余星昕，女，博士，華東理工大學藥學院副教授、碩士生導師。
基本介紹
- 中文名：余星昕
- 畢業院校：復旦大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：構建具有生物活性的類天然小分子化合物用於創新藥物研究
- 任職院校：華東理工大學
個人經歷,研究方向,學術成果,
個人經歷
2012年6月獲復旦大學有機化學博士學位，上海市優秀畢業生。畢業後赴美國明尼蘇達大學(University of Minnesota)藥學院從事小分子肺癌抑制劑研發的博士後研究。2013年8月加入華東理工大學藥學院，開展藥物小分子設計合成及其作用機制研究。2015年9月晉升副教授，同年被聘為碩士生導師。
研究方向
學術成果
作為項目負責人，主持國家自然科學基金（青年基金），主持教育部基本科研業務費探索研究基金（2項）；2014年入選上海市“浦江人才計畫”和上海市首批“青年科技英才揚帆計畫”；2015年被評為華東理工大學“青年英才引進與培育計畫”骨幹和2015年度“藥學院優秀青年教師”。
已在Org. Lett.;J. Org. Chem.;Chem. Commun.;Chem. Eur. J.;Chem. Soc. Rev.等國際核心期刊上發表SCI論文40餘篇，論文被引用1000餘次，h指數22。獲得中國發明專利授權1項。
近期發表論文
1. Hua Deng,‡ Renmeng Jia,‡ Wu-Lin Yang,Xingxin Yu*, Wei-Ping Deng*.Chem. Commun.,2019([‡] equal contribution)
Ligand-controlled switch in diastereoselectivities: catalytic asymmetric construction of spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives.
2. Jinbin Zhu, Linwei Huang, Wei Dong, Naikai Li,Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*.Angew. Chem. Int. Ed.,
Enantioselective Rhodium-Catalyzed Addition of Arylboroxines toN-Unprotected Ketimines: Efficient Synthesis of Cipargamin.
3. Renmeng Jia, Jiang Meng, Jiaying Leng,Xingxin Yu*, Wei-Ping Deng*.Chem. Asian. J.,2018,
Rhodium(II)-Catalyzed Reaction of 1-Tosyl-1,2,3-triazoles with Morita-Baylis-Hillman Adducts: Synthesis of 3,4-Fused Pyrroles.
4. Jiang Meng, Renmeng Jia, Jiaying Leng, Min Wen,Xingxin Yu*, Wei-Ping Deng*.Org. Lett.,2017,
Carbon-Carbon Bond Formation by Reaction of Rhodium Azavinylcarbenes with Secondary Amides: Access to Indigo Analogues from Isatins.
5. Jiang Meng, Min Wen, Shiwei Zhang, Peiwen Pan,Xingxin Yu*, Wei-Ping Deng*.J. Org. Chem.,2017,Highlighted bySynfacts,2017,
Unexpected O-H Insertion of Rhodium-Azavinylcarbenes withN-Acylhydrazones: Divergent Synthesis of 3,6-Disubstituted- and 3,5,6-Trisubstituted-1,2,4-Triazines.
6. Jiang Meng, Xiangfeng Ding,Xingxin Yu*, Wei-Ping Deng.Tetrahedron,2016,
Synthesis of 2,5-epoxy-1,4-benzoxazepinesviarhodium(II)-catalyzed reaction of 1-tosyl-1,2,3-triazoles and salicylaldehydes.
7. Bo Zhou,Xingxin Yu, Chunlin Zhuang*, Peter Villalta, Yong Lin, Junxuan Lu, Chengguo Xing*.ChemMedChem,2016,(equal contribution)
Unambiguous Identification ofβ-Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling.
8. Linwei Huang, Jinbin Zhu, Guangjun Jiao, Zheng Wang,Xingxin Yu, Wei-Ping Deng*, Wenjun Tang*.Angew. Chem. Int. Ed.,2016,Highlighted bySynfacts,2016,
Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram.
9. Fu-Sheng He, Jing-Hai Jin, Zhong-Tao Yang,Xingxin Yu, John S. Fossey, Wei-Ping Deng*.ACS Catal.,2016,Highlighted bySynfacts,2016,
Direct Asymmetric Synthesis ofβ-Bis-Aryl-α-Amino Acid EstersviaEnantioselective Copper-Catalyzed Addition ofp-Quinone Methides.
10. Wu-Lin Yang, Chun-Yan Li, Wen-Jing Qin, Fei-Fei Tang,Xingxin Yu, Wei-Ping Deng*.ACS Catal.,2016,Highlighted bySynfacts,2016,
Cu(I)-Catalyzed Chemoselective and Stereoselective [3+3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines.
11. Wu-Lin Yang, Fei-Fei Tang, Fu-Sheng He, Chun-Yan Li,Xingxin Yu*, Wei-Ping Deng*.Org. Lett.,2015,
Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinedionesviaN,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones.
12. Fu-Sheng He, Han Zhu, Zheng Wang, Ming Gao,Xingxin Yu*, Wei-Ping Deng*.Org. Lett.,2015,
Asymmetric Construction of 3,4-Diamino PyrrolidinesviaChiral N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides withβ-Phthalimidonitroethene.
13. Zheng Wang,Xingxin Yu*, Bo-Xue Tian, Daniel T. Payne, Wu-Lin Yang, Yang-Zi Liu, John S. Fossey, Wei-Ping Deng*.Chem. Eur. J.,2015,
ChiralN,O-Ligand/Cu(OAc)2Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivativesvia1,3-Dipolar Cycloaddition of Azomethine Ylides withα-phthalimidoacrylates.
14. Wu-Lin Yang, Yang-Zi Liu, Shuai Luo,Xingxin Yu*, John S. Fossey, Wei-Ping Deng*.Chem. Commun.,2015,
The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeletonvia1,3-dipolar cycloaddition of azomethine ylides toα-alkylidene succinimides.
15. Fei-Fei Tang, Wu-Lin Yang,Xingxin Yu*, Wei-Ping Deng*.Catal. Sci. Technol.,2015,
Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivativesviaasymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethynyl ketones.
16. Shan-Shan Jiang, Qin-Chang Xu, Ming-Yu Zhu,Xingxin Yu*, Wei-Ping Deng*.J. Org. Chem.,2015,
Kinetic Resolution ofα-Methylene-β-hydroxy Esters Catalyzed by Acyl Transfer CatalystAn-PIQ.
17. Shan-Shan Jiang, Bo-Qi Gu, Ming-Yu Zhu,Xingxin Yu*, Wei-Ping Deng*.Tetrahedron,2015,
Nonenzymatic kinetic resolution ofα-aryl substituted allylic alcohols catalyzed by acyl transfer catalystNp-PIQ.
18. Wen-Jing Qin, Yi Li,Xingxin Yu*, Wei-Ping Deng*.Tetrahedron,2015,
TBAI/TBHP catalyzed directN-acylation of sulfoximines with aldehydes.
19. Jiang Meng, Di Wu, Ying Shi,Xingxin Yu*, Wei-Ping Deng.Tetrahedron,2015,
Construction of 1H-pyrrol-2-ylphosphonatesvia[3+2] cycloaddition of phosphate azomethine ylides with ynones.
20. Xianbo Wang,Xingxin Yu*.J. Org. Chem.,2014,
Silver(I) and Copper(I) Co-catalyzed Tandem Reaction of 2-Alkynylbenzaldoximes with Aldehydes or Alcohols: Approach to 4-Carboxylated Isoquinolines.
21. Shanshan Jiang, Bin Hu,Xingxin Yu*, Weiping Deng*.Chin. J. Chem.,2014,
Fc-PIP Catalyzed Asymmetric Synthesis ofcis-2,3-Dihydrobenzofurans.
22. Yong Luo, Xiaolin Pan,Xingxin Yu*, Jie Wu*.Chem. Soc. Rev.,2014,
Double Carbometallation of Alkynes: An Efficient Strategy for the Construction of Polycycles.
