基本介紹
- 中文名：吳海波
- 學位/學歷：博士
- 專業方向：研究細菌或病毒
- 職務：重慶大學生命科學學院博士生導師
研究方向,主講課程,學術兼職,學術成果,獲獎記錄,
研究方向
研究細菌或病毒（目前主要為結核分枝桿菌）在侵入機體過程中，宿主的免疫應答反應以及客體的免疫逃避機制。
主講課程
細胞生物學
學術兼職
中國細胞生物學學會及中國生物化學與分子生物學會會員。受邀擔任Ageing Research Reviews (IF=7.45), Cellular and Molecular Life Sciences (IF=5.78)等國際著名雜誌的審稿人。
學術成果
研究論文 （#第一作者；*通訊作者）
1. Wu H#, Wu Y, Ai Z, Yang L, Gao Y, Du J, Guo Z, Zhang Y*. Vitamin C enhances nanog expression via activation of the JAK/STAT signaling pathway. Stem Cells. 32(1):166-76, 2014. (中科院1區，IF=7.701)
2. Wu H#, Wang Y, Zhang Y, Yang M, Lv J, Liu J, and Zhang Y*. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci U S A, Mar 31; 112(13): E1530–E1539, 2015. (中科院1區，IF=9.809. Featured article, highlighted by Christopher K. Tuggle, Proc Natl Acad Sci U S A, 112(13): 3854-3855, 2015)
3. Gao Y#, Wu H#, Wang Y#, Liu X, Chen L, Li Q, Cui C, Liu X, Zhang J, Zhang Y*. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biol;18(1):13,2017. (中科院1區，IF=11.908)
4. Wu H#*, Song C, Zhang J, Zhao J, Fu B, Mao T, Zhang Y*.Melatonin-mediated upregulation of GLUT1 blocks exit from pluripotency by increasing the uptake of oxidized vitamin C in mouse embryonic stem cells. FASEB J;31(4):1731-1743, 2017. (中科院2區TOP，IF=5.498)
5. Wu H#*, Zhao J, Fu B, Yin S, Song C, Zhang J, Zhao S, Zhang Y*. Retinoic acid-induced upregulation of miR-219 promotes the differentiation of embryonic stem cells into neural cells. Cell Death Dis;8(7):e2953,2017. (中科院2區，IF=5.965)
6. Song C, Zhao J, Fu B, Dan Li, Mao T, Peng W, Wu H*, Zhang Y*. Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway.Free Radic Biol Med;112:616-630, 2017. (中科院2區TOP，IF=5.605)
7. Song C, Fu B, Zhang J, Zhao J, Yuan M, Peng W, Zhang Y*, Wu H*. Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway. Sci Rep. 6;7(1):672,2017. (中科院2區，IF=5.228)
8. Song C, Peng W, Yin S, Zhao J, Fu B, Zhang J, Mao T, Wu H*, Zhang Y*. Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. Sci Rep. 12;6:35165,2016. (中科院2區，IF=5.578)
9. Fu B, Zhao J, Peng W, Wu H*, Zhang Y*. Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1α and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 cells. Biochemical and Biophysical Research Communications, 486(1): 198-204, 2017.
10. Zhao J, Fu B, Peng W, Mao T, Wu H*, Zhang Y*. Melatonin protect the development of preimplantation mouse embryos from sodium fluoride-induced oxidative injury. Environmental Toxicology and Pharmacology, 54, 133-141, 2017.
1. Wu H#, Wu Y, Ai Z, Yang L, Gao Y, Du J, Guo Z, Zhang Y*. Vitamin C enhances nanog expression via activation of the JAK/STAT signaling pathway. Stem Cells. 32(1):166-76, 2014. (中科院1區，IF=7.701)
2. Wu H#, Wang Y, Zhang Y, Yang M, Lv J, Liu J, and Zhang Y*. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci U S A, Mar 31; 112(13): E1530–E1539, 2015. (中科院1區，IF=9.809. Featured article, highlighted by Christopher K. Tuggle, Proc Natl Acad Sci U S A, 112(13): 3854-3855, 2015)
3. Gao Y#, Wu H#, Wang Y#, Liu X, Chen L, Li Q, Cui C, Liu X, Zhang J, Zhang Y*. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biol;18(1):13,2017. (中科院1區，IF=11.908)
4. Wu H#*, Song C, Zhang J, Zhao J, Fu B, Mao T, Zhang Y*.Melatonin-mediated upregulation of GLUT1 blocks exit from pluripotency by increasing the uptake of oxidized vitamin C in mouse embryonic stem cells. FASEB J;31(4):1731-1743, 2017. (中科院2區TOP，IF=5.498)
5. Wu H#*, Zhao J, Fu B, Yin S, Song C, Zhang J, Zhao S, Zhang Y*. Retinoic acid-induced upregulation of miR-219 promotes the differentiation of embryonic stem cells into neural cells. Cell Death Dis;8(7):e2953,2017. (中科院2區，IF=5.965)
6. Song C, Zhao J, Fu B, Dan Li, Mao T, Peng W, Wu H*, Zhang Y*. Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway.Free Radic Biol Med;112:616-630, 2017. (中科院2區TOP，IF=5.605)
7. Song C, Fu B, Zhang J, Zhao J, Yuan M, Peng W, Zhang Y*, Wu H*. Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway. Sci Rep. 6;7(1):672,2017. (中科院2區，IF=5.228)
8. Song C, Peng W, Yin S, Zhao J, Fu B, Zhang J, Mao T, Wu H*, Zhang Y*. Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. Sci Rep. 12;6:35165,2016. (中科院2區，IF=5.578)
9. Fu B, Zhao J, Peng W, Wu H*, Zhang Y*. Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1α and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 cells. Biochemical and Biophysical Research Communications, 486(1): 198-204, 2017.
10. Zhao J, Fu B, Peng W, Mao T, Wu H*, Zhang Y*. Melatonin protect the development of preimplantation mouse embryos from sodium fluoride-induced oxidative injury. Environmental Toxicology and Pharmacology, 54, 133-141, 2017.
獲獎記錄
陝西省青年人才托舉計畫（2017），陝西省優秀博士學位論文（2017）。
