夏強(浙江大學醫學院教授)

夏強，男，1961年2月出生，浙江蕭山人，內科學博士、教授、博導，是浙江大學醫學院生理學系主任。

基本介紹

• 中文名：夏強
• 國籍：中國
• 民族：漢
• 出生地：浙江蕭山
• 出生日期：1961年2月
• 職業：教師
• 畢業院校：浙江大學

人物經歷

1983-1987 助教，浙江醫科大學生理學教研室。

1987-1992 講師，浙江醫科大學生理學教研室，室主任。

1992-1996 副教授，浙江醫科大學生理學教研室，室主任。

浙江大學教授夏強

1991-1992, 1995, 1996 訪問學者，香港大學生理系。

1996-1998 教授，浙江醫科大學生理學教研室，室主任。

1998- 教授，浙江大學醫學院生理學系，系主任。

2000.1-2000.9 德國基爾大學醫學院，高訪。

中國生理學會常務理事，中國生理學會血液循環專業委員會副主任委員、外事工作委員會委員、教育工作委員會委員、青年工作委員會委員、儀器工作委員會主任委員。浙江省生理科學會副理事長兼秘書長。《生理學報》常務編委、《中國套用生理學雜誌》、《浙江大學學報（醫學版）》編委，《生理通訊》副主編。

研究方向

1、細胞應激與細胞保護機制；

2、心血管系統細胞因子網路；

3、心肌主動與被動電學特性；

4、心肌/腦缺血與復灌損傷機制以及對抗措施研究；

5、糖尿病性血管功能障礙機制以及防治。

主要貢獻

1.Xia Q, Tai KK, Wong TM. Chronic morphine treatment increases the number, but decreases the affinity of [3H]-U69,593 binding sites in the rat heart.

Life Sci. 1992;50(16):1143-8.

2.Xia Q, Sheng JZ, Tai KK, Wong TM. Effects of chronic U50,488H treatment on binding and mechanical responses of the rat hearts.

J Pharmacol Exp Ther. 1994 Feb;268(2):930-4.

3.Xia Q, Zhang WM, Shen YL, Wong TM. Decreased affinity of K-receptor binding during reperfusion following ischaemic preconditioning in the rat heart.

Life Sci. 1996;58(16):1307-13.

4.Zhang WM, Wang HX, Xia Q, Wong TM. Inhibition of [3H]-U69593 binding and the cardiac effects of U50, 488H by calcium channel blockers in the rat heart.

Br J Pharmacol. 1997 Mar;120(5):827-32.

5.Cao CM, Xia Q, Chen YY, Zhang X, Shen YL. Opioid receptor-mediated effects of interleukin-2 on the [Ca2+]i transient and contraction in isolated ventricular myocytes of the rat. Pflugers Arch. 2002 Feb;443(4):635-42.

6.Cao CM, Xia Q, Zhang X, Xu WH, Jiang HD, Chen JZ. Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium induced by anoxia and reoxygenation in rat cardiomyocytes. Life Sci. 2003 Apr 18;72(22):2451-63.

7.Cao CM, Xia Q, Bruce IC, Zhang X, Fu C, Chen JZ. Interleukin-2 increases activity of sarcoplasmic reticulum Ca2+-ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes. J Pharmacol Exp Ther. 2003 Aug;306(2):572-80.

8.Cao CM, Xia Q, Bruce IC, Shen YL, Ye ZG, Lin GH, Chen JZ, Li GR. Influence of interleukin-2 on Ca2+ handling in rat ventricular myocytes. J Mol Cell Cardiol. 2003; 35:1491-1503.

9.Cao CM, Xia Q, Tu J, Chen M, Wu S, Wong TM. Cardioprotection of interleukin-2 is mediated via kappa-opioid receptors. J Pharmacol Exp Ther. 2004;309:560-567.

10.Shen YL, Chen YY, Wu XD, Bruce IC, Xia Q. Activation of mitochondrial ATP-sensitive potassium channels delays ischemia-induced cellular uncoupling in rat heart. Acta Pharmacol Sin. 2004 Jan;25(1):22-8.

11.Jiang H, Xia Q, Xu W, Zheng M. Chrysanthemum morifolium attenuated the reduction of contraction of isolated rat heart and cardiomyocytes induced by ischemia/reperfusion. Pharmazie. 2004 Jul;59(7):565-7.

12.Lin R, Zhang ZW, Xiong QX, Cao CM, Shu Q, Bruce IC, Xia Q. Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest. Ann Thorac Surg. 2004;78:970-975.

13.Tu J, Shan QX, Jin HF, Bourreau JP, Xia Q. Endothelin-1-mediated coronary vasoconstriction deteriorates myocardial depression in hearts isolated from lipopolysaccharide-treated rats: Interaction with nitric oxide. Clin Exp Pharmacol Physiol. 2004; 31:571-574.

14.Cao CM, Xia Q, Gao Q, Chen M, Wong TM. Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning. J Pharmacol Exp Ther. 2005;312:644-650.

15.Liang HW, Xia Q, Bruce IC. Reactive oxygen species mediate the neuroprotection conferred by a mitochondrial ATP-sensitive potassium channel opener during ischemia in the rat hippocampal slice. Brain Res. 2005;1042(2):169-75.

16.Jiang HD, Cai J, Xu JH, Zhou XM, Xia Q. Endothelium-dependent and direct relaxation induced by ethyl acetate extract from Flos Chrysanthemi in rat thoracic aorta. J Ethnopharmacol. 2005 Oct 3;101(1-3):221-6.

17.Jiang H, Xia Q, Wang X, Song J, Bruce IC. Luteolin induces vasorelaxion in rat thoracic aorta via calcium and potassium channels. Pharmazie. 2005 Jun;60(6):444-7.

18.Chen BP, Mao HJ, Fan FY, Bruce IC, Xia Q. Delayed uncoupling contributes to the protective effect of heptanol against ischaemia in the rat isolated heart. Clin Exp Pharmacol Physiol. 2005;32(8):655-62.

19.Zhang SZ, Gao Q, Cao CM, Bruce IC, Xia Q. Involvement of the mitochondrial calcium uniporter in cardioprotection by ischemic preconditioning. Life Sci. 2006 Jan 11;78(7):738-45.

20.Gao Q, Zhang SZ, Cao CM, Bruce IC, Xia Q. The mitochondrial permeability transition pore and the Ca2+-activated K+ channel contribute to the cardioprotection conferred by tumor necrosis factor-alpha. Cytokine. 2005 Dec 7;32(5):199-205.

21.Gao Q, Pan HY, Qiu S, Lu Y, Bruce IC, Luo JH, Xia Q. Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart. Life Sci. 2006 Jun 13;79(3):217-24.

22.Wu L, Shen F, Lin L, Zhang X, Bruce IC, Xia Q. The neuroprotection conferred by activating the mitochondrial ATP-sensitive K(+) channel is mediated by inhibiting the mitochondrial permeability transition pore. Neurosci Lett. 2006 Jul 10;402(1-2):184-9

23.Huang H, Shan J, Pan XH, Wang HP, Qian LB, Xia Q. Carvedilol improved diabetic rat cardiac function depending on antioxidant ability. Diabetes Res Clin Pract. 2007 Jan;75(1):7-13.

24.Qian LB, Wang HP, Qiu WL, Huang H, Bruce IC, Xia Q. Interleukin-2 protects against endothelial dysfunction induced by high glucose levels in rats. Vascul Pharmacol. 2006 Dec;45(6):374-82.

25.Wang HP, Gao Q, Mei RH, Zhao MH, Lu Y, Li XY, Bruce IC, Xia Q. Mechanisms underlying biochanin A-induced relaxation of the aorta differ between normotensive and hypertensive rats. Clin Exp Pharmacol Physiol. 2006 Sep;33(9):802-7.

26.Zhang SZ, Wang NF, Xu J, Gao Q, Lin GH, Bruce IC, Xia Q. Kappa-opioid receptors mediate cardioprotection by remote preconditioning. Anesthesiology. 2006 Sep;105(3):550-6.

27.Fu GS, Huang H, Chen F, Wang HP, Qian LB, Ke XY, Xia Q. Carvedilol ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2007 Jul 19;567(3):223-30.

28.Gao Q, Yang B, Ye ZG, Wang J, Bruce IC, Xia Q. Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. Eur J Pharmacol. 2007 Nov 28;574(2-3):179-84.

29.Wang JY, Shen J, Gao Q, Ye ZG, Yang SY, Liang HW, Bruce IC, Luo BY, Xia Q. Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. Stroke. 2008 Mar;39(3):983-90.

30.Liang HW, Qiu SF, Shen J, Sun LN, Wang JY, Bruce IC, Xia Q. Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus. Neurosci Lett. 2008 Jun 13;438(1):116-20.

31.Ru XC, Qian LB, Gao Q, Li YF, Bruce IC, Xia Q. Alcohol induces relaxation of rat thoracic aorta and mesenteric arterial bed. Alcohol Alcohol. 2008 Sep-Oct;43(5):537-43.

32.Ma X, Li YF, Gao Q, Ye ZG, Lu XJ, Wang HP, Jiang HD, Bruce IC, Xia Q. Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and apigenin in rat mesenteric artery. Life Sci. 2008 Jul 18;83(3-4):110-7.

33.Xia M, Qian L, Zhou X, Gao Q, Bruce IC, Xia Q. Endothelium-independent relaxation and contraction of rat aorta induced by ethyl acetate extract from leaves of Morus alba (L.). J Ethnopharmacol. 2008 Dec 8;120(3):442-6.

獲獎記錄

1、心臟－阿片受體效應及其調節，教育部科技進步二等獎，第一完成者，1998。

2、多種細胞因子的心血管作用及其機制，浙江省高校優秀科研成果二等獎，2005。

3、免疫調節因子白細胞介素-2的心臟效應機制，浙江省高校優秀科研成果二等獎，2003。

4、心肌損傷的保護作用研究，浙江省教委科技進步二等獎，第一完成者，1996。

5、浙江省優秀教師（1999）。

6、浙江省中青年學科帶頭人（1997）。

7、浙江省“151人才工程”第一層次人選（1997）。

8、國家精品課程《生理學》課程負責人（2005）。

9、浙江省教學名師（2006）。