《Kisspeptin 54添加在IVM中有效性和安全性研究》是趙紅翠為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：Kisspeptin 54添加在IVM中有效性和安全性研究
- 項目類別 ：青年科學基金項目
- 依託單位 ：北京大學
- 項目負責人：趙紅翠
科研成果,項目摘要,
科研成果
序號鞏己拜去 | 標艱匪臭題 | 類型 | 作者 |
|---|---|---|---|
1 | ECAT1 is essential for human oocyte maturation and preimplantation development of the resulting embryos | 期刊論主酷埋文 | Liu, Changyu(#); Li, Min; Li, Tianjie; Zhao, Hongcui; Huang, Jin; Wang, Yun; Gao, Qian; Yu, Yang(*); Shi, QH(*) |
2 | Metabolite availability as a window to view the early embryo microenvironment in vivo | 期刊論文 | Hu, Kailun(#); Yu, Yang(*) |
3 | Potential roles for the kisspeptin/ kisspeptin receptor system in implantation and placentation | 期刊論文 | Hu, Kailun(#); Chang, Hsun-Ming; Zhao, Hongcui; Yu, Yang(*); Li, Rong(*); Qiao, Jie |
4 | Epigenetic regulation of an adverse metabolic phenotype in polycystic ovary syndrome: the impact of the leukocyte methylation of PPARGC1A promoter | 期刊論舉匙設捆墊重店文 | Zhao, Hongcui(#); Zhao, Yue(#); Ren, Yun(#); Li, Min; Li, Tianjie; Li, Rong; Yu, Yang(*); Qiao, Jie |
5 | Kisspeptin/Kisspeptin Receptor System in the Ovary | 期刊論文 | Hu, Kai-Lun(#); Zhao, Hongcui(*); Chang, Hsun-Ming; Yu, Yang(*); Qiao, Jie |
6 | Increased Expression ofKISS1 andKISS1 Receptor inHuman Granulosa Lutein Cells—Potential Pathogenesis ofPolycystic OvarySyndrome | 期刊論文 | Hu, Kailun(#); Zhao, Hongcui; Min, Zheying; He, Yilei; Li, Tianjie; Zhen, Xiumei; Ren, Yun; Chang, Hsun-Ming; Yu, Yang; Li, Rong(*) |
7 | Single-Cell Transcriptomics of Human Oocytes: Environment-Driven Metabolic Competition and Compensatory Mechanisms During Oocyte Maturation | 期刊炒連懂論文 | Zhao, Hongcui(#); Li, Tianjie(#); Zhao, Yue(#); Tan, Tao(#); Liu, Changyu; Liu, Yali; Chang, Liang; Huang, Ning; Li, Chang; Fan, Yong(*); Yu, Yang(*); Li, Rong(*); Qiao, Jie |
8 | Regulation of LH secretion by RFRP-3 – From the hypothalamus to the pituitary | 期刊論文 | Hu, Kailun(#); Chang, Hsun-Ming; Li, Rong; Yu, Yang(*); Qiao, Jie |
9 | DNA methylation reprogramming of functional elements during mammalian embryonic development | 期刊論遙棵文 | Li, Congru(#); Fan, Yong(#); Li, Guoqiang(#); Xu, Xiaocui(#); Duan, Jialei; Li, Rong; Kang, Xiangjin; Ma, Xin; Chen, Xuepeng; Ke, Yuwen; Yan, Jie; Lian, Ying; Liu, Ping; Zhao, Yue; Zhao, Hongcui; Chen, Yaoyong; Yu, Yang(*); Liu, Jiang(*) |
10 | Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults | 期刊論文 | Huang, Ying(#); Gao, Jiang-Man(#); Zhang, Chun-Mei; Zhao, Hong-Cui; Zhao, Yue(*); Li, Rong(*); Yu, Yang(*); Qiao, Jie |
11 | Role of Sirt3 in mitochondrial biogenesis and developmental competence of human in vitro matured oocytes | 期刊論文 | Zhao, Hong-Cui(#); Ding, Ting(#); Ren, Yun; Li, Tian-Jie; Li, Rong; Fan, Yong; Yan, Jie; Zhao, Yue; Li, Mo; Yu, Yang(*); Qiao, Jie(*) |
項目摘要
卵母細胞體外成熟（in vitro maturation，IVM）技術在輔助生殖領域，特別是PCOS和腫瘤患者，已展現出重要的套用潛力，但是IVM低效率限制了其臨床套用。IVM卵母細胞核質發育不同步是其效率低下的核心因素，因此探討促進卵母細胞胞質成熟的分子機制和解決新策略，將有助於推動其臨床套用。Kisspeptins 是近年發現的一組下丘腦肽，在卵母細胞體內成熟及排卵過程中，通過調節線粒體功能及改善絲裂原活化蛋白激酶（MAPK）活性，在卵母細胞成熟過程中起關鍵作用。本研究利用小鼠IVM模型，通過體外添加Kisspeptin54，從分子，亞細胞，細胞，胚胎及成體水平，探討其對IVM卵母細胞發育潛能的改善及其使用對子代的長期安全性和風險性，並從線粒體功能及MAPK調控角度，對Kisspeptin54促進IVM卵母細胞發育的分子機制進行詮釋。研究成果為IVM效率改善及臨床推廣提供理論基礎。
