周宏灝長期從事遺傳藥理學和藥物基因組學的教學、研究和轉化。發現和闡明了遺傳因素引起藥物種族和個體差異的若干現象和機制及其規律，建立了有國家和民族特色的遺傳藥理學理論體系。周宏灝教授在New England Journal of Medicine等國際SCI期刊上發表300餘篇論文，出版了《遺傳藥理學》中、英文專著和研究生教材5部、高等醫藥院校五年制和八年制《藥理學》中、英文教材6部。
● The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype
● Stereoselective disposition of carvedilol is determined by CYP2D6
● Induction of polymorphic4`-hydroxylation of S-mephenytoin by rifampicin
● Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2
● Differences in the Incidence of the CYP2C19 Polymorphism Affecting the S-Mephenytoin Phenotype in Chinese Han and Bai Populations and Identification of a New Rare CYP2C19 Mutant Allele
● St John’s wort induces both cytochrome P450 3A4–catalyzed sulfoxidation and 2C19–dependent hydroxylation of omeprazole
● Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects
● Assessment of cytochrome P450 activity by a five-drug cocktail approach
● Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19
● Effect of the gene dosage of CYP2C19 on diazepam metabolism in Chinese subjects
● Ethnic differences in response to morphine
● Increased suppression of exercise-induced increase in renin by propranolol in Chinese subjects
● Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation
周宏灝