夏煒，男，1984年9月生，江西省景德鎮市人，博士，中山大學化學學院副教授、碩士生導師。
基本介紹
- 中文名：夏煒
- 國籍：中國
- 民族：漢
- 出生地：江西省景德鎮市
- 出生日期：1984年9月
- 職業：教師
- 畢業院校：香港大學
- 學位/學歷：博士
- 專業方向：生物無機化學方向
- 任職院校：中山大學
人物經歷,教育經歷,工作經歷,講授課程,科研方向,學術成果,
人物經歷
教育經歷
2002年09月—2006年07月 北京大學生命科學學院，生物科學專業，獲學士學位；
2006年11月—2011年11月 香港大學化學系，化學生物學專業， 獲博士學位。
工作經歷
2011年9月—2014年10月 哈佛大學醫學院/波士頓兒童醫院，博士後；
2014年11月至今 中山大學化學與化學工程學院，副教授，碩士生導師。
講授課程
化學生物學導論，配位化學（研究生），普通化學實驗，有機化學實驗
科研方向
生物無機化學方向：金屬抗菌、抗癌藥物設計合成及作用機理研究；小分子藥物靶點結構生物學研究。
學術成果
參與撰寫書章節：
1.“Nickel Metallochaperones: Structure, Function and Nickel-binding Properties.” W Xia*, H Li, H Sun*, The Biological Chemistry of Nickel; The Royal Society of Chemistry: 2017; pp 284-305.
2. “Competition for Iron between Host and Pathogen: A Case Study on Helicobacter pylori.” W. Xia*, Methods Mol. Biol., 2017, 1535, 65-75
綜述:
1.“Exploration into the nickel ‘Microcosmos’ in prokaryotes” T. Cheng, H. Li, W. Xia, L. Jin and H. Sun*, Coord. Chem. Rev., 2016, 311, 24-37.
發表文章 (*通訊作者）：
2017年：
4. “Bismuth-induced Inactivation of Ferric Uptake Regulator from Helicobacter pylori.” X He, X Liao, H Li, W Xia*, H Sun*, Inorg. Chem., 2017, 56, 15041-15048
3. “Targeting the Thioredoxin Reductase-Thioredoxin System from Staphylococcus aureus by Silver Ions.” X Liao, F Yang, H Li, PK So, Z Yao, YT, W Xia*, H Sun*, Inorg. Chem., 2017, 56, 14823-14830
2. “Identification of Catabolite Control Protein A from Staphylococcus aureus as a Target of Silver Ions.” X Liao, F Yang, R Wang, X He, H Li, YT Richard, W Xia*, H Sun*, Chem. Sci., 2017, 8, 8061-8066
1. “Integrative approach for the analysis of the proteome-wide response to bismuth drugs in Helicobacter pylori” Y Wang, L Hu, F Xu, Q Quan, YT Lai, W Xia, Y Yang, YY Chang, X Yang, Z Chai, J Wang, IK Chu, H Li, H Sun*, Chem. Sci., 2017, 8, 4626-4633
博士、博士後期間發表文章：
11. “Relating conformation to function in integrin α5β1.” Y. Su#, W. Xia#, J. Li, T. Walz, M. J. Humphries, D. Vestweber, C. Cabanas, C. Lu and T. A. Springer*, Proc. Natl. Acad. Sci. USA, 2016, 113, E3872-3881. (#: Co-first authors)
10. “Metal ion and ligand binding of integrin α5β1.” W. Xia and T. A. Springer*, Proc. Natl. Acad. Sci. USA, 2014, 111, 17863-17868.
9. “Functional disruption of HypB, a GTPase of Helicobacter pylori by bismuth.” W. Xia, H. Li and H. Sun*, Chem. Commun., 2014, 50, 1611-1614.
8. “Histidine-rich Proteins in Prokaryotes: Metal Homeostasis and Environmental Habitat-related Occurrence.” T. Cheng#, W. Xia#, P. Wang, F. Huang, J. Wang and H. Sun*, Metallomics, 2013, 5, 1423-1429. (#: Co-first authors)
7. “Metallo-GTPase HypB from Helicobacter pylori and Its Interaction with Nickel Chaperone Protein HypA.” W. Xia, H. Li, X. Yang, K.-B. Wong and H. Sun*, J. Biol. Chem., 2012, 287, 6753-6763.
6. “Structure of a Nickel Chaperone, HypA, from Helicobacter pylori Reveals Two Distinct Metal Binding Sites.”W. Xia, H. Li, K.-H. Sze and H. Sun*, J. Am. Chem. Soc., 2009, 131, 10031-10040.
5."Conformational equilibria and intrinsic affinities define integrin activation" J. Li, Y. Su, W. Xia, Y. Qin, M.J. Humphries, D. Vestweber, C. Cabañas, C. Lu, T. A. Springer*, EMBO J., 2017, 2017, 36, 629-645
4. “Nickel translocation between metallochaperones HypA and UreE in Helicobacter pylori.” X. Yang, H. Li, T. Cheng, W. Xia, Y.-T. T. Lai and H. Sun*, Metallomics, 2014, 6, 1731-1736.
3. “Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking.” T. Cheng, H. Li, X. Yang, W. Xia and H. Sun*, Metallomics, 2013, 5, 804-807.
10.“Multifaceted SlyD from Helicobacter pylori: implication in [NiFe] hydrogenase maturation.” T. Cheng, H. Li, W. Xia and H. Sun*, J. Biol. Inorg. Chem., 2011, 17, 331-343.
2. “Solution structure of GSP13 from Bacillus subtilis exhibits an S1 domain related to cold shock proteins.” W. Yu, J. Hu, B. Yu, W. Xia, C. Jin and B. Xia*, J. Biomol. NMR, 2009, 43, 255-259.
1. “1H, 13C, and 15N resonance assignments of a general stress protein GSP13 from Bacillus subtilis.” W. Yu, B. Yu, J. Hu, W. Xia, C. Jin and B. Xia*, Biomo.l NMR Assign., 2008, 2, 163-165.
