侯悅，女，博士，東北大學生命科學與健康學院教授、博士生導師。
基本介紹
- 中文名：侯悅
- 職業：教師
- 畢業院校：瀋陽藥科大學
- 學位/學歷：博士
- 專業方向：藥理學
- 任職院校：東北大學
人物經歷,研究方向,學術成果,科研項目,發表論文,
人物經歷
2000年畢業於瀋陽藥科大學日語藥學專業獲得學士學位，2005年畢業於瀋陽藥科大學獲得藥理學博士學位。
研究方向
主要研究方向為神經生物學及腫瘤生物學。
學術成果
作為負責人主持國家自然基金面上項目、國家自然科學基金青年基金項目、中國博士後科學基金、遼寧省高等學校優秀人才支持計畫、教育部高等學校博士學科點專項科研基金、遼寧省教育廳科學技術研究項目等多項課題，作為課題副組長參加國家科技重大專項課題3項，作為主要成員參加國家科技重大專項課題、遼寧省科學技術計畫重大重點項目、教育部重點實驗室基金項目、遼寧省自然基金等。曾獲遼寧省優秀博士學位論文、遼寧省自然科學學術成果二等獎及三等獎。目前，在國際學術期刊上發表SCI收載文章35篇，其中第一作者或通訊作者18 篇。
科研項目
1.國家自然科學基金面上項目：以抑制小膠質細胞活化為靶標探索龍血竭抗阿爾茨海默病的物質基礎及作用機制，項目負責人
2.國家自然科學基金青年基金：小膠質細胞-MAPK-PIC在精神分裂症中的作用機制研究，項目負責人
3.遼寧省高等學校優秀人才支持計畫：第一層次人才，項目負責人
4.教育部基本科研業務費創新團隊建設項目：BAP31在重大疾病中的作用研究，項目負責人
5.中國博士後科學基金：天然藥物中腫瘤多藥耐藥逆轉劑與抗癌藥的複方篩選及作用機制研究，項目負責人
6.遼寧省科學技術基金項目：基於高通量篩選的抗老年痴呆活性樣品發現及其作用研究，項目負責人
7.遼寧省教育廳創新團隊項目：抗老年痴呆新藥—白藜蘆醇衍生物RV的研究與開發，項目負責人
8.國家科技重大專項課題：動物實驗和藥效學評價試驗技術子平台，項目副組長
9.國家科技重大專項課題：抗老年痴呆一類新藥BQGY-8的研究開發，項目副組長
10.國家科技重大專項課題：臨床前WF-210的研究開發，項目副組長
發表論文
1. Hou Y, Xie G, Liu X, Li G, Jia C, Xu J, Wang B. Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice. Psychopharmacology (Berl). 2016;233(5):905-16.
2. Hou Y, Li N, Xie G, Wang J, Yuan Q, Jia C, Liu X, Li G, Tang Y, Wang B. Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-ctivated microglia via inhibition of MAPK signaling pathways. Journal of Functional Foods. 2015; 19: 676-687.
3. Hou Y, Xie G, Miao F, Ding L, Mou Y, Wang L, Su G, Chen G, Yang J, Wu C. Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2014;54:92-102.
4. Hou Y, Zhang H, Xie G, Cao X, Zhao Y, Liu Y, Mao Z, Yang J, Wu C. Neuronal injury, but not microglia activation, is associated with ketamine-induced experimental schizophrenic model in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2013;45:107-16.
5. Li N, Meng D, Pan Y, Cui Q, Li G, Ni H, Sun Y, Qing D, Jia X, Pan Y, Hou Y. Anti-neuroinflammatory and NQO1 inducing activity of natural phytochemicals from Coreopsis tinctoria. Journal of Functional Foods. 2015; 17: 837-846. （Corresponding author）
6. Li N, Ma Z, Li M, Xing Y, Hou Y. Natural potential therapeutic agents of neurodegenerative diseases from the traditional herbal medicine Chinese dragon’s blood. J Ethnopharmacol. 2014;152(3):508-521.（Corresponding author）
7. Xing Y, Li N, Zhou D, Chen G, Jiao K, Wang W, Si Y, Hou Y. Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors. Planta Med. 2016 Jul 15. [Epub ahead of print] （Corresponding author）
8. Li N, Wang Y, Li X, Zhang H, Zhou D, Wang W, Li W, Zhang X, Li X, Hou Y, Meng D. Bioactive phenols as potential neuroinflammation inhibitors from the leaves of Xanthoceras sorbifolia Bunge. Bioorg Med Chem Lett. 2016;26(20):5018-5023. （Corresponding author）
9. Hou Y, Wu CF, Yang JY, Guo T. Differential effects of haloperidol, clozapine and olanzapine on learning and memory functions in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30:1486-1495.
10. Hou Y, Wu CF, Yang JY, He X, Bi XL, Yu L, Guo T. Effects of clozapine, olanzapine and haloperidol on nitric oxide production by lipopolysaccharide-activated N9 cells. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30:1523-1528.
11. Hou Y, Yang JY, Wu CF, Huang M. Effects of clozapine, olanzapine and haloperidol on ethanol-induced ascorbic acid release in mouse striatum. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:83-89.
12. Wang LH, Yang JY, Yang SN, Li Y, Ping GF, Hou Y, Cui W, Wang ZZ, Xiao W, Wu CF. Suppression of NF-κB signaling and P-glycoprotein Function by Gambogic Acid Synergistically Potentiates Adriamycin -induced Apoptosis in Lung Cancer. Curr Cancer Drug Targets. 2014;14(1):91-103.
13. Wang LH, Li Y, Yang SN, Wang FY, Hou Y, Cui W, Chen K, Cao Q, Wang S, Zhang TY, Wang ZZ, Xiao W, Yang JY, Wu CF. Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling. Br J Cancer. 2014;110(2):341-352.
14. Zheng HL, Yang J, Hou Y, Sun B, Zhang Q, Mou Y, Wand L, Wu C. Oligomer procyanidins (F2) isolated from grape seeds inhibits tumor angiogenesis and cell invasion by targeting HIF-1α in vitro. Int J Oncol. 2015;46:708-720.
17. Bi X, Liu W, Xia X, Chen L, Mu T, Liu J, Hou Y, Zhao Y. Effects of Callistephus chinensis flower polyphones on improving metabolic disorders in high-fat diet-induced mice. Food Funct. 2014;5:3304-3310.
15. Su GY, Yang JY, Wang F, Xiong ZL, Hou Y, Zhang K, Song C, Ma J, Song SJ, Teng HF, Wu CF. Xiaochaihutang prevents depressive-like behaviour in rodents by enhancing the serotonergic system. J Pharm Pharmacol. 2014;66:823-834.
16. Yang J, Wang Q, Zhao R, Sun B, Wang L, Hou Y, Li X, Wu C. Identification of oligomer proanthocyanidins (F2) isolated from grape seeds as a formyl peptide receptor 1 partial agonist. Int Immunopharmacol. 2013;15(4):756-63.
18. Xia X, Bi X, Wu W, Mou Y, Hou Y, Zhang K, Zhao Y. Inhibition of β-Catenin Signaling Involved in the Biological Activities of a Lignan E2S Isolated from Carya cathayensis Fruits. Planta Med. 2013;79(17):1648-1652.
19. Mou YH, Yang JY, Cui N, Wang JM, Hou Y, Song S, Wu CF. Effects of cobalt chloride on nitric oxide and cytokines/chemokines production in microglia. Int Immunopharmacol. 2012;13(1):120-125.
20. Bi X, Xia X, Mou T, Jiang B, Fan D, Wang P, Liu Y, Hou Y, Zhao Y. Anti-tumor activity of three ginsenoside derivatives in lung cancer is associated with Wnt/β-catenin signaling inhibition. Eur J Pharmacol. 2014;742:145-152.
