何金林(蘇州大學副教授)

何金林，在高分子科學與工程系任教。

基本介紹

• 中文名：  何金林
• 國籍：中國
• 畢業院校：蘇州大學
• 性別：男
• 職稱：副教授、碩士生導師 

人物經歷

2006年本科畢業於蘇州大學化學工程與工藝專業，從事氧負離子聚合的研究工作；2006年9月開始在蘇州大學攻讀高分子化學與物理專業碩士學位，2008年被保送提前攻讀博士學位，從事生物可降解聚磷酸酯的合成及其用於藥物控釋載體的研究工作，博士論文課題獲“江蘇省2009年度普通高校研究生科研創新計畫項目”資助。博士在讀期間，獲得2010年國際高分子化學學術討論會（PC2010）—“優秀牆報獎”和2010年江蘇省博士生學術論壇（化學與綠色化工）—“優秀論文獎”，並榮獲國家留學基金委公派留學基金資助，於2010年8月至2011年10月，在美國Akron大學高分子科學與工程學院、美國工程院院士程正迪教授課題組進行聯合培養博士學習，從事高真空活性負離子聚合方法及其在星形聚合物合成中的套用工作。2012年6月畢業於蘇州大學高分子化學與物理專業，獲理學博士學位並留校任教，2015年7月晉升為副教授。目前已在PNAS、Macromolecules、Soft Matter、Polym. Chem.、Bioconjugate Chem.、J. Mater. Chem. B、Macromol. Rapid Commun.、《高分子學報》等專業刊物發表研究論文60餘篇，現主持國家自然科學基金面上項目1項、江蘇省自然科學基金面上項目1項，已順利結題國家自然科學基金青年基金、江蘇省自然科學基金青年基金、高等學校博士學科點專項科研基金等科研項目6項。受邀為Chem. Mater.、ACS Appl. Mater. Interfaces、Chem. Commun.、ACS Biomater. Sci. Eng.、J. Mater. Chem. B、Polym. Chem.、Polymer、Mater. Today Chem.、Appl. Surface Sci.、Drug Delivery等重要SCI學術期刊的審稿專家。

研究方向

1. 高分子合成方法與高效的有機化學反應相結合，製備功能性拓撲結構聚合物，實驗室擁有一套可用於活性負離子聚合研究的高真空裝置；

2. 基於生物可降解聚合物（聚磷酸酯、脂肪族聚酯、葡聚糖、透明質酸等）的抗腫瘤高分子藥物載體/聚合物前藥、以及水凝膠支架材料。

主要貢獻

代表性論文

(1)Xiao-Man Wang,Yu Shao,Peng-Fei Jin,Wenbo Jiang,Wei Hu,Shuguang Yang,Weihua Li,* Jinlin He,* Peihong Ni, Wen-Bin Zhang*. “Influence of regio-configuration on the phase diagrams of double-chain giant surfactants”, Macromolecules, 2018, 51, 1110-1119. (Equal contribution)

(2)Peng-Fei Jin,Yu Shao,Guang-Zhong Yin, Shuguang Yang, Jinlin He, Peihong Ni, Wen-Bin Zhang*. “Janus [3:5] polystyrene-polydimethylsiloxane star polymers with a cubic core”, Macromolecules, 2018, 51, 419-427. (Equal contribution)

(3)Youwen Cao, Jinlin He, Jie Liu, Mingzu Zhang, and Peihong Ni*. “Folate-conjugated polyphosphoester with reversible cross-Linkage and reduction sensitivity for drug delivery”, ACS Appl. Mater. Interfaces, 2018, doi: 10.1021/acsami.7b18887.

(4)Xiao-Yan Tu, Chao Meng, Yun-Fei Wang, Li-Wei Ma, Bao-Yan Wang, Jin-Lin He, Pei-Hong Ni, Xiang-Ling Ji, Ming-Zhu Liu,* and Hua Wei*. “Fabrication of Thermosensitive cyclic brush copolymer with enhanced therapeutic efficacy for anticancer drug delivery”, Macromol. Rapid Commun., 2018, doi: 10.1002/marc.201700744.

(5)Xiao-Man Wang,Yu Shao,Jun Xu, Xin Jin, Rui-Hao Shen, Peng-Fei Jin, Dong-Wei Shen, Jing Wang, Weihua Li, Jinlin He*, Peihong Ni and Wen-Bin Zhang*. “Precision synthesis and distinct assembly of double-chain giant surfactant regio-isomers”, Macromolecules, 2017, 50, 3943-3953. (Equal contribution)

(6)徐俊, 錢強雨,何金林*, 張明祖, 戴禮興, 倪沛紅. “負離子聚合製備環氧化八臂星形聚異戊二烯及其表征”, 高分子學報, 2018, doi: 10.11777/j.issn1000-3304.2017.17087.

(7)晏雪生,徐俊,何金林*, 張明祖, 戴禮興, 倪沛紅. “活性負離子聚合法製備POSS基七臂星形聚合物及其表征”, 高分子學報, 2017, 3, 454-463.(共同第一作者)

(8)Yu Shao, Hang Yin, Xiao-Man Wang, Shuai-Yuan Han, Xuesheng Yan, Jun Xu, Jinlin He*,Peihong Ni and Wen-Bin Zhang*. “Mixed [2:6] hetero-arm star polymers based on Janus POSS with precisely defined arm distribution”, Polym. Chem., 2016, 7, 2381-2388.

(9)Jian Tian,Jie Chen,Cuicui Ge, Xu Liu, Jinlin He*, Peihong Ni and Yue Pan*. “Synthesis of PEGylated ferrocene nanoconjugates as the radiosensitizer of cancer cells”, Bioconjugate Chem., 2016, 27, 1518-1524. (Equal contribution)

(10)Kan Yue,Mingjun Huang,Ryan Marson,Jinlin He, Jiahao Huang, Zhe Zhou, Jing Wang, Chang Liu, Xuesheng Yan, Kan Wu, Zaihong Guo, Hao Liu, Wei Zhang, Peihong Ni, Chrys Wesdemiotis, Wen-Bin Zhang,* Sharon C. Glotzer* and Stephen Z. D. Cheng*. “Geometry induced sequence of nanoscale Frank-Kasper and quasicrystal mesophases in giant surfactants”, Proc. Natl. Acad. Sci. USA, 2016, 113, 14195-14200. (Equal contribution)

(11)Sen Li, Jinlin He*, Mingzu Zhang, Hairong Wang and Peihong Ni*. “Multicompartment morphologies self-assembled from fluorinated ABC triblock terpolymers: Effects of flexible and rigid hydrophobic moieties”, Polym. Chem., 2016, 7, 1773-1781.

(12)Dongling Cao, Jinlin He, Jiaying Xu, Mingzu Zhang, Lin Zhao, Guangxin Duan, Youwen Cao, Ruhong Zhou* and Peihong Ni*. “Polymeric prodrugs conjugated with reduction-sensitive dextran-camptothecin and pH-responsive dextran-doxorubicin: An effective combinatorial drug delivery platform for cancer therapy”, Polym. Chem., 2016, 7,4198-4212.

(13) Qingqing Zhang, Jinlin He*, Mingzu Zhang and Peihong Ni*, “Polyphosphoester-conjugated camptothecin prodrug with disulfide linkage for potent reduction-triggered drug delivery”, J. Mater. Chem. B, 2015, 3, 4922-4932.

(14) Fei Li, Jinlin He*, Mingzu Zhang, Kam Chiu Tam, Peihong Ni*, “A pH-sensitive and biodegradable supramolecular hydrogel constructed from PEGylated polyphosphoester-doxorubicin prodrug and a-cyclodextrin”, Polym. Chem., 2015, 6, 5009-5014.

(15) Fei Li, Jinlin He, Mingzu Zhang, Kam Chiu Tam, Peihong Ni*, “Injectable supramolecular hydrogels fabricated from PEGylated doxorubicin prodrug and a-cyclodextrin for pH-triggered drug delivery”, RSC Adv., 2015, 5, 54658-54666.

(16) Jian Hu, Jinlin He, Dongling Cao, Mingzu Zhang, Peihong Ni*, “Core cross-linked polyphosphoester micelles with folate-targeted and acid-cleavable features for pH-triggered drug delivery”, Polym. Chem., 2015, 6, 3205-3216. (封面文章)

(17) Jian Hu, Jinlin He*, Mingzu Zhang, Peihong Ni*, “Precise modular synthesis and structure-property study of acid-cleavable star-block copolymers for pH-triggered drug delivery”. Polym. Chem., 2015, 6, 1553-1566.

(18) Hairong Wang,Jinlin He, Dongling Cao, Mingzu Zhang, Fei Li, Kam Chiu Tam and Peihong Ni*, “Synthesis of an acid-labile polymeric prodrug DOX-acetal-PEG-acetal-DOX with high drug loading content for pH-triggered intracellular drug release”, Polym. Chem., 2015, 6, 4809-4818.

(19) Hairong Wang, Jinlin He, Mingzu Zhang, Kam Chiu Tam*, Peihong Ni*, “A new pathway towards polymer modified cellulose nanocrystals via a “grafting onto” process for drug delivery”, Polym. Chem., 2015, 6, 4206-4209.

(20) Dazhao Wu, Jinlin He, Mingzu Zhang*, Peihong Ni, Xiaofei Li, Jiankang Hu, “Fabrication of a novel sandwich-like composite separator with enhanced physical and electrochemical performances for lithium-ion battery”, J. Power Sources, 2015, 290, 53-60.

(21) Xiaofei Li, Jinlin He, Dazhao Wu, Mingzu Zhang*, Juwen Meng, Peihong Ni, “Development of plasma-treated polypropylene nonwoven-based composites for high-performance lithium-ion battery separators”, Electrochim. Acta, 2015, 167, 396-403.

(22) Xingqiang Huang, Jinlin He, Ying Hao, Min Ye, Qi Zhang, Peihong Ni, Jian Liu*, “Synthesis of PEGylated brush-type copolymers for a plurality of plug-and-play functions”, RSC Adv., 2015, 5, 50019-50023.

(23) Yang Zhang, Jinlin He*, Dongling Cao, Mingzu Zhang, Peihong Ni*, “Galactosylated reduction and pH dual-responsive triblock terpolymer Gal-PEEP-a-PCL-ss-PDMAEMA: a multifunctional carrier for targeted and simultaneous delivery of doxorubicin and DNA”. Polym. Chem., 2014, 5, 5124-5138.

(24) Jiao Bian, Ying Hao, Jinlin He*, Wenling Zhang, Mingzu Zhang, Peihong Ni*, “Synthesis and characterization of a biodegradable ABC triblock terpolymer as co-delivery carrier of doxorubicin and DNA”. J. Polym. Sci., Part A: Polym. Chem., 2014, 52, 3005-3016.

(25) Wen-Bin Zhang, Jinlin He, Kan Yue, Chang Liu, Peihong Ni, Roderic P. Quirk,* Stephen Z. D. Cheng*. “Rapid and efficient anionic synthesis of well-defined eight-arm star polymers using octavinylPOSS and poly(styryl)lithium”. Macromolecules, 2012, 45, 8571-8579. (共同第一作者)

(26) Jinlin He, Mingzu Zhang, Peihong Ni*. “Rapidly in situ forming polyphosphoester-based hydrogels for injectable drug delivery carriers”. Soft Matter, 2012, 8, 6033-6038.

(27) Jinlin He, Kan Yue, Yuqing Liu, Xinfei Yu, Peihong Ni, Kevin A. Cavicchi,Roderic P. Quirk, Erqiang Chen*, Stephen Z. D. Cheng*, Wen-Bin Zhang*. “Fluorinated polyhedral oligomeric silsesquioxane-based shape amphiphiles: Molecular design, topological variance, and facile synthesis”. Polym. Chem., 2012, 3, 2112-2120. (共同第一作者)

(28) Jinlin He, Haiyan Shao, Mingzu Zhang, Peihong Ni*, “Novel pH-responsive polyphosphoester-based hydrogels with fast gelation”. J. Controlled Release, 2011, 152, e232-e233.

(29) Jinlin He, Peihong Ni*, Sai Wang, Haiyan Shao, Mingzu Zhang, Xiulin Zhu*. “Synthesis and physicochemical characterization of biodegradable and pH-responsive hydrogels based on polyphosphoester for protein delivery”. J. Polym. Sci., Part A: Polym. Chem., 2010, 48, 1919-1930.

(30) Jinlin He, Peihong Ni*, Cuicui Liu. “Synthesis and characterization of amphiphilic fluorinated pentablock copolymers based on Pluronic F127”. J. Polym. Sci., Part A: Polym. Chem., 2008, 46, 3029-3041.

(31) 何金林, 顧子旭, 梁駿, 倪沛紅*，“殼聚糖接枝PDMAEMA共聚物的聚集行為”. 高分子材料科學與工程，2008, 24(12), 126-129.

(32) 胡健,何金林, 張明祖, 倪沛紅*. “點擊化學在拓撲結構聚合物合成中的套用”, 高分子學報, 2013, 3, 300-319. (共同第一作者)

(33) Ying Hao, Jinlin He, Sen Li, Jian Liu, Mingzu Zhang, Peihong Ni, “Synthesis of acid-cleavable and fluorescent amphiphilic block copolymer as a combined delivery vector of DNA and doxorubicin”, J. Mater. Chem. B, 2014, 2, 4237-4249.

(34) Yunfeng Tao, Jinlin He, Mingzu Zhang, Ying Hao, Jian Liu, Peihong Ni*. “Galactosylated biodegradable poly(ε-caprolactone-co-phosphoester) random copolymer nanoparticles for potent hepatoma-targeting delivery of doxorubicin”, Polym. Chem., 2014, 5, 3443-3452.

(35) Hairong Wang, Jinlin He, Mingzu Zhang, Yunfeng Tao, Fei Li, Kam Chiu Tam, Peihong Ni*. “Biocompatible and acid-cleavable poly(ε-caprolactone)-acetal-poly(ethylene glycol)-acetal-poly(ε-caprolactone) triblock copolymers: synthesis, characterization and pH-triggered doxorubicin delivery”, J. Mater. Chem. B, 2013, 1, 6596-6607. (內封面文章)

(36) 肖燕, 何金林, 陶雲鋒, 張明祖, 胡健, 倪沛紅*. “基於功能化聚磷酸酯嵌段共聚物的微凝膠和水凝膠的製備與表征”, 高分子學報, 2014, 1, 122-130.

(37) Ying Hao, Jinlin He, Mingzu Zhang, Yunfeng Tao, Jian Liu, Peihong Ni*. “Synthesis and characterization of novel brush copolymers with biodegradable polyphosphoester side chains for gene delivery”. J. Polym. Sci., Part A: Polym. Chem., 2013, 51, 2150-2160.

(38) Kan Yue, Jinlin He, Chang Liu, Mingjun Huang, Xue-Hui Dong, Kai Guo, Peihong Ni, Chrys Wesdemiotis, Roderic P. Quirk,* Stephen Z. D. Cheng,* Wen-Bin Zhang*. “Anionic synthesis of a “Clickable” middle-chain azide-functionalized polystyrene and its application in shape amphiphiles”. Chinese J. Polym. Sci., 2013, 31(1), 71-82.

(39) Wen-Bin Zhang, Jinlin He, Xuehui Dong, Chien-Lung Wang, Hui Li, Fuai Teng, Xiaopeng Li, Chrys Wesdemiotis, Roderic P. Quirk*, Stephen Z.D. Cheng*. “Improved synthesis of fullerynes by Fisher esterification for modular and efficient construction of fullerene polymers with high fullerene functionality”. Polymer, 2011, 52, 4221-4226.

(40) Wenling Zhang, Jinlin He, Zhuang Liu, Peihong Ni*, Xiulin Zhu*. “Biocompatible and pH-responsive triblock copolymer mPEG-b-PCL-b-PDMAEMA: Synthesis, self-assembly and application”. J. Polym. Sci., Part A: Polym. Chem., 2010, 48, 1079-1091.

(41) Mingzu Zhang, Jinlin He, Jiang Mao, Cuicui Liu, Hairong Wang, Yinfeng Huang, Peihong Ni*. “Kinetics of styrene miniemulsion polymerization using poly[(stearyl methacrylate-co-(N, N-dimethylamino)ethyl methacrylate] as surfactant”. Colloid. Surface. A: Physicochem. Eng. Asp., 2010, 360, 190-197.

(42) Cuicui Liu, Jinlin He, Qun Zhao, Mingzu Zhang, Peihong Ni*. “Well-defined poly[(dimethylamino)ethyl methacrylate]-b-poly(fluoroalkyl methacrylate) diblock copolymers: Effects of different fluoroalkyl groups on the solution properties”, J. Polym. Sci., Part A: Polym. Chem.,2009, 47, 2702-2712.

(43) Xiaofei Li, Mingzu Zhang*, Jinlin He, Dazhao Wu, Juwen Meng, Peihong Ni. “Effects of fluorinated SiO₂ nanoparticles on the thermal and electrochemical properties of PP nonwoven/PVdF-HFP composite separator for Li-ion batteries”, J. Membr. Sci., 2014, 455, 368-374.

(44) 郝瑩, 張洋, 何金林, 尚修娟, 張明祖, 倪沛紅*. “半乳糖胺修飾陽離子型刷形嵌段共聚物的合成與表征”, 化學學報, 2014, 72, 569-576.

(45) Guoyi Zhang, Mingzu Zhang, Jinlin He, Peihong Ni*. “Synthesis and characterization of a new multifunctional polymeric prodrug paclitaxel-polyphosphoester-folic acid for targeted drug delivery”,Polym. Chem., 2013, 4, 4515-4525.

(46) Ying Hao, Mingzu Zhang, Jinlin He, Peihong Ni*. “Magnetic DNA vector constructed from PDMAEMA polycation and PEGylated brush-type polyanion with cross-linkable shell”. Langmuir, 2012, 28, 6448-6460.

申請專利

(1) 倪沛紅, 何金林, 王賽, 張明祖, “生物可降解的溫度/pH雙重回響性水凝膠”, 中國發明專利: ZL 2008 10022216.2。（授權公告日2010年6月9日）

(2) 倪沛紅, 劉旭, 何金林, 張明祖, 朱秀林, “pH/溫度回響的雙親水性嵌段共聚物及其製備方法”,中國發明專利: ZL 2009 100344713.3。（授權公告日2011年5月25日）

(3) 倪沛紅, 邵海燕, 何金林, 張明祖, 李陽, “側鏈功能化修飾的生物可降解型兩親性聚酯”,中國發明專利: ZL 201110202438.4。

(4) 顧子旭, 倪沛紅, 袁媛, 何金林, “一種新型非病毒陽離子型基因載體及其製備方法”, 中國發明專利: ZL 2008 10018650.3。(授權公告日：2011年6月15日).

(5) 張明祖, 徐玲妍, 倪沛紅, 何金林, 孟菊雯, “一種無機/有機複合多孔性鋰電池隔膜及其製備方法”, 中國專利申請號: 201210018087.6。(2012.1.20 受理)

科研項目

(1)國家自然科學基金面上項目（21774081），2018.01-2021.12，項目負責人。

(2) 江蘇省自然科學基金面上項目（BK20171212），2017.07-2020.06，項目負責人。

(3) 江南大學合成與生物膠體教育部重點實驗室開放課題基金（JDSJ2017-05），2018.01-2019.12，項目負責人。

(4)北京分子科學國家實驗室開放課題基金（20140152），2015.01-2016.12，項目負責人。

(5) 國家自然科學基金青年科學基金項目（21304061），2014.01-2016.12，項目負責人。

(6) 江蘇省自然科學基金青年基金項目，2013.07-2016.06，項目負責人。

(7) 江蘇省高校自然科學研究面上項目（13KJB150034），2013.08-2015.12，項目負責人。

(8) 中國博士後科學基金（2013M531396），2012.09-2014.09，項目負責人。

(9) 江蘇省普通高校研究生創新計畫項目（CX09B_021Z），2009.08-2012.06，項目負責人。

(10) 國家自然科學基金面上項目（21074078），2011.01-2013.12，第二參加人。

(11) 國家自然科學基金面上項目（20974074），2010.01-2012.12，第三參加人。

獲獎記錄

博士在讀期間，獲2010年國際高分子化學會議（PC2010）優秀牆報獎，2010年江蘇省博士生學術論壇（化學與綠色化工）優秀論文獎，並獲得國家留學基金委資助於2010年8月至2011年10月。