人物簡介
周欣是超靈敏磁共振技術方面的青年科學家之一,主要從事磁共振成像與波譜儀器和技術的研究,建立了國內第一套流動系統超極化Xe裝置,發明了增強磁共振信號的Hyper-SAGE新技術。利用自主搭建的超極化裝置成功獲得國內首幅小動物活體肺部的MRI影像,成功點亮了磁共振成像中的盲區——肺部。在PNAS、CC、JMR、PRB 和NMR Bio等學術刊物上發表論文40餘篇,外文專著2章,主編外文專著1本,美國發明專利2項,中國發明專利10餘項。入選中科院“百人計畫”、湖北省“新世紀高層次人才工程”,2012年任國家重大儀器研製專項首席科學家,2013年帶領研究團隊獲“中國產學研合作創新成果獎”。
研究方向
超靈敏磁共振小組主要從事以下4個方面的研究:
用於磁共振醫學成像和化學分析的超極化儀器研發
肺部MRI方法和技術研究
超靈敏分子探針與分子影像學
原子磁力計和雷射探測磁共振
部分論文
1. Qianni Guo, Qingbin Zeng, Xiaoxiao Zhang, Xin Zhou*.Highly sensitive detection of mercury (II) in aqueous media by tetraphenylporphyrin with a metal ion receptor.Supramolecular Chemistry. (2014). (Accepted)
2. Ji Zhang, Weiping Jiang, Qing Luo, Xiaoxiao Zhang, Qianni Guo, Maili Liu, Xin Zhou*. Rational Design of Hyperpolarized Xenon NMR Molecular Sensor for Selective and Sensitive Determination of Zinc Ions. Talanta.Vol 122, 101-105.(2014).
3. Shizhen Chen, Yuqi Yang, Haidong Li, Xin Zhou*, Maili Liu.pH-Triggered Au-fluorescent Mesoporous Silica Nanoparticles for19F MR/Fluorescent Multimodal Cancer Cellular Imaging.Chemical Communications,Vol 50, 283-285. (2014).
4. Guobin Liu, Xiaofeng Li, Xianping Sun, Jiwen Feng, Chaohui Ye, Xin Zhou*.Ultralow Field NMR Spectrometer With An Atomic Magnetometer Near Room Temperature.Journal of Magnetic Resonance,Vol 237, 158-163. (2013).
5. Yuanyuan Du, Wenxian Lan, Zhusheng Ji, Xu Zhang, Bin Jiang, Xin Zhou, Conggang Li, and Maili Liu*NMR Spectroscopic Approach Reveals Metabolic Diversity of Human Blood Plasma Associated with Protein-Drug Interaction. Analytical Chemistry (2013) 85 (18), 8601.
6. Mary Mazzanti ,Ronn Walvick, Xin Zhou*, Yanping Sun, Niral Shah, et al. Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings.PLoS ONE(2011)6(7) 2 ,1607.
7. Xin Zhou*, Yanping Sun, Mary Mazzanti , Nils Henninger, Joey Mansour, Marc Fisher, Mitchell Albert: MRI of Stroke usingHyperpolarized129Xe.NMR in Biomedicine, Vol 24,170-175 (2011).
8. Xin Zhou, Dominic Graziani, Alexander Pines: Hyperpolarized Xenon NMR and MRI Signal Amplification by Gas Extraction.The Proceedings of the National Academy of Sciences, USA, Vol 106, 16903-16906 (2009).
9. Xin Zhou, Xianping Sun, Jun Luo, Mingsheng Zhan, Maili Liu: Quantitative Estimation of SPINOEEnhancement in Solid State.Journal of Magnetic Resonance, Vol196, 200-203 (2009).
10. Xin Zhou, Mary Mazzanti, Jianbing James Chen, Joey Mansour, Jessica Gereige , Yang-Sheng Tzeng, Arvind Venkatesh, Yanping Sun, Robert Mulkern, Mitchell Albert: Reinvestigating Hyperpolarized129Xe Longitudinal Relaxation Time in the Rat Brain with Noise Considerations.NMR in Biomedicine, Vol 21, 217-225 (2008).
論著
1. Xin Zhou. Chapter<<Hyperpolarized Xenon Brain MRI >>in book <<Advances in Brain Imaging >>, InTech, USA. 2012
2. Xin Zhou. Chapter <<Hyperpolarized Noble Gases as Contrast Agents>> in book <<In vivo NMR Imaging: Methods and Protocols>>, Humana Press, USA. 2011
相關信息
新華網武漢2015年9月7日電,由中科院武漢物數所波譜與原子分子物理國家重點實驗室周欣研究員領銜的研究團隊,歷時五年攻關,獲得中國首幅超極化氙—129人體肺部磁共振影像。讓健康“殺手”無處遁形,“點亮”肺部的角角落落,不僅能“讀懂”肺部氣體與氣體交換的信息,而且能“捕獲”氣體與血交換的信息,早期發現、全面評價肺部功能,中國科學家是如何做到的?日前,新華社記者專訪了37歲的哈佛“海歸中科院武漢物數所“點亮肺部”項目首席科學家周欣。