占艷艷

占艷艷，女，博士，廈門大學醫學院副教授，碩士生導師。

現掛職任廈門市思明區衛生健康局副局長。

基本介紹

• 中文名：占艷艷
• 畢業院校：廈門大學生命科學學院
• 學位/學歷：博士
• 職業：教師
• 專業方向：腫瘤發生髮展機制及靶向藥物篩選
• 任職院校：廈門大學醫學院

個人經歷

學習經歷

2000~2004 廈門大學生命科學學院生物科學專業理學學士；

2004~2010 廈門大學生命科學學院細胞生物學專業理學博士。

工作經歷

2011~2013 廈門大學附屬第一醫院博士後；

2013~至今廈門大學醫學院副教授。

2022年10月頸嬸享，掛職任廈門市思明區衛生健康局副局長。

職務任免

2022年10月31日，廈門市思明區人民政府決定：占艷艷掛職任廈門市思影戶捆明區衛生健康局店跨副笑頸糊局長，掛職時間從2022年11月至2023年10月，掛職期滿掛任職務自然免除，不再另行發文。

研究方向

Exo70是胞外分泌複合體（exocyst）的關鍵亞基，參與囊泡與質膜汗捉艱鴉的栓系、錨定和融合過程。Exo70在腫瘤發生髮展求鍵己過程中發揮重要的作用，但其作用機制目前尚不清楚。對Exo70在細胞外泌、自噬、侵襲和遷移等過程中的作用達婆料應及相關分子機制的研究，將有助於探索腫瘤的發生及發展機制，並進一步指導靶向性抗腫瘤藥物的篩選和開發。

學術成果

代表成果

1.Ruan H, Zhan YY(corresponding)*, Hou J, Xu B, Chen B, Tian Y, Wu D, Zhao Y, Zhang Y, Chen X, Mi P, Zhang L, Zhang S, Wang X, Cao H, Zhang W, Wang H, Li H, Su Y, Zhang XK*and Hu T*. Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells. Oncogene, 2017, 36(50): 6906-6918.

2.Li D, Zhang Y, Liu K, Zhao Y, Xu B, Xu L, Tan L, Tian Y, Li C, Zhang W, Cao H, Zhan YY(corresponding)*, Hu T*. Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. Laboratory Investigation, 2017,97(11): 1343-1353.

3.Xiao L, Zheng K, Lv X, Hou J, Xu L, Zhao Y, Song F, Fan Y, Cao H, Zhang W, Hong X, Zhan YY(corresponding)*, Hu T*. Exo70 is an independent prognostic factor in colon cancer. Scientific Reports, 2017, 7(1): 5039.

4.Xu B, Xu M, Tian Y, Yu Q, Zhao Y, Chen X, Mi P, Cao H, Zhang B, Song G, Zhan YY(corresponding)*, Hu T*. Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discovery, 2017, 3: 16096.

5.Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, Xiao L, Cao H, Zhang W, Zhang B, Song G, Hu T*, Zhan YY(corresponding)*. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget, 2016, 7(8): 9150-9162.

6.Zhou H, Xu M, Gao Y, Deng Z, Cao H, Zhang W, Wang Q, Zhang B, Song G*, Zhan Y(corresponding)*, Hu T*. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Molecular Cancer, 2014, 13: 59.

7.Zhan YY, He JP, Chen HZ, Wang WJ, Cai JC*. Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells. Cancer Letters, 2013, 329(1): 37-44.

8.Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T*, Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology, 2012, 8(11): 897-904.

9.Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC*, Shen Y*, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology, 2008, 4(9): 548-556.

科研課題

1.國家自然科學基金面上項目，2016.12-2019.12

2.國家自然科學基金青年項目，2014.01-2016.12

3.福建省基金傑出青年項目，2017.01-2020.12

4.福建省省屬公益類科研院所基本科研專項項目，2017.01-2018.12

5.福建省省屬公益類科研院所基本科研專項項目，2015.01-2016.12

6.廈門市重要重大疾病聯合攻關項目(聯合方)，2016.01-2018.12

7.廈門大學中央高校基本科研業務費，2015.01-2017.12

8.廈門大學中央高校基本科研業務費，2013.05-2013.12

9.中國博士後科學基金面上資助，2012.09-2013.03

專利

吳喬、占艷艷、陳航姿、田敏、陳艷、鄭忠輝，《以Nur77-LKB1相互作用為靶點的抗糖尿病藥物篩選方法》，專利號ZL201110200520.3

論文

1.Ruan H, Zhan YY*, Hou J, Xu B, Chen B, Tian Y, Wu D, Zhao Y, Zhang Y, Chen X, Mi P, Zhang L, Zhang S, Wang X, Cao H, Zhang W, Wang H, Li H, Su Y, Zhang XK*and Hu T*. Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells. Oncogene, 2017, 36(50): 6906-6918.

2.Li D, Zhang Y, Liu K, Zhao Y, Xu B, Xu L, Tan L, Tian Y, Li C, Zhang W, Cao H, Zhan YY*, Hu T*. Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. Laboratory Investigation, 2017,97(11): 1343-1353.

3.Xiao L, Zheng K, Lv X, Hou J, Xu L, Zhao Y, Song F, Fan Y, Cao H, Zhang W, Hong X, Zhan YY*, Hu T*. Exo70 is an independent prognostic factor in colon cancer. Scientific Reports, 2017, 7(1): 5039.

4.Xu B, Xu M, Tian Y, Yu Q, Zhao Y, Chen X, Mi P, Cao H, Zhang B, Song G, Zhan YY*, Hu T*. Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discovery, 2017, 3: 16096.

5.Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, Xiao L, Cao H, Zhang W, Zhang B, Song G, Hu T*, Zhan YY*. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget, 2016, 7(8): 9150-9162.

6.Zhou H, Xu M, Gao Y, Deng Z, Cao H, Zhang W, Wang Q, Zhang B, Song G*, Zhan Y*, Hu T*. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Molecular Cancer, 2014, 13: 59.ential for the maintenance of stem-like properties in gastric cancer cells. Cancer Letters, 2013, 329(1): 37-44.

8.Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T*, Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology, 2012, 8(11): 897-904.

9.Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen Wei, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signaling. Gut, 2012, 61(5): 714-724.

10.Liu JJ, Zeng HN, Zhang LR, Zhan YY, Chen Y, Wang Y, Wang J, Xiang SH, Liu WJ, Wang WJ, Chen HZ, Shen YM, Su WJ, Huang PQ, Zhang HK*, and Wu Q*. A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro. Cancer Research, 2010, 70(9): 3628-3637.

11.Lei NZ, Zhang XY, Chen HZ, Wang Yuan, Zhan YY, Zheng ZH, Shen YM, Wu Q*. A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3. Nucleic Acids Research, 2009, 37(3): 832-848.

12.Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC*, Shen Y*, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology, 2008, 4(9): 548-556.

13.Liu B, Wu JF, Zhan YY, Chen HZ, Zhang XY, and Wu Q*. Regulation of the orphan receptor TR3 nuclear functions by JNK phosphorylation. Endocrinology, 2007, 148(1): 34-44.

4.Xu B, Xu M, Tian Y, Yu Q, Zhao Y, Chen X, Mi P, Cao H, Zhang B, Song G, Zhan YY(corresponding)*, Hu T*. Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discovery, 2017, 3: 16096.

5.Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, Xiao L, Cao H, Zhang W, Zhang B, Song G, Hu T*, Zhan YY(corresponding)*. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget, 2016, 7(8): 9150-9162.

6.Zhou H, Xu M, Gao Y, Deng Z, Cao H, Zhang W, Wang Q, Zhang B, Song G*, Zhan Y(corresponding)*, Hu T*. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Molecular Cancer, 2014, 13: 59.

7.Zhan YY, He JP, Chen HZ, Wang WJ, Cai JC*. Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells. Cancer Letters, 2013, 329(1): 37-44.

8.Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T*, Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology, 2012, 8(11): 897-904.

9.Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC*, Shen Y*, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology, 2008, 4(9): 548-556.

科研課題

1.國家自然科學基金面上項目，2016.12-2019.12

2.國家自然科學基金青年項目，2014.01-2016.12

3.福建省基金傑出青年項目，2017.01-2020.12

4.福建省省屬公益類科研院所基本科研專項項目，2017.01-2018.12

5.福建省省屬公益類科研院所基本科研專項項目，2015.01-2016.12

6.廈門市重要重大疾病聯合攻關項目(聯合方)，2016.01-2018.12

7.廈門大學中央高校基本科研業務費，2015.01-2017.12

8.廈門大學中央高校基本科研業務費，2013.05-2013.12

9.中國博士後科學基金面上資助，2012.09-2013.03

專利

吳喬、占艷艷、陳航姿、田敏、陳艷、鄭忠輝，《以Nur77-LKB1相互作用為靶點的抗糖尿病藥物篩選方法》，專利號ZL201110200520.3

論文

1.Ruan H, Zhan YY*, Hou J, Xu B, Chen B, Tian Y, Wu D, Zhao Y, Zhang Y, Chen X, Mi P, Zhang L, Zhang S, Wang X, Cao H, Zhang W, Wang H, Li H, Su Y, Zhang XK*and Hu T*. Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells. Oncogene, 2017, 36(50): 6906-6918.

2.Li D, Zhang Y, Liu K, Zhao Y, Xu B, Xu L, Tan L, Tian Y, Li C, Zhang W, Cao H, Zhan YY*, Hu T*. Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. Laboratory Investigation, 2017,97(11): 1343-1353.

3.Xiao L, Zheng K, Lv X, Hou J, Xu L, Zhao Y, Song F, Fan Y, Cao H, Zhang W, Hong X, Zhan YY*, Hu T*. Exo70 is an independent prognostic factor in colon cancer. Scientific Reports, 2017, 7(1): 5039.

4.Xu B, Xu M, Tian Y, Yu Q, Zhao Y, Chen X, Mi P, Cao H, Zhang B, Song G, Zhan YY*, Hu T*. Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discovery, 2017, 3: 16096.

5.Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, Xiao L, Cao H, Zhang W, Zhang B, Song G, Hu T*, Zhan YY*. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget, 2016, 7(8): 9150-9162.

6.Zhou H, Xu M, Gao Y, Deng Z, Cao H, Zhang W, Wang Q, Zhang B, Song G*, Zhan Y*, Hu T*. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Molecular Cancer, 2014, 13: 59.ential for the maintenance of stem-like properties in gastric cancer cells. Cancer Letters, 2013, 329(1): 37-44.

8.Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T*, Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology, 2012, 8(11): 897-904.

9.Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen Wei, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signaling. Gut, 2012, 61(5): 714-724.

10.Liu JJ, Zeng HN, Zhang LR, Zhan YY, Chen Y, Wang Y, Wang J, Xiang SH, Liu WJ, Wang WJ, Chen HZ, Shen YM, Su WJ, Huang PQ, Zhang HK*, and Wu Q*. A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro. Cancer Research, 2010, 70(9): 3628-3637.

11.Lei NZ, Zhang XY, Chen HZ, Wang Yuan, Zhan YY, Zheng ZH, Shen YM, Wu Q*. A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3. Nucleic Acids Research, 2009, 37(3): 832-848.

12.Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC*, Shen Y*, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology, 2008, 4(9): 548-556.

13.Liu B, Wu JF, Zhan YY, Chen HZ, Zhang XY, and Wu Q*. Regulation of the orphan receptor TR3 nuclear functions by JNK phosphorylation. Endocrinology, 2007, 148(1): 34-44.