基本介紹
- 中文名：傅宏鑫
- 畢業院校：大連理工大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：微生物學、發酵工程、生物化工、合成生物學
- 職務：副研究員
- 任職院校：華南理工大學生物科學與工程學院
人物經歷,研究方向,學術成果,
人物經歷
教育經歷
2009-2016 大連理工大學生物化工博士
2013-2015 俄亥俄州立大學聯合培養博士
工作經歷
2016-2019 華南理工大學師資博士後
2018-至今 華南理工大學博士後副研究員
研究方向
微生物學、發酵工程、生物化工、合成生物學
學術成果
科研興趣
1. 代謝工程構建高效生產菌株;
2. 微生物發酵法生產生物基化學品和生物燃料;
3. 發酵過程控制及最佳化;
4. 生物基化學品和生物燃料的下游分離工藝。
科研項目
主持：
1. 中央高校基本科研業務費：外源電子載體誘導酪丁酸梭菌乙酸再利用和高純丁酸發酵的分子機制研究，2017.5-2018.12。
2. 博士後科學基金面上資助：酪丁酸梭菌胞內NADH調控強化丁酸生物合成，2017.5-2018.12。
參與：
1. 國家自然科學基金面上項目：嗜熱厭氧桿菌葡萄糖木糖共利用的分子機制研究，2017.1-2020.12。
2. 國家自然科學基金面上項目：生物基化學品的糖析萃取動力學及其耦合發酵研究，2015.1-2018.12。
3. 863子課題：大宗發酵產品的多相鹽析萃取技術及其關鍵裝備，2012.1-2015.12。
4. “年產千噸級生物基 1,3-丙二醇工業化示範”項目，2010-2013年。
第一作者或通訊作者論文
2018
[1] Ping Luo, Yanan Zhang, Yukai Suo, Zhengping Liao, Yi Ma, Hongxin Fu*, Jufang Wang*. The global regulator IrrE from Deinococcus radiodurans enhances the furfural tolerance of Saccharomyces cerevisiae. Biochemical Engineering Journal, 2018 (In Press).
[2] Yukai Suo, Mengmeng Ren, Xitong Yang, Zhengping Liao, Hongxin Fu*, Jufang Wang*. Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production with high butyrate/acetate ratio. Applied Microbiology and Biotechnology, 2018, 102(10): 4511-4522.
[3] Yukai Suo#, Hongxin Fu#, Mengmeng Ren, Zhengping Liao, Yi Ma, Jufang Wang*. Enhanced butyric acid production in Clostridium tyrobutyricum by overexpression of rate-limiting enzymes in the Embden-Meyerhof-Parnas pathway. Journal of Biotechnology, 2018, 272–273:14-21.
[4] Yukai Suo#, Hongxin Fu#, Mengmeng Ren, Xitong Yang, Zhengping Liao, Jufang Wang*. Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing Class I heat shock protein GroESL. Bioresource Technology, 2018, 250:691-698.
2017
[1] Hongxin Fu, Le Yu, Meng Lin, Jufang Wang, Zhilong Xiu, Shang-Tian Yang*. Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose. Metabolic Engineering, 2017, 40:50-58.
[2] Hongxin Fu, Shang-Tian Yang*, Minqi Wang, Jufang Wang, I-Ching Tang. Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose co-utilization. Bioresource Technology, 2017, 234:389-396.
[3] Hongxin Fu#, Xudong Wang#, Yaqin Sun, Ling Yan, Juntao Shen, Jufang Wang, Shang-Tian Yang, Zhilong Xiu*. Effects of salting-out and salting-out extraction on the separation of butyric acid. Separation and Purification Technology, 2017, 180:44-50.
2015
[1] Hongxin Fu, Shang-Tian Yang, Zhilong Xiu*. Phase separation in a salting-out extraction system of ethanol–ammonium sulfate. Separation and Purification Technology, 2015, 148: 32-37.
[2] Hongxin Fu, Yaqin Sun, Hu Teng, Daijia Zhang, Zhilong Xiu*. Salting-out extraction of carboxylic acids. Separation and Purification Technology, 2015, 139: 36-42.
[3] Hongxin Fu, Jianying Dai, Yaqin Sun, Daijia Zhang, Zhilong Xiu*. Partition behavior of hydrophilic diols in an ethanol/ammonium sulfate salting-out extraction system. Engineering in Life Sciences, 2015, 15(8): 797-803.
2013
[1] Hongxin Fu, Yaqin Sun, Zhilong Xiu*. Continuous countercurrent salting-out extraction of 1,3-propanediol from fermentation broth in a packed column. Process Biochemistry, 2013, 48(9):1381-1386.
共同作者論文
2018
[1] Ling Yan, Yaqin Sun, Xudong Wang, Hongxin Fu, Ying Mu, Zhilong Xiu*. Partition behavior of monocarboxylic acids in salting-out extraction systems of monohydric alcohols and dipotassium phosphate. Separation and Purification Technology, 2018, 199:351-358.
[2] Daiana Wischral*, Hongxin Fu, Fernando L. Pellegrini Pessoa, Nei Pereira Jr, Shang-Tian Yang. Effective and simple recovery of 1,3-propanediol from a fermented medium by liquid–liquid extraction system with ethanol and K3PO4. Chinese Journal of Chemical Engineering, 2018, 26(1):104-108.
[3] 鄢凌, 傅宏鑫, 王旭東, 孫亞琴, 戴建英, 修志龍*. 生物基有機酸提取分離技術研究進展. 過程工程學報, 2018(1):1-10.
2017
[1] 屈春雲, 傅宏鑫, 馬毅, 王菊芳*. Pro-sigmaK inhibitor-BofA基因敲除對嗜熱厭氧桿菌SCUT27葡萄糖和木糖利用的影響. 高校化學工程學報, 2017, 31(5):1150-1155.
2016
[1] Peilian Wei#, Meng Lin#, Zhongqiang Wang#, Hongxin Fu, Hopen Yang, Wenyan Jiang, Shang-Tian Yang*. Metabolic engineering of Propionibacterium freudenreichii, subsp. shermanii, for xylose fermentation. Bioresource Technology, 2016, 219:91-97.
[2] Juntao Shen, Jinjie Zhou, Hongxin Fu, Ying Mu, Yaqin Sun, Yongping Xu, Zhilong Xiu*. A Klebsiella pneumoniae bacteriophage and its effect on 1,3-propanediol fermentation. Process Biochemistry, 2016, 51(10): 1323-1330.
[3] 修志龍*, 姜莉莉, 傅宏鑫, 周瑾潔, 權春善. 微生物發酵法生產1,3-丙二醇的研究新進展. 微生物學雜誌, 2016, 36(6):1-9.
2014
[1] Yaqin Sun, Ling Yan, Hongxin Fu, Zhilong Xiu*. Salting-out extraction and crystallization of succinic acid from fermentation broths. Process Biochemistry, 2014, 49(3):506-511.
2013
[1] Yaqin Sun, Ling Yan, Hongxin Fu, Zhilong Xiu*. Selection and optimization of a salting-out extraction system for recovery of biobutanol from fermentation broth. Engineering in Life Sciences, 2013, 13(5): 464-471.
著作
[1] Yanqin Sun, Chengwei Ma, Hongxin Fu, Ying Mu, Zhilong Xiu*. Bioprocessing of renewable resources to commodity products (Chapter 11: 1,3-propanediol). John Wiley & Sons, Inc., New York, NY, 2014.
