劉弘光

劉弘光

劉弘光，男，博士，東北大學生命科學與健康學院教授。

基本介紹

  • 中文名：劉弘光
  • 職業：教師
  • 畢業院校：北京協和醫學院
  • 學位/學歷：博士
  • 專業方向：腫瘤靶向分子探針的研製和新型分子影像學顯像技術開發
  • 任職院校：東北大學
人物經歷,學習經歷,工作經歷,研究方向,學術成果,獲獎記錄,

人物經歷

學習經歷

2003年畢業於中國醫科大學臨床醫學專業，2003-2006年在中國醫科大學發育生物學系獲碩士學位，2007-2010年在北京協和醫學院放射醫學研究所學習獲博士學位。攻讀博士期間，2008至2010年在美國史丹福大學程震教授實驗室學習分子影像學技術。2010年至2012年在史丹福大學醫學院分子影像中心做博士後，從事分子探針和藥物的設計及評價、癌症檢測和治療、以及生物納米技術等研究。

工作經歷

2013年至今，在東北大學生命科學與健康學院工作。

研究方向

  • 主要從事腫瘤靶向分子探針的研製和新型分子影像學顯像技術開發
  • 1. 分子顯像：利用多種影像技術在活體內進行細胞和分子水平的生物過程研究
  • 2. 分子探針：設計、合成和體內外評價分子探針
  • 3. 腫瘤放射靶向治療：利用治療性核素標記靶向探針用於治療腫瘤

學術成果

.在SCI收錄期刊發表論文41篇。持有多項美國專利，多次參加分子影像協會年會和美國核醫學年會，並做大會報告和交流研究論文等。
1. Liu H, Liu S, Miao Z, Deng Z, Shen B, Hong X, Cheng Z “Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma.” J Med Chem 2013; 56: 3: 895-901.
2. Kothapalli SR, Liu H, Liao JC, Cheng Z, Gambhir SS “Endoscopic imaging of Cerenkov luminescence.” Biomed Opt Express 2012; 3: 6: 1215-25.
3. Liu H, Carpenter CM, Jiang H, Pratx G, Sun C, Buchin MP, Gambhir SS, Xing L, Cheng Z “Intraoperative imaging of tumors using Cerenkov luminescence endoscopy: a feasibility experimental study.” J Nucl Med 2012; 53: 10: 1579-84.
4. Liu S, Liu H, Jiang H, Xu Y, Zhang H, Cheng Z “One-step radiosynthesis of 18F-AlF-NOTA-RGD2 for tumor angiogenesis PET imaging.” Eur J Nucl Med Mol Imaging 2011; 38: 9: 1732-41.
5. Liu S, Liu H, Ren G, Kimura RH, Cochran JR, Cheng Z “PET Imaging of Integrin Positive Tumors Using F Labeled Knottin Peptides.” Theranostics 2011; 1: 403-12.
6. Liu H, Ren G, Liu S, Zhang X, Chen L, Han P, Cheng Z “Optical imaging of reporter gene expression using a positron-emission-tomography probe.” J Biomed Opt 2010 Nov-Dec; 15: 6: 060505.
7. Liu H, Ren G, Miao Z, Zhang X, Tang X, Han P, Gambhir SS, Cheng Z “Molecular optical imaging with radioactive probes.” PLoS One 2010; 5: 3: e9470.
8.Liu H, Zhang X, Xing B, Han P, Gambhir SS, Cheng Z “Radiation-luminescence-excited quantum dots for in vivo multiplexed optical imaging.” Small 2010; 6: 10: 1087-91.
9. Jiang L, Miao Z, Liu H, Ren G, Bao A, Cutler CS, Shi H, Cheng Z “177Lu-labeled RGD-BBN heterodimeric peptide for targeting prostate carcinoma.”Nucl Med Commun 2013.
10. Hackel BJ, Kimura RH, Miao Z, Liu H, Sathirachinda A, Cheng Z, Chin FT, Gambhir SS “18F-Fluorobenzoate-Labeled Cystine Knot Peptides for PET Imaging of Integrin αvβ6.” J Nucl Med 2013.
11. Yang M, Cheng K, Qi S, Liu H, Jiang Y, Jiang H, Li J, Chen K, Zhang H, Cheng Z “Affibody modified and radiolabeled gold-Iron oxide hetero-nanostructures for tumor PET, optical and MR imaging.”Biomaterials 2013; 34: 11: 2796-806.
12. Natarajan A, Habte F, Liu H, Sathirachinda A, Hu X, Cheng Z, Nagamine CM, Gambhir SS “Evaluation of (89)Zr-rituximab Tracer by Cerenkov Luminescence Imaging and Correlation with PET in a Humanized Transgenic Mouse Model to Image NHL.” Mol Imaging Biol 2013.
13. Persson M, Liu H, Madsen J, Cheng Z, Kjaer A “First (18)F-labeled ligand for PET imaging of uPAR: In vivo studies in human prostate cancer xenografts.” Nucl Med Biol 2013; 40: 5: 618-24.
14. Habte F, Ren G, Doyle TC, Liu H, Cheng Z, Paik DS “Impact of a Multiple Mice Holder on Quantitation of High-Throughput MicroPET Imaging With and Without Ct Attenuation Correction.” Mol Imaging Biol 2013.
15. Zhao P, Yang X, Qi S, Liu H, Jiang H, Hoppmann S, Cao Q, Chua MS, So SK, Cheng Z “Molecular imaging of hepatocellular carcinoma xenografts with epidermal growth factor receptor targeted affibody probes.” Biomed Res Int 2013; 2013: 759057.
16. Qin C, Cheng K, Chen K, Hu X, Liu Y, Lan X, Zhang Y, Liu H, Xu Y, Bu L, Su X, Zhu X, Meng S, Cheng Z “Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging.”Sci Rep 2013; 3: 1490.
17. Hoppmann S, Qi S, Miao Z, Liu H, Jiang H, Cutler CS, Bao A, Cheng Z “177Lu-DO3A-HSA-Z EGFR:1907: characterization as a potential radiopharmaceutical for radionuclide therapy of EGFR-expressing head and neck carcinomas.” J BiolInorgChem 2012; 17: 5: 709-18.
18. Li J, Chen K, Liu H, Cheng K, Yang M, Zhang J, Cheng JD, Zhang Y, Cheng Z “Activatable near-infrared fluorescent probe for in vivo imaging of fibroblast activation protein-alpha.” BioconjugChem 2012; 23: 8: 1704-11.
19. Xu Y, Liu H, Chang E, Jiang H, Cheng Z “Cerenkov Luminescence Imaging (CLI) for cancer therapy monitoring.” J Vis Exp 2012; 69: e4341.
20. Parashurama N, O’Sullivan TD, De La Zerda A, El Kalassi P, Cho S, Liu H, Teed R, Levy H, Rosenberg J, Cheng Z, Levi O, Harris JS, Gambhir SS “Continuous sensing of tumor-targeted molecular probes with a vertical cavity surface emitting laser-based biosensor.” J Biomed Opt 2012; 17: 11: 117004.
21. Qi S, Miao Z, Liu H, Xu Y, Feng Y, Cheng Z “Evaluation of Four Affibody-Based Near-Infrared Fluorescent Probes for Optical Imaging of Epidermal Growth Factor Receptor Positive Tumors.” BioconjugChem 2012.
22. Seo J, Ren G, Liu H, Miao Z, Park M, Wang Y, Miller TM, Barron AE, Cheng Z “In Vivo Biodistribution and Small Animal PET of (64)Cu-Labeled Antimicrobial Peptoids.” BioconjugChem 2012.
23. Ren G, Webster JM, Liu Z, Zhang R, Miao Z, Liu H, Gambhir SS, Syud FA, Cheng Z “In vivo targeting of HER2-positive tumor using 2-helix affibody molecules.” Amino Acids 2012; 43: 1: 405-13.
24. Miao Z, Ren G, Liu H, Qi S, Wu S, Cheng Z “PET of EGFR expression with an 18F-labeled affibody molecule.” J Nucl Med 2012; 53: 7: 1110-8.
25. Xu Y, Chang E, Liu H, Jiang H, Gambhir SS, Cheng Z “Proof-of-concept study of monitoring cancer drug therapy with cerenkov luminescence imaging.”J Nucl Med 2012; 53: 2: 312-7.
26. Carpenter CM, Sun C, Pratx G, Liu H, Cheng Z, Xing L “Radioluminescentnanophosphors enable multiplexed small-animal imaging.” Opt Express 2012; 20: 11: 11598-604.
27. Miao Z, Ren G, Jiang L, Liu H, Webster JM, Zhang R, Namavari M, Gambhir SS, Syud F, Cheng Z “A novel 18F-labeled two-helix scaffold protein for PET imaging of HER2-positive tumor.” Eur J Nucl Med Mol Imaging 2011; 38: 11: 1977-84.
28. Xu Y, Liu H, Cheng Z “Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging.” J Nucl Med 2011; 52: 12: 2009-18.
29. Zhang X, Liu H, Miao Z, Kimura R, Fan F, Cheng Z “Macrocyclicchelator assembled RGD multimers for tumor targeting.” Bioorg Med ChemLett 2011; 21: 11: 3423-6.
30. Ren G, Blum G, Verdoes M, Liu H, Syed S, Edgington LE, Gheysens O, Miao Z, Jiang H, Gambhir SS, Bogyo M, Cheng Z “Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.” PLoS One 2011; 6: 11: e28029.
31. Jiang L, Miao Z, Kimura RH, Liu H, Cochran JR, Culter CS, Bao A, Li P, Cheng Z “Preliminary evaluation of (177)Lu-labeled knottin peptides for integrin receptor-targeted radionuclide therapy.” Eur J Nucl Med Mol Imaging 2011; 38: 4: 613-22.
32. Hoppmann S, Miao Z, Liu S, Liu H, Ren G, Bao A, Cheng Z “Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting.” BioconjugChem 2011; 22: 3: 413-21.
33. Sun C, Pratx G, Carpenter CM, Liu H, Cheng Z, Gambhir SS, Xing L “Synthesis and radioluminescence of PEGylatedEu(3+) -doped nanophosphors as bioimaging probes.” Adv Mater 2011; 23: 24: H195-9.
34. Miao Z, Ren G, Liu H, Jiang L, Cheng Z “Cy5.5-labeled Affibody molecule for near-infrared fluorescent optical imaging of epidermal growth factor receptor positive tumors.” J Biomed Opt 2010 May-Jun; 15: 3: 036007.
35. Cheng Z, De Jesus OP, Kramer DJ, De A, Webster JM, Gheysens O, Levi J, Namavari M, Wang S, Park JM, Zhang R, Liu H, Lee B, Syud FA, Gambhir SS “64Cu-labeled affibody molecules for imaging of HER2 expressing tumors.” Mol Imaging Biol 2010; 12: 3: 316-24.
36. Jiang L, Kimura RH, Miao Z, Silverman AP, Ren G, Liu H, Li P, Gambhir SS, Cochran JR, Cheng Z “Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.” J Nucl Med 2010; 51: 2: 251-8.
37. Ren G, Liu S, Liu H, Miao Z, Cheng Z “Radiofluorinated rhenium cyclized α-MSH analogues for PET imaging of melanocortin receptor 1.” BioconjugChem 2010; 21: 12: 2355-60.
38. Miao Z, Ren G, Liu H, Jiang L, Cheng Z “Small-animal PET imaging of human epidermal growth factor receptor positive tumor with a 64Cu labeled affibody protein.” BioconjugChem 2010; 21: 5: 947-54.
39. Miao Z, Ren G, Liu H, Kimura RH, Jiang L, Cochran JR, Gambhir SS, Cheng Z “An engineered knottin peptide labeled with 18F for PET imaging of integrin expression.” BioconjugChem 2009; 20: 12: 2342-7.
40. Ren G, Miao Z, Liu H, Jiang L, Limpa-Amara N, Mahmood A, Gambhir SS, Cheng Z “Melanin-targeted preclinical PET imaging of melanoma metastasis.” J Nucl Med 2009; 50: 10: 1692-9.
41. Ren G, Liu Z, Miao Z, Liu H, Subbarayan M, Chin FT, Zhang L, Gambhir SS, Cheng Z “PET of malignant melanoma using 18F-labeled metallopeptides.” J Nucl Med 2009; 50: 11: 1865-72.

獲獎記錄

獲得2010年美國核醫學會（SNM）分子影像學年輕學者獎第一名（Molecular Imaging Young Investigator Award）。

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