吳一諾(中山大學藥學院副教授)

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吳一諾，博士，中山大學藥學院副教授、碩士研究生導師。主要從事磷酸二酯酶抑制劑的發現 及其在肺部、神經系統疾病中的套用。已在 J. Med.Chem, Org. Lett., Chem.Commun.,E. J. Med.Chem, Chem.Eur. J., Adv. Synth. Catal.等國際權威雜誌發表SCI收錄論文30餘篇。共主持國家自然科學基金等項目7項，並作為課題骨幹參與國家科技部重點研發計畫。

基本介紹

  • 中文名：吳一諾
  • 畢業院校：中山大學
  • 學位/學歷：博士研究生
  • 職業：教師
  • 職務：碩士研究生導師
  • 職稱：副教授
人物經歷,教育經歷,工作經歷,教授課程,科研項目,學術成果,發表論文,發明專利,

人物經歷

教育經歷

2006/09 - 2011/06，中山大學，藥學院，藥物化學，博尋糊拒士
2002/09 - 2006/06，中山大學，化學與化學工程學院，套用化學系，學士

工作經歷

2018/04- ，中山大學，藥學院，副教授
2013/07 - 2018/04，中山大學，藥學院，講師
2011/07 - 2013/06，香港理工大學，套用生物與化學科技系，博士後

教授課程

《現代分析技術與套用》
《基礎化學實驗》

科研項目

1.國家自然科學基金青年項目，鈀催化下甲苯類醯化試劑參與的鄰位和間位C-H醯基化反應槳斷蒸婆，項目編號：21402243；2015.01 - 2017.12; 25萬元
2.國家重點研發計畫，課題骨幹，基於E 級高性能計算生物醫藥套用軟體系統研製及套用。課題四：癌症、糖尿病與感染性疾病新藥研究與軟體套用驗證, 課題編號：2017YFB0202604; 2017.07 - 2020.12; 749萬元。
3. 廣州市科技計畫項目珠江科技新星專題，新型萘內醯亞胺類磷酸二酯酶二型抑制劑的合理化設計、合成及其抗阿爾茨海默症藥效研究，2018.01 - 2020.12；30萬元。
4. 廣東省醫學科研基金，C-H鍵磷酯方法高效構建HIV-1非核苷類逆轉錄酶抑制劑，項目編號：B2014106；2014.06 - 2016.06；旋祖擊譽1萬元。
5. 廣東省中醫藥局面上項目，透骨草中天然磷酸二酯酶4型抑制劑的發現及結構改造，項目編號：20171049；2017.01 - 2018.12；0.5萬元。
6. 中山大學青年教師培育基金，C-H鍵磷酯方法高效構建苯（雜）環類有機磷化合物新型方法研究，項目編號：13ykpy10；2013.11 - 2016.12；15萬元。
7. 中山大學青年教師起步基金，鈀催化C-H醯基化反應在芳（雜）環酮類物質製備中的套用，項目編號：31101402；2013.11 - 2014.12；2萬元。
8. 國家自然科學基金青年項目，合作單位負責人，可支配經費10萬勸少棄元；凝漿吡喃並吡唑類AKR1C3選擇性抑制劑的設計、最佳化和分子機制研究，項目編號：81602968；2017.01 - 2019.12

學術成果

近年來共發表論文35篇，其中第一作者或共同通訊作者論文23篇，8篇屬於中科院JCR分區一區論文；總引用請拔寒次數884次，單篇最高他引次數為125次。以第二發明人申請中國專利2項，第三發明阿說檔人申請歐洲專利1項。

發表論文

  1. Wu, Yinuo#;Zhou, Q.#; Zhang, T.#; Li, Z.; Chen, Y. P.; Zhang, P.; Yu, Y. F.; Geng, H.; Tian, Y. J.; Zhang, C.; Wang, Y.; Chen, J. W.*; Chen, Y.*; Luo, H. B.*, Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.J. Med. Chem.2019,62(8), 4218-4224.（IF:6.253 )
  2. Huang, Y. Y.; Yu, Y. F.; Zhang, C.; Chen, Y.; Zhou, Q.; Li, Z.; Zhou, S.; Li, Z.; Guo, L.; Wu, D. *;Wu, Yinuo;*; Luo, H. B. *, Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.J. Med. Chem.2019,62(7), 3707-3721.（IF:6.253 )
  3. Wu, Yinuo; Li, Z.; Huang, Y.-Y.; Wu, D.; Luo, H.-B. *, Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer's Disease.J. Med. Chem.2018,61(13), 5467-5483.（IF:6.253)
  4. Wu, X. N.; Huang, Y. D.;Li, J.; Yu, Y.-F.;Zhou, Q.;Zhang, C.;Wu, Yinuo*and Luo, H.-B.*Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors.Acta Pharmaceutica Sinica B.2017,2018,8(4), 615-628.（IF:6.014)
  5. Li, J.; Chen, J.-Y.; Deng, Y.-L.; Zhou, Q.;Wu, Yinuo*; Wu, D. *; Luo, H.-B., Structure-based design, synthesis, biological evaluation, and molecular docking of novelPDE10 inhibitorswith antioxidant activities.Front. Chem.2018,6, 167/1-167/12.（IF: 4.155 )
  6. Zhang, C.; Zhou, Q.; Wu, X. N.; Huang, Y. D.; Zhou, J.; Lai, Z.;Wu, Yinuo*; Luo, H.-B.Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease.J. Enzym. Inhib. Med. Chem.2018,33(1), 260-270.（IF:3.638)
  7. Yu, Y. F.; Huang, Y. D.; Zhang, C; Wu, X. N.; Zhou, Q; Wu, D. Y.;Wu, Yinuo*; Luo, H. B. * Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer's Disease.ACS Chem. Neurosci.2017, 8, 2522.（IF:4.211)
  8. .Zhang, C; Feng, L. J.; Huang, Y. Y.; Wu, D. Y.; Li, Z.; Zhou, Q.;Wu, Yinuo*;Luo, H. B.* Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.J. Chem. Inf. Model.2017, 57, 355.（IF: 3.804).
  9. Zheng, X. H.; Zhou, S. Y.;Zhang, C.; Wu, D. Y.; Luo, H. B.;Wu, Yinuo*Docking-assisted 3D-QSAR studies on xanthones as alpha-glucosidase inhibitors.J. Mol. Model.2017,23, DOI: 10.1007/s00894-017-3438-1.
  10. Tan, B.X.; Yang, L.; Huang, Y. Y.; Chen, Y. Y.; Peng, G. T.; Yu, S.;Wu, Yinuo*; Luo, H. B.; He, X. X. Bioactive triterpenoids from the leaves of Eriobotrya japonica as the natural PDE4 inhibitors. Natural Product Research,2017,31, 2836.
  11. Zheng, X.; Wu, X. N.; Chen, J. Y.; Luo, H. B.; Wu, D.*;Wu, Yinuo*.Transitional Metal-free catalyzed C-H arylation of unactivated arenes with 8-hydroxyquinoline as a promoter.Synthesis2017，Just Accepted.
  12. Wu, Yinuo;Jiang, C.; Wu, D.; Gu, Q.; Luo, Z. Y.; Luo, H. B.*.Palladium-catalyzed C–H bond carboxylation of acetanilides: an efficient usage of N, N-dimethyloxamic acid as the carboxylate source.Chem. Commun.2016,52,1286.
  13. Wu, Yinuo;Sun, L.; Chen, Y.; Zhou, Q.; Huang, J. W.; Miao, H.; Luo, H. B.*Palladium-catalyzed decarboxylative acylation of N-nitrosoanilines with α-oxocarboxylic acids.J. Org. Chem.2016,81, 1244.
  14. Cai, Y. H.; Guo, Y.; Li, Z.;Wu, D.; Li, X.; Zhang, H.; Yang, J.; Lu, H.; Sun. Z.; Luo, H. B.; Yin, S.*;Wu, Yinuo*. Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4.Eur. J. Med. Chem.2016,114,134.
  15. Yang, Q. J.; Choy, P. Y.;Wu, Yinuo*;Fan, B. M.*; Kwong, F. Y.* Oxidative coupling between C(sp(2))-H and C(sp(3))-H bonds of indoles and cyclic ethers/cycloalkanes.Org. Biomo. Chem.2016,14, 2608.
  16. Li, Z.; Lu, X.; Feng, L.-J.; Gu, Y.; Li, X.;Wu, Yinuo*; Luo, H.-B.*Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds.Mol. BioSyst.2015,11,115.
  17. Wu, Yinuo;Feng, L. J.; Lu, X.; Kwong, F. Y.*; Luo, H. -B.*.Palladium-catalyzed oxidative C–H bond acylation ofN-nitrosoanilines with toluene derivatives: a traceless approach to synthesizeN-alkyl-2-aminobenzophenones.Chem. Commun.2014,50,15352.
  18. Wu, Yinuo*;Choy, P. Y.; Kwong, F. Y.Direct intermolecular C–H arylation of unactivated arenes with aryl bromides catalysed by 2-pyridyl carbinol.Org. Biomo. Chem.2014,12, 6820.
  19. Wu, Yinuo;Choy, P. Y.; Kwong, F. Y.* A Direct C-H Arylation of Unactivated Arenes Promoted by Mixed Potassium Alkoxides.Asian J. Org. Chem.2014,3, 1262.
  20. Wu, Yinuo;Choy P. Y., Mao F., Kwong F. Y.* Toluene Derivatives as Simple Coupling Precursors for Cascade Palladium-Catalyzed Oxidative C-H bond Acylation of Acetanilides. Chem. Commun.2013,49, 689.
  21. Wu, Yinuo; Kwong, F. Y.; Li, P. ; Chan, A. S. C.AnEfficient Oxidative Cross-Coupling Reaction between CH and NH Bonds; A Transition-Metal-Free Protocol at Room Temperature.Synlett,2013,24, 2009.
  22. Wu, Yinuo;Wong, S. M.; Mao, F.; Chan, T. L.; Kwong, F. Y. *Intramolecular Direct C-H Bond Arylation from Aryl Chlorides: A Transition-Metal-Free Approach for Facile Access of Phenanthridines.Org. Lett.2012,14,5306.（IF: 6.290)
  23. Wu, Yinuo;Wang, J.; Li, P. *; Kwong, F. Y.*Catalyst-free efficient aza-michael addition of azoles to nitroalkenes,Synlett,2012,23, 788
  24. Wu, Yinuo;Li, B.; Mao, F.; Li, X.;* Kwong, F. Y.*Palladium -Catalyzed Oxidative C-H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilide.Org. Lett.2011,13, 3258.
  25. Wu, Yinuo;Mao, F.; Meng, F.; Li. X.*Enantioselective Vanadium-Catalyzed Oxidation of 1,3-Dithianes from Aldehydes and Ketones using beta-Amino Alcohol Derived Schiff Base Ligands.Adv. Synth.Catal.2011,353,1707.
  26. Wu, Yinuo;Wang, J. *; Mao, F.; Kwong F. Y.*Palladium-catalyzed cross-dehydrogenative functionalization of C (sp (2))-H Bonds.綜述，Chem. Asian J.2014,9, 26.
  27. Chan T. L.;Wu, Yinuo*;Choy P. Y.; Kwong F. Y.* A Radical Process towards the Development of Transition Metal-Free Aromatic Carbon-Carbon Bond-Forming Reactions.綜述，Chem. Eur. J.2013,19,15802

發明專利

1.羅海彬；吳一諾；張佩；周倩；陳儀萍；張天華；於艷發；吳旭年。一種N-取代吡唑並[3 ,4-d ]嘧啶酮類化合物及其製備方法和套用. 專利申請號：CN201810858465.9，2018年7月
2. 羅海彬；吳一諾；吳旭年；黃雅丹；周倩。一種N-取代吡唑並[3 ,4-d ]嘧啶酮類化合物及其製備方法和套用. 專利申請號：CN201711315731.5， 2017年12月
2.Luo, Haibin;Wu, Yinuo; Deng, Yalin; Huang, Yiyou; Wu, Xunian .Preparation of quinazoline compounds as inhibitors of phosphodiesterase type 10。專利號：CN 106632089；專利申請日：2016年9月4日，專利類型：A，公開日期：2017年5月10日
3.Luo, H. B.;Wu, Yinuo; Wu, X.; Huang, Y.; Zhou, Q. N-Substituted pyrazolo[3,4-d]pyrimidinone compound, preparation method and application thereof。專利號：CN 106977518；專利申請日：2017年3月6日，專利類型：A，公開日期：2017年7月25日
4.Kwong, Fuk Yee; Choy, Pui Ying;Wu, Yinuo; Yang, Qingjing Synthesis of phosphine ligands bearing tunable linkage and methods of their use in catalysis，專利號：WO2017193288；專利申請日：2016年5月10日，專利類型：A1，公開日期：2017年9月16日
5.Wu, Yinuo;Wang, J.；Kwong F. Y. C-C Cross-Coupling Reactions of Acidic C-H Nucleophiles with Two Activating Groups,Science of synthesis,Cross Coupling and Heck-Type Reactions 2. 2.7.2. 2012年11月21日

學術成果

近年來共發表論文35篇，其中第一作者或共同通訊作者論文23篇，8篇屬於中科院JCR分區一區論文；總引用次數884次，單篇最高他引次數為125次。以第二發明人申請中國專利2項，第三發明人申請歐洲專利1項。

發表論文

  1. Wu, Yinuo#;Zhou, Q.#; Zhang, T.#; Li, Z.; Chen, Y. P.; Zhang, P.; Yu, Y. F.; Geng, H.; Tian, Y. J.; Zhang, C.; Wang, Y.; Chen, J. W.*; Chen, Y.*; Luo, H. B.*, Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.J. Med. Chem.2019,62(8), 4218-4224.（IF:6.253 )
  2. Huang, Y. Y.; Yu, Y. F.; Zhang, C.; Chen, Y.; Zhou, Q.; Li, Z.; Zhou, S.; Li, Z.; Guo, L.; Wu, D. *;Wu, Yinuo;*; Luo, H. B. *, Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.J. Med. Chem.2019,62(7), 3707-3721.（IF:6.253 )
  3. Wu, Yinuo; Li, Z.; Huang, Y.-Y.; Wu, D.; Luo, H.-B. *, Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer's Disease.J. Med. Chem.2018,61(13), 5467-5483.（IF:6.253)
  4. Wu, X. N.; Huang, Y. D.;Li, J.; Yu, Y.-F.;Zhou, Q.;Zhang, C.;Wu, Yinuo*and Luo, H.-B.*Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors.Acta Pharmaceutica Sinica B.2017,2018,8(4), 615-628.（IF:6.014)
  5. Li, J.; Chen, J.-Y.; Deng, Y.-L.; Zhou, Q.;Wu, Yinuo*; Wu, D. *; Luo, H.-B., Structure-based design, synthesis, biological evaluation, and molecular docking of novelPDE10 inhibitorswith antioxidant activities.Front. Chem.2018,6, 167/1-167/12.（IF: 4.155 )
  6. Zhang, C.; Zhou, Q.; Wu, X. N.; Huang, Y. D.; Zhou, J.; Lai, Z.;Wu, Yinuo*; Luo, H.-B.Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease.J. Enzym. Inhib. Med. Chem.2018,33(1), 260-270.（IF:3.638)
  7. Yu, Y. F.; Huang, Y. D.; Zhang, C; Wu, X. N.; Zhou, Q; Wu, D. Y.;Wu, Yinuo*; Luo, H. B. * Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer's Disease.ACS Chem. Neurosci.2017, 8, 2522.（IF:4.211)
  8. .Zhang, C; Feng, L. J.; Huang, Y. Y.; Wu, D. Y.; Li, Z.; Zhou, Q.;Wu, Yinuo*;Luo, H. B.* Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.J. Chem. Inf. Model.2017, 57, 355.（IF: 3.804).
  9. Zheng, X. H.; Zhou, S. Y.;Zhang, C.; Wu, D. Y.; Luo, H. B.;Wu, Yinuo*Docking-assisted 3D-QSAR studies on xanthones as alpha-glucosidase inhibitors.J. Mol. Model.2017,23, DOI: 10.1007/s00894-017-3438-1.
  10. Tan, B.X.; Yang, L.; Huang, Y. Y.; Chen, Y. Y.; Peng, G. T.; Yu, S.;Wu, Yinuo*; Luo, H. B.; He, X. X. Bioactive triterpenoids from the leaves of Eriobotrya japonica as the natural PDE4 inhibitors. Natural Product Research,2017,31, 2836.
  11. Zheng, X.; Wu, X. N.; Chen, J. Y.; Luo, H. B.; Wu, D.*;Wu, Yinuo*.Transitional Metal-free catalyzed C-H arylation of unactivated arenes with 8-hydroxyquinoline as a promoter.Synthesis2017，Just Accepted.
  12. Wu, Yinuo;Jiang, C.; Wu, D.; Gu, Q.; Luo, Z. Y.; Luo, H. B.*.Palladium-catalyzed C–H bond carboxylation of acetanilides: an efficient usage of N, N-dimethyloxamic acid as the carboxylate source.Chem. Commun.2016,52,1286.
  13. Wu, Yinuo;Sun, L.; Chen, Y.; Zhou, Q.; Huang, J. W.; Miao, H.; Luo, H. B.*Palladium-catalyzed decarboxylative acylation of N-nitrosoanilines with α-oxocarboxylic acids.J. Org. Chem.2016,81, 1244.
  14. Cai, Y. H.; Guo, Y.; Li, Z.;Wu, D.; Li, X.; Zhang, H.; Yang, J.; Lu, H.; Sun. Z.; Luo, H. B.; Yin, S.*;Wu, Yinuo*. Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4.Eur. J. Med. Chem.2016,114,134.
  15. Yang, Q. J.; Choy, P. Y.;Wu, Yinuo*;Fan, B. M.*; Kwong, F. Y.* Oxidative coupling between C(sp(2))-H and C(sp(3))-H bonds of indoles and cyclic ethers/cycloalkanes.Org. Biomo. Chem.2016,14, 2608.
  16. Li, Z.; Lu, X.; Feng, L.-J.; Gu, Y.; Li, X.;Wu, Yinuo*; Luo, H.-B.*Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds.Mol. BioSyst.2015,11,115.
  17. Wu, Yinuo;Feng, L. J.; Lu, X.; Kwong, F. Y.*; Luo, H. -B.*.Palladium-catalyzed oxidative C–H bond acylation ofN-nitrosoanilines with toluene derivatives: a traceless approach to synthesizeN-alkyl-2-aminobenzophenones.Chem. Commun.2014,50,15352.
  18. Wu, Yinuo*;Choy, P. Y.; Kwong, F. Y.Direct intermolecular C–H arylation of unactivated arenes with aryl bromides catalysed by 2-pyridyl carbinol.Org. Biomo. Chem.2014,12, 6820.
  19. Wu, Yinuo;Choy, P. Y.; Kwong, F. Y.* A Direct C-H Arylation of Unactivated Arenes Promoted by Mixed Potassium Alkoxides.Asian J. Org. Chem.2014,3, 1262.
  20. Wu, Yinuo;Choy P. Y., Mao F., Kwong F. Y.* Toluene Derivatives as Simple Coupling Precursors for Cascade Palladium-Catalyzed Oxidative C-H bond Acylation of Acetanilides. Chem. Commun.2013,49, 689.
  21. Wu, Yinuo; Kwong, F. Y.; Li, P. ; Chan, A. S. C.AnEfficient Oxidative Cross-Coupling Reaction between CH and NH Bonds; A Transition-Metal-Free Protocol at Room Temperature.Synlett,2013,24, 2009.
  22. Wu, Yinuo;Wong, S. M.; Mao, F.; Chan, T. L.; Kwong, F. Y. *Intramolecular Direct C-H Bond Arylation from Aryl Chlorides: A Transition-Metal-Free Approach for Facile Access of Phenanthridines.Org. Lett.2012,14,5306.（IF: 6.290)
  23. Wu, Yinuo;Wang, J.; Li, P. *; Kwong, F. Y.*Catalyst-free efficient aza-michael addition of azoles to nitroalkenes,Synlett,2012,23, 788
  24. Wu, Yinuo;Li, B.; Mao, F.; Li, X.;* Kwong, F. Y.*Palladium -Catalyzed Oxidative C-H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilide.Org. Lett.2011,13, 3258.
  25. Wu, Yinuo;Mao, F.; Meng, F.; Li. X.*Enantioselective Vanadium-Catalyzed Oxidation of 1,3-Dithianes from Aldehydes and Ketones using beta-Amino Alcohol Derived Schiff Base Ligands.Adv. Synth.Catal.2011,353,1707.
  26. Wu, Yinuo;Wang, J. *; Mao, F.; Kwong F. Y.*Palladium-catalyzed cross-dehydrogenative functionalization of C (sp (2))-H Bonds.綜述，Chem. Asian J.2014,9, 26.
  27. Chan T. L.;Wu, Yinuo*;Choy P. Y.; Kwong F. Y.* A Radical Process towards the Development of Transition Metal-Free Aromatic Carbon-Carbon Bond-Forming Reactions.綜述，Chem. Eur. J.2013,19,15802

發明專利

1.羅海彬；吳一諾；張佩；周倩；陳儀萍；張天華；於艷發；吳旭年。一種N-取代吡唑並[3 ,4-d ]嘧啶酮類化合物及其製備方法和套用. 專利申請號：CN201810858465.9，2018年7月
2. 羅海彬；吳一諾；吳旭年；黃雅丹；周倩。一種N-取代吡唑並[3 ,4-d ]嘧啶酮類化合物及其製備方法和套用. 專利申請號：CN201711315731.5， 2017年12月
2.Luo, Haibin;Wu, Yinuo; Deng, Yalin; Huang, Yiyou; Wu, Xunian .Preparation of quinazoline compounds as inhibitors of phosphodiesterase type 10。專利號：CN 106632089；專利申請日：2016年9月4日，專利類型：A，公開日期：2017年5月10日
3.Luo, H. B.;Wu, Yinuo; Wu, X.; Huang, Y.; Zhou, Q. N-Substituted pyrazolo[3,4-d]pyrimidinone compound, preparation method and application thereof。專利號：CN 106977518；專利申請日：2017年3月6日，專利類型：A，公開日期：2017年7月25日
4.Kwong, Fuk Yee; Choy, Pui Ying;Wu, Yinuo; Yang, Qingjing Synthesis of phosphine ligands bearing tunable linkage and methods of their use in catalysis，專利號：WO2017193288；專利申請日：2016年5月10日，專利類型：A1，公開日期：2017年9月16日
5.Wu, Yinuo;Wang, J.；Kwong F. Y. C-C Cross-Coupling Reactions of Acidic C-H Nucleophiles with Two Activating Groups,Science of synthesis,Cross Coupling and Heck-Type Reactions 2. 2.7.2. 2012年11月21日

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