tuned inputs. Nature Neuroscience, 19, 308-315.
(Highlighted by HHMI Research News https://www.hhmi.org/news/adaptive-optics-helps-reveal-what-eyes-tell-brain)
19. Tan Z*, Sun W, Chen TW, Kim D & Ji N# (2015) Stimulus Feature Selectivity for Ultraviolet Light in Mouse Primary Visual Cortex. Scientific Reports, 5: 12597. doi: 10.1038/srep12597.
20. Wang K*, Sun W*, Richie CT, Harvey BK, Betzig E & Ji N# (2015), Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue. Nature Communications, 6:7276. doi: 10.1038/ncomms8276.
21. Wang C*, Liu R*, Milkie DE, Sun W , Tan Z, Kerlin A, Chen TW, Kim DS & Ji N# (2014) Multiplexed aberration measurement for deep tissue imaging in vivo. Nature Methods, 11: 1037–1040
22. Sun W*, Wagnon JL, Mahaffey CL, Briese M, Ule J & Frankel WN# (2013) Aberrant Sodium Channel Activity in the Complex Seizure Disorder of Celf4 Mutant Mice. Journal of Physiology, 591:241-255, (Highlighted in Future Neurology, 8(3):255-257)
23. Wagnon JL*, Briese M*, Sun W, Mahaffey CL, Li Y, Curk Y, Rot G, Lin D, Ule J & Frankel WN# (2012) CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function. PLoS Genetics, 8 (11), e1003067.
24. Wagnon JL*, Mahaffey CL, Sun W, Yang Y, Chao HT & Frankel WN# (2011) Etiology of a Genetically Complex Seizure Disorder in Celf4 Mutant Mice. Gene, Brain and Behavior, 10:765-777.
25. Sun W* & Dan Y# (2009) Layer-Specific Network Oscillation and spatiotemporal Receptive Field in the Visual Cortex, Proceedings of the National Academy of Sciences, 106:17986-17991.
26. Sun W*, Deng Q* & He S# (2006), ON direction-selective ganglion cells in the mouse retina. Journal of Physiology, 576:197-202.
27. Weng S*, Sun W & He S# (2005) Identification of ON-OFF direction-selective ganglion cells in the mouse retina. Journal of Physiology, 562: 915 – 923.
28. Diao L*, Sun W, Deng Q & He S# (2004) Development of the mouse retina: emerging morphological diversity of the ganglion cells. Journal of Neurobiology, 61: 236-249.
29. Dong W, Sun W, Zhang Y, Chen X & He S# (2004) Dendritic relationship between starburst amacrine cells and direction-selective ganglion cells in the rabbit retina. Journal of Physiology, 556: 11-17.
30. He S, Dong W, Deng Q, Weng S & Sun W (2003) Seeing More Clearly: Recent Advances in Understanding Retinal Circuitry. Science, 302:408-411. (Review)
31. Sun W, Li N & He S (2002) Large-scale morphological survey of rat retinal ganglion cells. Visual Neuroscience, 19:483-493.
32. Sun W*, Li N & He S# (2002) Large-scale morphological survey of mouse retinal ganglion cells. Journal of Comparative Neurology, 451:115-126.
*: first author; # corresponding author.
授權專利
1. 孫文智，一種小鼠立體定位儀，專利號：ZL2018209323416（實用新型）
2. 孫文智，一種毛細玻璃電極研磨儀，專利號：ZL2018211576367（實用新型）
3. 孫文智，一種小鼠通用氣體麻醉面罩組件，專利號：ZL2018221746693.9（實用新型）
4. 孫文智，一種情形小鼠頭部固定儀，專利號：ZL201821746677.X（實用新型）
5. 孫文智，一種陶瓷插芯固定器，專利號：ZL201821746691.X（實用新型）
6. 孫文智，一種微透鏡埋植準直儀，專利號：2019200280509（實用新型）
