黃青陽，湖北孝感人,華中師範大學生命科學學院教授。
1983年畢業於孝感學院農學系，1988年獲四川農業大學植物遺傳育種專業碩士學位，師從榮廷昭院士和高之仁教授，從事雜種優勢的機理研究, 其碩士論文“玉米自交系間遺傳距離與產量雜種優勢、雜種產量的關係”發表在《遺傳學報》上。1999年獲武漢大學遺傳學博士學位，師從朱英國教授。同年前往以色列Haifa University 進化研究所做博士後，師從美國科學院院士Eviatar Nevo教授和A.B.Korol教授，2001年前往美國克瑞屯大學醫學中心,開展人類分子與統計遺傳的研究工作。1988年7月任華中師範大學生命科學學院助研、教授。
黃青陽研究領域人類遺傳學與基因組學;生物統計與計算生物學;作物遺傳育種。
基本介紹
人物經歷,主要成就,科研成就,研究項目,代表論文,社會任職,人物評價,
人物經歷
1983年畢業於孝感學院農學系。
1985年8月- 1988年7月，四川農業大學作物遺傳育種碩士。
1996年8月- 1999年6月，武漢大學遺傳學博士。
1999年8月- 2001年1月，以色列Haifa大學進化研究所博士後。
2001年1月- 2003年6月，美國Creighton大學醫學中心Research Associate。
2005年9月- 2009年7月，香港大學醫學院助理教授。
1988年7月-，華中師範大學生命科學學院助研、教授。
主要成就
科研成就
- 人類複雜疾病(骨質疏鬆症、2型糖尿病、肥胖等)的遺傳學與基因組學
- 生物統計與計算生物學
- 作物遺傳育種
研究項目
⒉ 中國人群2型糖尿病樣本的收集與相關基因的研究，教育部留學回國人員科研啟動基金
⒊ 中國人群複雜疾病的遺傳學研究，華中師範大學引進傑出人才基金
代表論文
1. Wang Y, Lu L, Niu Y, Zhang Q, Cheng Cn,Huang H, Huang X, Huang Q. The osteoporosis risk variant rs9820407 at 3p22.1 acts as an allele-specific enhancer to regulate CTNNB1 expression by long-range chromatin loop formation. Bone, 2021, 153: 116165
2. Ye W*, Wang Y*, Hou S, Mei B, Liu X, Huang H, Zhou Q, Niu Y, Chen Y, Zhang M, Huang Q. USF3 modulates osteoporosis risk by targeting WNT16, RANKL, RUNX2, and two GWAS lead SNPs rs2908007 and rs4531631. Hum Mut, 2021, 42(1): 37-49
3. Wang Y*, Ye W*, Liu Y, Mei B, Liu X, Huang Q. Osteoporosis genome-wide association study variant c. 3781 C A is regulated by a novel anti-osteogenic factor miR-345-5p. Hum Mut, 2020, 41(3): 709-718
4. Cheng M, Huang X, Zhang M, Huang Q. Computational and functional analyses of T2D GWAS SNPs for transcription factor binding. Bioche Biophy Res Comm, 2020, 523(3): 658-665
5. Mei B, Wang Y, Ye W, Huang H, Zhou Q, Chen Y, Niu Y, Zhang M, Huang Q. LncRNA ZBTB40-IT1 modulated by osteoporosis GWAS risk SNPs suppresses osteogenesis. Hum Genet, 2019, 138(2): 151-166
6. Ye W, Wang Y, Mei B, Hou S, Liu X, Wu G, Qin L, Zhao K, Huang Q. Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis. Bone, 2018, 108: 132-144
7. Cheng M, Mei B, Zhou Q, Zhang M, Huang H, Han L, Huang Q.Computational analyses of obesity-associated loci generated by genome-wide association studies. PLoS One. 2018, 13(7): e0199987
8. Cheng M, Liu X, Yang M, Han L, Xu A, Huang Q. Computational analyses of type 2 diabetes-associated loci identified by genome-wide association studies. J Diabetes. 2017, 9(4):362-377
9. Yang J，Gu H，Jiang X，Huang Q，Hu X，Shen X. Identifying the risky SNP of osteoporosis with ID3-PEP decision tree algorithm. Complexity，2017，ID 9194801
10. Han Z, Huang H, Gao Y, Huang Q. Functional annotation of Alzheimer's disease associated loci revealed by GWASs. PloS One, 2017, 12(6):e0179677
11. Qin L, Liu Y, Wang Y, Wu G, Chen J, Ye W, Yang J, Huang Q. Computational characterization of osteoporosis associated SNPs and genes identified by genome-wide association studies. PloS One, 2016, 11(3): e0150070
12. Huang QY. Genetic study of complex diseases in the post-GWAS era. J Genet Genomics,2015, 42:87-98.
13. Chen J, Yang M, Zhao KH, Xu AM, Hang QY. Polymorphisms in FTO, TMEM18 and PCSK1 are associated with BMI in southern Chinese population. J Genet, 2014, 93(2): 509-512
14. Gao M, Ding D, Huang J, Qu Y, Wang Y, Huang Q*.Association of genetic variants in the adiponectin gene with metabolic syndrome：a case-control study and a systematic meta-analysis in the Chinese population. PLoS One,2013，8(4): e58412
15. Qin L, Lv Y, Huang Q. Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes，Genet Mol Res，2013，12(3):2990-3002
16. Qin L, Wen J, Qu Y, Huang Q. Lack of association of functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in the Chinese population based on a case-control study and a meta-analysis，Genet Mol Res, 2013, 12(3):3324-3334
17. Dehwah MAS, Xu A, Huang Q*. MicroRNAs and type 2 diabetes/obesity. J Genet Genomics，2012, 39(1):11-18
18. Li GH, Deng HW, Kung AW, Huang QY. Identification of genes for bone mineral density variation by computational disease gene identification strategy. J Bone Miner Metab. 2011, 29:709-716
19. Li GH, Cheung CL, Xiao SM, Lau KS, Gao Y, Bow CH, Huang QY, Sham PC, Kung AW. Identification of QTL genes for BMD variation using both linkage and gene-based association approaches. Hum Genet. 2011，130(4):539-46
20. Li GH, Kung AW, Huang QY. Bone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese population. J Bone Miner Metab, 2011,29(1):80-87
21. Dehwah MAS, Zhang S, Qu K, Huang H, Xu A, Huang Q.KCNQ1 and type 2 diabetes: study in Hubei Han Chinese and meta-analysis in East Asian populations. Genes & Genomics, 2010, 32：327-334
22. Dehwah MAS, Wang M, Huang Q. CDKAL1 and type 2 diabetes: a global meta-analysis. Genet Mol Res, 2010，9：1109-1120
23. Li GH, Kung AW, Huang QY. Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. Osteoporos Int, 2010, 21(6):1009-20
24. Huang QY, Li GH, Kung AW. The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis. Bone, 2009,45(2):289-94
25. Huang QY, Li GH, Kung AW. Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese. Bone, 2009, 44(5):984-8
26. Cheung CL, Chan BY, Chan V, Ikegawa S, Kou I, Ngai H, Smith D, Luk KD, Huang QY, Mori S, Sham PC, Kung AW. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. Hum Mol Genet, 2009,18(4):679-87
27. Huang QY, Li GH, Cheung WM, Song YQ, Kung AW. Prediction of osteoporosis candidate genes by computational disease-gene identification strategy. J Hum Genet, 2008, 53(7):644-55
28. Xiao SM, Huang QY, Kung AW. Genetics of osteoporosis in China. Int J Rheumatic Dis, 2008,11(4):359-365
29. Cheung CL, Huang QY, Chan V, Kung AW. Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women. Hum Hered, 2008, 65(4):232-239
30. Huang QY, KungAW. The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population. J Hum Genet, 2007, 52(9):757-62
31. Kung AW, Huang QY. Genetic and environmental determinants of osteoporosis. J Musculoskelet Neuronal Interact, 2007, 7(1):26-32
32. Huang QY, Shen H, Deng HY, Conway T, Elze L, Davies KM, Recker RR, Deng HW. CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasians populations. J Bone Mineral Metab, 2006, 24（2）：132-7
33. Huang QY, Kung AWC. Genetics of osteoporosis. Mol Genet Metab, 2006, 88: 295-3068.
34. Huang QY, Ng MYM, Cheung CL, Chan V, Sham PC, Kung AWC. Identification of two sex-specific quantitative trait loci in chromosome 11q for hip bone mineral density in Chinese. Hum Hered, 2006,61(4):237-43
35. Huang QY, Cheung CL, Ng MY, Chan V, Sham PC, Kung AW. Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese. Hum Genet, 2006,120(3):354-9
36. Huang QY，Chen MR, Ji SL. Linkage and association studies of the susceptibility genes for type 2 diabetes. J Genet Genomics，2006, 33(7):573-589
37. Huang QY，Shen H, Deng HY, Conway T, Elze L, Davies KM, Recker RR, Deng HW. Linkage and association between CA repeat polymorphism of the TNFR2 gene and obesity phenotypes in two independent Caucasians populations. J Genet Genomics，2006, 33(9):775-81
38. Zhang F, Chen G, Huang Q, Orion O, Krugman T, Fahima T, Korol AB, Nevo E, Gutterman Y. Genetic basis of barley caryopsis dormancy and seedling desiccation tolerance at the germination stage. Theor Appl Genet，2005，110：445-453
39. Huang QY, Xu FH, Shen H, Deng H, Conway T, Liu YJ, Liu YZ, Li JL, Davies KM, Recker RR，Deng HW. Genome wide screen for genes underlying bone sizes in ten refined skeletal sites: genetic heterogeneity and the significance of the refinement of traits. Physiol Genomics, 2004, 17（3）：326-331
40. Huang QY, Xu FH, Shen H, Liu YJ, Liu YZ，Zhao LZ，Deng H, Conway T, Li JL, Davies KM, Recker RR，Deng HW. The second stage genome scan for QTLs underlying BMD variation. Calcif Tissue Int, 2004, 75:138-143
41. Xu FH, Liu YJ, Deng H, Huang QY, Zhao LJ, Shen H, Liu YZ, Dvornyk V, Conway T, Li JL, Davies KM, Recker RR, Deng HW. A follow-up linkage study for bone size variation in an extended sample. Bone, 2004, 35(3):777-84
42. Liu YJ, Xu FH, Shen H, Liu YZ, Deng HY, Zhao LJ, Huang QY, Dvornyk V, Conway T, Davies KM, Li JL, Recker RR, Deng HW. A follow-up linkage study for quantitative trait loci contributing to obesity-related phenotypes. J Clin Endocrinol Metab, 2004, 89(2):875-882
43. Huang QY，Recker RR，Deng HW. Searching for the osteoporosis gene(s) in the post-genome era: progress and challenge. Osteoporos Int, 2003, 14(9):701-715
44. Huang QY，Shen H, Deng H, Conway T, Davies KM, Li JL, Recker RR，Deng HW. Linkage and association of the CA repeat polymorphism of the IL-6 gene, obesity-related phenotypes, and bone mineral density in two independent Caucasians populations. J Hum Genet, 2003, 48(8):430-437
45. Deng HW, Shen H, Xu FH, Deng H, Conway T, Liu YJ, Liu YZ, Li JL, Huang QY, Davies KM, Recker RR. Several genomic regions potentially containing QTLs for bone size variation were identified in a whole-genome linkage scan. Am J Med Genet, 2003, 119(2): 121-31
46. Liu YZ, Xu FH, Shen H, Deng H, Liu YJ, Zhao LJ, Dvornyk V, Conway T, Li JL, Huang QY, Davies KM, Recker RR, Deng HW. Confirmation linkage study in support of the X chromosome harbouring a QTL underlying human height variation. J Med Genet, 2003, 40(11):825-31
47. Deng HW, Xu FH, Huang QY, Shen H, Deng H, Conway T, Liu YJ, Liu YZ, Li JL, Zhang HT, Davies KM, Recker RR. A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait Loci for osteoporosis. J Clin Endocrinol Metab, 2002, 87(11): 5151-9
48. Deng HW, Xu FH, Liu YZ, Shen H, Deng H, Huang QY, Liu YJ, Conway T, Li JL, Davies KM, Recker RR. A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of stature. Am J Med Genet, 2002, 113(1): 29-39
49. Deng HW, Deng H, Liu YJ, Liu YZ, Xu FH, Shen H, Conway T, Li JL, Huang QY, Davies KM, Recker RR. A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am J Hum Genet, 2002, 70(5): 1138-51
50. Huang QY, Xu FH, Shen H, Deng HY, Liu YJ, Liu YZ, Li JL, Recker RR, Deng HW. Mutation patterns at dinucleotide microsatellite loci in humans. Am J Hum Genet, 2002, 70(3): 625-34
51. Huang QY, Beharav A, Li YC, Kirzhner V, Nevo E. Mosaic microecological differential stress causes adaptive microsatellite divergence in wild barley, Hordeum spontaneum, at Neve Yaar, Israel. Genome, 2002, 45(6): 1216-1229
52. Peng JH, Fahima T, Roder, Huang QY, Dahan A, Li YC, Grama A, Nevo E. High-density molecular map of chromosome region harboring stripe-rust resistance genes YrH52 and Yr15 derived from wild emmer wheat, Triticum dicoccoides. Genetica, 2000, 109(3): 199-210
53. Huang QY, He YQ, Jing RC, Zhu YG. Mapping of the nuclear fertility restorer gene for HL CMS in rice using microsatellite markers. Chinese Sci Bull, 2000，45：430-432
54. 黃青陽，高之仁，榮廷昭，1991，玉米自交系間遺傳距離與產量雜種優勢，雜種產量的關係。遺傳學報，18（3）：271-276
社會任職
- PLoS ONE的Academic Editor
- 湖北省遺傳學會理事
- 湖北省生物信息學會理事
人物評價
歷史的長河，大浪淘沙，驚濤拍岸，飛掠過多少歲月；時代的畫卷，色彩繽紛，波瀾壯闊，記載下無數英傑，他就是其中的一位。用勤奮收穫知識,用知識敲開科學的大門；種下希望，收穫快樂，成就不平凡的人生。（湖北工程學院生命科學技術學院評）
