周如鴻，男，舟山定海人，1984年畢業於舟山中學，後獲美國哥倫比亞大學博士學位。現為IBM Watson 研究院軟物質科學實驗室主任， IBM藍色基因計畫生命科學首席科學家，哥倫比亞大學化學系兼職教授，美國科學促進會院士。
基本介紹
- 中文名：周如鴻
- 國籍：中國
- 出生地：舟山定海
- 畢業院校：美國哥倫比亞大學
個人經歷,代表論文,獲獎情況,智慧財產權,
個人經歷
在分子動力學模擬蛋白質結構，功能，以及動態過程、納米尺度水的生物效應、以及納米顆粒與生物分子的相互作用等研究領域成就顯著。擁有或已申請14項美國專利。在權威學術刊物發表學術論文102篇，SCI引用3200餘次。應邀在世界各地大學、研究機構和國際學術會議上做邀請報120餘次，是期刊《Nanoscale》、《Current Physical Chemistry》客座主編， 也是 《Current Bioinformatics》等6家國際期刊的編委。
代表論文
1. R. H. Zhou, X. Huang, C. Margulius and B. J. Berne, Hydrophobic Collapse in Multi-domain Protein Folding, Science, 305, 1605-1609, 2004
2. P. Liu, X. Huang, R. H. Zhou and B. J. Berne, Observation of a dewetting transition in the collapse of melittin tetramer, Nature, 437, 159-162, 2005
3. L. Cong, R. H. Zhou, Y. C. Kuo, M. Cunniff, and F. Zhang, Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains, Nature Commun. 3, 968, 2012
4. Z. Xia, P. Clark, T. Huynh, P. Loher, Y. Zhao, H.W. Chen, P. Y. Ren, I. Rigoutsos, and R. H. Zhou, Molecular dynamics simulations of Ago silencing complexes reveal a large repertoire of admissible ‘seed-less’ targets, Scientific Reports, 2, 569, 2012
5. S. G. Kang, G. Q. Zhou, P. Yang, Y. Liu, B. Y. Sun, T. Huynh, H. Meng, L. Zhao, G. M. Xing, C. Y. Chen, Y. L. Zhao, R. H. Zhou, Molecular Mechanism of Pancreatic Tumor Metastases Inhibition by Metallofullerenol Gd@C82(OH)22: Implication for de novo Design of Nanomedicine, Proc. Natl. Acad. Sci., 109, in press, 2012
6. C. Ge, J. F. Du, L. Zhao, L. Wang, Y. Liu, D. H. Li, Y. Yang, R. H. Zhou, Y. L. Zhao, Z. F. Chai, C. Y. Chen, Binding of human serum proteins on single-wall carbon nanotubes reduces cytotoxicity, Proc. Natl. Acad. Sci, 108, 16968-16973, 2011 (featured article)
7. P. Das, J. A. King, and R. H. Zhou, Aggregation of ?D-Crystallin Associated with Human Cataracts via Domain Swapping at the C-terminal ?-strands, Proc. Natl. Acad. Sci. 108, 10514-10519, 2011 (featured article)
8. Y. Tu, P. Xiu, R. Wan, J. Hu, R. H. Zhou and H. Fang, Water-mediated signal multiplication with Y-shaped carbon nanotubes, Proc. Natl. Acad. Sci. 106, 18120-18124, 2009
9. L. Hua, R. H. Zhou, D. Thirumalai, B. J. Berne, Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding, Proc. Natl. Acad. Sci., 105, 16928-16933, 2008
10. J. Li, X. Gong, H. Lu, D. Li, H. Fang and R. H. Zhou, Electrostatic Gating of a Nanometer Water Channel, Proc. Natl. Acad. Sci., 104, 3687-3692, 2007
11. R. H. Zhou, M. Eleftheriou, A. Royyuru, B. J. Berne, Destruction of long-range interactions by a single mutation in lysozyme, Proc. Natl. Acad. Sci., 104, 5824-5829, 2007
12. R. H. Zhou, Trp-cage: Folding Free Energy Landscape in Explicit Water, Proc. Natl. Acad. Sci., 100, 13280， -13285, 2003
13. R. H. Zhou and B. D. Silverman, Detecting native protein folds among large decoy sets with hydrophobic moments profiling, Proc. Paci. Symp. Biocomp. 2002, Eds. R. B. Altman, A. K. Dunker, L. Hunter, K. Lauderdale and T. E. Klein, p673-684, World Scientific, Singapore, 2002
14. R. H. Zhou, B. J. Berne and R. Germain, Free energy landscape of a beta-hairpin folding in explicit water, Proc. Natl. Acad. Sci. 98, 14931-14936, 2001
2. P. Liu, X. Huang, R. H. Zhou and B. J. Berne, Observation of a dewetting transition in the collapse of melittin tetramer, Nature, 437, 159-162, 2005
3. L. Cong, R. H. Zhou, Y. C. Kuo, M. Cunniff, and F. Zhang, Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains, Nature Commun. 3, 968, 2012
4. Z. Xia, P. Clark, T. Huynh, P. Loher, Y. Zhao, H.W. Chen, P. Y. Ren, I. Rigoutsos, and R. H. Zhou, Molecular dynamics simulations of Ago silencing complexes reveal a large repertoire of admissible ‘seed-less’ targets, Scientific Reports, 2, 569, 2012
5. S. G. Kang, G. Q. Zhou, P. Yang, Y. Liu, B. Y. Sun, T. Huynh, H. Meng, L. Zhao, G. M. Xing, C. Y. Chen, Y. L. Zhao, R. H. Zhou, Molecular Mechanism of Pancreatic Tumor Metastases Inhibition by Metallofullerenol Gd@C82(OH)22: Implication for de novo Design of Nanomedicine, Proc. Natl. Acad. Sci., 109, in press, 2012
6. C. Ge, J. F. Du, L. Zhao, L. Wang, Y. Liu, D. H. Li, Y. Yang, R. H. Zhou, Y. L. Zhao, Z. F. Chai, C. Y. Chen, Binding of human serum proteins on single-wall carbon nanotubes reduces cytotoxicity, Proc. Natl. Acad. Sci, 108, 16968-16973, 2011 (featured article)
7. P. Das, J. A. King, and R. H. Zhou, Aggregation of ?D-Crystallin Associated with Human Cataracts via Domain Swapping at the C-terminal ?-strands, Proc. Natl. Acad. Sci. 108, 10514-10519, 2011 (featured article)
8. Y. Tu, P. Xiu, R. Wan, J. Hu, R. H. Zhou and H. Fang, Water-mediated signal multiplication with Y-shaped carbon nanotubes, Proc. Natl. Acad. Sci. 106, 18120-18124, 2009
9. L. Hua, R. H. Zhou, D. Thirumalai, B. J. Berne, Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding, Proc. Natl. Acad. Sci., 105, 16928-16933, 2008
10. J. Li, X. Gong, H. Lu, D. Li, H. Fang and R. H. Zhou, Electrostatic Gating of a Nanometer Water Channel, Proc. Natl. Acad. Sci., 104, 3687-3692, 2007
11. R. H. Zhou, M. Eleftheriou, A. Royyuru, B. J. Berne, Destruction of long-range interactions by a single mutation in lysozyme, Proc. Natl. Acad. Sci., 104, 5824-5829, 2007
12. R. H. Zhou, Trp-cage: Folding Free Energy Landscape in Explicit Water, Proc. Natl. Acad. Sci., 100, 13280， -13285, 2003
13. R. H. Zhou and B. D. Silverman, Detecting native protein folds among large decoy sets with hydrophobic moments profiling, Proc. Paci. Symp. Biocomp. 2002, Eds. R. B. Altman, A. K. Dunker, L. Hunter, K. Lauderdale and T. E. Klein, p673-684, World Scientific, Singapore, 2002
14. R. H. Zhou, B. J. Berne and R. Germain, Free energy landscape of a beta-hairpin folding in explicit water, Proc. Natl. Acad. Sci. 98, 14931-14936, 2001
獲獎情況
1. CAREER Award for Researchers “most likely to have the greatest scientific impact for IBM and the world” (at most five scientists chosen each year among eight IBM Labs worldwide), IBM Research, May, 2012
2. IBM Outstanding Innovation Award (OIA), IBM Corp. 2012
3. IBM Research Division Award, IBM Research (2012)
4. William E. Schiesser Lecture, Lehigh University, April 2012
5. Elected to AAAS Fellow (American Association of Advancement of Science), 2011
6. Elected to APS Fellow (American Physical Society), 2011
7. Part of the IBM BlueGene Team who won 2009 National Medal on Innovation and Technology (presented by President Obama), 2009
8. IBM Invention Plateau Achievement Award, IBM Corporation (2009)
9. IBM Outstanding Technical Achievement Award (OTAA, the highest technical award of IBM), IBM Corp. (2008)
10. IBM Outstanding Technical Achievement Award (OTAA), IBM Corp. (2005)
11. IBM Research Division Award, IBM Research (2005)
12. IBM Invention Plateau Achievement Award, IBM Corporation (2004)
13. IBM Invention Achievement Award, IBM Corporation (2002)
14. The Hammett Award for Best Ph.D. Graduates, Columbia University (1997)
15. ACS Award on Computational Chemistry (DEC Award), American Chemical Society (1995)
16. Faculty Fellowship, Columbia University (1994-1997)
17. Second Prize, Research in Science & Technology, China Ministry of Education (1993)
18. Best Paper Award for Outstanding Research, Zhejiang University (1993)
19. Award for Outstanding Research, Zhejiang University (1992)
3. IBM Research Division Award, IBM Research (2012)
4. William E. Schiesser Lecture, Lehigh University, April 2012
5. Elected to AAAS Fellow (American Association of Advancement of Science), 2011
6. Elected to APS Fellow (American Physical Society), 2011
7. Part of the IBM BlueGene Team who won 2009 National Medal on Innovation and Technology (presented by President Obama), 2009
8. IBM Invention Plateau Achievement Award, IBM Corporation (2009)
9. IBM Outstanding Technical Achievement Award (OTAA, the highest technical award of IBM), IBM Corp. (2008)
10. IBM Outstanding Technical Achievement Award (OTAA), IBM Corp. (2005)
11. IBM Research Division Award, IBM Research (2005)
12. IBM Invention Plateau Achievement Award, IBM Corporation (2004)
13. IBM Invention Achievement Award, IBM Corporation (2002)
14. The Hammett Award for Best Ph.D. Graduates, Columbia University (1997)
15. ACS Award on Computational Chemistry (DEC Award), American Chemical Society (1995)
16. Faculty Fellowship, Columbia University (1994-1997)
17. Second Prize, Research in Science & Technology, China Ministry of Education (1993)
18. Best Paper Award for Outstanding Research, Zhejiang University (1993)
19. Award for Outstanding Research, Zhejiang University (1992)
智慧財產權
1. Bruce J. Berne and Ruhong Zhou, Fast methods for simulating biomolecular systems with long-range electrostatic interactions by molecular dynamics, US patent No. 5,915,230, Jun 22, 1999
2. Ruhong Zhou, Huafeng Xu, Ed Harder, and Bruce J. Berne, System and Method for Molecular Dynamics Simulation , US patent, No. 7,096,167 B2, August 22, 2006
3. Prasanna Athma, Ajay Royyuru, David Silverman and Ruhong Zhou, Method and apparatus for protein structure analysis, US Patent, No. 7,499,805, March 3, 2009
4. Ruhong Zhou, David Silverman, Ajay Royyuru, and Prasanna Athma, Hydrophobic Moment of Multi-domain Proteins, United States, US patent No. 7,877,214, Jan, 25, 2011
5. Ruhong Zhou, David Silverman, Ajay Royyuru, and Prasanna Athma, Hydrophobic Dipole Orientational Analysis for Multi-domain Protein Structures, US patent No. 8,010,332, Jan, 2012
6. Ruhong Zhou, and David Silverman, Method and Apparatus for Protein Structure Analysis, US patent filed (IBM Docket No. YOR920020224US1), Nov. 15, 2002
7. David Silverman, Ruhong Zhou and Ajay Royyuru, Hydrophobic Fourier Transform for Protein Structure Prediction Validation, US patent search (IBM Docket No. YOR820030692), September, 2003
8. Laxmi Parida and Ruhong Zhou, Pattern Discovery Analysis for Protein Folding Trajectories, US patent search (IBM Docket No. YOR820040227), April, 2004
9. Laxmi Parida and Ruhong Zhou, Clustering of Multidimentional Real-valued Data Using Signature Patterns, US patent (IBM Docket No. YOR820040321), May, 2004
10. Laxmi Parida and Ruhong Zhou, Visual Analysis of Pattern Landscape Animation, US patent (IBM Docket No. YOR920060233US1), March, 2006
11. Zhen Xia and Ruhong Zhou, Prediction of Influenza A Virus' Genetic Evolution with a Mutual Information Based Site Transition Network, IBM Docket No. YOR820090279, July 1, 2009
12. Payel Das and Ruhong Zhou, A biomimetic nano-pump for automatic separation of urea from water, DISCLOSURE NO. YOR820101155, November 12, 2010
13. Zhen Xia, Tien Hyunh, and Ruhong Zhou, Weighted mutual information method and automatic web server for influenza genetic variation prediction, DISCLOSURE NO. YOR820101065, October 18, 2010
14. James Kozloski, Cliff Pickover, Jacinta Wubben and Ruhong Zhou, System and Method for Competitive Binding of Sequence Annotations and Analysis Tools to Sequences in a Biological Data Repository, YOR820110975, October, 2011
15. Binquan Luan and Ruhong Zhou, Base-by-base Ratcheting DNA in a Y-shaped Carbon Nanotube, YOR820120589, May, 2012
16. Binquan Luan and Ruhong Zhou, Nanopore-Based Sensors for Detecting Nanotoxicity of a Carbon Nanotube to Proteins, YOR820120951, July, 2012
