基本信息
中國科學院力學研究所, 生物力學與生物工程中心
中國科學院微重力重點實驗室, 中國.北京
研究方向
結合分子動力學模擬和分子生物力學實驗方法考察細胞粘附分子選擇素、beta2整合素的結構-功能關係。
教育經歷
博士 中國科學院力學研究所 2006
主要獎勵
中國科學院力學研究所,郭永懷獎學金一等獎 2006
中國科學院劉永齡冠名獎 2006
主要論文
Lü S.Q., and Long M. 2004. Forced extension of P-selectin construct using steered molecular dynamics. Chin. Sci. Bull
Lü S.Q., Long M. 2005. Forced dissociation of selectin-ligand interactions using steered molecular dynamics simulation. MCB: Mol Cell Biomech
Lü S.Q., Ye Z.Y., Zhu, C., and Long M. 2006. Quantifying the effects of contact duration, loading rate and approach velocity on P-selectin-PSGL-1 interactions using AFM. Polymer
Long M., Lü S.Q., and Sun G.Y. 2006. Kinetics of receptor-ligand interactions in immune responses. Cell Mol Immunol
Lü S.Q.,Zhang Y., and Long M. 2010. Visualization of allostery in P-selectin lectin domain using MD simulations. PLoS One
Zhang M.H., Lü S.Q., Li G.W., Yu X., Sun W.N., Tang Z.C., Long M., and Su W.A. 2010. Residue identification in molecular aqueous pathway determines water permeability of rice PIPs. J. Biol. Chem
Mao D.B., Lü S.Q., Li N., Zhang Y., and Long M. 2011. Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1. PLoS One
Kang Y.Y., Lü S.Q., Ren P., Huo B., and Long M. 2012. Shear- and stretch-induced dissociation of P-selectin/PSGL-1 complex using molecular dynamics simulation. Biophys
Lü S.Q., and Long M. 2012. Molecular dynamics simulation and molecular biomechanics. Acta Biophysica Sinica (In Chinese)
Xiao B.T., Tong C.F., Jia X.L., Guo R., Lü S.Q., Zhang Y., McEver R.P., Zhu C., and Long M.2012. Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-Selectin on the cell membrane. Biophys
An H.L.Lü S.Q., Li J.W., Meng X.Y., Zhan Y., Cui M., Long M., Zhang H.L., Logothetis D.E., The Cytosolic GH Loop Regulates the Phosphatidylinositol4,5-Bisphosphate-induced Gating Kinetics of Kir2 Channels.J. Biol. Chem., Accepted