劉映樂，武漢大學生命科學學院副教授。
基本介紹
- 中文名：劉映樂
- 職業：教師
- 任職院校：武漢大學生命科學學院
- 系別：病毒學系
教育經歷
1999.09-2004.06 武漢大學生命科學學院，研究生，博士學位
1995.09-1999.06 武漢大學生命科學學院，本科，學士學位；
工作經歷
2021- 武漢大學生命科學學院病毒學系，教授
病毒學國家重點實驗室，固定研究人員
2006-2021武漢大學生命科學學院病毒學系，副教授
病毒學國家重點實驗室，固定研究人員
2004-2006武漢大學生命科學學院病毒學系，講師
學術兼職
中國微生物學會病毒學專業委員會，青年委員
湖北省生物工程學會，理事
主持項目（限10項）
1. 國家“十三五”“重大傳染病防治”科技重大專項（項目編號：2017ZX10103005）
課題名稱：湖北及周邊省傳染病病原譜和流行規律研究
執行年限：2017-2020
承擔角色：項目負責人
資助金額：2130.38萬元
2. 國家863目標導向課題（項目編號：2007AA02Z156）
課題名稱: 溶瘤單純皰疹病毒mtHSV安全性關鍵技術及臨床套用研究
執行年限:2007-2010
承擔角色:項目負責人
資助金額: 298萬元
3. 國家自然科學基金面上項目（項目編號：81871251）
課題名稱：干擾素刺激基因15對NLRP3炎症小體及相關炎症性疾病的調控功能與機制研究
執行年限：2019-2022
承擔角色：項目負責人
資助金額：57萬元
成果（限40篇）
1. Wang W, Li G, De Wu, Luo Z, Pan P, Tian M, Wang Y, Xiao F, Li A, Wu K, Liu X, Rao L, Liu F*, Liu Y*, Wu J*. Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleuin-1β secretion. Nat Commun. 2018 Jan 9;9(1):106. doi: 10.1038/s41467-017-02645-3.
2. Luo Z, Ge M, Chen J, Geng Q, Tian M, Qiao Z, Bai L, Zhang Q, Zhu C, Xiong Y, Wu K, Liu F*, Liu Y*, Wu J*. HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection. PLoS Pathog. 2017 Aug 30;13(8):e1006585. doi: 10.1371/journal.ppat.1006585. eCollection 2017 Aug.
3. Zhang XW, Zhu CL, Jiang H, Ren YH, Zhang Q, Wu KL, Liu F*, Liu YL*, Wu JG*. GP73 Represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. PLoS Pathog 2017. PLoS Pathog. 2017 Apr 10;13(4):e1006321. doi: 10.1371/journal.ppat.1006321. eCollection 2017 Apr.
4. Wang WB#, Xiao F#, Wan P, Pan P, Zhang YC, Liu F, Wu KL, Liu YL*, Wu JG*. EV71 3D protein binds with NLRP3 and enhances the assembly of inflammasome complex. EV71 3D protein binds with NLRP3 and enhances the assembly of inflammasome complex. PLoS Pathog 2017; 13(1):e1006123. (IF:7.003)
5. Wan P, Zhang Q, Liu W, Jia Y, Ai S, Wang T, Wang W, Pan P, Yang G, Xiang Q, Huang S, Yang Q, Zhang W, Liu F, Tan Q, Zhang W, Wu K*, Liu Y* & Wu J*. Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation. FASEB J. 2019 Apr; 33(4), 5793-5807, doi:10.1096/fj.201801681R.
6. Xu W, Ma C, Zhang Q, Zhao R, Hu D, Zhang X, Chen J, Liu F, Wu K, Liu Y*, Wu J*.PJA1 Coordinates with the SMC5/6 Complex to Restrict DNA Viruses and Episomal Genes through Interferon-independent Manner. J Virol. 2018 Sep 5. pii: JVI.00825-18. doi: 10.1128/JVI.00825-18.
7. Chen JB, Xu W, Chen YN, Xie XP, Zhang YC, Ma CQ, Yang QY, Han Y, Zhu CL, Xiong Y, Liu F, Wu KL, Liu YL*, Wu JG*. MMP-9 facilitates hepatitis B virus replication through binding with IFNAR1 to repress IFN/JAK/STAT signaling. J Virol 2017; 91(8):e01824-16.
8. Ge M, Luo Z, Qiao Z, Zhou Y, Cheng X, Geng Q, Cai Y, Wan P, Xiong Y, Liu F, Wu K*, Liu Y*, Wu J*. HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress. J Immunol. 2017 Nov 1;199(9):3280-3292. doi: 10.4049/jimmunol.1700376. Epub 2017 Sep 27.
9. Wang K, Li S, Gao Y, Feng X, Liu W, Luo R, Song Y, JiTu, Liu Y*, Yang C*. BCL3 regulates RANKL-induced osteoclastogenesis by interacting with TRAF6 in bone marrow-derived macrophages. Bone. 2018 Jun 19. pii: S8756-3282(18)30247-3. doi: 10.1016/j.bone.2018.06.015.
10.Liu Z, Dai X, Wang T, Zhang C, Zhang W, Zhang W, Zhang Q, Wu K, Liu F, Liu Y*, Wu J*. Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. Cancer Lett. 2017 Aug 1;400:149-160. doi: 10.1016/j.canlet.2017.04.017. Epub 2017 Apr 25.
11.Yu Y, Wan P, Cao Y, Zhang W, Chen J, Tan L, Wang Y, Sun Z, Zhang Q, Wan Y, Zhu Y, Liu F, Wu K, Liu Y*, Wu J*. Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action. Sci Rep. 2017 May 11;7(1):1729. doi: 10.1038/s41598-017-01773-6.
12.Wang K, Liu W, Song Y, Wu X, Zhang Y, Li S, Gao Y, Tu J, Liu Y*, Yang C*. The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degeneration. Lab Invest. 2017 Aug;97(8):971-982. doi: 10.1038/labinvest.2017.35. Epub 2017 Apr 10.
13.Zhang W, Han DJ, Wan P, Pan P, Cao YH, Liu YL*, Wu LK*, Wu JG*. ERK/c-Jun recruits Tet1 to induce Zta expression and Epstein-Barr virus reactivation through DNA demethylation. Sci Rep 2016; 6:34543.
14.Han Y, Wang LY, Cui J, Song Y, Luo Z, Chen JB, Xiong Y, Zhang Q, Liu F, Ho WZ, Liu YL*, Wu KL*, Wu JG*. SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5’UTR RNA. J Cell Sci 2016; 129:4534-4547.
15.Zhang XW, Wang TC, Dai XC, Zhang YC, Jiang H, Zhang Q, Liu F, Wu KL, Liu YL*, Zhou H*, Wu JG*. Golgi protein 73 facilitates the interaction of hepatitis C virus NS5A with apolipoprotein E to promote viral particle secretion. Biochem Biophys Res Commun 2016; 479(2016):683-689.
16.Liu J, Ai H, Xiong Y, Li F, Wen Z, Liu W, Li T, Qin K, Wu JG*, Liu YL*. Prevalence and correlation of infectious agents in hospitalized children with acute respiratory tract infections in central China. PLoS One 2015; 10(3):e0119170.
17.Liu WY, Wu SM, Xiong Y, Li TY, Wen Z, Yan MZ, Qin K, Liu YL*, Wu JG*. Co-circulation and genomic recombination of coxsackievirus A16 and enterovirus 71 during a large outbreak of hand, foot, and mouth disease in central China. PLoS One 2014; 9(4):e96051.
18.Zou T, Ouyang L, Chen L, Dong W, Qiao H, Liu YL*, Qi YP*. The role of microtubule-associated protein 1S in SOCS3 regulation of IL-6 signaling. FEBS Lett 2008; 582(29):4015-22.
19.Chen L, Dong W, Zou T, Ouyang L, He G, Liu YL*, Qi YP*. Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6. FEBS Lett 2008; 582(19):2843-2849.
20.Wan Q, Kuang E, Dong W, Zhou S, Xu H, Qi YP, Liu YL*. Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. Apoptosis 2007; 12(2):319.
21.Xiang R#, Liu YL#, Zhu L, Dong W, Qi YP*. Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes. Apoptosis 2006; 11(11):1923-1932.
22.Zhu H, Su Y, Zhou S, Xiao W, Ling W, Hu B, Liu YL*, Qi YP*. Immune analysis on mtHSV mediated tumor therapy in HSV-1 seropositive mice. Cancer Biol Ther 2007; 6(5):724-731.
23.Su Y, Zhu H, Xiao W, Xu Q, Zhu L, Zhang X, Wan Q, Zhou S, Du E, Xu H, Yao L, Lv S, Hu B, Liu YL*, Qi YP*. Selectively oncolytic mutant of HSV-1 lyses HeLa cells mediated by Ras/RTN3. Cancer Biol Ther 2007; 6(2):202-208.
24.Peng J, Dong W, Chen L, Zou T, Qi YP*, Liu YL*. Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation. Mol Cell Biochem 2007; 294(1-2):45-54.
25.Xu Q, Zhang P, Hu C, Liu X, Qi YP*, Liu YL*. Identification of amino acid residues involved in the interaction between measles virus Haemagglutin (MVH) and its human cell receptor (signaling lymphocyte activation molecule, SLAM). J Biochem Mol Biol 2006; 39(4):406-411.
26.Dong W#, Liu YL#,*, Peng J, Chen L, Zou T, Xiao H, Liu Z, Li W, Bu Y, Qi YP*. The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 2006; 281(36):26029-26040.
27.Liu YL#, Dong W#, Chen L, Zhang P, Qi YP*. Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB. Biochem Biophys Res Commun 2004; 320(1):1-6.
28. Liu YL#, Dong W#, Chen L, Xiang R, Xiao H, De G, Wang Z, Qi YP*. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. J Biol Chem 2004; 279(36):37436.
獎勵
2020年 教育部“獎勵計畫”新冠特崗教授
2010年 吳建國，葉林柏，朱應，劉映樂，鄔開朗。湖北省自然科學獎一等獎。
2006年 劉映樂、董偉、齊義鵬。湖北省自然科學優秀學術論文特等獎。
2007年 董偉、劉映樂、齊義鵬。湖北省自然科學優秀學術論文一等獎。
