①在美國哈佛大學醫學院學習期間，師從美國科學院院士Charles C. Richardson教授開展T7噬菌體病毒DNA複製的研究，發現了病毒的單鏈DNA結合蛋白C-末端小肽對其DNA聚合酶、DNA解旋酶以及引發酶等多個複製關鍵酶的功能有重要調控作用，在國際著名雜誌JBC上發表研究論文2篇，有關研究結果最近被Nature等雜誌引用；
1. Manman Guo, Hui Feng, Jun Zhang, Wenqin Wang, Yi Wang, Yuqing Li, Chunhui Gao, Huanchun Chen, Ying Feng and Zheng-Guo He（通訊作者）. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Reseearch. 2009. 19: 1301-1308 . IF= 11.342
2. Lu Zhang, Lei Zhang, Yi Liu, Shifan Yang, Chunhui Gao, Hongchao Gong, Ying Feng, and Zheng-Guo He (通訊作者).Archaeal eukaryote-like Orc1/Cdc6 initiators physically interact with DNA polymerase B1 and regulate its functions. PNAS, 2009 vol. 106 no. 19 7792-7797 .IF= 9.432
3. Feng Huang and Zheng-Guo He* (correspond author).Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I .Nucl. Acids Res. (2010) doi: 10.1093/nar/gkq737. IF = 7.479
4.Bin Wang,Shifan Yang,Lei Zhang,and Zheng-Guo He(correspond author). Archaeal Eukaryote-Like Serine/Threonine Protein Kinase Interacts with and Phosphorylates a Forkhead-Associated-Domain-Containing Protein .Journal of Bacteriology, 2010, Vol. 192,p. 1956-1964. IF= 3.94
5. Lei Zhang and Zheng-Guo He* (correspond author) , Radiation-sensitive gene A (RadA) targets DisA, DNA integrity scanning protein A, to negatively affect its cyclic-di-AMP synthesis activity in Mycobacterium smegmatis . J. Biol. Chem. 2013
6. Lei Zhang, Weihui Li, and Zheng-Guo He* (correspond author) . DarR, a TetR-like Transcriptional Factor, Is a Cyclic Di-AMP-responsive Repressor in Mycobacterium smegmatis . J. Biol. Chem. 2013,288: 3085-3096.
7 . Muding Rao, Huicong Liu, Min Yang, Chunchao Zhao, and Zheng-Guo He* (correspond author). A Copper-responsive Global Repressor Regulates Expression of Diverse Membrane-associated Transporters and Bacterial Drug Resistance in Mycobacteria. J. Biol. Chem. 2012, 287: 39721-39731.
8. Yi Wang, Yuanxia Huang, Chaolun Xue, Yang He, and Zheng-Guo He* (correspond author). ClpR Protein-like Regulator Specifically Recognizes RecA Protein-independent Promoter Motif and Broadly Regulates Expression of DNA Damage-inducible Genes in Mycobacteria. J. Biol. Chem. 2011 286: 31159-31167.
9. Weihui Li and Zheng-Guo He* (correspond author). LtmA, a novel cyclic di-GMP-responsive activator, broadly regulates the expression of lipid transport and metabolism genes inMycobacterium smegmatis. Nucl. Acids Res. (2012) 40 (22): 11292-11307
10. Min Yang, Chunhui Gao, Tao Cui, Jingning An, and Zheng-Guo He* (correspond author) . A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis. Nucl. Acids Res. (2012) 40 (3): 1009-1020
11. Yuqing Li, Jumei Zeng, Jianfang Shi, Mingchao Wang, Muding Rao, Chaolun Xue, Yanli Du and Zheng-Guo He* (correspond author) .A Proteome-Scale Identification of Novel Antigenic Proteins in Mycobacterium tuberculosistoward Diagnostic and Vaccine Development . J. Proteome Res., 2010
12. Yi Wang, Tao Cui, Cong Zhang, Min Yang, Yuanxia Huang, Weihui Li, Lei Zhang, Chunhui Gao, Yang He, Yuqing Li, Feng Huang, Jumei Zeng, Cheng Huang, Qiong Yang, Yuxi Tian, Chunchao Zhao, Huanchun Chen, Hua Zhang, and Zheng-Guo He* (correspond author). Global Protein−Protein Interaction Network in the Human Pathogen Mycobacterium tuberculosisH37Rv. J. Proteome Res. , 2010
13. Jumei Zeng, Tao Cui, and Zheng-Guo He* (correspond author).A Genome-Wide Regulator–DNA Interaction Network in the Human Pathogen Mycobacterium tuberculosisH37Rv. J. Proteome Res. , 2012
14.Zheng-Guo He, Charles Richardson (2004) Effect of single-stranded DNA-binding proteins on the helicase and primase activities of bacteriophage T7 gene 4 protein. Journal of Biological Chemistry. 279(21):22190-22197. IF:5.854
15.Zheng-Guo He, Lisa Rezende, S Willocox, Jack Griffith, Charles Richardson (2003) The carboxyl-terminal domain of bacteriophage T7 single-stranded DNA-binding protein modulates DNA binding and interaction with T7 DNA polymerase. Journal of Biological Chemistry. 278(32): 29538-29545. IF:5.854
16. Zheng-Guo He, Huifang Zhong, Yaqin Li. (2004) Acidianus tengchongenesis. sp.nov., a new species of acidothermophilic archaeon from hot spring. Current Microbiology. 48(2): 159-163. IF:1.059 8 . Zhengguo He, Li Y, Zhou P, Liu S-J. (2000). Cloning and heterologeous expression of sulfur oxygenase/reductase gene of a thermoacidophilic archae Acidianus sp. S5 in Escherichia coli. FEMS Microbiological Letter 193(2):217-221. IF:2.507
