龔健科

龔健科,華中科技大學博士生導師,學科專業:生物物理

基本介紹

  • 中文名:龔健科
  • 畢業院校:華南農業大學、華中科技大學
教育經歷,工作經歷,研究方向,科研成果,發表論著,

教育經歷

2004.9—2007.7,華南農業大學 本科(提前畢業)
2009.9—2017.3,華中科技大學 博士
2010.10—2017.3,美國密西根大學,聯合培養博士

工作經歷

2017.3—2018.10,美國密西根大學 博士後
2018.10—今,華中科技大學 教授

研究方向

感知外周環境的變化並對這些變化做出正確的反應是生命有機體賴以生存的基本。在神經系統的感知生物學領域,本實驗室主要關注兩個重要的科學問題:(1)感知外周環境的各種變化所對應的一系列蛋白質受體,例如光受體和溫度受體,即:感受輸入機理;(2)傳導各種感知所需要的信號通路基因與其對應功能,即:功能輸出機理

科研成果

以第一作者身份,在Cell (2016)發表有關新型紫外光受體蛋白的吸收光機理,此工作被同期Science頭條評論並給予高度評價;
以第一作者身份,在Cell (2019)發表關於冷感受的作用機制,這是首次發現並闡明低溫感受的受體蛋白工作原理;以共同第一作者身份,在Science Advances、Genes and Development和 Cell Reports國際著名學術期刊上發表高水平研究論文3篇;
以共同作者身份在Cell、Molecular Cell、Nature Medicine、Nature Communications和Current Biology發表論文7篇。2018年被評為湖北省“楚天學者”。

發表論著

1. Gong, J., Liu, J., Ronan, E., He, F., Cai, W., Fatima, M., Zhang, W., Lee, H., Li, Z., Kim, G., Pipe, K., Duan, B., Liu, J., Xu, X.Z.S. (2019) A Cold-Sensing Receptor Encoded by A Glutamate Receptor Gene. Cell 178, 1-12
2. Gong, J., Yuan, Y., Ward, A., Kang, L., Zhang, B., Wu, Z., Peng, J., Feng, Z., Liu, J., Xu, X.Z.S. (2016) The C. elegans taste receptor homolog LITE-1 is a photoreceptor. Cell 167, 1252-1263 (Previewed by Science)
3. Li, G.*, Gong, J.*, Liu, J., Liu, J., Li, H., Hsu, A., Liu, J., Xu, X.Z.S. (2019) Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in C. elegans. Science Advances 5, eaau5041 (*co-first authors)
4. Zhang, B.*, Gong, J.*, Zhang, W., Liu, J., Xu, X.Z.S.(2018) Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity in C. elegans. GenesDev 32, 258-270 (*co-first authors)
5. Rauthan, M.*, Gong, J.*, Wescott, S., Liu, J., Xu, X.Z.S. (2017) MicroRNA regulation of nicotine-dependent behavior in C. elegans. Cell Reports 21, 1434-1441 (*co-first authors)
6. Jun, H., Yu, H., Gong, J., Jiang, J., Qiao, X., Perkey, E., Kim, D., Emont, M., Zestos,A., Rainey, W., Cho, J., Liu, J., Kennedy, R., Maillard, I., Xu, X.Z.S., Wu, J. (2018) An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling. Nature Medicine 24, 1-9
7. Meng, Z., Gong, J., Chen, Z., Sun, J., Xiao, Y., Wang, L., Li, Y., Liu, J., Xu, X.Z.S, Lin, J. (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis. Molecular Cell 66,332-344 (Cover Story)
8. Li, G., Gong, J., Lei, H., Liu, J., Xu, X.Z.S. (2016) Promotion of behavior and neuronal function by reactive oxygen species in C. elegans. Nature Communications 7:13234
9. Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, H.,Chamoli, M., Le, H., Liu, J., Lithgow, G., Ramanathan, A., Xu, X.Z.S., Kapahi, P.(2016) A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive α-dicarbonyl detoxification. Current Biology 26, 1-12
10. Chun, L., Gong, J., Yuan, F., Zhang, B., Liu, H., Zheng, T., Yu, T., Xu, X.Z.S., Liu, J. (2015) Metabotropic GABA signalling modulates longevity in C. elegans. Nature Communications 6:8828
11. Xiao, R., Zhang, B.*, Dong, Y.*, Gong, J.*, Xu, T., Liu, J., and Xu, X.Z.S. (2013) A genetic program promotes C. elegans longevity via a thermosensitive TRP channel. Cell 152, 806-817

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