博士，浙江大學博士研究生導師，長期從事腦疾病的神經影像學研究，曾赴美國國立衛生研究院、哈佛大學、荷蘭烏特勒支大學等知名機構進行短期交流學習。曾主持國家自然科學基金項目3項，浙江省自然科學基金重點項目2項，以骨幹成員身份參與了“十三五”國家重點研發計畫項目2項，以及十餘項其他國家省部級課題。參與獲得浙江省醫藥衛生科技獎一等獎1項，浙江省科技進步二等獎2項、三等獎1項。
擔任中華醫學會放射學分會第十六屆委員會青年學組委員、浙江省醫學會放射學分會委員、浙江省神經科學學會理事、浙江省生物醫學工程學會放射青年委員會副主任委員、浙江省醫學會放射醫師分會人工智慧專業委員會副主任委員、浙江省神經科學學會神經影像分會委員等學術職務。擔任JNNP, Ebiomedicine, Neuroimage, Human Brain Mapping, Stroke and Vascular Neurology, Neurobiology of Disease, Ageing Research Reviews，磁共振成像等學術期刊的審稿專家。
基本介紹
- 中文名：黃沛鈺
- 國籍：中國
- 民族：漢族
- 出生地：陝西鹹陽
研究課題,發表論文,獲獎記錄,
研究課題
- 國家自然科學基金面上項目，題目：血管運動障礙參與阿爾茨海默病早期演進機制的磁共振成像研究（編號：82371907），2024.01-2027.12，項目經費48萬元，項目負責人。
- 浙江省自然科學基金重點項目，題目：腦類淋巴系統功能障礙參與帕金森病演進機制的磁共振成像（編號：Z24H180011），2024.01-2026.12，項目經費30萬元，項目負責人。
- 國家自然科學基金面上項目，題目：不同階段PD患者抑鬱發生的情感環路基礎及其主導損害機制的磁共振影像學研究（編號：81771820），2018.01-2021.12，項目經費50萬元，項目負責人。
- 國家自然科學基金青年項目，題目：帕金森患者抑鬱高發的情感環路機制研究（編號：81301190），2014.01-2016.12，項目經費23萬元，項目負責人。
- 浙江省自然科學基金-數理醫學學會聯合基金重點項目，題目：基於磁共振影像放射組學的帕金森病大腦退變規律及早期智慧型診斷研究（編號：LSZ19H180001）。2019.01-2022.12，項目經費35萬元，項目負責人。
- 國家重點研發計畫，題目：帕金森病早期生物標誌物與綜合診斷體系的建立（編號：2016YFC1306600）。2016.09-2018.12，項目經費603萬元，項目骨幹成員。
- 國家重點研發計畫，題目：基於影像組學的腦出血微創治療規範化體系建立及套用評價（編號：2018YFC1312600）。2018.09-2020.12，項目經費1037萬元，項目骨幹成員。
發表論文
1. Luo, X., Hong, H., Li, K., Zeng, Q., Wang, S., Li, Z., ... Huang, P. (co-corresponding author), Zhang M., & Alzheimer's Disease Neuroimaging Initiative (ADNI). (2023). Distinct cerebral small vessel disease impairment in early‐and late‐onset Alzheimer's disease. Annals of Clinical and Translational Neurology.
2. Yu, X., Yin, X., Hong, H., Wang, S., Jiaerken, Y., Xu, D., ... & Huang, P. (2023). Presumed periventricular venous infarction on magnetic resonance imaging and its association with increased white matter edema in CADASIL. European Radiology, 1-10.
3. Huang, P., Chen, K., Liu, C., Zhen, Z., & Zhang, R. (2023). Visualizing Cerebral Small Vessel Degeneration During Aging and Diseases Using Magnetic Resonance Imaging. Journal of Magnetic Resonance Imaging.
4. Xu, S., Xie, L., Zhang, Y., Wu, X., Hong, H., Zhang, R., ... & Huang, P. (2023). Inferior Frontal Sulcal Hyperintensity on FLAIR Is Associated with Small Vessel Disease but not Alzheimer’s Disease Pathology. Journal of Alzheimer's Disease, (Preprint), 1-9.
5. Zhou, G., Ren, J., Rong, D., Zhou, H., Ning, H., Wang, H., ... Huang, P. (co-corresponding author) & Liu, W. (2023). Monitoring Substantia Nigra Degeneration Using Free Water Imaging across Prodromal and Clinical Parkinson's Disease. Movement Disorders, 38(5), 774-782.
6. Zhang Y, Zhang R, Wang S, Hong H, Jiaerken Y, Li K, Zeng Q, Luo X, Yu X, Zhang M, Huang P. (2022) Reduced coupling between the global blood-oxygen-level-dependent signal and cerebrospinal fluid inflow is associated with the severity of small vessel disease. NeuroImage: Clinical. Jan 1;36:103229.
7. Li K, Zeng Q, Luo X, Qi S, Xu X, Fu Z, Hong L, Liu X, Li Z, Fu Y, Chen Y, Liu Z, Calhoun V, Huang P (co-corresponding author), Zhang M. (2022) Neuropsychiatric symptoms associated multimodal brain networks in Alzheimer's disease. Human Brain Mapping
8. Huang P, Tian S, Zhang R, Biessels GJ. (2022) Reduced white matter microstructural integrity in prediabetes: Is early glucose dysmetabolism the culprit?. eBioMedicine. 1;83.
9. Mao H, Zhang Y, Zou M, Lv S, Zou J, Zhang M, Zhao Z, Huang P. (2022) The interplay between small vessel disease and Parkinson disease pathology: a longitudinal study. European Journal of Radiology. 2022 Jul 21:110441.
10. Huang P, Zhang M. (2022) Magnetic Resonance Imaging Studies of Neurodegenerative Disease: From Methods to Translational Research. Neuroscience Bulletin. 2022 Jun 30:1-4.
11. Hong H, Wang S, Yu X, Jiaerken Y, Guan X, Zeng Q, Yin X, Zhang R, Zhang Y, Zhu Z, Huang, P. (co-corresponding author) & Zhang, M. White matter tract injury by MRI in CADASIL patients is associated with Iron accumulation. Journal of Magnetic Resonance Imaging. 2022 Jun 23.
12. Zeng, Q., Li, K., Luo, X., Wang, S., Xu, X., Jiaerken, Y., ... Huang, P. (co-corresponding author) & Zhang, M. behalf of Alzheimer's Disease Neuroimaging Initiative. (2022). The association of enlarged perivascular space with microglia-related inflammation and Alzheimer's pathology in cognitively normal elderly. Neurobiology of Disease, 105755.
13. Zhang, R., Huang, P. (co-first author), Wang, S., Jiaerken, Y., Hong, H., Zhang, Y., ... & Zhang, M. Decreased cerebral blood flow and delayed arterial transit are independently associated with white matter hyperintensity. Frontiers in Aging Neuroscience, 527.
14. Zhu, Z., Zeng, Q., Zhang, R., Luo, X., Li, K., Xu, X., ... Huang, P. (corresponding author). Alzheimer’s Disease Neuroimaging Initiative. (2022). White Matter Free Water Outperforms Cerebral Small Vessel Disease Total Score in Predicting Cognitive Decline in Persons with Mild Cognitive Impairment. Journal of Alzheimer's Disease, (Preprint), 1-11.
15. Hong, L., Zeng, Q., Li, K., Luo, X., Xu, X., Liu, X., ... Huang, P. (co-corresponding author) & Zhang, M. (2021). Intrinsic Brain Activity of Inferior Temporal Region Increased in Prodromal Alzheimer's Disease With Hearing Loss. Frontiers in aging neuroscience, 13.
16. Luo, X., Hong, H., Wang, S., Li, K., Zeng, Q., Hong, L., ... Huang, P. (co-corresponding author) & Zhang, M. (2021). Exploration of the Mechanism Underlying the Association of Incident Microinfarct and Motor Deficit: A Preliminary Functional MRI Study. Journal of Alzheimer's Disease, (Preprint), 1-10.
17. Zhang, Y., Zhang, R., Ye, Y., Wang, S., Jiaerken, Y., Hong, H., ... & Huang, P. (corresponding author) (2021). The Influence of Demographics and Vascular Risk Factors on Glymphatic Function Measured by Diffusion Along Perivascular Space. Frontiers in Aging Neuroscience, 393.
18. Zhu, Z., Zeng, Q., Kong, L., Luo, X., Li, K., Xu, X., ... Huang, P. (co-corresponding author) & Yang, Y. Altered spontaneous brain activity in subjects with different cognitive states of biologically defined Alzheimer's disease: a surface-based functional brain imaging study. Frontiers in Aging Neuroscience, 548.
19. Luo, X., Wang, S., Jiaerken, Y., Li, K., Zeng, Q., Zhang, R., ... Huang, P. (co-corresponding author), Zhang M. & Alzheimer’s Disease Neuroimaging Initiative (ADNI). (2021). Distinct fiber-specific white matter reductions pattern in early-and late-onset Alzheimer’s disease. Aging (Albany NY), 13(9), 12410.
20. Yu, X., Yin, X., Hong, H., Wang, S., Jiaerken, Y., Zhang, F., ... & Huang, P. (corresponding author) (2021). Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging. Fluids and Barriers of the CNS, 18(1), 1-13.
21. Xu X., Wu X., Zhu C., Zhang R., Jiaerken Y., Wang S., Hong H., Yu W., Li K., Zeng Q., Luo X., Yu X., Sun J., Zhang M., Huang P. (corresponding author) (2021).Characterization of lenticulostriate arteries and its associations with vascular risk factors in community dwelling elderly. Frontiers in Aging Neuroscience, 10.3389/fnagi.2021.685571
22. Wang, S., Huang, P. (co-corresponding author), Zhang, R., Hong, H., Jiaerken, Y., Lian, C., Yu, X., Luo, X., Li, K., and Zeng, Q. (2021). Quantity and Morphology of Perivascular Spaces: Associations With Vascular Risk Factors and Cerebral Small Vessel Disease. Journal of Magnetic Resonance Imaging.
23. Hong, H., Yu, X., Zhang, R., Jiaerken, Y., Wang, S., Luo, X., Lou, M., Huang, P.(co-corresponding author), and Zhang, M. (2021). Cortical degeneration detected by neurite orientation dispersion and density imaging in chronic lacunar infarcts. Quantitative Imaging in Medicine and Surgery 11, 2114.
24. Huang, P., Zhang, R., Jiaerken, Y., Wang, S., Hong, H., Yu, W., Lian, C., Li, K., Zeng, Q., and Luo, X. (2021). White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration. Translational Stroke Research, 1-9.
25. Huang, P., Zhang, R., Jiaerken, Y., Wang, S., Yu, W., Hong, H., Lian, C., Li, K., Zeng, Q., and Luo, X. (2021). Deep white matter hyperintensity is associated with the dilation of perivascular space. Journal of Cerebral Blood Flow & Metabolism, 0271678X211002279.
26. Huang, P., Zhu, Z., Zhang, R., Wu, X., Jiaerken, Y., Wang, S., Yu, W., Hong, H., Lian, C., and Li, K. (2021). Factors associated with the dilation of perivascular space in healthy elderly subjects. Frontiers in Aging Neuroscience 13, 125.
27. Zeng, Q., Li, K., Luo, X., Wang, S., Xu, X., Li, Z., Zhang, T., Liu, X., Fu, Y., Xu, X, Huang P. (co-corresponding author), Zhang M. (2020). Distinct Atrophy Pattern of Hippocampal Subfields in Patients with Progressive and Stable Mild Cognitive Impairment: A Longitudinal MRI Study. Journal of Alzheimer's Disease, 1-11.
28. Zhang, R., Huang, P. (co-first author), Jiaerken, Y., Wang, S., Hong, H., Luo, X., Xu, X., Yu, X., Li, K., and Zeng, Q. (2021). Venous disruption affects white matter integrity through increased interstitial fluid in cerebral small vessel disease. Journal of Cerebral Blood Flow & Metabolism 41, 157-165.
29. Zhang, R., Yu, W., Wu, X., Jiaerken, Y., Wang, S., Hong, H., Li, K., Zeng, Q., Luo, X., and Yu, X. Huang, P. (corresponding author). (2021). Disentangling the pathologies linking white matter hyperintensity and geriatric depressive symptoms in subjects with different degrees of vascular impairment. Journal of Affective Disorders.
30. Hong, H., Zhang, R., Yu, X., Jiaerken, Y., Wang, S., Luo, X., Lou, M., Huang, P. (co-corresponding author), and Zhang, M. (2020). Factors Associated With the Occurrence and Evolution of Recent Small Subcortical Infarcts (RSSIs) in Different Locations. Frontiers in Aging Neuroscience 12, 264.
31. Zhou, J., Li, K., Luo, X., Zeng, Q., Jiaerken, Y., Wang, S., Xu, X., Liu, X., Li, Z., Zhang, T., Huang P. (co-corresponding author), Zhang M. (2021). Distinct impaired patterns of intrinsic functional network centrality in patients with early-and late-onset Alzheimer’s disease. Brain Imaging and Behavior, 1-10.
32. Li Y, Guo T, Guan X, Gao T, Sheng W, Zhou C, Wu J, Song Z, Xuan M, Gu Q, Zhang M, Yang Y, Huang P (co-corresponding author) (2020) Fixel-based analysis reveals fiber-specific alterations during the progression of Parkinson’s disease. NeuroImage: Clinical. E-pub
33. Huang P, Guan X, Guo T, Zeng Q, Xuan M, Gu Q, Xu X, Zhou C, Wu J, Zhang M (2020) Damaged insula network contributes to depression in Parkinson’s disease. Frontiers in Psychiatry 11.
34. Li K, Wang S, Luo X, Zeng Q, Jiaerken Y, Xu X, Wang C, Liu X, Li Z, Zhao S, Huang P (co-corresponding author), Zhang M (2020) Progressive memory circuit impairments along with Alzheimer’s disease neuropathology spread: evidence from in vivo neuroimaging. Cerebral Cortex. E-pub
35. Li Y, Huang P (co-first author), Guo T, Guan X, Gao T, Sheng W, Zhou C, Wu J, Song Z, Xuan M (2020) Brain structural correlates of depressive symptoms in Parkinson's disease patients at different disease stage. Psychiatry Research: Neuroimaging 296:111029.
36. Li Y, Zhu Z, Chen J, Zhang M, Yang Y, Huang P (corresponding author) (2020) Dilated Perivascular Space in the Midbrain May Reflect Dopamine Neuronal Degeneration in Parkinson’s Disease. Frontiers in Aging Neuroscience 12:161.
37. Wang S, Jiaerken Y, Yu X, Shen Z, Luo X, Hong H, Sun J, Xu X, Zhang R, Zhou Y, Huang P (co-corresponding author), Zhang M(2020) Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi‐modality MR imaging study. Human Brain Mapping 41:605-616.
38. Yu X, Jiaerken Y, Wang S, Hong H, Jackson A, Yuan L, Lou M, Jiang Q, Zhang M, Huang P(corresponding author) (2020) Changes in the Corticospinal Tract Beyond the Ischemic Lesion Following Acute Hemispheric Stroke: A Diffusion Kurtosis Imaging Study. Journal of Magnetic Resonance Imaging. E-pub
39. Guan X, Huang P (co-first author), Zeng Q, Liu C, Wei H, Xuan M, Gu Q, Xu X, Wang N, Yu X (2019) Quantitative susceptibility mapping as a biomarker for evaluating white matter alterations in Parkinson’s disease. Brain Imaging and Behavior 13:220-231.
40. Li K, Luo X, Zeng Q, Jiaerken Y, Wang S, Xu X, Xu X, Xu J, Wang C, Zhou J, Huang P (co-corresponding author), Zhang M (2019) Interactions between sleep disturbances and Alzheimer’s disease on brain function: a preliminary study combining the static and dynamic functional MRI. Scientific Reports 9:1-13.
41. Qian W, Huang P (co-first author), Shen Z, Wang C, Yang Y, Zhang M (2019) Brain gray matter volume and functional connectivity are associated with smoking cessation outcomes. Frontiers in Human Neuroscience.
42. Huang P, Shen Z, Wang C, Qian W, Zhang H, Yang Y, Zhang M (2017) Altered White Matter Integrity in Smokers Is Associated with Smoking Cessation Outcomes. Frontiers in Human Neuroscience 11:438.
43. Li D, Huang P (co-first author), Zang Y, Lou Y, Cen Z, Gu Q, Xuan M, Xie F, Ouyang Z, Wang B (2017) Abnormal baseline brain activity in Parkinson's disease with and without REM sleep behavior disorder: A resting‐state functional MRI study. Journal of Magnetic Resonance Imaging 46:697-703.
44. Huang P, Lou Y, Xuan M, Gu Q, Guan X, Xu X, Song Z, Luo W, Zhang M (2016) Cortical abnormalities in Parkinson’s disease patients and relationship to depression: A surface-based morphometry study. Psychiatry Research: Neuroimaging 250:24-28.
45. Song Z, Zhang M, Huang P (corresponding author) (2016) Aberrant emotion networks in early major depressive disorder patients: an eigenvector centrality mapping study. Translational psychiatry 6:e819.
46. Huang P, Xuan M, Gu Q, Yu X, Xu X, Luo W, Zhang M (2015) Abnormal amygdala function in Parkinson's disease patients and its relationship to depression. Journal of affective disorders 183:263-268.
47. Lou Y, Huang P (co-first author), Li D, Cen Z, Wang B, Gao J, Xuan M, Yu H, Zhang M, Luo W (2015) Altered brain network centrality in depressed Parkinson's disease patients. Movement Disorders 30:1777-1784.
48. Huang P, Xu X, Gu Q, Xuan M, Yu X, Luo W, Zhang M (2014) Disrupted white matter integrity in depressed versus non-depressed Parkinson's disease patients: A tract-based spatial statistics study. Journal of the neurological sciences 346:145-148.
49. Huang X, Huang P (co-first author), Li D, Zhang Y, Wang T, Mu J, Li Q, Xie P (2014) Early brain changes associated with psychotherapy in major depressive disorder revealed by resting-state fMRI: evidence for the top-down regulation theory. International Journal of Psychophysiology 94:437-444.
50. Huang P, Qiu L, Shen L, Zhang Y, Song Z, Qi Z, Gong Q, Xie P (2013) Evidence for a left‐over‐right inhibitory mechanism during figural creative thinking in healthy nonartists. Human Brain Mapping 34:2724-2732.
51. Wang T, Huang X, Huang P (co-first author), Li D, Lv F, Zhang Y, Zhou L, Yang D, Xie P (2013) Early-stage psychotherapy produces elevated frontal white matter integrity in adult major depressive disorder. PloS one 8:e63081.
獲獎記錄
- 浙江省科技進步獎，二等獎，老年認知障礙進展機制影像研究及預測模型構建，張敏鳴、黃沛鈺、羅驍、徐曉俊等，2021.7
- 浙江省科技進步獎，三等獎，新型冠狀病毒肺炎檢出及重症化預測的影像AI模型構建與套用，張敏鳴、林斌、黃沛鈺等，2020.10
- 浙江省科技進步獎，二等獎，帕金森病影像學生物標誌研究和評估體系構建，張敏鳴、徐曉俊、夏順仁、黃沛鈺、羅 巍，2017.10
- 浙江省醫藥衛生科技獎，一等獎，帕金森病影像學生物標誌研究和評估體系構建，張敏鳴、羅 巍、徐曉俊、夏順仁、黃沛鈺，2017.6
