周田彥

周田彥，女，博士，北京大學教授。

基本介紹

• 中文名：周田彥
• 學位/學歷：博士
• 職業：教師
• 專業方向：基於機制的藥物動力學/藥效動力學
• 任職院校：北京大學

個人經歷

分別於1992年、1998年在北京醫科大學藥學院獲得學士和碩士學位，1998年留校至今一直在北京大學藥學院藥劑教研室工作，並於2006年取得藥劑學博士學位。曾到香港理工大學(2002-2004)和美國奧克拉荷馬州立大學(2007-2008)作訪問研究。現任北京大學藥學院教授、碩士生導師、中國藥理學會定量藥理學專業委員會委員。

持了北京大學藥學院青年啟動基金，教育部留學回國人員啟動基金以及國家自然科學基金等項目，是北京大學創新藥物平台代謝子平台的骨幹成員。擔任國家自然科學基金等項目的評審專家。

擔任《中國臨床藥理學與治療學》編委，以及中國藥學雜誌、中國藥學(英文版)、Expert Opinion On Drug Metabolism and Toxicology, Acta Pharmacologica Sinica, Cancer Chemotherapy and Pharmacology, PLoS One,Current Analytical Chemistry等學術期刊的評審。

主講課程

主講本科生《生物藥劑學與藥物動力學》以及研究生《藥物動力學》、《高等藥物動力學》等課程。

研究方向

• 基於機制的藥物動力學/藥效動力學
• 藥物代謝酶的調控機理及功能

學術成果

在國內外發表論文70餘篇，編寫教材與專著6部，申請專利3項。

論文成果

1. Yuan, Y; Zhou, X; Ren, YP; Zhou, SP, Wang, LJ; Ji, SM; Hua, M; Li L; Lu, W;Zhou, TY*. Semi-Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for the Combination Use of Dexamethasone and Gemcitabine in Breast Cancer. J Pharm Sci. 2015, 104, 4399–4408.

2. Wang, SY; Mou, ZZ; Ma, YH; Li, J; Li, JY; Ji, XW; Wu, KH; Li, L; Lu, W;Zhou, TY*. Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: involvement of eradicating cancer stem-like cells. Biochem Pharmacol. 2015 May, 95(2), 98-109.

3. Ji, XW;Zhou, TY; Lu, Y; Wei, MJ, Lu; W; Cho, William Cs. Breast cancer treatment and sulfotransferase. Expert Opinion on Therapeutic Targets. 2015 Jun, 19(6), 821-34.

4. Ji, XW; Chen, GP; Song, Y; Li, L; Yuan, Y; Wang, SY;Zhou, TY*; Lu, W. Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208. Acta Pharmacol Sin. 2015 OCT, 36, 1246-55.

5. Li, J; Ji, XW; Yuan, Y; Fan, R; Shao, XY; Su, QH; Wang, SY; Li, L;Zhou, TY*; Lu, W. A simple LC-MS/MS method for the determination of moxifloxacin N-sulfate in rat plasma and its application to a pharmacokinetic study. J AOAC INT. 2015 July, 98(4), 921-926.

6. Li, JY; Li, J; Wang, SY; Yuan, Y; Su, QH; Lu, W;Zhou, TY*. Simultaneous determination of sunitinib and its active metabolites N-desethylsunitinib (SU12662) in nude mice plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. J Chinese Pharm Sci. 2015, April, 24(4), 217-224.

7. Yuan, Y; Zhou, X; Li, J; Ye, S., Ji, XW; Li, L;Zhou, TY*; and Lu, W. Development and validation of a highly sensitive LC-MS/MS method for the determination of dexamethasone in nude mice plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2015 Apr, 29(4), 578-83.

8. Shao, XY; Li, J; Wang, SY; Chen, GP; Xu, JJ; Ji, XW; Li, L; Lu, W;Zhou, TY*. Exogenous dopamine induces dehydroepiandrosterone sulfotranferase (rSULT2A1) in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats. Drug Metab Pharmacok. 2015 Jan, 30, 97-104.

9. Li, XG; Zhao, ZG; Li, L;Zhou, TY*;and Lu, W*. Pharmacokinetics, in vitro and in vivo correlation, and efficacy of exenatide microspheres in diabetic rats. Drug Deliv. 2015 Jan, 22(1), 86–93.

10. Shao, XY; Li, J; Wang, SY; Chen, GP; Xu, JJ; Ji, XW; Li, L; Lu, W;Zhou, TY*. Comparison of dopamine with levodopa in the induction of aryl sulfotransferases and estrogen sulfotransferase in rat liver. J Chinese Pharm Sci. 2014 Jul, 23(7), 471-479.

11. Xu, JJ; Wang, SY; Chen, Y; Chen, GP; Li ZQ; Shao, XY; Li, L; Lu, W;Zhou, TY*. Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. Acta Pharmacol Sin. 2014, 35(7), 889-898.

12. Ji, XW; Li, RT; Li, ZQ; Li, L; Shao, XY; Wang, SY; Yuan, Y;Zhou, TY*; Lu, W*. Inhibition of autophosphorylation of EGFR plays an important role in the anti-breast cancer efficacy of a dithiocarbamate derivative TM208. Acta Pharmacol Sin. 2014, 35, 239–247.

13. Li, MY; Li, HQ; Cheng, XL; Wang, XP; Li, L;Zhou, TY*, and Lu, W*. Preclinical Pharmacokinetic/Pharmacodynamic Models to Predict Schedule-Dependent Interaction between Erlotinib and Gemcitabine. Pharm Res. 2013, 30, 1400-1408.

14.Zhou, TY; Huang, CQ; Chen, Y; Xu, JJ; Shanbhag, PD; Chen, GP. Methamphetamine Regulation of Sulfotransferase 1A1 and 2A1 Expression in Rat Brain Sections. Neurotoxicology. 2013, 34, 212-218.

15. Wu, Q; Li, MY; Li, HQ; Deng, CH; Li, L;Zhou, TY*, and Lu, W*. Pharmacokinetic and pharmacodynamic study of erlotinib based upon phosphorylated epidermal growth factor receptor and tumor volume in human non-small cell lung cancer xenograft mouse mode. Acta Pharmacol Sin. 2013, 34, 1427–1436.

16. Cheng, XL; Guo,LP; Li, ZQ; Li, L;Zhou, TY*, Lu, W*. A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study. J Chromatogr B. 2013, 915–916, 64–70.

17.Zhou, TY; Chen, Y; Huang, CQ; Chen, GP. Caffeine induction of sulfotransferases in rat liver and intestine. J Appl Toxicol. 2012, 32, 804-809.

18. Zhou, X; Shang, DW; Zhang, TL; Li, L;Zhou, TY*; Lu, W*. Modeling of Angiotensin II-Angiotensin-(1-7) Counterbalance in Disease Progression in Spontaneously Hypertensive Rats Treated With/Without Perindopril. Pharmacol Res. 2012, 66, 177-184.

19. Li, XG; Li, L; Wang, XP; Ren, YP;Zhou, TY*; Lu, W*. Application of Model-Based Methods to Characterize Exenatide-Loaded Double-Walled Microspheres: In Vivo Release, Pharmacokinetic/Pharmacodynamic Model, and In Vitro and In Vivo Correlation. J Pharm Sci. 2012, 101, 3946-3961.

20. Xu, JJ; Chen, Y; Li, L; Li, ZQ; Wang, CA;Zhou, TY*, Lu, W*. An improved HPLC method for the quantitation of 3′-phosphoadenosine 5′-phosphate (PAP) to assay sulfotransferase enzyme activity in HepG2 cells. J Pharmaceut Biomed Analysis. 2012, 62, 182-186.

21. Ji, XW; Chen, Y; Li, RT;Zhou, TY*; Lu, W*. A high-sensitivity LC-MS/MS method for determination of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenylpropyl ester hydrochloride in rat plasma and its application to pharmacokinetics study. Biomed Chromatogr. 2012, 26, 1196-1201.

22. Li, XG; Li,L; Zhou,X; Chen,Y; Ren,YP;Zhou, TY*; Lu, W*. Pharmacokinetic/pharmacodynamic studies for exenatide in diabetic rats. Acta Pharmacol Sin. 2012, 33, 1379-1386.

23. Li, L; Li, ZQ; Deng, CH; Ning, MR; Li, HQ; Bi, SS;Zhou, TY* and Lu, W*. Mechanism-based Pharmacokinetic/Pharmacodynamic Model for CYP3A1/2 Induction by Dexamethasone in Rats. Acta Pharmacol Sin. 2012, 33, 127-136.

24. Li, MY; Wu, Q; Li, HQ; Ning, MR; Chen, Y; Li, L;Zhou, TY*; and Lu, W*. A high-sensitive LC-MS/MS method to determine the concentrations of erlotinib and its active metabolite OSI-420 in BALB/c nude mice simultaneously and its application to a pharmacokinetic study. J Chin Pharm Sci. 2012, 21, 296-303.

25. Chen, Y; Li, HQ; Xu, JJ; Jiu, XF; Deng, CH; Li, XG; Li, L; Xu, XQ;Zhou, TY*; and Lu, W*. Determination of metformin in diabetic rat plasma by an improved ion-pair high-performance liquid chromatography: Application to pharmacokinetic study, J Chin Pharm Sci. 2012, 21, 211-218.

26. Ning, MR; Li, L; Li, J; Li, ZQ; Li, RT;Zhou, TY*; Lu, W*. In-vitro screen of reversible and time-dependent inhibition of CYP3A by TM208 and TM209 in rat liver microsomes. Acta Pharm Sin B. 2012, 2, 179-185.

27. Shang, DW; Wang, XP; Zhao, XT; Huang, FM; Tian, GZ; Lu, W*;Zhou, TY*. Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction. J Chromatogr B. 2011, 879,　3459-3464．

28. Li, HQ; Li, MY; Li, ZQ; Li, L; Bi, SS; Deng, CH; Chen, R;Zhou,TY* and Lu, W*. New synthetic route of two active isomeric metabolites of erlotinib and their bioactivity studies against several tumor cell lines. Chin J Chem, 2011, 29, 1709-1714.

29. Jiu, XF; Shang, DW; Chen, Y; Li, XG; Wan, XM;Zhou, TY*; Lu, W*. A high performance liquid chromatography method for the quantitative determination assay of sitagliptin in rat plasma and its application in pharmacokinetics study. J Chin Pharm Sci. 2011, 20, 63-69.

30. Li, L; Li, ZQ; Li,HQ; Bi, SS; Li, Bo; Xu, JJ;Zhou, TY* and Lu, W*. Development of a quantitative real time PCR assay for absolute detection and quantification of CYP3A1 and CYP3A2 mRNA induction in rat liver. J Chin Pharm Sci. 2011, 20, 597-603.

31. Li, HQ; Chen, Y; Li, ZQ; Deng, CH; Li, L; Bi, SS; Li, MY;Zhou, TY*; Lu, W*. A high performance liquid chromatography method for the quantitative determination of erlotinib in the plasma of tumor bearing BALB/c nude mice and its application in a pharmacokinetic study. J Chin Pharm Sci. 2011, 20, 245-252.

32.Zhou, TY; Huang, CQ; Chen, Y; Shanbhag, PD; Chen, GP. Methamphetamine regulation of sulfotransferases in rat liver and brain. Am J Pharmacol Toxicol, 2010, 5, 125-132.

33.Zhou, TY; Li, XM; Ng, MTT; Wang, YF; Quek, NM; Luo, J; Yuan, WX; Tan, CH; Zeng, HQ; Li, TH. Synthesis and Characterization of Circular Structures of i-Motif Tagged with Fluoresceins. Bioconjugate Chem, 2009, 20, 644-647.

34.Zhou, TY; Wang, YF; Li, XM; Zhang, Q; Li, TH. Synthesis and characterization of a fluorescein-labeled circular G-quadruplex. B Chem Soc Jpn, 2006, 79(8), 1300-1302.

35.Zhou, TY; Chen, GS; Wang, YF; Zhang, Q; Yang, M; Li, TH. Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes. Nucleic Acids Res.2004, 32, e173/1-e173/9.

榮譽獎項

獲得獎勵主要包括北京大學醫學部教學優秀獎(2013、2010)，北京大學醫學部優秀青年學者(2010)，教育部“高等學校科學技術獎”自然科學二等獎(2006)，北京大學醫學部優秀SCI論文三等獎(2004)等。