基本介紹
- 中文名：魏泓
- 學位/學歷： 博士
- 職業：教師
- 專業方向：獸醫病理學等
- 任職院校：華中農業大學動物科學技術學院動物醫學院
個人經歷,研究方向,出版圖書,學術成果,榮譽獎項,
個人經歷
教育經歷
1979.9-1983.7，西南農業大學獸醫專業，學士
1985.9-1988.7，東北農業大學獸醫病理學專業，碩士
工作經歷
1988.7-1993.6 中國人民解放軍陸軍軍醫大學基礎醫學院，講師
1993.7-1998.6 中國人民解放軍陸軍軍醫大學基礎醫學院，副教授
1998.7-今 中國人民解放軍陸軍軍醫大學基礎醫學院，教授，主任
2018.8-今 華中農業大學動科動醫學院，特聘教授
研究方向
小型豬遺傳工程技術、無菌動物技術與畜禽微生物組研究等。
出版圖書
作者類型：
作者時間：
《醫學動物實驗技術》是2016年6月1日人民衛生出版社出版的圖書，作者是魏泓。
學術成果
A著作類
1.《醫學動物實驗技術》，2012年國家科學技術學術著作出版基金資助,人民衛生出版社，2016，主編
3.《實驗動物學》（第二版），全國高等學校長學制臨床醫學專業第三輪國家衛生和計畫生育委員會規劃教材，人民衛生出版社，2015，共同主編
4.《實驗動物學》，全國高等學校八年制臨床醫學專業衛生部規劃教材, 人民衛生出版社， 2010，副主編
5.《感染微生態學》人民衛生出版社，2012，參編
6.Science增刊Regenerative Medicine in China中的Promoting wound healing in burn patients：pig-derived tissues, S. Sanders Ed. (Science/AAAS, Washington, DC, 2012), pp.40-41，參編(並列通訊作者)
7.Skin grafts-indications, applications and current research 中的Chapter 13 Skin graft preservation，In Tech出版社，2011，參編
8.2008-2009實驗動物學學科發展報告，中國科學技術出版社，2009，參編
B論文類
1.Li B, Ge Y, Cheng L, Zeng B, Yu J, Peng X, Zhao J, Li W, Ren B, Li M, Wei H, Zhou X. Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice. Int J Oral Sci. 2019 Mar 5;11(1):10. doi: 10.1038/s41368-018-0043-9. [共同通訊作者，IF: 4.138]
2.Peng Zheng ,Benhua Zeng , Meiling Liu , Jianjun Chen , Junxi Pan ,Yu Han ,Yiyun Liu , Ke Cheng , Chanjuan Zhou , Haiyang Wang , Xinyu Zhou , Siwen Gui ，Seth W. Perry , Ma-Li Wong 8, Julio Licinio , Hong Wei , Peng Xie . The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice. SCIENCE ADVANCES, 2019; 5 : eaau8317.[共同通訊作者，IF:11.5]
3.Ma C, Sun Z, Zeng B, Huang S, Zhao J, Zhang Y, Su X, Xu J*, Wei H* and Zhang H*. Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis. Microbiome. 2018, 6:200. [共同通訊作者，IF: 9.133]
4.Luo Y#, Zeng B#, Zeng L#, Du X#, Li B, Huo R, Liu L, Wang H, Dong M, Pan J, Zheng P, Zhou C, Wei H*, Xie P*. Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus. Transl Psychiatry. 2018 Sep 7;8(1):187. [共同通訊作者，IF: 4.691]
5.Hao QQ#, Li L#, Chen W, Jiang QQ, Ji F, Sun W, Wei H*, Guo WW*, Yang SM*. Key Genes and Pathways Associated With Inner Ear Malformation in SOX10 (p.R109W) Mutation Pigs. Front Mol Neurosci. 2018 Jun 5;11:181. [共同通訊作者，IF: 3.902]
6.Wu H, Zeng B, Li B, Ren B, Zhao J, Li M, Peng X, Feng M, Li J, Wei H#, Cheng L#, Zhou X#. Research on oral microbiota of monozygotic twins with discordant caries experience - in vitro and in vivo study. Sci Rep. 2018, 8;8(1):7267. [共同通訊作者，IF: 4.259]
7.Banru Chen, Xiang Ni, Rui Sun, Benhua Zeng, Hong Wei#, Zhigang Tian#, Haiming Wei#. Commensal bacteria-dependent CD8αβ+ T cells in the intestinal epithelium produce antimicrobial peptides. Frontiers in Immunology. 2018, DOI: 10.3389/fimmu.2018.01065. [共同通訊作者，IF: 6.429]
8.Wang L*, Zeng B*, Liu Z, Liao Z, Zhong Q, Gu L, Wei H#, Fang X#. Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High-Fat Diet Treated HFA Mice. J Food Sci. 2018, 83(3):864-873. [共同通訊作者，IF: 1.815]
9.Li B*, Guo K*, Zeng L*, Zeng B*, Huo R, Luo Y, Wang H, Dong M, Zheng P, Zhou C, Chen J, Liu Y, Liu Z, Fang L, Wei H*, Xie P*. Metabolite identification in fecal microbiota transplantation mouse livers and combined proteomics with chronic unpredictive mild stress mouse livers. Translational Psychiatry. 2018,31;8(1):34. doi: 10.1038/s41398-017-0078-2. [共同通訊作者，IF: 4.73]
10.Huo R#, Zeng B#, Zeng L#, Cheng K#, Li B, Luo Y, Wang H, Zhou C, Fang L, Li W, Niu R, Wei H*, Xie P*, Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis. Front. Cell. Infect. Microbiol. 7:489. doi: 10.3389/fcimb.2017.00489. [共同通訊作者，IF: 4.3]
11.Hai T#, Guo W#, Yao J#, Cao C, Luo A, Qi M, Wang X, Wang X, Huang J, Zhang Y, Zhang H, Wang D, Shang H, Hong Q, Zhang R, Jia Q, Zheng Q, Qin G, Li Y, Zhang T, Jin W, Chen ZY, Wang H, Zhou Q, Meng A, Wei H*, Yang S*, Zhao J*. Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis.. Human genetics,2017. doi: 10.1007/s00439-017-1851-2. [共同通訊作者，IF: 5.34]
12.Zhang Y#, Xue Y#, Cao C#, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi G, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H*, Liu F*, Zhao J*. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017.doi: 10.1182/blood-2017-05-783043. [共同通訊作者，IF: 13.164]
13.Sunny H Wong#, Liuyang Zhao#, Xiang Zhang, Geicho Nakatsu, Juqiang Han, Weiqi Xu1, Xue Xiao, Thomas NY Kwong, Ho Tsoi, William KK Wu, Zeng Benhua, Francis KL Chan, Joseph JY Sung, Hong Wei*, Jun Yu*, Gavage of Fecal Samples From Patients with Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-free and Conventional Mice, Gastroenterology, 2017. [共同通訊作者，IF: 18.392]
14.Hai T#, Cao C#, Shang H#, Guo W#, Mu Y#, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. A pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017 doi: 10.7554/eLife.26248. [共同通訊作者，IF: 8.282]
15.Geng X, Li W, Shang H, Gou Q, Zhang F, Zang X, Zeng B, Li J, Wang Y, Ma J, Guo J, Jian J, Chen B, Qiao Z, Zhou M, Wei H*, Fang X*, Xu C*. A reference gene set construction using RNA-seq of multiple tissues of Chinese Giant Salamander, Andrias davidianus. Gigascience. 2017, doi: 10.1093/gigascience/gix006. [共同通訊作者，IF:7.463]
16.Chen JJ, Zeng BH, Li WW, Zhou CJ, Fan SH, Cheng K, Zeng L, Zheng P, Fang L, Wei H*, Xie P*. Effects of gut microbiota on the microRNA and mRNA expression in the hippocampus of mice. Behav Brain Res. 2017, 322(Pt A):34-41. doi:10.1016/ j.bbr.2017.01.021. [共同通訊作者，IF: 3.002]
17.Yong Wang, Yinnan DU, Xiaoyang Zhou, Lulu Wang, Jian Li, Fengchao Wang,Zhengen Huang, Xingxu Huang, Hong Wei. Efficient generation of B2m-nullpigs via injection of zygote with TALENS. Sci Rep. 2016 , 6:38854. doi: 10.1038/srep38854 . [通訊作者，IF: 5.228]
18.Diao H, Yan HL, Xiao Y, Yu B, Yu J, He J, Zheng P, Zeng BH, Wei H*, Mao XB*, Chen DW*. Erratum to: Intestinal microbiota could transfer host Gut characteristics from pigs to mice. BMC Microbiol. 2016, 16(1):253. [共同通訊作者，IF:2.582]
19.Wang L, Zeng B, Zhang X, Liao Z, Gu L, Liu Z, Zhong Q, Wei H*, Fang X*. The effect of green tea polyphenols on gut microbial diversity and fat deposition in C57BL/6J HFA mice. Food Funct. 2016, 7(12):4956-4966. [共同通訊作者，IF: 2.686]
20.Yan H, Diao H, Xiao Y, Li W, Yu B, He J, Yu J, Zheng P, Mao X, Luo Y, Zeng B, Wei H*, Chen D*. Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice. Sci Rep. 2016, 6:31786. doi: 10.1038/srep31786. [共同通訊作者，IF: 5.228]
21.Liu X, Zeng B, Zhang J, Li W, Mou F, Wang H, Zou Q, Zhong B, Wu L, Wei H*, Fang Y*. Role of the Gut Microbiome in Modulating Arthritis Progression in Mice. Sci Rep. 2016, 6:30594. doi: 10.1038/srep30594. [共同通訊作者，IF: 5.228]
22.Zeng L, Zeng B, Wang H, Li B, Huo R, Zheng P, Zhang X, Du X, Liu M, Fang Z, Xu X, Zhou C, Chen J, Li W, Guo J, Wei H*, Xie P*. Microbiota Modulates Behavior and Protein Kinase C mediated cAMP response element-binding protein Signaling. Sci Rep. 2016, 6:29998. doi: 10.1038/srep29998. [共同通訊作者，IF: 5.228]
23.Zheng P, Zeng B, Zhou C, Liu M, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X, Zhang X, Yang D, Yang Y, Meng H, Li W, Melgiri ND, Licinio J, Wei H*, Xie P. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism. Mol Psychiatry. 2016, 21(6):786-96. doi: 10.1038/mp.2016.44. [共同通訊作者，IF: 13.314]
24.Shibin Zhang, Kenan Guo, Dying Kong, Yu Liu, Haitao Shang, Hong Wei. Semen quality and fertility of Bama miniature pig (Susscrofadomestica). India Journal of Animal Research. 2016, 50(3): 434-6.[通訊作者，IF: 0.044] 25.Shibin Zhang, Kenan Guo, FeiXie, Yu Liu, Haitao Shang, Hong Wei. The normal electrocardiograms of Bama miniature pigs (Susscrofadomestica). JAALAS. 2016, 55(2):152-154. [通訊作者，IF: 1.115]
26.Zhou X, Wang L, Du Y, Xie F, Li L, Liu Y, Liu C, Wang S, Zhang S, Huang X, Wang Y, Wei H. Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes. Hum Mutat. 2015. doi: 10.1002/humu.22913. [通訊作者，IF: 5.144]
27.Qing-hua WANG, Yun PENG, Xin-yong CAI, Meng WAN, Yu LIU, Hong WEI. The Nucleus Transfer Vigor of Ear Fibroblast Cells Isolated from Bama Miniature Pig at the Various Ages. Journal of Huazhong University of Science and Technology Medical Sciences, 2015.35(4):585-590. [共同通訊作者，IF: 0.834]
28.Q. H. Wang J. Y. Chen, K. N. Guo, X. B. Zheng, Q. Wu, H. Wei*,Y. Liu*. A Correlation Study of Boar taint-Related Genes, Boar Taint Substances, and Sex Hormones in Bama Miniature Pigs at Different Ages. Indian Journal of Animal Research,2015, DOI: 10.18805/ijar.5962.[ 共同通訊作者，IF: 0.044]
29.Peng J, Wang Y, Jiang J, Zhou X, Song L, Wang L, Ding C, Qin J, Liu L, Wang W,Liu J, Huang X, Wei H*, Zhang P*. Production of Human Albumin in Pigs ThroughCRISPR/Cas9-Mediated Knockin of Human cDNA into Swine Albumin Locus in theZygotes. Sci Rep. 2015, 5:16705. doi: 10.1038/srep16705.[共同通訊作者，IF: 5.578]
30.Bian Y, Yao Q, Shang H, Lei J, Hu H, Guo K, Jiang H, Yu L, Wei H*, Zeng S*.Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the CatalyticCharacteristics with Each Other and Their Liver Microsomes. Drug MetabDispos.2015, 43(9):1336-40. [共同通訊作者，IF: 3.334]
31.Zhang Q, Pan Y, Yan R, Zeng B, Wang H, Zhang X, Li W, Wei H*, Liu Z*. Commensal bacteria direct selective cargo sorting to promote symbiosis. Nat Immunol. 2015, 16(9):918-26.[ 共同通訊作者，IF: 20.004 ]
32.Wang Y, Yang HQ, Jiang W, Fan NN, Zhao BT, Ou-Yang Z, Liu ZM, Zhao Y, Yang DS, Zhou XY, Shang HT, Wang LL, Xiang PY, Ge LP, Wei H*, Lai LX*. Transgenic expression of human cytoxic T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) by porcine skin for xenogeneic skin grafting. Transgenic Res. 2015, 24(2):199-211. [通訊作者，IF:2.609]
33.Wang Y, Du Y, Shen B, Zhou X, Li J, Liu Y, Wang J, Zhou J, Hu B, Kang N, Gao J, Yu L, Huang X, Wei H. Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA. Sci Rep. 2015, 5:8256.[通訊作者，IF: 5.078] 34.Chongli Xu, Yu Liu, Yuchen Gong, XinpingDuan, Xiaochun Tang, Mingjun Zhang, Daxin Pang, Liqing Yu, Hong Wei*, Hongsheng Ouyang*. Overexpression of NPC1L1 in the livers of transgenic Bama miniature pigs accelerates lipid peroxidation. Genes Genom. 2014, DOI 10.1007/s13258-014-0235-4. [共同通訊作者，IF=0.565]
35.Zhang X, Zeng B, Liu Z, Liao Z, Li W, Wei H*, Fang X*. Comparative diversityanalysis of gut microbiota in two different human flora-associated mouse strains.CurrMicrobiol. 2014,69(3):365-73. [通訊作者，IF=1.52].
36.Wang Y, Zhou XY, Xiang PY, Wang LL, Tang H, Xie F, Li L, Wei H. The meganuclease I-SceI containing nuclear localization signal (NLS-I-SceI) efficiently mediated mammalian germline transgenesis via embryo cytoplasmic microinjection. PLoS One. 2014,9(9):e108347. [通訊作者，IF: 3.534]
37.Shang H, Guo K, Liu Y, Yang J, Wei H. Constitutive expression of CYP3A mRNA in Bama miniature pig tissues. Gene. 2013. 524(2): 261-7. [通訊作者，IF: 2.196]
38.Xie CH, Zhang L, Zeng BH, Yuan J, Tang H, Wei H.Hypercholesterolemia in pregnant mice increases the susceptibility to atherosclerosis in adult life. Vascular 2013 Jun 18. [通訊作者，IF: 0.86]
39.Liu X, Zou Q, Zeng B, Fang Y*, Wei H*.Analysis of fecal Lactobacillus community structure in patients with early rheumatoid arthritis.CurrMicrobiol. 2013, 67(2):170-6. [共同通訊作者，IF=1.52]
Zeng B, Li G, Yuan J, Li W, Tang H, Wei H. Effects of age and strain on the microbiota colonization in an infant human flora-associated mouse model. CurrMicrobiol. 2013 Sep;67(3):313-21.[通訊作者，IF: 1.52]
科研項目
1. 以腸道菌群為靶點的擬人化倉鼠冠心病模型建立；國家自然科學基金面上項目2018.01
3. 小型豬CYP藥物代謝動物模型關鍵問題基礎研究；國家自然科學基金面上項目2012.01
5. 基於組學策略研究EGCG在人源菌群小鼠結腸的代謝通道；國家自然科學基金面上項目（合作）2018.01
6. 人源菌群小鼠結腸多樣性與脂肪代謝對飲食變化的回響；國家自然科學基金面上項目（合作）2011.01
8. 幽門螺桿菌感染與胃內菌群結構及功能的關係研究；國家自然科學基金面上項目（合作）2011.01
9. 小型豬和小鼠等醫學實驗哺乳動物模型建立與基礎數據集成；國家重點基礎研究發展計畫（973計畫子課題） 2011.01
10. 重大疾病動物模型製作與評價體系研究；國家科技支撐計畫（合作）2011.01
11. 誘導多功能幹細胞（iPS）豬與小型豬疾病模型；科技部項目 2011.01
12. 感染微生態動物模型的建立、評價及套用；科技部973課題 2007.01
13. 益生菌定向篩選關鍵技術及產品開發研究； 科技部863課題 2007.01
14. 抗生素殘留引起細菌耐藥性安全評價技術研究；科技部子課題 2006.01
15. 殼多糖和動物源性材料組織工程皮膚關鍵技術的研究；科技部項目 2006.01
16. 小鼠疾病模型資源、數據或信息共享網路的建立和套用示範；科技部項目 2006.01
17. 中國實驗用小型豬資源開發和研究套用；科技部項目 2004.01
18. 異種皮膚移植轉基因小鼠模型的研究；科技部項目 2003.01
19. 中國三種實驗用小型豬遺傳監測及近交培育的研究；國家自然科學基金面上項目1998.01
20. 中國三種實驗用小型豬遺傳檢檢測標準的建立；科技部項目 1997.01
榮譽獎項
1. 重慶市研究生教育優質課程（實驗動物學，2013，排名第一）
2. 重慶市科技進步二等獎（醫用小型豬標準化、套用關鍵技術及重要特性研究，2011，排名第一）
3. 首屆中國實驗動物學會科學技術二等獎（醫用小型豬標準化、套用關鍵技術及重要特性研究，2010，排名第一）
4. 重慶市科技進步二等獎（高等級實驗動物生產技術研究及基地建設，2009，排名第三）
5. 國家科技進步二等獎（嚴重燒傷救治新技術的基礎與臨床研究，2007，排名第十）
6. 全軍教學成果一等獎（醫學實驗動物學課程的創建與實踐，1997，排名第一）
