劉志剛，男，博士，西北農林科技大學食品科學與工程學院食品安全與營養系副教授，碩士研究生導師，食品營養與衛生教研室主任。入選德國洪堡學者，美國康奈爾大學唐氏·康奈爾-中國學者，“陝西省高校科協青年人才托舉計畫”。
基本介紹
- 中文名：劉志剛
- 職業：博士
- 畢業院校：西北農林科技大學
- 學位/學歷：博士
- 專業方向：食品科學
- 任職院校：西北農林科技大學
人物經歷,開設課程,研究方向,學術成果,科研項目,外文專著,代表性論文,國際會議,
人物經歷
2017年2月－至今，西北農林科技大學食品科學與工程學院，副教授；
2019年7月－至今，美國康奈爾大學農業與生命科學學院食品科學系，客座副教授；
2015年9月－2017年1月，西北農林科技大學食品科學與工程學院，講師；
2013年8月－2015年8月，美國南加州大學藥學院，聯合培養博士；
2010年9月－2015年6月，西北農林科技大學食品科學與工程學院，食品科學，博士；
2006年9月－2010年6月，西北農林科技大學食品科學與工程學院，食品質量與安全，工學學士。
開設課程
本科課程：《食品營養學》、《食品化學安全性分析與控制教學實習》、《食品學科前沿討論課》
研究生課程：《高級食品化學》、《食品科學Seminar》
研究方向
主要從事食品營養方向研究，主要研究內容具體包括：
1. 食品營養功能組分發掘與功效評價；
2. 新型膳食模式對代謝綜合徵的干預作用機制；
3. 最佳化膳食構成對腦衰老及阿爾茲海默症的改善作用與機制研究。
學術成果
研究發現了高脂高果糖等不合理膳食模式會誘導腦部胰島素抵抗及認知功能障礙，並嘗試探索了通過改變膳食結構和營養組分，干預由於遺傳、衰老、不合理飲食、社會壓力等因素引起的認知記憶功能紊亂及情緒變化。近年來在食品營養及生物化學領域共發表論文五十餘篇，主要成果發表在食品營養與生物化學領域等具有國際影響力的期刊上，論文總引次數超過800餘次，H-index 17，i10index 25。其中ESI前1%高被引論文3篇，封面文章1篇，參編英文專著1部。
近5年來主持包括國家自然科學基金面上項目、青年項目、陝西省重點研發計畫、中國博士後特別資助、企業橫向課題等科研項目10餘項，榮獲2018年陝西省科學技術進步獎二等獎（排名第二）及陝西省高等學校科學技術一等獎（排名第二）。目前任Frontiers in Aging Neuroscience審稿編輯，Free radical biology & medicine, Journal of Agricultural and Food Chemistry, Journal of Nutrition, Journal of Functional Foods等食品營養學雜誌審稿人。美國營養學會、歐洲自由基研究學會會員。多次受邀參與多個國際重要學術會議，包括美國營養學會（American Societyof Nutrition）、美國加州自由基協會（Oxygen California Club）以及戈登會議（Gordon Research Seminar & Gordon Research Conference）、國際脂質科學與健康研討會等國際會議並做學術報告。
科研項目
1. 國家自然科學面上項目，No. 81871118，主持；
2. 國家自然科學基金青年項目，No. 81803231，主持；
3. 陝西省重點研發計畫，No. 2018NY-100，2018-2020，主持；
4. 中國博士後科學基金委特別資助，No. 2018T1104，2018-2020，主持；
5. 陝西省高校科協青年人才托舉計畫，No. 201770201，2017-2019，主持；
6. 國家“十三五”重點研發計畫，現代食品加工及糧食收儲運技術與裝備專項，項目子課題，No. 2017YFD0400200，2017-2021，子課題研究骨幹；
7. 中國博士後科學基金面上資助，No. 2016M602867，2016/01- 2018/12，主持；
8. 西北農林科技大學博士科研啟動基金，No. 2452015305，2015/9- 2018/9，主持。
外文專著
Liu, Z., Sancheti, H., Cadenas, E.*, and Yin, F.*(2015) Chapter 2:Energy-redox axis in mitochondria. Mitochondria in Liver Disease (Han, D. and Kaplowitz, N., Eds), pp. 29-43. CRC Press, Boca Raton.
代表性論文
1.Yan S.#, Shi R.#, Li L., Ma S., Zhang H., ……., Liu X, Liu Z* (2019) Mannan oligosaccharide suppresses lipid accumulation and appetite in Western diet-induced obese mice via reshaping gut microbiome and enhancing short-chain fatty acids production.Mol. Nutr. Food Res. DOI: 10.1002/mnfr.201900521.
2.Tan, X., Li, L., Wang, J., Zhao, B., Pan, J., Wang, L., Liu, X., Liu, X., Liu, Liu, Z.* (2019): Resveratrol prevents acrylamide-induced mitochondrial dysfunction and inflammatory responses via targeting circadian regular Bmal1 and Cry1 in hepatocytes. J. Agric. Food Chem. 67:8510-8519.
3.Yuan T., Chu C., Shi R., Cui T., …….Pan J, .Qian R., Dai X., Liu, Z.*, Liu X*(2019): ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut-Brain Axis. J Agric. Food Chem. 67:6190-6201.
4. Qi, G., Mi, Y., Fan, R., Liu, Z.*, Liu, X.*. (2019) Nobiletin Protects Against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways. J. Agric. Food Chem. 67(18):5122-5134.
5.Zhao, Y., Wang, Q., Jia, M., Fu, S., Pan, J., Chu, C., Liu X., Liu, Z.* (2018): (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation. J. Nutr. Biochem. 64: 61-71.
6.Wang, J., Wang Z., Li, B., Qiang, Y., Yuan, T., Tan, X., Wang, Z., Liu, Z.*, Liu, X.*. (2018): Lycopene attenuates western-diet induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis. Int. J. Obesity 43(9):1735-1746.
7.Guo, R., Zhao, B., Wang, Y., Wu, D., Wang, Y., Yu, Y., Yan, Y., Zhang, W., Liu, Z.* and Liu, X.* (2018): Cichoric acid prevents free fatty acids induced lipid metabolism disorders via regulating Bmal1 in HepG2 cells. J. Agric. Food Chem. 66: 9667-9678.
8.Wang, J., Li, L., Wang, Z., Cui, Y., Tan, X., Yuan, T., Qian, Liu, Liu, Z.*, Liu, X.* (2018): Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress, J. Nutr. Biochem. 56: 16-25.
9.Liu, Z.#, Liu, X#, Luo, S., Chu, C., Wu, D., Liu, R., Wang, L., Wang, J., Liu, X.* (2018): Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits, J. Funct. Foods 42: 237-247.
10.Zhao, B., Liu, H., Wang, J., Liu, P., Tan, X., Ren, B., Liu, Z.*, Liu, X.*. (2018): Lycopene Supplementation attenuates oxidative stress, neuroinflammation, and cognitive impairment in aged CD-1 mice. J. Agric. Food Chem. 66(12): 3127-3136.
11.Liu, Z.#, Chen, Y.#, Qiao, Q., Sun, Y., Liu, Q., Ren, B., and Liu, X.* (2017): Front Cover: Sesamol supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappa B. Mol. Nutr. Food Res. 61(5): 1600734
12.Liu, Z.#, Qiao Q.#, Sun Y., Chen Y., Ren B., Liu X.* (2017): Sesamol ameliorates diet-induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3-L1 cells via regulating mitochondria-lipid metabolism. Mol. Nutr. Food Res. 61(8): 1600717
13.Liu, Z., Patil, I., Sancheti, H., Yin, F., and Cadenas, E. (2017): Effects of lipoic acid on high-fat diet-induced alteration of synaptic plasticity and brain glucose metabolism: a PET/CT and 13C-NMR study. Sci. Rep. 7:5391.
14.Liu, Z.#, Sun, Y.#, Qiao, Q., Zhao, T., Zhang, W., Ren, B., Liu, Q., and Liu, X.* (2017): Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in central nervous system. Food Funct. 8:710-719
15. Liu, Z., Ren, B., Wang, Y., Zou, C., Qiao, Q., Diao, Z., Mi, Y., Zhu, D., and Liu, X.* (2017) Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagy. Sci. Rep. 7: 45728
16.Song, G.#, Liu, Z. #, Wang, L., Shi, R., Chu, C., Xiang, M., Tian, Q., and Liu, X.* (2017): Protective effects of lipoic acid against acrylamide-induced neurotoxicity: involvement of mitochondrial energy metabolism and autophagy. Food Funct. 8: 4657-4667.
17.Qi, G.#, Liu, Z.#, Fan, R, Yin, Z., Mi, Y., Ren, B., and Liu, X.* (2017): Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells. Sci. Rep. 7: 2275
18.Liu, Q., Hu, Y., Cao, Y., Song, G., Liu, Z.*, and Liu, X.* (2017): Chicoric acid ameliorates lipopolysaccharide induced oxidative stress via promoting Keap1/Nrf2 transcriptional signaling pathway in BV-2 microglial cells and mice brain. J. Agric. Food Chem. 65: 338-347
19.Liu, Q., Chen, Y., Shen, C., Xiao, Y., Wang, Y., and Liu, Z.*, and Liu, X.* (2016): Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. FASEB J. 31(4):1494-1507
20.Liu, Z., Song, G., Zou, C., Liu, G., Wu, W., Yuan, T., and Liu, X.* (2015): Acrylamide induces mitochondrial dysfunction and apoptosis in BV2 microglial cells. Free Radic. Biol. Med. 84: 42-53.
21.Liu, Z., Patil, I. Y., Jiang, T., Sancheti, H., Walsh, J. P., Stiles, B. L., Yin, F., Cadenas, E.* (2015): High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity. PLoS One, 10: e0128274.
22.Liu, Z., Xiang, Q., Du L.,Song G., Wang, Y., Liu, X.* (2013): The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells. Food Chem. 141: 289-296.
國際會議
1. Intermittent Fasting Alleviates Diabetes-induced Cognitive Decline via Gut Microbiota-metabolites-brain Axis, American Society of Nutrition; Baltimore, Maryland, United States,2019 (Selected Oral Presentation).
2. The neuroprotective effects of sesamol and underlying molecular mechanisms. 3rdInternational Symposium of Food Science and Human Wellness; Changchun, Jilin, China, 2017 (Selected Oral Presentation).
3.芝麻酚改善認知記憶損傷的功能與分子機制探索，第三屆中國食品科學青年論壇，中國·上海 (Speaker).
4.Liu, Z., Liu, X.*The neuroprotective effects of sesamol. 3rdChinese Institute of Food Science Youth Forum; Shanghai, China, 2017 (Selected Oral Presentation).
5.Liu, Z., Liu, X.*The Glorious history of sesame food，2017 Industry Conference of White Sesame in Pingyu Country; Pingyu, Henan, China, 2017 (Invited Speaker).
6.Liu, Z., Chen, Y., and Liu, X.*Sesamol supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappaB. International Conference on Aging Research; Hangzhou, Zhejiang, China, 2016 (Poster).
7.Liu, Z., Cadenas, E.*, Effect of lipoic acid on high-fat diet-induced alteration of synaptic plasticity and brain glucose metabolism. Gordon Research Conference: Oxidative Stress & Disease; Ventura, California, United States. 2015.3 (Selected Oral Presentation).
8.Liu, Z., Cadenas, E.*,High-fat diet induces a systemic insulin resistance that impairs synaptic Plasticity. Oxygen Club of California (OCC) World Congress; UC Davis, Davis, California, United States. 2014.5 (Poster).
