基本介紹
- 中文名：吳明雨
- 學位/學歷：博士
- 職業：教師
- 專業方向：有機化學
- 任職院校：西南交通大學
個人經歷,主講課程,研究方向,學術成果,
個人經歷
2010年畢業於四川大學化學學院化學專業，獲理學學士學位；同年保送四川大學化學學院有機化學專業，於2015年獲理學博士學位，師從教育部長江學者特聘教授，國家傑出青年基金獲得者余孝其教授。隨後於2015年7月加入西南交通大學生命科學與工程學院從事教學和科學研究。2018年06月-2020.06月於瑞典卡羅林斯卡醫學院從事博士後研究。
主講課程
(1)有機化學
(2)Organic Chemistry (生物工程中美班)
(3)有機化學實驗
(4)工程化學實驗
研究方向
(1)細胞器靶向螢光螢光成像和疾病檢測；
(2)腫瘤的診斷和癌細胞耐藥性研究；
(3)腫瘤靶向光敏劑；
(4)細胞膜化學生物學研究。
學術成果
先後主持或參與包括國家自然科學基金面上項目，自然科學基金青年項目和中央高校科技創新項目等。先後在Biomaterials， Chem. Commun.， J Mat Chem B, Sci. Rep.， J. Org. Chem.， Analyst， Org. Biomol. Chem. 等雜誌中發表SCI論文30餘篇，並發表一篇授權專利。其中單篇論文最高被引用173次，被引用超過100次的論文四篇，論文總共被引用超過1100次。H-index：16。
科學研究
國家自然科學基金青年科學基金項目：近紅外線粒體靶向pH螢光探針的合成及其在生物成像中的套用研究， 2018.01-2020.12，主持；
國家自然科學基金面上項目：多孔磁性固定化金屬親和色譜納米材料的製備及其在生命分析中的套用，2018.01-2021.12，主研；
中央高校基本科研業務費理工科科技創新項目：基於二氫卟吩的腫瘤和線粒體雙靶向光敏劑的性質及性質研究，2016.01-2018.12，主持。
論文成果
(1)Li Liu, Rui-Jie Lv, Jong-Kai Leung, Qian Zou, Yue Wang, Fei Li, Wang Liang, Shun Feng,Ming-Yu Wu*. “A near-infrared biothiol-specific fluorescent probe for cancer cell recognition”. Analyst,2019, (Inside cover)
(2)Yue Wang, Li Liu, Xian-Li Zhou,Ming-Yu Wu*. “Lysosome-Targeted Single Fluorescence Probe for Two-Channel Imaging Intracellular SO2 and Biothiols”. Molecules,2019, 24, 618.
(3)Ming-Yu Wu*, Yue Wang, Yan-Hong Liu, Xiao-Qi Yu*. “Dual-site lysosome-targeted fluorescent probe for separate detection of endogenous biothiols and SO2 in living cells”. J. Mater. Chem. B,2018, 6, 4232-4238.(Journal of Materials Chemistry B top 5% most-read Q2 2018)
(4)Ming-Yu Wu*, Jing WU, Yan-Hong Liu, Xiao-Qi Yu*. “A Novel Colorimetric Fluorescent Probe for SO2 and Its Application in Living Cells Imaging” Molecules,2018, 23, 871.
(5)Ming-Yu Wu, Gerard Esteban, Simone Brogi, Masahi Shionoya, Li Wang, Giuseppe Campiani, Mercedes Unzeta*, Tsutomu Inokuchi*, Stefania Butini*, Jose Marco-Contelles*. “Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation”. Eur. J. Med. Chem.,2016, 121, 864-879.
(6)Ming-Yu Wu, Kun Li,* Yan-Hong Liu, Kang-Kang Yu, Yong-Mei Xie Xue-dong Zhou* Xiao-Qi Yu*. “Mitochondria-targeted ratiometric fluorescent probe for real time monitoring pH in living cells”. Biomaterials,2015, 53, 669-678.
(7)Ming-Yu Wu, Kun Li*, Chun-Yan Li, Ji-Ting Hou, Xiao-Qi Yu*. “A water-soluble near-infrared probe forcolorimetric and ratiometric sensing of SO2 derivatives in living cells”. Chem. Commun.,2014, 50, 183-185.
(8)Ming-Yu Wu, Elkhabiry Shaban, Marta Switalska, Ning Wang, Miho Shimodo, Yusuke Mizutani, Megumi Yoshida, Zhen-Wu Mei, Hiroyuki Kawafuchi, Junzo Nokami, Joanna Wietrzky, Xiao-Qi Yu, Tsutomu Inokuchi*. “Synthetic access to poly-substituted 11H-pyrido[3,2-a]carbazole, a DNA-intercalating Ellipticine related structure, and their antiproliferative activity”. Heterocycles,2014, 89, 1427-1440.
(9)Ming-Yu Wu, Ting He, Kun Li*, Ming-Bo Wu, Zheng Huang, Xiao-Qi Yu*. “A real-time colorimetric and ratiometric fluorescent probe for sulfite”. Analyst.2013, 138, 3018-3025.（Top ten accesed articles from the online version during the months of April-June in 2013）
(10)Ming-Yu Wu, Kun Li,* Ji-Ting Hou, Zheng Huang, Xiao-Qi Yu*. “A selective colorimetric and ratiometric ?uorescent probe for hydrogen sul?de”. Org. Biomol. Chem.,2012, 10, 8342–8347.
(11)Ming-Yu Wu, Kun Li*, Ting He, Xing-Wen Feng, Na Wang, Xiao-Yan, Wang, Xiao-Qi Yu*. “A novel enzymatic tandem process: utilization of biocatalytic promiscuity for high stereoselective synthesis of 5-hydroxyimino-4,5-dihydrofurans”. Tetrahedron,2011, 67, 2681-2688.
(12)Ming-Yu Wu, Ming-Qi Wang, Kun Li*, Xing-Wen Feng, Ting He, Na Wang, Xiao-Qi Yu*. “An efficient, transition-metal-free process for the synthesis of substituted dihydrofurans via a Michael/Cyclization tandem reaction”. Tetrahedron. Lett.,2011, 52, 679-683.
(13)Ming-Yu Wu, Kun Li*, Na Wang, Ting He, Xiao-Qi Yu*. “A novel catalyst-free tandem reaction for the synthesis of 5-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones in water medium”. Synthesis-Stuttgart,2011, 12, 1831-1839.
(14)Kang-Kang Yu, Ji-Ting Hou, Kun Li*, Qian Yao, Jin Yang,Ming-Yu Wu, Yong-Mei Xie, Xiao-Qi Yu*. “A single design strategy for dual sensitive pH probe with a suitable range to map pH in living cells”. Sci. Rep.,2015, 5, 15540-15549.
(15)Yu Liu, Kun Li*,Ming-Yu Wu, Yan-Hong Liu, Yong-Mei Xie*, Xiao-Qi Yu*. “A mitochondria-targeted colorimetric and ratiometric fluorescent probe for biological SO2 derivatives in living cells”. Chem. Commun.,2015, 51, 10236-10239.
(16)Ye-Xin Liao, Mao-Die Wang, Kun Li*, Zhao-Xuan Yang, Ji-Ting Hou,Ming-Yu Wu, Yan-Hong Liu, Xiao-Qi Yu*. “A highly sensitive and selective "turn-on" fluorescent probe for hypochlorous acid monitoring”. RSC Adv.,2015, 5, 18275-18278.
(17)Ji-Ting Hou,Ming-Yu Wu, Kun Li*, Jin Yang, Kang-Kang Yu, Yong-Mei Xie, Xiao-Qi Yu*. “Mitochondria-targeted colorimetric and fluorescent probes for hypochlorite and their applications for in vivo imaging”. Chem. Commun.,2014, 50, 8640-8643.
(18)Ting He, Kun Li,Ming-Yu Wu, Ye-Xin Liao, Xiao-Qi Yu. “Visual detection of amino acids by supramoleculargel collapse”. RSC Adv.,2014, 4, 2119–2123.
(19)Ye-Xin Liao, Kun Li,*Ming-Yu Wu, Tong Wu Xiao-Qi Yu*. “A selenium-contained aggregation-induced “turn on” fluorescent probe for hydrogen peroxide” Org. Biomol. Chem.,2014, 12, 3004–3008.
(20)Ning Wang , Marta Switalska ,Ming-Yu Wu, Kento Imai, Tran Anh Ngoc, Cui-Qing Pang, Li Wang, Joanna Wietrzyk*, Tsutomu Inokuchi*. “Synthesis and in vitro cytotoxic effect of 6-amino-substituted 11H- and 11Me-indolo[3,2-c]quinolones”. Eur. J. Med. Chem.,2014, 78, 314-323.
(21)Elkhabiry Shaban, Md Imran Hossain,Ming-Yu Wu, Yoshihiko Takemasa, Sachie Nagae, Wei Peng, Hiroyuki Kawafuchi, Tsutomu Inokuchi*. “Microwave-irradiated synthesis of 1,2-dihydropyridines from N-functionalized enaminones and enals through Domino condensation and 6II-azaelectrocyclization”. Heterocycles,2014, 89, 171-182.
(22)Ting He, Kun Li*,Ming-Yu Wu, Ming-Bo Wu, Na, Wang, Lin Pu, Xiao-Qi Yu*. “Water promoted enantioselective aldol Reaction by proline-cholesterol and -diosgenin based amphiphilic organocatalysts”. Tetrahedron,2013, 69, 5136-5143.
(23)Ji-Ting Hou, Kun Li,* Kang-Kang Yu,Ming-Yu Wu, Xiao-Qi Yu*. Coumarin–DPA–Cu( II ) as a chemosensing ensemble towards histidine determination in urine and serum. Org. Biomol. Chem.,2013, 11, 717–720.
(24)Ming-Qi Wang, Kun Li,* Ji-Ting Hou,Ming-Yu Wu, Xiao-Qi Yu*. BINOL-based fluorescent sensor for recognition of Cu(II) and sul?de anion in water. J. Org. Chem.2012, 77, 8350 – 8354.
(25)Zong-Bo Xie, Na Wang*,Ming-Yu Wu, Ting He, Zhang-Gao Le, Xiao-Qi Yu*. Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method. Beilstein J. Org. Chem.,2012, 8, 534–538.
