黎星術，男，1954年生，中山大學藥學院教授，博士生導師，2005年起被聘為香港理工大學榮譽研究員。
基本介紹
- 中文名：黎星術
- 出生日期：1954年
- 畢業院校：四川大學
- 學位/學歷：博士
- 職務：博士生導師
- 職稱：教授
人物經歷,研究方向,研究課題,教授課程,代表性論文,獲獎記錄,
人物經歷
四川師範大學化學系畢業；四川大學工學碩士，理學博士。1997 年起在香港理工大學，台灣中興大學，日本崗山理科大學任博士後研究員，研究員(Research Fellow)多年，2005年到中山大學工作。
研究方向
1．手性配體的設計合成及在不對稱合成，藥物合成中的套用研究.
2．多鍵捆紙靶點抗老年痴精姜愉呆藥物的設計、合成和生物活性研究漏棄捆
3. 多靶點抗哮喘、慢性阻說戶凳塞性肺病藥物的設計、合成和生物活性研究
研究課題
1. 國家自然科學基金課題（2項，22萬，35萬）；
2. 國家863課題（分課轎危題，8萬）；
3. 中山大學引進人才科研啟動基金（50萬）；
4. 廣東省自然科學基金 （6萬）茅乘糊廈；
5. 廣州市科技攻關項目（30萬）；
6. 廣東一力藥物集團公司合作項目（100萬）；
7. 廣東理文化工研發有限公司合作研究項目（175萬）。
教授課程
1．有機化學
2．高等有機化學與藥物合成
3．有機化學藥物化學進展（講座）
代表性論文
近3年發表的部分文章:
1. Wu, Yinuo; Mao, Fei; Meng, Fanchao;Li, Xing-Shu*. Enantioselective Vanadium-Catalyzed Oxidation of 1,3-Dithianes from Aldehydes and Ketones using β-Amino Alcohol Derived Schiff Base Ligands.Advanced Synthesis & Catalysis (2011),353(10),1707-1712.
2. Wu, Yinuo; Li, Baozhu; Mao, Fei;Li, Xing-Shu*; Kwong, Fuk Yee. Palladium-Catalyzed Oxidative C-H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilides. Organic Letters (2011), 13(12), 3258-3261.
3. Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Jiang, Huai-Lei; Luo, Zong-Hua; Lai, Ke-fang;Li, Xing-Shu*. Dualβ 2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD. Bioorganic &習鍵項您 Medicinal Chemistry Letters (2012), 22(4), 523-1526.
4. Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Meng, Fan-Chao;Li, Xing-Shu*. Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-βaggregation. European Journal of Medicinal Chemistry (2011), 46(12), 5885-5893.
5. Jiang, Huailei; Wang, Xu; Huang, Ling; Luo, Zonghua; Su, Tao; Ding, Ke;Li, Xingshu*.Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer's disease. Bioorganic & Medicinal Chemistry (2011), 19(23), 7228-7235.
6. Shi, Anding; Huang, Ling; Lu, Chuanjun; He, Feng;Li, Xing-Shu*. Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. Bioorganic & Medicinal Chemistry (2011), 19(7), 2298-2305.
7. Huang, Ling; Luo, Zonghua; He, Feng; Shi, Anding; Qin, Fangfei;Li, Xing-Shu*.Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters (2010), 20(22), 6649-6652.
8. Huang, Ling; Luo, Zonghua; He, Feng; Lu, Jing;Li, Xing-Shu*. Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorganic & Medicinal Chemistry (2010), 18(12), 4475-4484.
9. Huang, Xiaoguang; Zhang, Aiqin; Chen, Dongliang; Jia, Zhenhua;Li, Xing-Shu*.4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: Novel C7 moieties of fluoroquinolones as antibacterial agents. 10. Huang, Ling; Shi, Anding; He, Feng;Li,Xing-Shu*. Synthesis,biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorganic & Medicinal Chemistry (2010), 18(3), 1244-1251.
11. Huang, Xiaoguang; Chen, Dongliang; Wu, Ning; Zhang, Aiqin; Jia, Zhenhua;Li, Xingshu*.The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents. Bioorganic & Medicinal Chemistry Letters (2009), 19(15), 4130-4133.
12. Wu, Yinuo; Liu, Juntao;Li, Xing-Shu*; Chan, Albert S. C. Vanadium-Catalyzed Asymmetric Oxidation of Sulfides Using Schiff Base Ligands Derived from β-Amino Alcohols with Two Stereogenic Centers. European Journal of Organic Chemistry (2009),（16), 2607-2610.
13. Lu, Chuanjun; Luo, Zonghua; Huang, Ling;Li, Xing-Shu*. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol. Tetrahedron: Asymmetry (2011), 22(7), 722-727.
14. Shan, Wenjun; Meng, Fanchao; Wu, Yinuo; Mao, Fei;Li, Xing-Shu*. The synthesis of a new nitrogen joined N-PEG-TsDPEN ligand and its application in asymmetric transfer hydrogenation of ketones in neat water. Journal of Organometallic Chemistry (2011), 696(8), 1687-1690.
15. Wei, Hui; Yin, Lu; Luo, Haibin;Li, Xing-Shu*; Chan, Albert S. C. Structural influence of chiral tertiary aminonaphthol ligands on the asymmetric phenyl transfer to aromatic aldehydes. Chirality (2011), 23(3), 222-227.
16. Yin, Lu; Zheng, Yourou; Jia, Xian;Li, Xingshu*; Chan, Albert S. C. Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts. Tetrahedron: Asymmetry (2010), 21(19), 2390-2393.
17. Huang, Ling; Liu, Juntao; Shan, Wenjun; Liu, Bao; Shi, Anding;Li, Xingshu*. The asymmetric synthesis of (R,R)-formoterol via transfer hydrogenation with polyethylene glycol bound Rh catalyst in PEG2000 and water. Chirality (2010), 22(2), 206-211.
18. Yin, Lu; Jia, Xian;Li, Xingshu*; Chan, Albert S. C. A rapid and green approach to chiral α-hydroxy esters: asymmetric transfer hydrogenation (ATH) of α-keto esters in water by use of surfactants. Tetrahedron: Asymmetry (2009), 20(17), 2033-2037.
19. Chen, Xueming; Wei, Hui; Chen, Yunyun;Li, Xingshu*. A Convenient synthesis of imidazolidin-4-ones via Domino reactions. Helvetica Chimica Acta (2009), 92(8), 1550-1557.
20. Yin, Lu; Shan, Wenjun; Jia, Xian;Li, Xingshu*; Chan, Albert S. C. Ru-catalyzed enantioselective preparation of methyl (R)-o-chloromandelate and its application in the synthesis of (S)-Clopidogrel. Journal of Organometallic Chemistry (2009), 694(13), 2092-2095.
21. Wu, Yinuo; Lu, Chuanjun; Shan, Wenjun;Li, Xingshu*. A practical process to chiral ferrocenyl alcohols via asymmetric transfer hydrogenation catalyzed with a PEG-bound Ru catalyst in water and its application in preparing Ugi's amine. Tetrahedron: Asymmetry (2009), 20(5), 584-587.
22. Liu, Bao; Zhong, Yao;Li, Xingshu*. Enantioselective addition of phenylacetylene to N-aryl arylimines catalyzed by Cu(II)-pyridine containing N-tosylated aminoimine ligand complex. Chirality (2009), 21(6), 595-599.
23. Chen, Xueming; Hou, Lei;Li, Xingshu*. An easy one-pot synthesis of tetrasubstituted 3-alkynylpyrroles via multicomponent coupling reaction. Synlett (2009), (5), 828-832.
獲獎記錄
1. 2005年國家自然科學二等獎；
2. 2004－2007年國際重要刊物Tetrahedron: Asymmetry最高引用率獎。
5. Jiang, Huailei; Wang, Xu; Huang, Ling; Luo, Zonghua; Su, Tao; Ding, Ke;Li, Xingshu*.Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer's disease. Bioorganic & Medicinal Chemistry (2011), 19(23), 7228-7235.
6. Shi, Anding; Huang, Ling; Lu, Chuanjun; He, Feng;Li, Xing-Shu*. Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. Bioorganic & Medicinal Chemistry (2011), 19(7), 2298-2305.
7. Huang, Ling; Luo, Zonghua; He, Feng; Shi, Anding; Qin, Fangfei;Li, Xing-Shu*.Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters (2010), 20(22), 6649-6652.
8. Huang, Ling; Luo, Zonghua; He, Feng; Lu, Jing;Li, Xing-Shu*. Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorganic & Medicinal Chemistry (2010), 18(12), 4475-4484.
9. Huang, Xiaoguang; Zhang, Aiqin; Chen, Dongliang; Jia, Zhenhua;Li, Xing-Shu*.4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: Novel C7 moieties of fluoroquinolones as antibacterial agents. 10. Huang, Ling; Shi, Anding; He, Feng;Li,Xing-Shu*. Synthesis,biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorganic & Medicinal Chemistry (2010), 18(3), 1244-1251.
11. Huang, Xiaoguang; Chen, Dongliang; Wu, Ning; Zhang, Aiqin; Jia, Zhenhua;Li, Xingshu*.The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents. Bioorganic & Medicinal Chemistry Letters (2009), 19(15), 4130-4133.
12. Wu, Yinuo; Liu, Juntao;Li, Xing-Shu*; Chan, Albert S. C. Vanadium-Catalyzed Asymmetric Oxidation of Sulfides Using Schiff Base Ligands Derived from β-Amino Alcohols with Two Stereogenic Centers. European Journal of Organic Chemistry (2009),（16), 2607-2610.
13. Lu, Chuanjun; Luo, Zonghua; Huang, Ling;Li, Xing-Shu*. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol. Tetrahedron: Asymmetry (2011), 22(7), 722-727.
14. Shan, Wenjun; Meng, Fanchao; Wu, Yinuo; Mao, Fei;Li, Xing-Shu*. The synthesis of a new nitrogen joined N-PEG-TsDPEN ligand and its application in asymmetric transfer hydrogenation of ketones in neat water. Journal of Organometallic Chemistry (2011), 696(8), 1687-1690.
15. Wei, Hui; Yin, Lu; Luo, Haibin;Li, Xing-Shu*; Chan, Albert S. C. Structural influence of chiral tertiary aminonaphthol ligands on the asymmetric phenyl transfer to aromatic aldehydes. Chirality (2011), 23(3), 222-227.
16. Yin, Lu; Zheng, Yourou; Jia, Xian;Li, Xingshu*; Chan, Albert S. C. Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts. Tetrahedron: Asymmetry (2010), 21(19), 2390-2393.
17. Huang, Ling; Liu, Juntao; Shan, Wenjun; Liu, Bao; Shi, Anding;Li, Xingshu*. The asymmetric synthesis of (R,R)-formoterol via transfer hydrogenation with polyethylene glycol bound Rh catalyst in PEG2000 and water. Chirality (2010), 22(2), 206-211.
18. Yin, Lu; Jia, Xian;Li, Xingshu*; Chan, Albert S. C. A rapid and green approach to chiral α-hydroxy esters: asymmetric transfer hydrogenation (ATH) of α-keto esters in water by use of surfactants. Tetrahedron: Asymmetry (2009), 20(17), 2033-2037.
19. Chen, Xueming; Wei, Hui; Chen, Yunyun;Li, Xingshu*. A Convenient synthesis of imidazolidin-4-ones via Domino reactions. Helvetica Chimica Acta (2009), 92(8), 1550-1557.
20. Yin, Lu; Shan, Wenjun; Jia, Xian;Li, Xingshu*; Chan, Albert S. C. Ru-catalyzed enantioselective preparation of methyl (R)-o-chloromandelate and its application in the synthesis of (S)-Clopidogrel. Journal of Organometallic Chemistry (2009), 694(13), 2092-2095.
21. Wu, Yinuo; Lu, Chuanjun; Shan, Wenjun;Li, Xingshu*. A practical process to chiral ferrocenyl alcohols via asymmetric transfer hydrogenation catalyzed with a PEG-bound Ru catalyst in water and its application in preparing Ugi's amine. Tetrahedron: Asymmetry (2009), 20(5), 584-587.
22. Liu, Bao; Zhong, Yao;Li, Xingshu*. Enantioselective addition of phenylacetylene to N-aryl arylimines catalyzed by Cu(II)-pyridine containing N-tosylated aminoimine ligand complex. Chirality (2009), 21(6), 595-599.
23. Chen, Xueming; Hou, Lei;Li, Xingshu*. An easy one-pot synthesis of tetrasubstituted 3-alkynylpyrroles via multicomponent coupling reaction. Synlett (2009), (5), 828-832.
獲獎記錄
1. 2005年國家自然科學二等獎；
2. 2004－2007年國際重要刊物Tetrahedron: Asymmetry最高引用率獎。
