周 嚴：武漢大學生命科學學院 教授、博士生導師。學科專業：發育神經生物學、幹細胞生物學 研究方向：神經幹細胞的命運決定。
學習經歷：
2000－2002 中國協和醫科大學 醫學博士
1997－2000 中國協和醫科大學 理學博士
1991－1997 同濟醫科大學 醫學學士
2000－2002 中國協和醫科大學 醫學博士
1997－2000 中國協和醫科大學 理學博士
1991－1997 同濟醫科大學 醫學學士
主要工作經歷與任職情況：
2011至今：武漢大學生命科學學院 教授、博士生導師
2007－2011：耶魯大學 副研究科學家 (Associate Research Scientist)
2002－2007：耶魯大學 博士後
主要研究領域及興趣：
本實驗室主要套用胚胎學、遺傳學和細胞生物學手段研究哺乳動物神經系統發育過程中，神經幹細胞如何進行命運選擇，特別是神經幹細胞如何套用非對稱細胞分裂產生分化細胞並同時自我更新。主要研究領域包括：
1）各種外源信號和內源命運決定因子如何共同影響神經幹細胞的命運決定；
2）非編碼RNA如何調控神經幹細胞非對稱分裂；
3）神經系統腫瘤發生髮展過程中，腫瘤幹細胞樣細胞的生物學特性。
主持課題項目：
承擔國家重點基礎研究發展計畫（973）項目子課題和國家自然科學基金面上項目
代表性論文:
1. Zhou, Y. (2012) Cortical development and asymmetric cell division. Frontiers in Biology. 7(4):297-306
2. Zhou, Y., Atkins, J., Rompani, S., Bancescu, D., Tang, H., Petersen, P., Zou, K., Stewart, S., Zhong, W. (2007) The mammalian Golgi regulates Numb signaling in asymmetric cell division by releasing ACBD3 during mitosis. Cell 129 (1): 163-78
3. Zhou, Y., Du, G., Hu, X., Yu, S., Liu, Y., Xu, Y., Huang, X., Liu, J., Yin, B., Fan, M., Peng, X., Qiang, B., Yuan, J. (2005) Nectin-like molecule 1 is a protein 4.1 N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochimica et Biophysica Acta-Biomembranes, 1669(2): 142-54
4. Tang, H., Rompani, S. B., Atkins, J. B., Zhou, Y., Osterwalder, T., and Zhong, W. (2005). Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular Cellular Biology 25: 2899-2909.
5. Yang, H., Zhou, Y., Hu, X., Xu, Y., Yin, B., Zhu, S., Fan, W., Fan, M., Qiang, B., Yuan, J., and Peng, X. (2005) Human nectin-like 1, a novel membrane protein interacting with protein 4.1 R. Progress in Natural Science, 15 (2) : 189-192.
6. Huang, X., Yang, H., Zhou, Y., Liu, J., Yin, B., Peng, X., Qiang, B., and Yuan, J. (2004). Overexpression of human reticulon 3 (hRTN3) in astrocytoma. Clinical Neuropathology, 23: 1-7.
7. Zhou, Y., Hu, S., Huang, X., Zhou, H., Tan, X., Peng, X., Qiang, B., Yuan, J. (2002) Construction of human and mouse brain cDNA libraries and isolation of full-length cDNAs. Progress in Natural Science, 12(6): 477-480
8. Liu, Y., Fan, M., Yu, S., Zhou, Y., Wang, J., Yuan, J., and Qiang, B. (2002). cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. Brain Research 928:147-155.
9. Wang, J., Zhou, Y., Yin, B., Du, G., Huang, X., Li, G., Shen, Y., Yuan, J., and Qiang, B. (2001). ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Journal of Molecular Medicine, 79, 399-405.
10. Liu, Y., Yu, S., Zhou, Y., Wang, J., Liu, S., Yuan, J., Qiang, B, Fan, M. (2001). cDNA isolation, chromosomal mapping and genomic analysis of human homeobox gene LHX4. Chinese Journal of Biochemistry and Molecular Biology, 17 (5): 552-556
11. Zhou, H., Huang, X., Zhou, Y., Li, G., Yin, B., Ma, Y., Peng, X., Yuan, J., Qiang, B. Cloning and prokaryotic expression of HGLP cDNA. (2001) Chinese Science Bulletin, 46 (13), 1089-1092
12. Du, G., Pan, M., Zhou, Y., Chen, J., Yao, H., Yuan, J., Qiang, B. (2000) Cloning of human and mouse GRY-RBP cDNA. Chinese Science Bulletin, 45 (4), 343-350
13. Chen, J., Luo, W., Zhou, Y., Tan, X., Li, G., Huang, X., Zhou, H., Li, W., Yuan, J., Qiang, B. (2000) Cloning and eukaryotic expression of Human HCL cDNA. Progress in Natural Science, 10 (11): 1001-1005
14. Du, G., Zhou, Y., Chen, J., Wang, J., Yin, B., Yuan, J., Qiang, B. (2000). Clonng and expression analysis of MBLL cDNA. Chinese Science Bulletin, 45(7): 620-625.
15. Du, G., Zhou, Y., Chen, J., Wang, J., Huang, X., Yuan, J., Qiang, B. (1999) Expression of human GRY-RBP and analysis of its RNA binding activities. Chinese Journal of Biochemistry and Molecular Biology, 15 (6): 866-870
16. Zhou, Y., Du, G., Wang, J., Chen, J., Yuan, J., Qiang, B. (1999) Isolation and cloning of a novel cDNA LDB1 encoding human LIM domain binding protein. Chinese Science Bulletin, 44(12): 1114-1119.
17. Wang, J., Du, G., Zhou, Y., Yin, B., Yuan, J., Qiang, B. (1999) Cloning and identification of PHF2 cDNA and its alternatively spliced transcripts. Chinese Science Bulletin, 44(15), 1382-1387
18.《基因組學》主譯：袁建剛 周嚴 強伯勤 (原著：Genomes by Brown, T.A., 2000) ISBN 7-03-010114-6/Q.1136, 507頁
