刁妍妍，女，1987年9月生，碩士，華東理工大學藥學院在職博士研究生。
基本介紹
個人經歷,教育經歷,工作經歷,研究方向,學術成果,榮譽獎勵,
個人經歷
教育經歷
1. 2016.9-至今 華東理工大學 藥學院 博士研究生（在職）；
2. 2009.9-2012.3 華東理工大學 藥學院 碩士研究；
3. 2005.9-2009.6 青島科技大學 化工學院 本科生。
工作經歷
1. 2012.7-至今 華東理工大學 藥學院 工程師。
研究方向
主要研究方向為藥物設計方法學、先導化合物發現及結構最佳化。
學術成果
目前已發表SCI論文18篇，總計被引用197次，其中以第一及共同第一作者發表SCI論文8篇（含藥物化學領域權威期刊《J. Med. Chem》3篇，IF=6.253）；已申請化合物發明專利10餘項，獲授權專利4項（含瑞士專利1項），其中DHODH抑制劑相關專利已完成成果轉化。作為項目骨幹，參與國家重點研發計畫課題1項、“重大新藥創製”國家科技重大專項1項。
代表論文
1. Yanyan Diao, Feng Hu, Zihao Shen, Honglin Li*. MacFrag: segmenting large-scale molecules to obtain diverse fragments with high qualities. Bioinformatics, 2023. 39(1) : btad012
2. Dou Dou#, Yanyan Diao# (共一作), Wenjie Sha#, Rongrong Su, Linjiang Tong, Wenjie Li, Limin Leng, Lijuan Xie, Zhixiao Yu, Haoming Song, Zihao Shen, Lili Zhu, Zhenjiang Zhao, Hua Xie, Zhuo Chen*, Honglin Li*, Yufang Xu*. Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK). J. Med. Chem., 2022. 65(3) : 2694–2709
3. Yanyan Diao, XiaoyuFang, PeiranSong, MengzhenLai, LinjiangTong, YongjiaHao, DouDou, YingqiangLiu, JianDing, ZhenjiangZhao*, HuaXie*, HonglinLi*, Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton’s tyrosine kinase inhibitors, Bioorg. Med. Chem., 2019, 27(15) : 3390-3395
4. Yanyan Diao, Jing Jiang, Shoude Zhang, Shiliang Li, Lei Shan, Jin Huang, Weidong Zhang, Honglin Li*. Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening. Front. Chem., 2018, 6, 140
5. Junsheng Zhu#, Le Han#, Yanyan Diao# (共一作), Xiaoli Ren, Minghao Xu, Liu-Xin Xu, Shiliang li, Qiang Li, Dong Dong, Jin Huang, Xiaofeng Liu, Zhenjiang zhao, Rui Wang, Lili Zhu*, Yufang Xu, Xuhong Qian*, and Honglin Li*. Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole-Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase. J. Med. Chem., 2015, 58(3), 1123-1139
6. Minghao Xu#, Junsheng Zhu#, Yanyan Diao#(共一作), Hongchang Zhou, Xiaoli Ren, Deheng Sun, Jin Huang, Dongmei Han, Zhenjiang Zhao, Lili Zhu*, Yufang Xu*, and Honglin Li*. Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives. J. Med. Chem., 2013, 56 (20), 7911–7924
7. Yanyan Diao, Weiqiang Lu, Huangtao Jin, Junsheng Zhu, Le Han, Minghao Xu, Rui Gao, Xu Shen, Zhenjiang Zhao, Xiaofeng Liu, Yufang Xu, Jin Huang*, and Honglin Li*. Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as Immunosuppressive Agents by Structure-Based Virtual Screening. J. Med. Chem., 2012, 55, 8341-8349
榮譽獎勵
碩士畢業論文於2014年獲上海市研究生優秀成果（學位論文）獎。
