吳聰明

人物經歷

1992.7，在四川農業大學獸醫系學習獲學士學位（獸醫公共衛生專業）；

1992.9-1995.7，在四川農業大學動物科技學院學習獲碩士學位（預防獸醫學專業）端汗拳；

1995.7-2000.8，在廣東海洋大學從事獸醫教學科研工作；

2000.9-2003.7，在華南農業大學獸醫學院學習獲博漿探阿士學位（基礎獸醫學專業）；

2003.8-2005.8，在中國農業大學獸醫學博士後流動站工作；

2005.9至今在中國農業大學動物醫學院從事獸醫藥鍵捆紙理學與毒理學科研教學工作。

主研方向

獸藥有效性和安全性評價、動物白拜臘戶源耐藥病原菌產生機制及風險評轎危估。

學術成果

科研項目

近茅乘祖騙5年來先後主持承擔國家自然科學基金項目、國家科技支撐計畫項目、公益性行業（農業）科研專項、973項目、863項目/課題/子課題等10餘項；承擔輝瑞、禮來、勃林格殷格翰、拜耳等製藥企業委託的獸藥有效性和拒謎戒安全性評價項目課題20餘項。

論文著作

已發表學術論文近70篇（SCI收錄論文30餘篇）；申請國家發明專利10項（授權3項）；參加制定國家標準和行業標準19項（發布10項）；參編（譯）著作3部。

代表性論文

1. Li RC, Y Wang, JZ Shen, CM Wu. Development of a novel hexa-plex PCR method for identification and serotyping of Salmonella species. Foodborne Pathog Dis. 2014, 11: 75-77

2. He T, Y Wang, S Schwarz, Q Zhao, JZ Shen, CM Wu. Genetic environment of the multi-resistance gene cfr inmethicillin-resistant coagulase-negative staphylococci from chickens, ducks, and pigs in China. Int J Med Microbiol. 2013[doi: 10.1016ijmm.2013.10.005]

3. Wang SC, Y Wang, JZ Shen, YN Wu, CM Wu. Polymorphic mutation frequencies in clinical isolates of Staphylococcus aureus: the role of weak mutators in the development of fluoroquinolone resistance. FEMS Microbiol Lett. 2013, 341: 13-17

4. Wang SC, CM Wu, JZ Shen,YN Wu, Y Wang. Hypermutable Staphylococcus aureus strains present at high frequency in subclinical bovine mastitis isolates are associated with the development of antibiotic resistance. Vet Microbiol. 2013, 165: 410-415

5. Li RC, J Lai, Y Wang, SL Liu, Y Li, KY Liu, JZ Shen, CM Wu. Prevalence and characterization of Salmonella species isolated from pigs, ducks and chickens in Sichuan Province, China. Int J Food Microbiol. 2013, 163: 14-18

6. Lai J, Y Wang, JZ Shen, RC Li, Jing Han, SL Foley, CM Wu. Unique class 1 integron and multiple resistance genes co-located on IncHI2 plasmid is associated with the emerging multidrug resistance of Salmonella Indiana isolated from chicken in China. Foodborne Pathog Dis. 2013, 10: 581-588

7. Wang Y, J Yang, CM Logue, KY Liu, XY Cao, WJ Zhang, JZ. Shen, CM Wu. Methicillin-resistant Staphylococcus pseudintermedius isolated from canine pyoderma in North China. J Appl Microbiol. 2012, 112: 623-630

8. Zhang WJ, ZH Hao, Y Wang, XY Cao, CM Logue, B Wang, J Yang, JZ Shen, CM Wu. Molecular characterization of methicillin-resistant Staphylococcus aureus strains from pet animals and veterinary staff in China. Vet J. 2011, 190(2): e125-129

9. Wang Y, S Schwarz, Z Shen,W Zhang, J Qi, Y Liu, T He,J Shen, CM Wu. Co-location of the multiresistance gene cfr and the novel streptomycin resistance gene aadY on a small plasmid in a porcine Bacillus strain. J Antimicrob Chemother. 2012, 67:1547-1549

10. NaRen GW, Y Wang, ZQ Shen, X Chen, JZ Shen, CM Wu.Rapid detection of point mutations in domain V of the 23S rRNA gene in erythromycin-resistant Campylobacter isolates by pyrosequencing.Foodborne Pathog Dis. 2011, 8:375-379

11. Huang SY, XQ Zhu, Y Wang, L Dai, ZH Wang, BB Li, CM Wu, JZ Shen.Correlation of fluoroquinolone resistance with expression of qnrA gene in Kluyvera spp. Foodborne Pathog Dis.2011, 8:1039-1044

12. Zhang WJ, CM Wu, Y Wang, ZQ Shen, L Dai, J Han, SL Foley, JZ Shen, QJ Zhang.The new genetic environment of cfr on plasmid pBS-02 in a Bacillus strain.J Antimicrob Chemother. 2011, 66: 1174-1191

13. Li L, ZG Jiang, LN Xia, JZ Shen, L Dai, Y Wang, SY Huang, CM Wu.Characterization of antimicrobial resistance and molecular determinants of beta-lactamase in Escherichia coli isolated from chickens in China during 1970–2007. Vet Microbiol. 2010, 144:505-510

14. Li BB, CM Wu, Y Wang, JZ Shen.Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit. J Antimicrob Chemother. 2011, 66:1983-1986

15. Li BB, JZ Shen, XY Cao, Y Wang, L Dai, SY Huang, CM Wu. Mutations in 23S rRNA gene associated with decreased susceptibility to tiamulin and valnemulin in Mycoplasma gallisepticum.FEMS Microbiol Lett. 2010, 308:144-149

16. Lu LM, L Dai, Y Wang, CM Wu, X Chen, L Li, YH Qi, LN Xia, JZ Shen. Characterization of antimicrobial resistance and integrons among Escherichia coli isolated from animal farms in Eastern China. Acta Tropica. 2010, 113: 20–25

17. Xia LN, L Li, CM Wu, YQ Liu,XQ Tao, L Dai, YH Qi, LM Lu, JZ Shen. A Survey of Plasmid-Mediated Fluoroquinolone Resistance Genes from Escherichia Coli Isolates and Their Dissemination in China. Foodborne Pathog. Dis. 2010, 7: 207-215

18. Dai L, CM Wu, MG Wang, Y Wang, Y Wang, SY Huang, LN Xia, BB Li, JZ Shen.First Report of the Multidrug Resistance Gene cfr and the Phenicol Resistance Gene fexA in a Bacillus Strain from Swine Feces. Antimicrob Agents Chemother. 2010, 54:3953–3955

19. Chen X, GW Naren, CM Wu, Y Wang, L Dai, LN Xia, PJ Luo, QJ Zhang, JZ Shen. Prevalence and Antimicrobial Resistance of Campylobacter Isolates in Broilers from China. Vet. Microbiol. 2010, 144 : 133-139.

20. Wu CM, Y Li, JZ Shen, LL Cheng, YS Li, CY Yang, PS Feng, SX Zhang.LC–MS–MS Quantification of Four Quinoxaline-1,4-Dioxides in Swine Feed.Chromatographia. 2009, 70: 1605-1611

21. Huang SY, L Dai, LN Xia, XD Du, YH Qi, HB Liu, CM Wu, JZ Shen.Increased Prevalence of Plasmid-Mediated Quinolone Resistance Determinants in Chicken Escherichia coli Isolates from 2001 to 2007.Foodborne Pathog Dis. 2009, 6:1203-1209

22. Du XD, CM Wu, HB Liu, XS L, RC Beier, F Xiao, SS Qin, SY Huang, JZ Shen. Plasmid-mediated ArmA and RmtB 16S rRNA Methylases in Escherichia coli isolated from chickens. J. Antimicrob. Chemother. 2009, 64: 1328-1330

23. Qi YH, CM Wu, SX Zhang, ZH Wang, SY Huang, L Dai, SC Wang, LN Xia, K Wen, XY Cao, YN Wu, JZ Shen. Selection of Anti-Sulfadimidine Specific ScFvs from a Hybridoma Cell by Eukaryotic Ribosome Display. PloS ONE. 2009, 4: e6427

24. Liu MC, CM Wu, YC Liu, JC Zhao, YL Yang, JZ Shen. Identification, susceptibility, and detection of integron-gene cassettes of Arcanobacterium pyogenes in bovine endometritis. J. Dairy Sci. 2009, 92: 3659–3666

25. Wang SC, CM Wu, SC Xia, YH Qi, LN Xia, JZ Shen. Distribution of superantigenic toxin genes in Staphylococcus aureus isolates from milk samples of bovine subclinical mastitis cases in two major diary production regions of China. Vet. Microbiol. 2009, 137: 276–281

26. Wu CM, Y Wang, XY Cao, JC Lin, SS Qin, TJ Mi, SY Huang, JZ Shen.Emergence of plasmid-mediated quinolone resistance genes in Enterobacteriaceae isolated from chickens in China.J Antimicrob Chemother. 2008, 63:408-411

27. Wang GQ, CM Wu, XD Du, ZQ Shen, LH Song, X Chen, JZ Shen. Characterization of integrons-mediated antimicrobial resistance among Escherichia coli strains isolated from bovine mastitis. Vet. Microbiol. 2008, 127: 73-78

28. Wang Y, CM Wu, LM Lu, GW Naren, XY Cao, JZ Shen. Macrolide-lincosamide-resistant phenotypes and genotypes of Staphylococcus aureus isolated from bovine clinical mastitis. Vet. Microbiol. 2008, 130 : 118-125

29. Dai L, LM Lu, CM Wu, BB Li, SY Huang, SC Wang, YH Qi, JZ Shen. Characterization of antimicrobial resistance among Escherichia coli isolates from chickens in China between 2001 and 2006. FEMS Microbiol. Lett. 2008, 286: 178-183

30. Cao XY, M Dong, JZ Shen, BB Wu, CM Wu, XD Du, Z Wang, YT Qi, BY Li. Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophage and monocytes. International J Antimicrob Agents. 2006, 27: 431-438

31. Wu CM, HM Wu, YB Ning, JG Wang, XD Du, JZ Shen. Induction of macrolide resistance in Mycoplasma gallisepticum in vitro and its resistance-related mutations within domain V of 23S rRNA. FEMS Microbiol Letters. 2005, 247: 199-205

吳聰明

基本介紹

人物經歷

主研方向

學術成果

科研項目

論文著作

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