姚建莊，男，博士，濟南大學講師。
基本介紹
- 中文名：姚建莊
- 學位/學歷：博士
- 職業：教師
- 專業方向：酶反應機理和酶的再設計（大分子製藥）
- 任職院校：濟南大學
個人經歷,主講課程,研究方向,學術成果,
個人經歷
教育經歷：
2009.08-2014.07：美國田納西大學，生物化學和分子，細胞生物學系，博士
2006.09-2009.07：首都師範大學，細胞生物學，碩士
2002.09-2006.07：大連大學，生物工程，學士
工作經歷：
2016.09-至今：濟南大學，生物科學與技術學院，講師
2014.08-2016-07：博士後，美國肯塔基大學，藥學院
主講課程
承擔本科生課程：生物化學、生物物理、結構生物學
承擔研究生課程：數值分析
研究方向
酶反應機理和酶的再設計（大分子製藥）
學術成果
1.Yao, J.（通訊作者）, et al., Understanding the catalytic mechanism and the substrate specificity of an engineered gluten hydrolase by QM/MM MD and free energy simulations. Journal of Chemical Information and Modeling, 2017.DOI:10.1021/acs.jcim.7b00167
2.Yao, J., et al., Unexpected Reaction Pathway for butyrylcholinesterase-catalyzed inactivation of “hunger hormone” ghrelin. Scientific Reports, 2016. 6: p. 22322.
3.Yao, J., H. Guo, and X. Yang, PPCM: Combing Multiple Classifiers to Improve Protein-Protein Interaction Prediction. International Journal of Genomics, 2015. 2015: p. 7.
4.Yao, J., et al., Substrate-Assisted Catalysis in the Reaction Catalyzed by Salicylic Acid Binding Protein 2 (SABP2), a Potential Mechanism of Substrate Discrimination for Some Promiscuous Enzymes. Biochemistry, 2015. 54(34): p. 5366-5375.
5.Yao, J., Q. Xu, and H. Guo, QM/MM and Free-Energy Simulations of Deacylation Reaction Catalysed by Sedolisin, a Serine-Carboxyl Peptidase. Molecular Simulation, 2013. 39(3): p. 206-213.
6.Yao, J., A. Wlodawer, and H. Guo, Understanding the Autocatalytic Process of Pro-Kumamolisin Activation from Molecular Dynamics and Quantum Mechanical/Molecular Mechanical (QM/MM) Free-Energy Simulations. Chemistry-A European Journal, 2013. 19(33): p. 10849-10852.
7.Yao, J., et al., Understanding Product Specificity of Protein Lysine Methyltransferases from QM/MM Molecular Dynamics and Free Energy Simulations: The Effects of Mutation on SET7/9 beyond the Tyr/Phe Switch. Journal of chemical information and modeling, 2012. 52(2): p. 449-456.
8.Yao, J., et al., Stability and sugar recognition ability of ricin-like carbohydrate binding domains. Biochemistry, 2011. 50(19): p. 4097-4104.
9.Yao, J., et al., QM/MM Free Energy Simulations of Salicylic Acid Methyltransferase: Effects of Stabilization of TS-like Structures on Substrate Specificity. The Journal of Physical Chemistry B, 2010. 115(2): p. 389-396.
