基本介紹
- 中文名：于海佳
- 學位/學歷：博士
- 職業：教師
- 專業方向：糖穩態維持的調控機制
- 任職院校：南京師範大學
個人經歷,研究方向,學術成果,
個人經歷
教育和工作經歷：
2017年12月至今，南京師範大學生命科學學院分子細胞生物學研究所，教授；
2009年10月-2017年8月，美國科羅拉多大學博爾德分校分子細胞發育生物系，博士後研究助理；
2003年9月-2009月1月，中國科學院長春套用化學研究所化學生物學實驗室，獲博士學位；
1999年9月-2003年6月，東北師範大學，獲學士學位。
學術會員：
美國科學促進會、生物化學與分子生物學會會員
研究方向
糖穩態維持的調控機制；
神經遞質分泌過程的分子機理；
細胞內膜接觸位點和細胞間通訊的功能研究。
學術成果
承擔科研項目：
國家自然科學基金面上項目 （2019-2022）
國家自然科學基金重大研究計畫培育項目 （2019-2021）
江蘇省特聘教授科研啟動（2018-2020）
論文著作：
1. Chong Shen#, Yinghui Liu#, Haijia Yu*, Daniel R. Gulbranson, Igor Kogut, Ganna Bilousova, Chen Zhang, Michael H. B. Stowell, Jingshi Shen*, The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis，J. Biol. Chem., 2018, 293，18309-18317. ( #共同一者，*通訊作者)
2. Haijia Yu*, Lauren Crisman, Michael H. B. Stowell, and Jingshi Shen*, Functional reconstitution of intracellular vesicle fusion using purified SNAREs and Sec1/Munc18 (SM) proteins. Methods Mol. Biol. 2018, 1860, 237-249.
3. Haijia Yu, Chong Shen, Yinghui Liu, Bridget L. Menasche, Yan Ouyang, Michael H. B. Stowell*, and Jingshi Shen*，SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins，Proc. Natl. Acad. Sci. U S A, 2018, 115, E8421-8429.
4. Daniel R. Gulbranson, Eric M. Davis, Brittany A. Demmitt, Yan Ouyang, Yihong Ye, Haijia Yu*, Jingshi Shen*, RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc. Natl. Acad. Sci. U S A, 2017, 114, E8224-E8233.
(Faculty of 1000推薦點評)
5. Haijia Yu, Yinghui Liu, Daniel R. Gulbranson, Alex Paine, Shailendra S. Rathore, and Jingshi Shen*，Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites，Proc. Natl. Acad. Sci. U S A, 2016, 113, 4362-4367.
(Faculty of 1000推薦點評)
6. Chong Shen#, Shailendra S. Rathore#, Haijia Yu#, Daniel R. Gulbranson, Rui Hua, Chen Zhang, Nathan E. Schoppa, and Jingshi Shen*，The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis, Nat. Commun., 2015, 6, 8852.
7. Haijia Yu#, Shailendra S. Rathore#, Chong Shen, Yinghui Liu, Yan Ouyang, Michael H. Stowell, Jingshi Shen*, Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding, J. Am. Chem. Soc., 2015, 137, 12873-12883.
8. Haijia Yu, Shailendra S. Rathore, Daniel R. Gulbranson, Jingshi Shen*, The N- and C-terminal domains of tomosyn play distinct roles in SNARE binding and fusion regulation, J. Biol. Chem., 2014, 289, 25571-25580.
9. Haijia Yu, Shailendra S. Rathore, Jamie A. Lopez, Eric M. Davis, David E. James, Jennifer L. Martin, Jingshi Shen*, Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins, Proc. Natl. Acad. Sci. U S A, 2013, 110, E3271-3280.
(同期PNAS雜誌專題評論: Yeon-Kyun Shin, Two gigs of Munc18 in membrane fusion. Proc. Natl. Acad. Sci. U S A, 2013, 110, 14116-14117.)
10. Haijia Yu, Shailendra S. Rathore, Eric M Davis, Yan Ouyang, Jingshi Shen*, Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner, Mol. Biol. Cell., 2013, 24, 1176-1184.
11. Haijia Yu, Shailendra S. Rathore, Jingshi Shen*, Synip Arrests Soluble N- Ethylmale imide-sensitive Factor Attachment Protein Receptor (SNARE)-dependent Membrane Fusion as a Selective Target Membrane SNARE-binding Inhibitor，J. Biol. Chem., 2013, 288，18885-18893.
12. Haijia Yu#, Meng Li#, Gongping Liu#, Jie Geng, Jianzhi Wang, Jinsong Ren, Chuanqi Zhao, Xiaogang Qu*, Metallosupramolecular complex targeting an α/β discordant stretch of amyloid β peptide, Chem. Sci., 2012, 3, 3145-3153.
13. Shailendra S. Rathore, Eric G. Bend, Haijia Yu, Marc Hammarlund, Erik M. Jorgensen, Jingshi Shen*, Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex, Proc. Natl. Acad. Sci. U S A, 2010, 107, 22399-22406.
14. Haijia Yu, Chuanqi Zhao, Yong Chen, Manliang Fu, Jinsong Ren, Xiaogang Qu*, DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity, J. Med. Chem., 2010, 53, 492–498.
15. Haijia Yu, Xiaohui Wang, Manliang Fu, Jinsong Ren, Xiaogang Qu*, Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA, Nucleic Acids Res., 2008, 36, 5695-5703.
16. Haijia Yu, Jinsong Ren, Jonathan B. Chaires, Xiaogang Qu*, Hydration of Drug-DNA Complexes: Greater Water Uptake for Adriamycin Compared to Daunomycin, J. Med. Chem., 2008, 51, 5909–5911.
17. Haijia Yu, Jinsong Ren, Xiaogang Qu*, Different Hydration Changes Accompanying Copper and Zinc Binding to Amyloid β-Peptide: Water Contribution to Metal Binding, ChemBioChem, 2008, 9, 879-882.
18. Jie Geng, Haijia Yu, Jinsong Ren, Xiaogang Qu*, Rapid label-free detection of metal-induced Alzheimer's amyloid beta-peptide aggregation by electrochemical method, Electrochem. commun., 2008, 10, 1797-1800.
19. Haijia Yu, Jinsong Ren, Xiaogang Qu*, Time-Dependent DNA Condensation Induced by Amyloid β-Peptide, Biophys. J., 2007, 92, 185-191.
20. Haiyuan Zhang, Haijia Yu, Haixia Xu, Jinsong Ren, Xiaogang Qu*, Structural diversity of lanthanide-amino acid complexes under near physiological pH conditions and their recognition of single-stranded DNA, Polyhedron, 2007, 26, 5250-5256.
21. Huixin Bao, Xiaohui Wang, Haijia Yu, Manliang Fu, Xiaogang Qu*,Yongchen Zheng, Jinsong Ren, Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs, Chem. Phys. Lett., 2007, 436, 252-257.
22. Haiyuan Zhang, Haijia Yu, Jinsong Ren, Xiaogang Qu*, Reversible B/Z-DNA transition under the low salt condition and non-B-form polydApolydT selectivity by a cubane-like europium-L-aspartic acid complex, Biophys. J., 2006, 90, 3203-3207.
23. Haiyuan Zhang, Haijia Yu, Jinsong Ren, Xiaogang Qu*, PolydA and polyrA self-structured by a europium and amino acid complex, FEBS Lett., 2006, 580, 3726-3730.
