女，有機化學博士，教授
研究方向： 生物有機化學、天然有機化學、有機合成化學
研究興趣： 酶催化的有機合成與生物轉化；生物活性天然產物的全合成，天然產物類似物 分子的設計、合成及構效關係研究；藥物中間體合成；合成方法研究。
基本介紹
- 中文名：何延紅
- 國籍：中國
- 民族：漢族
- 職業：教授
- 畢業院校：雲南大學化學系
基本信息,工作和學習簡歷,任課情況,主持科研項目,近年來發表的代表性學術論文,參編書目,
基本信息
工作和學習簡歷
1984.09 - 1988.06 本科，雲南大學化學系
1988.07 - 1996.08 實習研究員、助理研究員，雲南省熱帶作物科學研究所
1996.09 - 1999.06 碩士研究生，中山大學化學與化學工程學院
1999.06 - 2001.02 講師, 中山大學化學與化學工程學院
2001.03 - 2004.11 博士研究生，瑞典隆德大學（Lund University）生物有機 化學系
2005.12 - 目前 特聘教授，西南大學化學化工學院
任課情況
曾承擔或正在主講的本科課程：《生物化學》(雙語)、《有機化學》、《有機製備》
曾承擔或正在主講的研究生課程：《生物化學》
主持科研項目
1. 教育部留學回國人員科研啟動基金（第30批），具有特殊生物活性的真菌代謝產物Conidiogenone 全合成研究，2006.09-2008.08.
2. 重慶市自然科學基金（CSTC 2006BB5377），具有特殊生物活性的新穎二萜類似物分子的設計與合成研究，2006.08-2008.07.
3. 教育部資助聘請外國文教專家重點項目，青黴菌的萜類分生孢子誘導因子， 2008年度
4. 西南大學高新技術培育基金（XSGX0601），青黴菌分生孢子誘導劑的合成研究，2006.12-2008.11，(與官智共同主持)
5. 西南大學博士基金（SWNUB2005012），真菌代謝產物Conidiogenone及其類似物的全合成與生物活性研究， 2006.01-2007.12.
申請專利5項
[1] 何延紅，官智，李海虹，地衣芽孢桿菌鹼性蛋白酶作為不對稱直接Aldol反應催化劑的套用，2010，中國專利申請號：201010042093.6
[2] 何延紅，官智，蔡光容，碳環化合物的合成方法，2009，中國專利申請號：200910103960.X
[3] 何延紅，官智，汪鋼強，多取代吡咯的綠色合成方法，2009，中國專利申請號：200910103956.3
[4] 何延紅，官智，汪鋼強，2,5-二甲基呋喃-3-甲酸乙酯的製備方法，2009，中國專利申請號：200910103289.9
[5] 何延紅；官智；汪鋼強 多取代呋喃的綠色合成方法，2009，中國專利申請: 200910103962.9
近年來發表的代表性學術論文
1. Yan-Hong He, Wen Hu, Zhi Guan, Enzyme-catalyzed direct three-component aza-Diels-Alder reation using hen egg white lysozyme, J. Org. Chem. 2012, 77(1), 200-207.
2. Yan-Hong He, Hai-Hong Li, Yan-Li Chen, Yang Xue, Yi Yuan, Zhi Guan, Chymopapain-catalyzed direct asymmetric aldol reaction, Adv. Synth. Catal. 2012, 354(4), 712-719
3. Bang-Hua Xie, Wei Li, Yan Liu, Hai-Hong Li, Zhi Guan, Yan-Hong He, The enzymatic asymmetric aldol reaction using acidic protease from Aspergillus usamii, Tetrahedron, 2012, 68(15), 3160-3164.
4. Wen Hu, Zhi Guan, Xiang Deng, Yan-Hong He, Enzyme catalytic promiscuity: The papain-catalyzed Knoevenagel reaction, Biochimie 2012, 94(3), 656-661.
5. Bang-Hua Xie, Zhi Guan, Yan-Hong He, Biocatalytic Knoevenagel reaction using alkaline proteinase from Bacillus licheniformis, Biocatal. Biotransfor. 2012, 30(2), 238-244.
6. Chang-Heng Wang, Zhi Guan, Yan-Hong He, Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis, Green Chem. 2011, 13(8), 2048-2054.
7. Hai-Hong Li, Yan-Hong He, Yi Yuan, Zhi Guan, Nuclease p1: A new biocatalyst for direct asymmetric aldol reaction under solvent-free conditions, Green Chem. 2011, 13(1), 185-189.
8. Hai-Hong Li, Yan-Hong He, Zhi Guan, Protease-catalyzed direct aldol reaction, Catal. Commun. 2011, 12(7), 580-582.
9. Jian-Ping Fu, Yan-Hong He, Jun Zhong, Yang Yang, Xiang Deng, Zhi Gian, An efficient and general route to the synthesis of diethyl a,a-bromofluorophosphonates, J. Fluor. Chem. 2011, 132(9), 636-640.
10. Jian-Feng Cai, Zhi Guan, Yan-Hong He, The lipase-catalyzed asymmetric C-C Michael addition, J. Mol. Catal. B: Enzym. 2011, 68(3-4), 240-244.
11. Ke-Ling Xu, Zhi Guan, Yan-Hong He, Acidic proteinase from Aspergillus usamii catalyzed Michael addition of ketones tonitroolefins, J. Mol. Catal. B: Enzym. 2011, 71(3-4), 108-112.
12. Yan-Hong He, Gang-Qiang Wang, Ke-Ling Xu, Zhi Guan, An efficient procedure for the synthesis of polysubstituted pyrroles in an ionic liquid, Z. Naturforsch. 2011, 66b, 191-196.
13. Yan-Hong He, Ying Hu, Zhi Guan, Natural a-amino acid L-lysine catalyzed Knoevenagel condensations of a,b-unsaturated aldehydes and 1,3-dicarbonyl compounds, Synth. Commun. 2011, 41(11), 1617-1628.
14. Guang-Rong Cai, Zhi Guan, Yan-Hong He, Synthesis of six-membered functionalized carbocyclic compounds by one-pot reaction of hydroquinone derivatives and dienes, Synth. Commun. 2011, 41(20), 3016-3025.
15. Yang Yang, Yan-Hong He, Zhi Guan, Wei-Da Huang, A highly efficient large-scale asymmetric direct intermolecular aldol reaction employing L-prolinamide as a recoverable catalyst, Adv. Synth. Catal. 2010, 352(14-15), 2579-2587.
16. Ying Hu, Yan-Hong He, Zhi Guan, A simple method for the preparation of functionalized trisubstituted alkenes and a,b,g,d-unsaturated carbonyl compounds by using natural amino acid L-tryptophan, Catal. Commun. 2010, 11(7), 656-659.
17. Rong-Chang Tang, Zhi Guan, Yan-Hong He, Wen Zhu, Enzyme-catalyzed Henry (nitroaldol) reaction, J. Mol. Catal. B: Enzym. 2010, 63(1-2), 62-67.
18. Yan-Hong He, Gang-Qiang Wang, Zhi Guan, N-Substituted pyrrole synthesis by Paal-Knorr condensation using recyclable cationic exchange resin in water, J. Hetercyclic Chem. 2010, 47 (2), 486-489.
19. Gangqiang Wang, Zhi Guan, Rongchang Tang, Yanhong He, Ionic liquid as catalyst and reaction medium: A simple and efficient procedure for Paal-Knorr furan synthesis, Synth. Commun. 2010, 40(3), 370-377.
20. Ying Hu, Zhi Guan, Yan-Hong He, Nathan Louwagie, Meng-Jie Yao, L-Arginine used as a cost-effective and recyclable catalyst in ionic liquid for synthesis of a,b-unsaturated nitriles and ketones, J. Chem. Res. 2010, (1), 22-24.
21. Zhi Guan, Di Wu, Jian-Ping Fu, Yan-Hong He, A facile and efficient synthesis of diethyl aa-chlorofluoroalkanephosphonates, Heteroatom Chem. 2010, 21(4), 250-255.
22. Shuai Zhao, Yan-Hong He, Di Wu, Zhi Guan, A new general approach to 4-substituted-3-halo-2-quinolones, J. Fluor. Chem. 2010, 131(5), 597-605.
23. Gang-Qiang Wang, Zhi Guan, Rong-Chang Tang, Zeljko Ostojic, T. Nicholas Jones, Ting-Ting Wu, Yan-Hong He, A simple preparation of ethyl 2,5-dimethylfuran-3-carboxylate and 2,5-dimethylfuran-3,4-dicarboxylic acid from diethyl 2,3-diacetylsuccinate, J. Hetercyclic Chem. 2009, 46(3), 540-543.
24. Di Wu, Yanhong He, Rongchang Tang, Zhi Guan, The first synthesis of diethyl a,a-chlorofluorobenzylphosphonates, Synlett, 2009, (13), 2180-2182.
25. Yanhong He, Martin Johansson and Olov Sterner, Mild microwave-assisted hydrolysis of acetals under solvent-free conditions, Synthetic Communications, 2004, 34(22), 4153-4158.
26. Tomas Roncal, Shandra Cordobes, Unai Ugalde, Yanhong He and Olov Sterner, Novel diterpenes with potent conidiation inducing activity, Tetrahedron Letters, 2002, 43(38), 6799-6802.
參編書目
Yan-Hong He, Zhi Guan and Jian-Feng Cai,《Practical Methods for Biocatalysis and Biotransformations 2》Volume 2 edition, Editors: John Whittall and Peter W. Sutton, Publisher: Wiley-Blackwell, 2012 中編寫了10.7 The lipase-catalyzed asymmetric Michael addition of thienyl nitroolefin to acetylacetone. ISBN-13: 978-1119991397.
