劉小華：女，四川大學化學學院教授。
基本介紹
- 中文名：劉小華
- 職業：四川大學化學學院教授
- 學位/學歷：理學博士
劉小華：女，四川大學化學學院教授。
簡 歷
1996年－2000年於湖北師範學院化學系學習，獲理學學士學位。
2000年－2003年於四川大學化學學院分析化學專業學習，獲理學碩士學位。
2003年－2006年於四川大學化學學院有機化學專業學習，獲理學博士學位。
2006年－2010年，四川大學化學學院副教授，碩士生導師。
2010年－至今，四川大學化學學院教授，2012年擔任博士生導師。
主要研究方向
主要從事不對稱合成方法學及生理活性化合物的合成研究。
主要工作業績
主要從事不對稱合成方法學及生理活性化合物的合成研究。目前研究工作集中在新型手性雙功能胍-醯胺和胺類配體和催化劑的設計合成，基於雙活化策略、胍基的鹼性及氫鍵活化模式，在溫和條件下，高效高選擇性地實現了多個不對稱催化反應。
作為第二完成人獲2009年教育部自然科學獎一等獎和2012年國家自然科學二等獎。獲國家自然科學基金委優秀青年基金和教育部新世紀優秀人才支持計畫資助，獲德國Thieme Chemistry Journals Award 2013。
代表性成果 （獲獎成果、專著、論文、專利）
1. Shunxi Dong, Xiaohua Liu*, Yin Zhu, Peng He, Lili Lin, Xiaoming Feng*, Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones, J. Am. Chem. Soc. 2013, 135, 10026-10029.
2. Jing Wang, Xiaohua Liu*, Shunxi Dong, Lili Lin, Xiaoming Feng*, Asymmetric Organocatalytic Cyclopropanation of Cinnamone Derivatives with Stabilized Sulfonium Ylides, J. Org. Chem. 2013, 78, 6322-6327.
3. Zhenling Chen, Lili Lin, Min Wang, Xiaohua Liu*, Xiaoming Feng*, Asymmetric Synthesis of trans-β-Lactams by a Kinugasa Reaction on Water, Chem. Eur. J. 2013, 19, 7561–7567.
4. Min Wang, Xiaohua Liu*, Peng He, Lili Lin, Xiaoming Feng*, Enantioselective Synthesis of 1,2,4-Triazolines by Chiral Iron(II)-Complex Catalyzed Cyclization of α-Isocyano Esters and Azodicarboxylates, Chem. Commun. 2013, 49, 2572–2574.
5. Yang Yang, Shunxi Dong, Xiaohua Liu*, Lili Lin, Xiaoming Feng*, Chiral Guanidine-Catalyzed Asymmetric Direct Vinylogous Michael Reaction of α,β-Unsaturated γ-Butyrolactams with Alkylidene Malonates, Chem. Commun. 2012, 48, 5040–5042.
6. Yangbin Liu, Xiaohua Liu*, Min Wang, Peng He, Lili Lin, Xiaoming Feng*, Enantioselective Synthesis of 3,4-Dihydropyran Derivatives via Organocatalytic Michael Reaction of α,β-Unsaturated Enones, J. Org. Chem. 2012, 77, 4136–4142.
7. Xiao Xiao, Xiaohua Liu*, Shunxi Dong, Yunfei Cai, Lili Lin, Xiaoming Feng*, Asymmetric Synthesis of 2,3-Dihydroquinolin-4-one Derivatives Catalyzed by Chiral Bisguanidium Salt, Chem. Eur. J. 2012, 18, 15922–15925.
8. Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral N,N'-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions, Acc. Chem. Res. 2011, 44, 574–587.
9. Shunxi Dong, Xiaohua Liu*, Yulong Zhang, Lili Lin, and Xiaoming Feng*, Asymmetric Synthesis of 3,4-Diaminochroman-2-ones Promoted by Guanidine and Bisguanidium Salt, Org. Lett. 2011, 13, 5060–5063.
10. Jing Wang, Wentao Wang, Xiaohua Liu*, Zongrui Hou, Lili Lin, Xiaoming Feng*, Highly Enantioselective Direct Michael Addition of 1H-Benzotriazole to Chalcones Catalyzed by Sc(OTf)3/N,N-Dioxide Complex, Eur. J. Org. Chem. 2011, 2039–2042.
11. Xiaohong Chen, Shunxi Dong, Zhen Qiao, Yin Zhu, Mingsheng Xie, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Guanidine Organocatalyst for the Asymmetric Mannich-Type Reaction between α-Isothiocyanato Imide and Sulfonyl Imines, Chem. Eur. J. 2011, 17, 2583–2586.
12. Min Wang, Lili Lin, Jian Shi, Xiaohua Liu*, Yulong Kuang, Xiaoming Feng*, Asymmetric Crossed-Conjugate Addition of Nitroalkenes to Enones by a Chiral Bifunctional Diamine Organocatalyst, Chem. Eur. J. 2011, 17, 2365–2368.
13. Peng He, Xiaohua Liu*, Jian Shi, Lili Lin, Xiaoming Feng*, Organocatalytic Sequential Michael Reactions: Stereoselective Synthesis of Multifunctionalized Tetrahydroindan Derivatives, Org. Lett. 2011, 13, 936-939.
14. Zhenhua Dong, Xiaohua Liu*, Juhua Feng, Min Wang, Lili Lin, Xiaoming Feng*, Efficient Asymmetric Synthesis of 4H-Chromene Derivatives through a Tandem Michael Addition– Cyclization Reaction Catalyzed by a Salen–Cobalt(II) Complex, Eur. J. Org. Chem. 2011, 137–142.
15. Xuan Fu, Juhua Feng, Zhenhua Dong, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Enantioselective Synthesis of 2-Substituted-1,5-Benzodiazepines through Domino Reaction of o-Phenylenediamine and Chalcone Derivatives, Eur. J. Org. Chem. 2011, 5233–5236.
16. Yonghai Hui, Weiliang Chen, Wentao Wang, Jun Jiang, Yunfei Cai, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Highly Enantioselective Zinc-Catalyzed Friedel–Crafts Alkylation of Indoles with Ethyl Trifluoropyruvate, Adv. Synth. Catal. 2010, 352, 3174–3178.
17. Lin Zhou, Lili Lin, Wentao Wang, Jie Ji, Xiaohua Liu*, Xiaoming Feng*, Highly Enantioselective Michael Addition of Malonates to β,γ-Unsaturated α-Ketoesters Catalyzed by Chiral N,N'-dioxide-Yttrium(III) Complexes with Convenient Procedure, Chem. Commun. 2010, 46, 3601–3603.
18. Qi Zhang, Yonghai Hui, Xin Zhou, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Highly Efficient Asymmetric Three-Component Vinylogous Mannich Reaction Catalyzed by a Chiral Scandium(III)-N,N'-Dioxide Complex, Adv. Synth. Catal. 2010, 352, 976–980.
19. Xiaohua Liu, Lili Lin, Xiaoming Feng*, Amide Based Bifunctional Organocatalysts in Asymmetric Reactions (Feature Article), Chem. Commun. 2009, 6145–6158.
20. Xiaohua Liu, Bo Qin, Bin He, and Xiaoming Feng*, Catalytic Asymmetric Cyanosilylation of Ketones by a Chiral Amino Acid Salt, J. Am. Chem. Soc. 2005, 127, 12224-12225.
