劉亞平(廣州醫科大學附屬腦科醫院睡眠與節律醫學中心教授)

劉亞平(廣州醫科大學附屬腦科醫院睡眠與節律醫學中心教授)

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劉亞平，現任廣州醫科大學南山學者骨幹人才，特聘教授，歷任香港中文大學及牛津大學博士後、香港中文大學精神科學系助理教授。目前主要研究方向為睡眠障礙與神經變性病。主持 2 項香港政府基金。以第一或通訊作者（含共同）在 Ann Neurol、Neurology、Mov Disord 等專業權威期刊發表論著。研究成果他引 600 余次，H 指數 12，並被寫入神經病學英文教材。擔任中國睡眠研究會青年工作委員會常務委員以及生理與藥理專委會委員。為 Sleep Med Rev、Neurosci Biobehav Rev、Mov Disord 等期刊審稿人。獲第 8 屆世界睡眠大會青年科學家獎。

基本介紹

人物經歷,研究方向,研究項目,科研成果,獲獎情況,學術任職,擅長領域,

人物經歷

本科畢業於南方醫科大學
碩士畢業於暨南大學
博士畢業於香港中文大學

研究方向

  1. 基於大樣本人群佇列，探究快眼動睡眠行為障礙向alpha突觸核蛋白病進展的生物學機制（如腸道微生物學、遺傳學、神經免疫學、以及神經影像學機制等）
  2. 採用動物實驗，探討腸-腦軸 alpha 突觸核蛋白病進展機制及探尋其潛在干預靶點及手段

研究項目

  1. PI, Health and Medical Research Fund (08191416). Neural correlates of impulsivity in idiopathic REM sleep behavior disorder and Parkinson’s disease: a functional Magnetic Resonance Imaging case-control study. HK$ 1,122,120. 01/12/2021-30/11/2024.
  2. PI, Knowledge Transfer Project Fund (KPF21GWP26). Risk screening for prodromal Parkinson’s disease in elderly using smartphone. The Chinese University of Hong Kong. HK$ 395,380. 01/04/2021-31/03/2023
  3. PI, Direct Grant for Research (2020.084). Impact of Long COVID–Neurodegenerative Perspective. CUHK. HK$ 149,000. 30/06/2021-29/06/2022.
  4. Co-PI, Collaborative Research Fund (C4044-21GF). Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha-synucleinopathy Neurodegeneration, in a Prospective Family Cohort. HK$ 7,214,620. 01/04/2022-31/03/2025.
  5. Co-PI, Collaborative Research Fund (C4061-21GF). Neuropsychiatric ‘long-COVID’ in adult patients. HK$ 3,251,480. 01/04/2022-31/03/2023.
  6. Co-I, General Research Fund (14108722). Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing. HK$ 1,300,000. Starts in 2023.
  7. Co-I, Health and Medical Research Fund (18190931). AI-Based Day and Night Digital Phenotyping of Rapid Eye Movement (REM) Sleep Behaviors Disorder (RBD) and its Prediction towards α-Synucleinopathy. HK$ 1,495,330. Starts in 2023.
  8. Co-I, Health and Medical Research Fund (09202766). Randomized placebo- and active-controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson’s disease. HK$ 1,413,200. 01/08/2022-31/07/2025.
  9. Co-I, Health and Medical Research Fund (18190221). Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behaviour Disorder: tracing a subtype of depression with underlying neurodegeneration. HK$ 1,104,304. 01/10/2021-31/03/2024.
  10. Co-I, General Research Fund (14116121). Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study. HK$ 1,130,208. 01/01/2022-31/12/2025.
  11. Co-I, Health and Medical Research Fund (06170676). A 7-year prospective study of idiopathic REM sleep behavior disorder cohort in Chinese population: determining the optimal characteristics of prodromal markers to predict neurodegenerative diseases. HK$ 1,250,616. 01/07/2019-30/06/2022.
  12. Co-I, National Natural Science Foundation of China (81471348). Mechanisms of Circadian Rhythms in the Progression of REM sleep behavior disorder towards neurodegeneration. CNY 70,000. 01/01/2015-31/12/2018.

科研成果

發表SCI文章代表作:（*表示通訊作者，#表示共同第一作者）
  1. Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK*, Liu Y*. Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.J Sleep Res. 2022:e13791.
  2. Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK*.Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study.Neurology. 2022;99(6):e627-e637.
  3. Liu Y, Partinen E, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Thomas P, Holzinger B, Partinen M*, Wing YK*.Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.J Sleep Res. 2022:10.1111/jsr.13613.
  4. Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT*.Longitudinal changes in Parkinson’s disease symptoms with and without REM sleep behavior disorder: the Oxford Discovery Cohort study.Mov Disord. 2021;36(12):2821-2832.
  5. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MW, Chan NY, Chan JW, Li SX, Huang B, Feng H, Mok VCT, Wing YK*.Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.Mov Disord. 2020;35(11):2077-2085.
  6. Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen J, Mok VCT, Wing YK*, Zhang J*.Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.Ann Neurol. 2020;88(4):817-829.
  7. Liu Y, Zhang J, Lam SP, Zhou J, Yu MWM, Li SX, Chan JW, Postuma RB, Mok VCT, Wing YK*.A case-control-family study of idiopathic rapid eye movement sleep behavior disorder.Ann Neurol. 2019;85(4):582-592.
  8. Liu Y, Zhang J*, Lam SP, Yu MW, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan Anne, Mok VCT, Wing YK.Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.Sleep Med. 2019;56:128-134.
  9. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK*.Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.Sleep Med. 2018, 24;53:1-8.
  10. Liu Y, Zhang J, Lam V, Ho CK, Zhou J, Li SX, Lam SP, Yu MW, Tang X, Wing YK*.Altered Sleep Stage Transitions of REM Sleep: A Novel and Stable Biomarker of Narcolepsy.J Clin Sleep Med. 2015;11(8):885-94.
發表中文文章:
  1. 劉亞平，李陽華，馬文彬，劉帥，王靜，封紅亮，張繼輝.快速眼動睡眠行為障礙與帕金森病發病及防治的關係.中華醫學雜誌.2018;98:2299-302.
  2. 張繼輝，劉亞平，潘集陽.失眠與抑鬱關係2008-2013年研究進展及存在的問題.中國心理衛生雜誌,2015; 29(2):81-6.
  3. 宋偉東，潘集陽，劉亞平.失眠障礙的神經影像學研究進展.中國神經精神疾病雜誌,2015; (01):62-64.
  4. 劉亞平，潘集陽.非恢復性睡眠的研究現狀.實用醫學雜誌,2012; (07):1208-1210.
  5. 廖繼武，黃俏庭，潘集陽，劉亞平.原發性失眠患者與有失眠症狀抑鬱症患者的血清神經肽Y和P物質水準.中國心理衛生雜誌.2012; 26(7):490-494.
  6. 王雀良，潘集陽，劉亞平.抑鬱症動物模型的回顧與展望.廣東醫學,2011; 7: 932-935.

獲獎情況

  1. 2018年，香港中文大學-牛津大學臨床神經科學博士後獎學金
  2. 2017年，青年科學家獎, 世界睡眠醫學協會和世界睡眠聯合會

學術任職

Clinical Neurophysiology、Brain imaging and behavior、Translational Psychiatry 、Sleep medicine等學術期刊審稿人（Peer review）

擅長領域

各類睡眠障礙的診治

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