夏玉先，1964年生，重慶大學生命科學學院教授（二級）、博士生導師、生物學一級學科博士點學術帶頭人、教育部“新世紀優秀人才”、重慶市百名傑出科技領軍人才、重慶市微生物學科帶頭人、《中國生物防治學報》副主編、農業農村部專家指導委員會委員、國家標準委員會生物農藥分委會副秘書長。現任重慶大學基因工程研究中心主任、重慶市“殺蟲真菌農藥工程技術研究中心”主任、重慶市功能基因與調控技術重點實驗室主任。主要從事殺蟲真菌農藥研製相關的基礎研究和套用技術研究。先後主持國家級和省部級科研、中試和產業化項目20多項；主持完成的研究成果獲2009年度重慶市技術發明一等獎和2010年獲中國僑界貢獻獎（創新成果），獲得國家發明專利20項。以第一或通訊作者在PLoS Genetics, Environmental Microbiology, Microbiology-SGM, BMC Genomics，Applied Microbiology and Biotechnology等著名學術刊物發表SCI收錄論文60多篇；獲得國家發明專利20項。
基本介紹
- 中文名：夏玉先
- 畢業院校：英國Bath大學
- 學位/學歷：博士
- 專業方向：分子微生物學、昆蟲病理學、微生物分子育種
- 職務：重慶大學基因工程研究中心主任
人物經歷,學習經歷,工作經歷,研究方向,主講課程,學術兼職,發表論文,獲獎記錄,
人物經歷
學習經歷
1997-2000 英國Bath大學 獲博士學位（英國海外研究學生獎學金）
1988-1991 西南農業大學 獲碩士學位
1981-1985 四川農業大學 獲學士學位
1988-1991 西南農業大學 獲碩士學位
1981-1985 四川農業大學 獲學士學位
工作經歷
1996-1997 英國Bath大學訪問學者（中英友好獎學金）
1991-1997 西南大學 歷任助教、講師、副教授
2000-至今 重慶大學 教授
1991-1997 西南大學 歷任助教、講師、副教授
2000-至今 重慶大學 教授
研究方向
分子微生物學、昆蟲病理學、微生物分子育種。
圍繞殺蟲真菌農藥創製，以綠僵菌和東亞飛蝗為模式，開展昆蟲病原真菌重要性狀（產孢、致病、抗逆）形成的分子機制，發掘功能基因及調控方法（分子微生物學方向）；闡明昆蟲防衛病原真菌侵染的分子機制，發現新的殺蟲靶標及害蟲防控新途徑（昆蟲病理學方向）；開展殺蟲真菌菌株選育新技術研究，選育高產、抗逆和高殺蟲活性的菌株（微生物分子育種方向）。
圍繞殺蟲真菌農藥創製，以綠僵菌和東亞飛蝗為模式，開展昆蟲病原真菌重要性狀（產孢、致病、抗逆）形成的分子機制，發掘功能基因及調控方法（分子微生物學方向）；闡明昆蟲防衛病原真菌侵染的分子機制，發現新的殺蟲靶標及害蟲防控新途徑（昆蟲病理學方向）；開展殺蟲真菌菌株選育新技術研究，選育高產、抗逆和高殺蟲活性的菌株（微生物分子育種方向）。
主講課程
博士研究生：生物科學研究前沿
碩士研究生：專業英語
本科生：發酵工程學
碩士研究生：專業英語
本科生：發酵工程學
學術兼職
《中國生物防治學報》副主編
中國留學基金委終身評審。
中國留學基金委終身評審。
發表論文
【1】Zhang E。 , Cao Y., Xia Y。 Ethanol dehydrogenase I contributes to growth and sporulation under low oxygen condition via detoxification of
acetaldehyde in Metarhiziumacridum，Front. Microbiol.2018，9:1932
【2】Li G., Fan A., Peng G., Keyhani NO., Xin J., Cao Y. Xia Y，A bifunctional catalase-peroxidase, MakatG1, contributes to virulence of
Metarhizium acridum by overcoming oxidative stress on the host insect cuticle，Environ Microbiol，2017,19(10): 4365–4378
【3】Zhang W, Chen J, Keyhani NO, Jin K, Wei Q, Xia Y，Central Nervous System Responses of the Oriental migratory, Locusta migratoria manilensis,
to Fungal Infection.Sci Rep.2017 ;7(1):1034
【4】Zhang J,Jin K, Xia Y,Contributions of β-tubulin to cellular morphology, sporulation and virulence in the insect-fungal pathogen, Fungal Genet
Biol.2017, 103:16-24
【5】Hong M.，Peng G., Keyhani NO, Xia Y.Application of the entomogenous fungus, Metarhizium anisopliae, for leafroller (Cnaphalocrocis medinalis)
control and its effect on rice phyllosphere microbial diversity，Appl Microbiol Biotechnol，2017,101:6793–6807
【6】Hu J, Xia Y.Increased virulence in the locust-specific fungal pathogen Metarhizium acridum expressing dsRNAs targeting the host F1 F0 -ATPase
subunit genes.Pest Manag Sci，2018 May 23. doi: 10.1002/ps.5085
【7】Hu J, Xia Y.F1-ATP synthase α subunit: a potential target for RNAi-mediated pest management of Locusta migratoria manilensis.Pest Manag
Sci2016, 72:1433- 1439
【8】 Wang ZL, Jin K, Xia YX. Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in
response to different nutrients. BMC Genomics. 2016, 17: 586.
【9】 Zhang W., Wanchoo A., Ortiz-Urquiza., Yuxian Xia, and Nemat O. Keyhani. Tissue, developmental, and caste-specific expression of
odorant binding proteins in a eusocial insect, the red imported fire ant, Solenopsis invicta. Scientific Reports, 2016, 6.
【10】 Jin K, Peng GX, Liu YC, Xia YX. The acid trehalase, ATM1, contributes to the in vivo growth and virulence of the entomopathogenic fungus,
Metarhizium acridum. Fungal Genetics and Biology. 2015, 77: 61-67.
【11】 Ma QS, Jin K, Peng GX, Xia YX. An ENA ATPase, MaENA1, of Metarhizium acridum influences the Nai+-, thermo- and UV-tolerances of conidia and
is involved in multiple mechanisms of stress tolerance. Fungal Genetics and Biology.2015, 83: 68-77.
【12】 Peng GX, Jin K, Liu YC, Xia YX. Enhancing the utilization of host trehalose by fungal trehalase improves the virulence of fungal
insecticide. Applied Microbiology and Biotechnology. 2015, 99(20):8611-8618.
【13】 Zhang W, Chen J, Keyhani NO, Zhang Z, Li S, Xia Y. Comparative transcriptomic analysis of immune responses of the migratory locust, Locusta
migratoria, to challenge by the fungal insect pathogen, Metarhizium acridum. BMC genomics 2015, 16: 867-
【14】 Ming Y, Wei QL, Jin K, Xia YX. MaSnf1, a sucrose non-fermenting protein kinase gene, is involved in carbon source utilization, stress
tolerance and virulence in Metarhizium acridum. Applied Microbiology and Biotechnology. 2014, 98: 10153-10164.
【15】 Cao Y., Du M., Luo S., Xia Y. Calcineurin modulates growth, stress tolerance, and virulence in Metarhizium acridum and its regulatory
network. Applied Microbiology and Biotechnology. 2014, 98: 8253-8265
【16】 Zhang W., Xia Y. ER type I signal peptidase subunit (LmSPC1) is essential for the survival of Locusta migratoria manilensis and
affects moulting, feeding, reproduction and embryonic development. Insect molecular biology, 2014, 23(3): 269-285.
【17】 Jin K, Han LR, and Xia YX. MaMk1, a FUS3/KSS1-type mitogen-activated protein kinase gene, is required for appressorium formation, and
insect cuticle penetration of the entomopathogenic fungus Metarhizium acridum. Journal of Invertebrate Pathology. 2014, 115(1): 68-75.
【18】 Luo S., He M, Cao Y, Xia Y. The tetraspanin gene MaPls1 contributes to virulence by affecting germination, appressorial function and
enzymes for cuticle-degradation in the entomopathogenic fungus, Metarhizium acridium. Environmental Microbiology 2013, 15 (11): 2966-2979.
【19】 Jin K, Ming Y, and Xia YX. MaHog1, a Hog1-type mitogen-activated protein kinase gene, contributes to stress tolerance and virulence of the
entomopathogenic fungus Metarhizium acridum. Microbiology-SGM. 2012, 158(12): 2987-2996.
[【20】 Cao Y., Zhu X., Jiao R., Xia Y. The Magas1 gene is involved in pathogenesis by affecting penetration in Metarhizium acridum. Journal of
Microbio1ogy and Biotechnology. 2012, 22: 889–893 .
【21】 Cao Y., Jiao R., Xia Y. A strong promoter, PMagpd, provides a tool for high gene expression in entomopathogenic fungus, Metarhizium acridum.
Biotechnology letters, 2012, 34: 557 – 562.
【22】 Gao Q, Jin K, Ying S, Zhang Y, Xiao G, Shang Y, Duan Z, Hu X, Xie X, Zhou G, Peng G, Luo Z, Huang W, Wang B, Fang W, Wang S, Zhong Y, Ma L,
St. Leger RJ, Zhao G, Pei Y, Feng M*, Xia Y*, Wang C* Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi
Metarhizium anisopliae and M. acridum. PLoS Genet., 2011, 7: e1001264.
【23】 Jin K, Zheng X, Xia Y. Gene expression profiling via multigene concatemers. PLoS One. 2011, 6:e15711.
【24】 Cao Y., Li M., Xia Y. Mapmi contributes to growth, stress tolerance and virulence of the entomopathogenic fungus Metarhizium acridum, J.
Invert. Pathol., 2011, 108: 7-12.
【25】 Cao Y., Li K., Xia Y. Down-regulation of the pre-rRNA processing gene Mamrd1 decreases growth and virulence in the entomopathogenic fungus,
Metarhizium acridum. Res Microbiol, 2011, 162: 729-736.
【26】 Yang M, Jin K, Xia Y. MaFKS, a β-1,3-glucan synthase, is involved in cell wall integrity, hyperosmotic pressure tolerance and conidiation
in Metarhizium acridum. Curr Genet., 2011, 57:253-260.
【27】 Zheng XL. Xia YX. β-1,3-Glucan recognition protein (βGRP) is essential for resistance against fungal pathogen and opportunistic
pathogenic gut bacteria in Locusta migratoria manilensis. Developmental & Comparative Immunology, 2011, 36(3):602-609.
【28】 Leng YJ, Peng GX, Cao YQ, Xia YX (2011) Genetically altering the expression of neutral trehalase gene affects conidiospore thermotolerance
of the entomopathogenic fungus Metarhizium acridum. BMC Microbiology. 2011, 11:32
【39】 Zhang S, Xia Y, Kim B Keyhani NO. Two hydrophobins are involved in fungal spore coat rodlet layer assembly and each play distinct roles in
surface interactions, development and pathogenesis in the entomopathogenic fungus, Beauveria bassiana. Mol. Microbiol. 2011, 80:811-826.
【30】 Zhang C, Xia Y, Li Z. Identification of genes differentially expressed by Metarhizium anisopliae growing on Locusta migratoria wings using
suppression subtractive hybridization. Curr Microbiol. 2011, 62(5):1649-55.
【31】 Zhou X, Xia Y. Expression and characterization of recombinant Locusta migratoria manilensis acetylcholinesterase 1 in Pichia pastoris.
Protein Expr Purif. 2011, 77:62-67.
【32】 Peng GX, Xia YX. The mechanism of the mycoinsecticide diluent on the efficacy of the oil formulation of insecticidal fungus. Biocontrol,
2011, 56:893–902
acetaldehyde in Metarhiziumacridum，Front. Microbiol.2018，9:1932
【2】Li G., Fan A., Peng G., Keyhani NO., Xin J., Cao Y. Xia Y，A bifunctional catalase-peroxidase, MakatG1, contributes to virulence of
Metarhizium acridum by overcoming oxidative stress on the host insect cuticle，Environ Microbiol，2017,19(10): 4365–4378
【3】Zhang W, Chen J, Keyhani NO, Jin K, Wei Q, Xia Y，Central Nervous System Responses of the Oriental migratory, Locusta migratoria manilensis,
to Fungal Infection.Sci Rep.2017 ;7(1):1034
【4】Zhang J,Jin K, Xia Y,Contributions of β-tubulin to cellular morphology, sporulation and virulence in the insect-fungal pathogen, Fungal Genet
Biol.2017, 103:16-24
【5】Hong M.，Peng G., Keyhani NO, Xia Y.Application of the entomogenous fungus, Metarhizium anisopliae, for leafroller (Cnaphalocrocis medinalis)
control and its effect on rice phyllosphere microbial diversity，Appl Microbiol Biotechnol，2017,101:6793–6807
【6】Hu J, Xia Y.Increased virulence in the locust-specific fungal pathogen Metarhizium acridum expressing dsRNAs targeting the host F1 F0 -ATPase
subunit genes.Pest Manag Sci，2018 May 23. doi: 10.1002/ps.5085
【7】Hu J, Xia Y.F1-ATP synthase α subunit: a potential target for RNAi-mediated pest management of Locusta migratoria manilensis.Pest Manag
Sci2016, 72:1433- 1439
【8】 Wang ZL, Jin K, Xia YX. Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in
response to different nutrients. BMC Genomics. 2016, 17: 586.
【9】 Zhang W., Wanchoo A., Ortiz-Urquiza., Yuxian Xia, and Nemat O. Keyhani. Tissue, developmental, and caste-specific expression of
odorant binding proteins in a eusocial insect, the red imported fire ant, Solenopsis invicta. Scientific Reports, 2016, 6.
【10】 Jin K, Peng GX, Liu YC, Xia YX. The acid trehalase, ATM1, contributes to the in vivo growth and virulence of the entomopathogenic fungus,
Metarhizium acridum. Fungal Genetics and Biology. 2015, 77: 61-67.
【11】 Ma QS, Jin K, Peng GX, Xia YX. An ENA ATPase, MaENA1, of Metarhizium acridum influences the Nai+-, thermo- and UV-tolerances of conidia and
is involved in multiple mechanisms of stress tolerance. Fungal Genetics and Biology.2015, 83: 68-77.
【12】 Peng GX, Jin K, Liu YC, Xia YX. Enhancing the utilization of host trehalose by fungal trehalase improves the virulence of fungal
insecticide. Applied Microbiology and Biotechnology. 2015, 99(20):8611-8618.
【13】 Zhang W, Chen J, Keyhani NO, Zhang Z, Li S, Xia Y. Comparative transcriptomic analysis of immune responses of the migratory locust, Locusta
migratoria, to challenge by the fungal insect pathogen, Metarhizium acridum. BMC genomics 2015, 16: 867-
【14】 Ming Y, Wei QL, Jin K, Xia YX. MaSnf1, a sucrose non-fermenting protein kinase gene, is involved in carbon source utilization, stress
tolerance and virulence in Metarhizium acridum. Applied Microbiology and Biotechnology. 2014, 98: 10153-10164.
【15】 Cao Y., Du M., Luo S., Xia Y. Calcineurin modulates growth, stress tolerance, and virulence in Metarhizium acridum and its regulatory
network. Applied Microbiology and Biotechnology. 2014, 98: 8253-8265
【16】 Zhang W., Xia Y. ER type I signal peptidase subunit (LmSPC1) is essential for the survival of Locusta migratoria manilensis and
affects moulting, feeding, reproduction and embryonic development. Insect molecular biology, 2014, 23(3): 269-285.
【17】 Jin K, Han LR, and Xia YX. MaMk1, a FUS3/KSS1-type mitogen-activated protein kinase gene, is required for appressorium formation, and
insect cuticle penetration of the entomopathogenic fungus Metarhizium acridum. Journal of Invertebrate Pathology. 2014, 115(1): 68-75.
【18】 Luo S., He M, Cao Y, Xia Y. The tetraspanin gene MaPls1 contributes to virulence by affecting germination, appressorial function and
enzymes for cuticle-degradation in the entomopathogenic fungus, Metarhizium acridium. Environmental Microbiology 2013, 15 (11): 2966-2979.
【19】 Jin K, Ming Y, and Xia YX. MaHog1, a Hog1-type mitogen-activated protein kinase gene, contributes to stress tolerance and virulence of the
entomopathogenic fungus Metarhizium acridum. Microbiology-SGM. 2012, 158(12): 2987-2996.
[【20】 Cao Y., Zhu X., Jiao R., Xia Y. The Magas1 gene is involved in pathogenesis by affecting penetration in Metarhizium acridum. Journal of
Microbio1ogy and Biotechnology. 2012, 22: 889–893 .
【21】 Cao Y., Jiao R., Xia Y. A strong promoter, PMagpd, provides a tool for high gene expression in entomopathogenic fungus, Metarhizium acridum.
Biotechnology letters, 2012, 34: 557 – 562.
【22】 Gao Q, Jin K, Ying S, Zhang Y, Xiao G, Shang Y, Duan Z, Hu X, Xie X, Zhou G, Peng G, Luo Z, Huang W, Wang B, Fang W, Wang S, Zhong Y, Ma L,
St. Leger RJ, Zhao G, Pei Y, Feng M*, Xia Y*, Wang C* Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi
Metarhizium anisopliae and M. acridum. PLoS Genet., 2011, 7: e1001264.
【23】 Jin K, Zheng X, Xia Y. Gene expression profiling via multigene concatemers. PLoS One. 2011, 6:e15711.
【24】 Cao Y., Li M., Xia Y. Mapmi contributes to growth, stress tolerance and virulence of the entomopathogenic fungus Metarhizium acridum, J.
Invert. Pathol., 2011, 108: 7-12.
【25】 Cao Y., Li K., Xia Y. Down-regulation of the pre-rRNA processing gene Mamrd1 decreases growth and virulence in the entomopathogenic fungus,
Metarhizium acridum. Res Microbiol, 2011, 162: 729-736.
【26】 Yang M, Jin K, Xia Y. MaFKS, a β-1,3-glucan synthase, is involved in cell wall integrity, hyperosmotic pressure tolerance and conidiation
in Metarhizium acridum. Curr Genet., 2011, 57:253-260.
【27】 Zheng XL. Xia YX. β-1,3-Glucan recognition protein (βGRP) is essential for resistance against fungal pathogen and opportunistic
pathogenic gut bacteria in Locusta migratoria manilensis. Developmental & Comparative Immunology, 2011, 36(3):602-609.
【28】 Leng YJ, Peng GX, Cao YQ, Xia YX (2011) Genetically altering the expression of neutral trehalase gene affects conidiospore thermotolerance
of the entomopathogenic fungus Metarhizium acridum. BMC Microbiology. 2011, 11:32
【39】 Zhang S, Xia Y, Kim B Keyhani NO. Two hydrophobins are involved in fungal spore coat rodlet layer assembly and each play distinct roles in
surface interactions, development and pathogenesis in the entomopathogenic fungus, Beauveria bassiana. Mol. Microbiol. 2011, 80:811-826.
【30】 Zhang C, Xia Y, Li Z. Identification of genes differentially expressed by Metarhizium anisopliae growing on Locusta migratoria wings using
suppression subtractive hybridization. Curr Microbiol. 2011, 62(5):1649-55.
【31】 Zhou X, Xia Y. Expression and characterization of recombinant Locusta migratoria manilensis acetylcholinesterase 1 in Pichia pastoris.
Protein Expr Purif. 2011, 77:62-67.
【32】 Peng GX, Xia YX. The mechanism of the mycoinsecticide diluent on the efficacy of the oil formulation of insecticidal fungus. Biocontrol,
2011, 56:893–902
獲獎記錄
2009年主持完成的研究成果獲重慶市技術發明一等獎；
2010年獲中國僑界貢獻獎（創新成果）。
