何宏燕，女，1974年1月生，博士，華東理工大學材料科學與工程學院副教授。
基本介紹
- 中文名：何宏燕
- 出生日期：1974年1月
- 學位/學歷：博士
- 職業：教師
- 專業方向：生物材料的表界面改性；微流生物晶片的設計與開發等
- 職稱：副教授
- 任職院校：華東理工大學
個人經歷,學術兼職,研究方向,學術成果,專利,論文,主要承擔項目,榮譽獎項,
個人經歷
1997年畢業於清華大學, 化學工程與工業專業，學士；
2000年畢業於上海大學, 環境科學與工程專業，碩士；
2006.8-2008.8, 美國俄亥俄州NSF 納米科學與工程中心, 助理研究工程師；
2008.9-2013.3, 美國俄亥俄州BioLOC LLC., 資深研究員；
2013.7-至今，華東理工大學
學術兼職
研究方向
1.生物材料的表界面改性； 2.微流生物晶片的設計與開發； 3.藥物的可控緩釋
學術成果
科研成果已在Biomaterials、Journal of Controlled Release、Small等雜誌發表，SCI論文 30 余篇，申請發明專利2項，國際期刊撰寫邀請綜述2篇。
專利
2、餘波，李利，何宏燕，一種新型酶聯免疫生化光碟監測系統，公開號CN102967715 A,公開日2013年3月13日。
1、餘波，張鐵成，葉嘉明，何宏燕，李利，一種糖化血紅蛋白免疫檢測的微流控晶片，公開號CN103323605 A,公開日2013年9月25日。
論文
24、Yang Y, Zhao X, Wang L, Wang F*, He H*, Wang X. Photo-polymerization of monomer crystals producing thermo-responsive micropatterns to direct cell growth and cell selective harvest．Polym. 74(1):150-158, 2015.
23、Wang X, He H, Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensi．Biochimica Et Biophysica Acta, 1853(1):244-253,2015.
22、Zhang W, He H, Tian Y, Gan Q, Zhang J, YuanY *, Liu C.*. Calcium ion-induced formation of β-sheet/-turn structure leading to alteration of osteogenic activity of bone morphogenetic protein-2. Scientific Report5:12694-12700, 2015.
21、Wang LJ, Li L, Yu J, Wu Y, He H, Ouyang X, Zhao X, Yen Y, Lee LJ. Large-area graphene coating via superhydrophilic-assisted electro-hydrodynamic spraying deposition. Carbon 79:294-301, 2014.
20、Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJ. Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations. J Control Rel.172(3):690-698, 2013.
19、He H, Luedke E, et al., A naonoporous cell-therapy device with controllable biodegradation for long-term drug release. J Control Rel. 165(3): 226-233, 2013.
18、張娜，龍春光，何宏燕，劉春太，申長雨；碳納米纖維納米紙環氧複合材料對風力發電葉片的的影響；複合材料學報 30(1):90-95, 2013.
17、Wang F, He H(co-first), etc. Micropatterned thermoresponsive surfaces by polymerization of monomer crystals: modulating cellular morphology and cell substrate interactions. Analy Chem. 84(21): 9439- 9445, 2012.
16、He H, Grignol V, et al. Use of a Nanoporous Biodegradable Miniature Device to Regulate Cytokine Release for Cancer Treatment, J Control Rel. 151, 239-245, 2011.
15、Yen C, He H, Fei Z, Zhang X, Lee L J, and Winston Ho, Surface Modification of Nanoporous Poly(caprolactone) Membrane with Poly(ethylene glycol) to Prevent Biofouling: Part I. Effects of Plasma Power and Treatment Time. Inter J Poly Mater. 59 (11), 923, 2010.
14、Yen C, He H, Fei Z, Zhang X, Lee L J, and Winston Ho, Surface Modification of Nanoporous Poly(caprolactone) Membrane with Poly(ethylene glycol) to Prevent Biofouling: Part II. Effects of Graft Density and Chain Length. Inter J Poly Mater. 59 (11), 943, 2010.
13、He H,Yuan Y, Wang W, Chiou N-R, Epstein A J, and Lee L J, Design and testing of a CD-like biochip for enzyme-linked immunosorbent assay. Biomicrofluidics 3, 1-17, 2009.
12、Yuan Y, He H, and Lee L J,Protein A-based antibody immobilization onto polymeric microdevices for enhanced sensitivity of enzyme-linked immunosorbent assay. Biotech Bioeng. 102, 891-901, 2009.
11、Wen X, He H, and Lee L J,Antibody immobilization with biotin-poly(L-lysine)-g-poly(ethylene glycol) and protein A on microfluidic chips. J ImmunolMet.350, 97-105, 2009.
10、Yen C, He H, Lee L J,and W. Ho, Synthesis and characterization of polycaprolactone nanoporous membranes for biomedical applications. J Mem Sci.343, 180-188, 2009.
9、Zhang X, He H(co-first author), Yen C, Ho W, and Lee L J, A biodegradable, immunoprotective, dual nanoporous capsule for cell based therapies. Biomaterials29, 4253-4259, 2008.
8、He H, Zhang X, Yen C,and Lee L J, Advanced polymeric carriers for controlled protein delivery. CACS Communications, 2(1), 3-9, 2008.
7、He H, Li L, and Lee L J, Photopolymerization and structure formation of pH-sensitive methacrylic acid based hydrogels: the effect of light intensity. ReacFunc Polym.68(1), 103-113, 2008.
6、Guan J, He H, Yu B, and Lee L J, Polymeric nanoparticles and nanopore membranes for controlled drug and gene delivery, Biomed Nanostructures, 115-137, 2008.
5、Guan J, He H, Lee L J，and Hansford D J, Fabrication of particulate reservoir-containing, capsule-like, and self-foldable polymer microstructures for drug delivery. Small3, 412-418, 2007.
4、He H, Li L,and Lee L J, Photopolymerization and structure formation of methacrylic acid based hydrogels in water/ethanol mixture. Polym. 47, 1612-1619, 2006.
4、He H,Guan J, andLee L J, Oral delivery devices based on self-folding hydrogels. J ControlRel.110(2), 339-346, 2006.
3、 Guan J, He H, Hansford D J, and Lee L J, Self-folding hydrogel three-dimensional microstructures.J Phy Chem B. 109(49), 23134-23137, 2005.
2、He H,Guan J, Hansford D J, and Lee L J,Hydrogel-based multifunctional delivery devices for oral protein administration. Polym Mater: Sci Eng. 92, 28-30, 2005.
1、 He H, Cao X, and Lee L J, Design of a novel hydrogel-based intelligent system for controlled drug release. J ControlRel.95, 391-402, 2004.
主要承擔項目
6、新型骨誘導型降解塗層的研製及其生物活性調控的機制研究,國家自然科學基金面上項目,在研、主持。
5、微納尺度的鈦合金表面特性與骨形態發生蛋白微觀結構和活性的研究,上海市自然科學基金項目,在研、主持。
4、生化檢測光碟用於食品檢測, 江蘇省國際合作項目,完成、參與。
3、生化檢測光碟研發及產業化,江蘇南京321創業項目,完成、參與。
2、微流生物晶片用於免疫蛋白的檢測，美國國家科學基金 (NSF),完成、主持。
