周道國，1962出生，美國普渡大學生命科學系教授，現任南開大學講席教授；1983畢業於武漢大學微生物學專業，獲學士學位，1995年獲美國愛荷華大學博士學位，曾在美國紐約州立大學石溪分校、耶魯大學完成博士後研究，美國加州大學舊金山分校做訪問學者；2000年起在美國普渡大學先後任助理教授、副教授、教授。周教授長期致力於致病性細菌的分子遺傳學及致病性機理研究，研究領域涉及細胞微生物學、鼠傷寒沙門氏菌及III型分泌系統效應蛋白在細菌與宿主相互作用過程中的功能。累計在國際權威雜誌發表SCI收錄論文40餘篇，其中以第一作者或通訊作者身份發表論文30篇，包括《Science》發表1篇、《PNAS》發表2篇、《Nature Structural & Molecular Biology》發表1篇、《Molecular Microbiology》發表5篇等；參與編寫著作1部。
2001年主持國家自然科學基金委海外、港澳青年學者合作研究科學基金項目1項，國家自然科學基金委和美國國立衛生研究院中美生物醫學合作研究基金項目1項，美國國立衛生研究院（NIH）項目5項，美國心臟協會（AHA）項目1項。
基本介紹
- 中文名：周道國
- 國籍：中國
- 出生日期：1962年8月
- 職業：教師
- 專業方向：病原微生物學、細胞微生物學
- 性別：男
人物介紹,科研成果,
人物介紹
周道國
職稱：講席教授
1993年獲美國紐約大學Buffalo分校碩士學位，1995年獲美國Iowa大學博士學位。1996年至1998年，在美國紐約大學做博士後研究，1998年至2000年7月，在美國耶魯大學做博士後研究。2000年8月，在美國Purdue大學任助理教授。長期致力於致病性細菌的分子遺傳學及致病性機理研究，尤其在沙門菌與宿主細胞間相互作用研究方面取得突出的成績，研究成果發表在Science,PNAS和Molecular Microbiology威雜誌上。
2017年10月 南開大學講席教授
科研成果
發表論文：
1.Piscatelli, H. L., M. Li, and D. Zhou. 2015. Dual 4- and 5-phosphatase activities regulate SopB-dependent phosphoinositide dynamics to promote bacterial entry. Cell. Microbiol.
2.Zhao, E. Y., H. X. Bao, L. Tang, Q. H. Zou, W. Q. Liu, D. L. Zhu, J. Chin, Y. Y. Dong, Y. G. Li, F. L. Cao, C. Poppe, K. E. Sanderson, R. N. Johnston, D. Zhou, G. R. Liu, and S. L. Liu. 2013. Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains. Mol Genet Genomics 288:549-57.
3.Perrett, C. A., and D. Zhou. 2013. Salmonella type III effector SopB modulates host cell exocytosis. Emerg Microbes Infect 2:e32.
4.Myeni, S. K., L. Wang, and D. Zhou. 2013. SipB-SipC complex is essential for translocon formation. PLoS ONE 8:e60499.
5.Li, D., X. Wang, L. Wang, and D. Zhou. 2013. The actin-polymerizing activity of SipA is not essential for Salmonella enterica serovar Typhimurium-induced mucosal inflammation. Infect. Immun. 81:1541-9.
6.Piscatelli, H., S. A. Kotkar, M. E. McBee, S. Muthupalani, D. B. Schauer, R. E. Mandrell, J. M. Leong, and D. Zhou. 2011. The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. PLoS ONE 6:e19331.
7.Perrett, C. A., and D. Zhou. 2011. Type three secretion system effector translocation: one step or two? Front. Microbiol. 2:50.
8.Perrett, C. A., D. Y. Lin, and D. Zhou. 2011. Interactions of bacterial proteins with host eukaryotic ubiquitin pathways. Front. Microbiol. 2:143.
9.Lin, D. Y., J. Diao, D. Zhou, and J. Chen. 2011. Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7. J. Biol. Chem. 286:441-9.
10.Wang, X., D. Li, D. Qu, and D. Zhou. 2010. Involvement of TIP60 acetyltransferase in intracellular Salmonella replication. BMC Microbiol 10:228.
11.Srikanth, C. V., D. M. Wall, A. Maldonado-Contreras, H. N. Shi, D. Zhou, Z. Demma, K. L. Mumy, and B. A. McCormick. 2010. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science 330:390-3.
12.Myeni, S. K., and D. Zhou. 2010. The C terminus of SipC binds and bundles F-actin to promote Salmonella invasion. J. Biol. Chem. 285:13357-63.
13.Wang, X., and D. Zhou. 2009. Salmonella Invasion. J Microbes Infect 4:112-128.
14.Diao, J., Y. Zhang, J. M. Huibregtse, D. Zhou, and J. Chen. 2008. Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase. Nat. Struct. Mol. Biol. 15:65-70.
15.Dai, S., Y. Zhang, T. Weimbs, M. B. Yaffe, and D. Zhou. 2007. Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic 8:1365-74.
16.Chang, J., S. K. Myeni, T. L. Lin, C. C. Wu, C. J. Staiger, and D. Zhou. 2007. SipC multimerization promotes actin nucleation and contributes to Salmonella-induced inflammation. Mol. Microbiol. 66:1548-56.
17.Zuo, X., J. Zhang, Y. Zhang, S. C. Hsu, D. Zhou, and W. Guo. 2006. Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nat. Cell Biol. 8:1383-8.
18.Zhang, Y., W. M. Higashide, B. A. McCormick, J. Chen, and D. Zhou. 2006. The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase. Mol. Microbiol. 62:786-93.
19.Hu, H., Q. Sa, T. M. Koehler, A. I. Aronson, and D. Zhou. 2006. Inactivation of Bacillus anthracis spores in murine primary macrophages. Cell. Microbiol. 8:1634-1642.
20.Higashide, W., and D. Zhou. 2006. The first 45 amino acids of SopA are necessary for InvB binding and SPI-1 secretion. J. Bacteriol. 188:2411-20.
21.Zhang, Y., W. Higashide, S. Dai, D. M. Sherman, and D. Zhou. 2005. Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1. J. Biol. Chem. 280:38682-8.
22.Chang, J., J. Chen, and D. Zhou. 2005. Delineation and characterization of the actin nucleation and effector translocation activities of Salmonella SipC. Mol. Microbiol. 55:1379 - 89.
23.Zhou, D. 2004. Bacterial invasion into non-phagocytic cells, p. 247-273. In C. A. Nickerson and M. J. Schurr (ed.), Molecular Paradigms of Infectious Disease. Springer Ecience+Business Media, LLC.
24.Dai, S., and D. Zhou. 2004. Secretion and function of Salmonella SPI-2 effector SseF require its chaperone, SscB. J. Bacteriol. 186:5078-86.
25.Dai, S., P. D. Sarmiere, O. Wiggan, J. R. Bamburg, and D. Zhou. 2004. Efficient Salmonella entry requires activity cycles of host ADF and cofilin. Cell. Microbiol. 6:459-71.
26.Higashide, W., S. Dai, V. P. Hombs, and D. Zhou. 2002. Involvement of SipA in modulating actin dynamics during Salmonella invasion into cultured epithelial cells. Cell. Microbiol. 4:357-65.
27.Galkin, V. E., A. Orlova, M. S. VanLoock, D. Zhou, J. E. Galán, and E. H. Egelman. 2002. The bacterial protein SipA polymerizes G-actin and mimics muscle nebulin. Nat. Struct. Biol. 9:518-21.
28.Zhou, D., and J. E. Galán. 2001. Salmonella entry into host cells: the work in concert of type III secreted effector proteins. Microbes Infect. 3:1293-8.
29.Zhou, D., L. M. Chen, L. Hernandez, S. B. Shears, and J. E. Galán. 2001. A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. Mol. Microbiol. 39:248-59.
30.Zhou, D. 2001. Collective efforts to modulate the host actin cytoskeleton by Salmonella type III-secreted effector proteins. Trends Microbiol. 9:567-9; discussion 569-70.
31.Mitra, K., D. Zhou, and J. E. Galán. 2000. Biophysical characterization of SipA, an actin-binding protein from Salmonella enterica. FEBS Lett. 482:81-84.
32.Galan, J. E., and D. Zhou. 2000. Striking a balance: modulation of the actin cytoskeleton by Salmonella. Proc. Natl. Acad. Sci. U. S. A. 97:8754-61.
33.Zhou, D., M. S. Mooseker, and J. E. Galán. 1999. An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin. Proc. Natl. Acad. Sci. U. S. A. 96:10176-81.
34.Zhou, D., M. S. Mooseker, and J. E. Galán. 1999. Role of the S. typhimurium actin-binding protein SipA in bacterial internalization. Science 283:2092-5.
35.Zhou, D., W. D. Hardt, and J. E. Galan. 1999. Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island. Infect. Immun. 67:1974-81.
36.Estabrook, M. M., D. Zhou, and M. A. Apicella. 1998. Nonopsonic phagocytosis of group C Neisseria meningitidis by human neutrophils. Infect. Immun. 66:1028-36.
37.Zhou, D., and M. A. Apicella. 1996. Plasmids with erythromycin resistance and catechol 2,3-dioxygenase- or beta-galactosidase-encoding gene cassettes for use in Neisseria spp. Gene 171:133-4.
38.Apicella, M. A., M. Ketterer, F. K. Lee, D. Zhou, P. A. Rice, and M. S. Blake. 1996. The pathogenesis of gonococcal urethritis in men: confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae. J. Infect. Dis. 173:636-46.
39.Lee, F. K., D. S. Stephens, B. W. Gibson, J. J. Engstrom, D. Zhou, and M. A. Apicella. 1995. Microheterogeneity of Neisseria lipooligosaccharide: analysis of a UDP-glucose 4-epimerase mutant of Neisseria meningitidis NMB. Infect. Immun. 63:2508-15.
40.Zhou, D., D. S. Stephens, B. W. Gibson, J. J. Engstrom, C. F. McAllister, F. K. Lee, and M. A. Apicella. 1994. Lipooligosaccharide biosynthesis in pathogenic Neisseria. Cloning, identification, and characterization of the phosphoglucomutase gene. J. Biol. Chem. 269:11162-9.
41.Zhou, D., N. G. Lee, and M. A. Apicella. 1994. Lipooligosaccharide biosynthesis in Neisseria gonorrhoeae: cloning, identification and characterization of the alpha 1,5 heptosyltransferase I gene (rfaC). Mol. Microbiol. 14:609-18.
42.Stephens, D. S., C. F. McAllister, D. Zhou, F. K. Lee, and M. A. Apicella. 1994. Tn916-generated, lipooligosaccharide mutants of Neisseria meningitidis and Neisseria gonorrhoeae. Infect. Immun. 62:2947-52.
43.Kim, J. J., D. Zhou, R. E. Mandrell, and J. M. Griffiss. 1992. Effect of exogenous sialylation of the lipooligosaccharide of Neisseria gonorrhoeae on opsonophagocytosis. Infect. Immun. 60:4439-42
著作：
Zhou, D. 2003. Bacterial Invasion into Non-Phagocytic Cells. In Molecular Paradigms of Infectious Disease. In Press. Nickerson, C. and Schurr, M. (eds): Kluwer Academic/Plenum Publishers.
