高瑩(中國科學院上海營養與健康研究院研究員)

高瑩(中國科學院上海營養與健康研究院研究員)

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高瑩，女，博士、研究員、博士生導師。中科院營養代謝與食品安全重點實驗室，表觀遺傳和營養相關慢性病課題組組長。

基本介紹

  • 中文名：高瑩
  • 畢業院校：北京大學
  • 性別：女
  • 就職企業：中國科學院上海營養與健康研究院
  • 研究方向：營養分子流行病
人物經歷,研究方向,代表性論文,

人物經歷

2017-至 今：中國科學院上海營養與健康研究院，研究員
2012-2016：中國科學院上海生命科學研究院營養科學研究所，研究員
2007-2012：美國國立衛生研究院癌症研究所，博士後
2001-2007：美國康奈爾大學營養系，博士
2001-2007：美國康奈爾大學統計系，碩士
1998-2001：北京大學營養與食品衛生系，碩士

研究方向

以人群研究（流行病學）為基礎，結合表觀遺傳學組學和基因組學等研究方法，系統的探索表觀遺傳和遺傳因素，以及它們與營養等環境因素的相互作用，對生命全程的健康的影響。目前我們主要研究脂肪酸攝入和代謝在代謝紊亂、癌症和 生長發育中的作用。我們也感興趣與尋找可以和營養因素共同影響疾病危險性的表觀遺傳因素。我們也計畫通過人群干預研究來進一步評價營養因素的疾病預防和治療潛力。
1. 脂肪酸與癌症、代謝紊亂和生長發育的關係
2. 遺傳和表觀遺傳在癌症病因學中的意義
3. 人群干預研究

代表性論文

*通訊作者
  1. Peiqin Li, Boer Shan, Keyu Jia, Fan Hu, Ying Xiao, Jusheng Zhen, Yu-Tang Gao, Huaying Wang, Ying Gao*. Plasma Omega-3 Polyunsaturated Fatty Acids and recurrence of endometrial cancer. BMC Cancer 2020 Jun;20(1):576
  2. Xin Xu, Huigang Shi, Xiaowen Gong, Pu Chen, Ying Gao, Xinzheng Zhang, Song Xiang. Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump. eLife 2020 May;9:e53853
  3. Xiaoyang Wang, Jianbo Tian, Qianyu Zhao, Nan Yang, Pingting Ying, Xiating Peng, Danyi Zou, Ying Zhu, Rong Zhong, Ying Gao, Jiang Chang, Xiaoping Miao. Functional characterization of a low-frequency V1937I variant in FASN associated with susceptibility to esophageal squamous cell carcinoma. Arch Toxicol 2020 Jun;94(6):2039-2046
  4. 李吉, 方圓, 肖千一, 高瑩, 徐望紅. DNA甲基化在女性出生體重與成年期肥胖風險關聯中的中介效應. 中華流行病學雜誌 2019;40(5):590-595
  5. Shuchun Lin, Yun Liu, Lynn R Goldin, Chen Lyu, Xiangyin Kong, Yan Zhang, Neil E Caporaso, Song Xiang, Ying Gao*. Sex related DNA methylation differences in B cell chronic lymphocytic leukemia. Biol Sex Differ 2019 Jan 7;10(1):2
  6. Kangning Chen, Qianyu Zhao, Xiaofan Li, Jing Zhao, Peiqin Li, Shuchun Lin, Hongwei Wang, Jiajie Zang, Ying Xiao, Wanghong Xu, Fuxue Chen, Ying Gao*. Dietary fiber intake and endometrial cancer risk: A systematic review and meta-analysis. Nutrients 2018 Jul 22;10(7):945
  7. Jing Zhao, Xiaofan Li, Xiang Li, Qianqian Chu, Yunhua Zhou, Zi Li, Hong Zhang, Thomas J Brenna, Yiqing Song, Ying Gao*. Associations of plasma very-long-chain SFA and the metabolic syndrome in adults. Br J Nutr 2018 Oct;120(8):855-862
  8. Jie Liu, ShengQuan Mi, Li Du, Xiang Li, Jing Zhao, Hong Zhang, WenHua Zhao*, Ying Gao*. The associations between plasma phytoestrogens concentration and metabolic syndrome risks in Chinese population. PLoS One 2018 Mar 20;13(3):e0194639
  9. Peiqin Li, Jing Zhao, Kumar Kothapalli, Xiang Li, Hui Li, Yuxuan Han, Shengquan Mi, Wenhua Zhao, Qizhai Li, Hong Zhang, Yiqing Song, J. Thomas Brenna, Ying Gao*. A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study. Am J Clin Nutr 2018 Jun 1;107(6):867-875
  10. Xiang Li, Hui Li, Jing Zhao, Qi Dai, Chaoran Huang, Langping Jin, Fan Yang, Fuxue Chen, Ouchen Wang, Ying Gao*. Plasma ω-3 and ω-6 fatty acids in thyroid diseases. Oncol Lett 2018 Oct;16(4):5433-5440
  11. Xiaofan Li, Jing Zhao, Peiqin Li, Ying Gao*. Dairy products intake and endometrial cancer risk: a meta-analysis of observational studies. Nutrients 2017 Dec 28;10(1):25
  12. Hui Li, Xiang Li, Jie Liu, Langping Jin, Fang Yang, Junbo Wang, Ouchen Wang, Ying Gao*. Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. Int J Environ Health Res 2017 Oct;27(5):409-419
  13. 李慧, 郭倩穎, 柳鵬, 張岩春, 戴智勇, 高瑩, 王軍波. 不同時期母乳中脂肪酸水平的變化. 中國食物與營養 2017;23(5):54-58
  14. Yanhui Hao, Jing Zhao, Kan Wang, Nannan Feng, Pin Sun, Renjie Chen, Bin Han, Zhipeng Bai, Yiliang Zhu, Ying Gao*, Zhao-lin Xia*. The Association between Particulate Matter Air Pollution and Respiratory Health in Elderly with Type 2 Diabetes Mellitus. J Occup Environ Med 2017 Sep;59(9):830-834
  15. Li Du, Yulong Wang, Hang Zhang, Hong Zhang, Ying Gao*. Folate intake and the risk of endometrial cancer: A meta-analysis. Oncotarget 2016 Dec 20;7(51):85176-85184
  16. Jing Zhao, Lvy Chen, Jian Gao, Li Du, Boer Shan, Hong Zhang, Huaying Wang, Ying Gao*. Dietary fat intake and endometrial cancer risk: a dose-response meta-analysis. Medicine (Baltimore) 2016 Jul;95(27):e4121
  17. Jie Liu, Feixiang Yuan, Jian Gao, Boer Shan, Yulan Ren, Huaying Wang, Ying Gao*. Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials. Oncotarget 2016 Apr 5;7(14):17369-17379
  18. Jun Han, Yi Jiang, Xiao Liu, Qingyang Meng, Qiulei Xi, Qiulin Zhuang, Yusong Han, Ying Gao, Qiurong Ding, Guohao Wu. Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies. PLoS One 2015 Sep 24;10(9):e0138580
  19. Sigurdur Y. Kristinsson, Ying Gao, Magnus Bj？rkholm, Sigrun Helga Lund, Jan Sj？berg, Neil Caporaso, Lynn R Goldin, Ola Landgren. Hodgkin lymphoma risk following infectious and chronic inflammatory diseases: a large population-based case-control study from Sweden. Int J Hematol 2015 Jun;101(6):563-568 ( equal contribution)
  20. Jing Zhao, Jing Wang, Jinfeng Du, Hongli Xu, Wei Zhang, Quan-Xing Ni, Herbert Yu, Harvey A. Risch, Yu-Tang Gao, Ying Gao*. Urinary prostaglandin E2 metabolite and pancreatic cancer risk: case-control study in urban Shanghai. PLoS One 2015 Feb 13;10(2):e0118004
  21. Wen-Qing Li 1, Nan Hu, Paula L Hyland, Ying Gao, Zhao-Ming Wang, Kai Yu, Hua Su, Chao-Yu Wang, Le-Min Wang, Stephen J Chanock, Laurie Burdett, Ti Ding, You-Lin Qiao, Jin-Hu Fan, Yuan Wang, Yi Xu, Jian-Xin Shi, Fangyi Gu, William Wheeler, Xiao-Qin Xiong, Carol Giffen, Margaret A Tucker, Sanford M Dawsey, Neal D Freedman, Christian C Abnet, Alisa M Goldstein, Philip R Taylor. Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. Carcinogenesis 2013 Jul;34(7):1536-1542
  22. Ying Gao*, Keith Killian, Hong Zhang, Kai Yu, Qi-Zhai Li, Stephanie Weinstein, Jarmo Virtamo, Margaret Tucker, Philip Taylor, Demetrius Albanes, Paul Meltzer, Neil Caporas. Leukocyte DNA methylation and colorectal cancer among male smokers. World J Gastrointest Oncol 2012 Aug 15;4(8):193-201
  23. David E Capo-Ramos, Ying Gao, Jay H Lubin, David P Check, Lynn R Goldin, Angela C Pesatori, Dario Consonni, Pier Alberto Bertazzi, Andrew J Saxon, Andrew W Bergen, Neil E Caporaso, Maria Teresa Landi. Mood disorders and risk of lung cancer in the EAGLE Case-control study and in the U.S. Veterans Affairs inpatient cohort. Plos One 2012;7(8):e42945
  24. Qizhai Li, Dongdong Pan, Weihua Yue, Ying Gao, Kai Yu. Evaluating rare variants under two- stage design. J Hum Genet 2012 Jun;57(6):352-357
  25. Yoon Jung Park, Herry Herman, Ying Gao, Anders M Lindroth, Benjamin Y Hu, Patrick J Murphy, James R Putnam, Paul D Soloway. Sequences sufficient for programming imprinted germ line DNA methylation defined. PLoS One 2012;7(3):e33024
  26. Ying Gao*, Hormuzd Katki, Barry Graubard, Michael Pollak, Michael Martin, Yuzhen Tao, Robert E Schoen, Timothy Church, Richard B Hayes, Mark H Greene, Sonja I Berndt. Serum IGF1, IGF2, and IGFBP3 and risk of advanced colorectal adenoma. Int J Cancer 2012 Jul 15;131(2):E105-E113
  27. Gao Y*, Baccarelli A, Shu XO, Ji BT, Yu K, Tarantini L, Yang G, Li HL, Hou L, Rothman N, Zheng W, Gao YT, Chow WH. Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women’s Health Study. Br J Cancer 2012 Jan 31;106(3):585-591
  28. Freddy Sitas, Sam Egger, Margaret I Urban, Philip R Taylor, Christian C Abnet, Paolo Boffetta, Dianne L O'Connell, David C Whiteman, Paul Brennan, Reza Malekzadeh, Michael Pawlita, Sanford M Dawsey, Tim Waterboer, on behalf of the InterSCOPE Collaboration. Penelope M Webb, Adèle C Green, Nicholas K Hayward, David Zaridze, Ivana Holcatova, Dana Mates, Neonila Szeszenia-Dabrowska, Gilles Ferro, Vladimir Janout, Maria Paula Curado, Ana Maria Menezes, Sergio Koifman, Farhad Islami, Dariush Nasrollahzadeh, Nan Hu, Alisa M Goldstein, Ying Gao, Ti Ding, Farin Kamangar. InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers. J Natl Cancer Inst 2012 Jan 18;104(2):147-158
  29. Ying Gao*, Nan Hu, Xiao You Han, Ti Ding, Carol Giffen, Alisa M Goldstein, Philip R Taylor. Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case-control study. Cancer Epidemiol 2011 Dec;35(6):e91-e99
  30. Ying Gao*, Richard B. Hayes, Wen-Yi Huang, Neil E. Caporaso, Laurie Burdette, Meredith Yeager, Stephen J. Chanock, Sonja I. Berndt DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas. Carcinogenesis 2011;32:882-887
  31. Ying Gao*, Nan Hu, XiaoYou Han, Carol Giffen, Ti Ding, Alisa Goldstein, Philip Taylor. Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. BMC Cancer 2009;9:269
  32. Ying Gao*, Nan Hu, Xiaoyou Han, Carol Giffen, Ti Ding, Alisa M. Goldstein, Philip R.Taylor PR. Jasmine tea consumption and upper gastrointestinal cancer in China. Cancer Causes Control 2009 Dec;20(10):1997-2007
  33. Xueying Liang, Ying Gao, Tram K Lam, Qizhai Li, Cathy Falk, Xiaohong R Yang, Alisa M Goldstein, Lynn R Goldin. Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods. BMC Proc 2009 Dec 15;3 Suppl 7(Suppl 7):S79
  34. Ying Gao, Alisa M. Goldstein, Dario Consonni, Angela C. Pesatori, Sholom Wacholder, Margaret A. Tucker, Neil E. Caporaso, Lynn Goldin, Maria Teresa Landi. Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer. Int J Cancer 2009;125:146-152
  35. Ying Gao*, Sigurdur Y Kristinsson, Lynn R Goldin, Magnus Bj？rkholm, Neil E Caporaso, Ola Landgren. Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association. Gastroenterology 2009 Jan;136(1):91-98
  36. Ying Gao*, Martha S Linet, Gloria Gridley, Lene Mellemkjaer, Kari Hemminki, Lynn R Goldin, Ola Landgren. Shared susceptibility for celiac disease and inflammatory bowel disease? Scand J Gastroenterol 2008;43(10):1279-1280

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