高會樂，男，四川大學華西藥學院教授、博士生導師。2018年05月入選四川省學術與技術帶頭人後備人選。
基本介紹
- 中文名：高會樂
- 國籍：中國
- 畢業院校：復旦大學
- 學位/學歷：博士/研究生
- 職業：教師
- 職務：四川大學華西藥學院藥劑系黨支部書記
- 職稱：教授
人物經歷,研究方向,科研項目,社會任職,獲獎情況,研究論文,
人物經歷
2008.09-2013.06 復旦大學藥學院，獲藥劑學博士學位
2013.07-2014.06 四川大學華西藥學院講師
2014.07-2017.09 四川大學華西藥學院副教授、碩導（破格）
2015.10-2016.10 史丹福大學醫學院訪問學者
2016.12至今 四川大學華西藥學院藥劑系黨支部書記
2017.09至今 四川大學華西藥學院教授、博導（破格）
研究方向
1、新型腦靶向遞藥系統的設計和評價；
2、具有環境敏感的納米遞藥系統及其材料的設計、合成和評價。
科研項目
7. 國家自然科學基金國際(地區)合作與交流項目，腫瘤微環境回響性納米載體用於腦腫瘤及腦轉移瘤的診療一體化研究，81961138009，資助金額100萬元，實施年限：2020.1.1-2022.12.31，主持。
6. 四川省科技廳項目，“以提高細胞內納米載體轉運為基礎的腦腫瘤靶向遞藥系統構建和評價（省重）”，19YYJC2250，資助金額10萬元，實施年限：2019.1.1-2020.12.31，主持。
5. 四川省人力資源和社會保障廳留學歸國人員資助重點項目，“新型腦靶向遞藥系統的開發”，資助金額10萬元，實施年限：2019.1.1-2020.12.31，主持。
4.國家自然科學基金面上項目，“以提高納米載體跨血腦屏障轉運為基礎的阿爾茨海默症靶向遞藥系統構建和評價”，81872806，資助金額57萬元，實施年限：2019.01.01-2022.12.31，主持。
3. 國家自然科學基金面上項目，“基於生物點擊化學的腫瘤微環境回響性納米載體的腫瘤靶向遞藥研究”，31571016，實施年限：2016.01.01-2019.12.31，主持。
2. 國家自然科學基金青年項目，“基於粒徑智慧型調節、具有腫瘤微環境回響的腦轉移瘤靶向遞藥系統研究”，81402866，實施年限：2015.01.01-2017.12.31，主持。
1. 四川大學優秀青年基金項目，“基於生物點擊化學的腫瘤微環境回響性納米載體的腫瘤靶向遞藥研究”，2015SCU04A14，實施年限：2015.1-2017.12，主持。
社會任職
2019年06月起擔任《International Journal of Pharmaceutics》編委（IF=4.213）
2019年04月起擔任中國生物醫學工程學會納米醫學與工程分會青年委員
2018年09月主編專著《Brain Targeted Drug delivery system》，Elsevier出版社
2018年09月擔任《Current Drug Metabolism》（IF2.847）客座編輯，主編2018年第9期
2018年09月起擔任中國藥學會藥劑學專業委員會青年學術委員會委員
2018年08月起擔任中國抗癌協會納米腫瘤學專業委員會第一屆青年委員會委員
2018年04月起擔任Chinese Chemical Letters雜誌青年編委
2018年02月起擔任《Pharmaceutics》（IF3.75）編委
2017年05月起擔任《CNS & Neurological Disorders-Drug Targets》編委（IF=2.188）
2017年04月起擔任《Current Drug Metabolism》編委（IF=2.847）
2017年01月作為編委參與撰寫普通高等教育“十三五”規劃教材《生物藥劑學與藥物動力學》，科學出版社
2016年11月起擔任《Journal of Microencapsulation》（IF=1.631）編委
2016年09月主編專著《Neurotoxicity of Nanomaterials and Nanomedicine》，Elsevier出版社
2016年08月擔任《Current Drug Metabolism》（IF2.847）客座編輯，主編2016年第8期
2015年11月至今擔任《藥學學報》、《Acta Pharmaceutica Sinica B》青年編委
2015年08月至今擔任《中國醫院藥學雜誌》通訊編委
獲獎情況
2018年05月入選四川省學術與技術帶頭人後備人選
2018年05月獲得西部藥學之星
2018年05月獲四川大學好未來優秀學者獎二等獎
2018年01月入選中國科協“青年人才托舉工程”
2017年12月獲得四川大學“唐立新優秀學者獎”三等獎
2017年06月獲得四川大學青年科技人才獎
2015年10月獲中國藥學會中恆青年藥劑學獎
2015年04月博士論文獲上海市優秀博士論文
研究論文
2020
67. Cai Lulu, Yang Chuanyao, Jia Wenfeng, Liu Yuwei, Xie Rou, Lei Ting, Yang Zhihang, He Xueqin, Tong Rongsheng*, Gao Huile*. Endo/lysosome-escapable Delivery Depot for Improving BBB Transcytosis and Neuron targeted therapy of Alzheimer's disease. Adv Funct Mater, 2020, 30, 1909999. (IF=16.836)
66. Hu Chuan, Lei Ting, Wang Yazhen, Cao Jun, Yang Xiaotong, Qin Lin, Liu Rui, Zhou Yang, Tong Fan, Umeshappa Channakeshava Sokke*, Gao Huile*. Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity. Biomaterials, 2020, 255, 120159. (IF=10.317)
65. Liu Rui, An Yang, Jia Wenfeng, Wang Yushan, Wu Yue, Zhen Yonghuan, Cao Jun*, Gao Huile*. Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer. J Control Release, 2020, 321, 589-601. (IF= 7.727)
64.Yang Xiaotong, Chen Xianchun, Lei Ting, Qin Lin, Zhou Yang, Hu Chuan, Liu Qingfeng*, Gao Huile*. The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration. Acta Pharm Sin B, 2020, 10(6):1094-1105. (IF=7.097)
2019
60. Liu Rui, Yu Meinan, Yang Xiaotong, Umeshappa S. Channakeshava, Hu Chuan, Yu Wenqi, Qin Lin, Huang Yuan, Gao Huile*. Linear chimeric triblock molecules self-assembled micelles with controllably transformable property to enhance tumor retention for chemo- photodynamic therapy of breast cancer. Adv Funct Mater, 2019, accepted.(IF=13.325)
59. Yu Meinan, Su Dunyan, Yang Yuanyuan, Qin Lin, Hu Chuan, Liu Rui, Zhou Yang, Yang Chuanyao, Yang Xiaotong, Wang Guanlin*, Gao Huile*. D-T7 peptide-modified PEGylated bilirubin nanoparticles loaded with cediranib and paclitaxel for antiangiogenesis and chemotherapy of glioma.ACS Appl Mater Inter, 2019, 11(1):176-186. (IF=8.097)
58. Liu Rui, Hu Chuan, Yang Yuanyuan, Zhang Jingqing, Gao Huile*. Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment. Acta Pharm Sin B, 2019, 9(2):410-420. (IF=6.014)
2018
57. Ruan Shaobo, Qin Lin, Xiao Wei, Hu Chuan, Zhou Yang, Wang Ranran, Sun Xing, Yu Wenqi, He Qin, Gao Huile*. Acid-responsive transferrin dissociation and GLUT mediated exocytosis for increased blood-brain barrier transcytosis and programmed glioma targeting delivery. Adv Funct Mater, 2018, 28(30): 1802227.(IF=13.325)
56. Liu Rui, Xiao Wei, Hu Chuan, Xie Rou, Gao Huile*. Theranostic size-reducible and no donor conjugated gold nanocluster fabricated hyaluronic acid nanoparticle with optimal size for combinational treatment of breast cancer and lung metastasis. J Control Release, 2018, 278, 127-139.(IF=7.877)
55. Hu Chuan, Cun Xingli, Ruan Shaobo, Liu Rui, Xiao Wei, Yang Xiaotong, Yang Yuanyuan, Yang Chuanyao, Gao Huile*. Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy. Biomaterials, 2018, 168: 64-75.(IF=8.806)
54. Hu Chuan, Yang Xiaotong, Liu Rui, Ruan Shaobo, Zhou Yang, Xiao Wei, Yu Wenqi, Yang Chuanyao, Gao Huile*. Coadministration of iRGD with multistage responsive nanoparticles enhanced tumor targeting and penetration abilities for breast cancer therapy. ACS Appl Mater Inter, 2018, 10(26): 22571-22579. (IF=8.097)
53. Zhang Huajin, Wu Tianmu, Yu Wenqi, Ruan Shaobo, He Qin, Gao Huile*. Ligand size and conformation affect the behavior of nanoparticles coated with in vitro and in vivo protein corona. ACS Appl Mater Inter, 2018, 10(10): 9094-9103. (IF=8.097)
52. Xiao Wei, Xiong Jingyuan, Zhang Shuang, Xiong Yang, Zhang Huajin, Gao Huile*. Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability. Int J Pharm, 2018, 538(1-2): 105-111. (IF=3.994)
2017
51. Ruan Shaobo, Xiao Wei, Hu Chuan, Zhang Huajin, Rao Jingdong, Wang Sihan, Wang Xiao, He Qin*, Gao Huile*. Ligand mediated and enzyme-directed precise targeting and retention for enhanced treatment of glioblastoma. ACS Appl Mater Inter, 2017, 9(24): 20348–20360. (IF=7.504)
50. Xiao Wei, Ruan Shaobo, Yu Wenqi, Wang Ranran, Hu Chuan, Liu Rui, Gao Huile*. Normalizing tumor vessels to increase the enzyme-induced retention and targeting of gold nanoparticle for breast cancer imaging and treatment. Mol Pharm, 2017. (IF=4.440)
49. Xiao Wei, Li Yuan, Hu Chuan, Huang Yuan, He Qin, Gao Huile*. Melanin-originated carbonaceous dots for triple negative breast cancer diagnosis by fluorescence and photoacoustic dual-mode imaging.J Colloid Interf Sci, 2017, 497: 226-232.(IF=4.233)
2016
48. Ruan Shaobo, Hu Chuan, Tang Xian, Cun Xingli, Xiao Wei, Shi Kairong, He Qin, Gao Huile*. Increased gold nanoparticle retention in brain tumors by in situ enzyme-induced aggregation. ACS Nano, 2016, 10(11): 10086-10098. (IF=13.942)
47. Cun Xingli, Ruan Shaobo, Chen Jiantao, Zhang Li, Li Jianping, He Qin*, Gao Huile*. A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan. Acta Biomater, 2016, 31C: 186-196. (IF=6.319)
46. Hu Guanlian, Cun Xingli, Ruan Shaobo, Shi Kairong, Wang Yang, Kuang Qifang, Hu Chuan, Xiao Wei, He Qin, Gao Huile*. Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles. Sci Rep, 2016, 6:27669. (IF=4.259)
45. Hu Chuan, Liu Yongmei, Chen Jiantao, He Qin, Gao Huile*. A simple one-step synthesis of melanin-originated red shift emissive carbonaceous dots for bioimaging.J Colloid Interf Sci, 2016, 480: 85-90.(IF=4.233)
2015
44. Zheng Min, Ruan Shaobo, Liu Shi, Sun Tingting, Qu Dan, Zhao Haifeng, Xie Zhigang*,Gao Huile*, Jing Xiabin, Sun Zaicheng*. Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano, 2015, 9 (11): 11455–11461. (IF=13.334)
43. Ruan Shaobo, Cao Xi, Cun Xingli, Hu Guanlian, Zhou Yi, Zhang Yanling, Lu Libao, He Qin, Gao Huile*. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. Biomaterials, 2015, 60: 100-110. (IF=8.387)
42. Ruan Shaobo, Yuan Mingqing, Zhang Li, Hu Guanlian, Chen Jiantao, Cun Xingli, Zhang Qianyu, Yang Yuting, He Qin*, Gao Huile*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials, 2015, 37:425-435. (IF=8.387) ESI高被引論文
41. Ruan Shaobo, He Qin, Gao Huile*. Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. Nanoscale, 2015, 7(21): 9487-9496. (IF=7.76)
40. Cun Xingli, Chen Jiantao, Ruan Shaobo, Zhang Li, Wan Jingyu, He Qin,Gao Huile*. A novel strategy through combining iRGD peptide with tumor microenvironment responsive and multistage nanoparticles for deep tumor penetration. ACS Appl Mater Inter, 2015, 7, 27458−27466. (IF=7.145)
39. Hu Guanlian, Chun Xinli, Wang Yang, He Qin, Gao Huile*. Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment. Oncotarget, 2015, 6(38): 41258-41274.(IF=5.008)
38. Ruan Shaobo, Chen Jiantao, Cun Xingli, Long Yang, Tang Jie, Qian Jun, Shen Shun, Jiang Xinguo, Zhu Jianhua, He Qin*, Gao Huile*. Noninvasive in vivo diagnosis of brain gliomas using RGD-decorated fluorescent carbonaceous nanospheres. J Biomed Nanotech, 2015, 11(12): 2148-2157.(IF=3.929)
37. Gao Huile, Cao Shijie, Yang Zhi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo. Preparation, characterization and anti-glioma effects of docetaxel-loaded, lipoprotein-like nanoparticles. J Biomed Nanotech, 2015, 11(12):2137-2147. (IF=3.929)
36. Hu Guanlian, Wang Yang, He Qin*, Gao Huile*. Multistage drug delivery system based on microenvironment-responsive dendrimer-gelatin nanoparticles for deep tumor penetration. RSC Adv, 2015, 5: 85933-85937. (IF=3.289)
35. Ruan Shaobo, Zhang Li, Chen Jiantao, Cao Tingwei, Yang Yuting, Liu Yayuan, He Qin, Gao Fabao*, Gao Huile*. Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer.RSC Adv, 2015, 5:64303 - 64317. (IF=3.289)
34. Chen Jiantao, Cun Xingli, Ruan Shaobo, Wang Yang, Zhang Yanling, He Qin*, Gao Huile*. Glioma cell targeting doxorubicin delivery and redox-responsive release using angiopep-2 decorated carbonaceous nanodots. RSC Adv, 2015, 5: 57045 - 57049. (IF=3.289)
33. Chen Jiantao, Sun Huaqin, Ruan Shaobo, Wang Yang, Shen Shun, Xu Wenming, He Qin, Gao Huile*. In vitro and in vivo toxicology of bare and PEGylated fluorescent carbonaceous nanodots in mice and zebrafish: the potential relation with autophagy. RSC Adv, 2015, 5: 38547-38557. (IF=3.289)
32. Ruan Shaobo, Qian Jun, Shen Shun, Chen Jiantao, Cun Xingli, Zhu Jianhua, Jiang Xinguo, He Qin*, Gao Huile*. Non-invasive imaging of breast cancer using RGDyK functionalized fluorescent carbonaceous nanospheres. RSC Adv, 2015, 5: 25428-25436. (IF=3.289)
31. Hu Guanlian, Zhang Huiqing, Zhang Li, Ruan Shaobo, He Qin, Gao Huile*. Integrin-mediated active tumor targeting and tumor microenvironment response dendrimer-gelatin nanoparticles for drug delivery and tumor treatment. Int J Pharm, 2015, 496: 1057-1068.(IF=3.994)
30. Gao Huile*, Zhang Qianyu, Yang Yuting, Jiang Xinguo, He Qin*. Tumor homing cell penetrating peptide decorated nanoparticles used for enhanced tumor targeting delivery and therapy.Int J Pharm, 2015, 478: 240-250. (IF=3.994)
29. Chen Jiantao, Sun Huaqin, Wang Weiliang, Xu Wenming, He Qin, Shen Shun, Qian Jun*, Gao Huile*. Polyethylene glycol modification reduces the cardiac toxicity of carbonaceous dots in mice and zebrafish model. Acta Pharmacol Sin, 2015, 36(11): 1349-1355. (IF=3.166)
2014
28. Gao Huile, Yang Zhi, Cao Shijie, Xiong Yang, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment. Biomaterials, 2014, 35(7): 2374-2382. (IF=8.557)
27. Ruan Shaobo, Qian Jun, Shen Shun, Zhu Jianhua, Jiang Xinguo, He Qin,Gao Huile*. A simple one-step method to prepare fluorescent carbon dots and their potential application in non-invasive glioma imaging. Nanoscale, 2014, 6(17): 10040-10047. (IF=7.394)
26. Gao Huile, Yang Zhi, Zhang Shuang, Pang Zhiqing, Liu Qingfeng, Jiang Xinguo*. Study of the pharmacology mechanisms of dual targeting drug delivery system with tumor microenvironment assays. Acta Biomateria, 2014, 10(2): 858-867. (IF=6.025)ESI高被引論文
25. Gao Huile, Hu Guanlian, Zhang Qianyu, Zhang Shuang, Jiang Xinguo, He Qin*. Pretreatment with chemotherapeutics for enhanced nanoparticles accumulation in tumor: the potential role of G2 cycle retention effect. Sci Rep, 2014,4: 4492. (IF=5.578)
24. Ruan Shaobo, Qian Jun, Shen Shun, Chen Jiantao, Zhu Jianhua, Jiang Xinguo, He Qin*, Yang Wuli*, Gao Huile*. Near-infrared fluorescent carbonaceous nanodots for glioma imaging after angiopep-2 decoration. Bioconjug Chem, 2014, 25: 2252-2259.(IF=4.513)
23. Ruan Shaobo, Wan Jingyu, Fu Yao, Han Ke, Li Xiang, Chen Jiantao, Zhang Qianyu, Shen Shun, He Qin, Gao Huile*. PEGylated fluorescent carbon nanoparticles for noninvasive heart imaging. Bioconjug Chem, 2014,25(6): 1061-1068. (IF=4.513)
22. Gao Huile, Zhang Shuang, Cao Shijie, Yang Zhi, Pang Zhiqing, Jiang Xinguo*. Angiopep-2 and activatable cell penetrating peptide dual-functionalized nanoparticles for systemic glioma targeted delivery. Mol Pharm, 2014, 11(8): 2755-2763.(IF=4.384)
21. Gao Huile, Xiong Yang, Zhang Shuang, Yang Zhi, Cao Shijie, Jiang Xinguo*. RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration. Mol Pharm, 2014,11(3): 1042-1052. (IF=4.384)
20. Mei Ling, Zhang Qianyu, Yang Yuting, He Qin, Gao Huile*. Angiopep-2 and activatable cell penetrating peptide dual modified nanoparticles for enhanced tumor targeting and penetrating. Int J Pharm, 2014, 474: 95-102. (IF=3.65)
19. Gao Huile, Zhang Shuang, Yang Zhi, Cao Shijie, Jiang Xinguo, Pang Zhiqing*. In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide. Int J Pharm, 2014, 466(1-2): 8-17.(IF=3.65)
18. Gao H, Wang Y, Chen C, Chen J, Wei Y, Cao S, Jiang X*. Incorporation of lapatinib into core-shell nanoparticles improves both the solubility and anti-glioma effects of the drug. Int J Pharm, 2014; 461(1-2): 478– 488. (IF=3.65)
17. Qian Jun, Ruan Shaobo, Cao Xi, Cun Xingli, Chen Jiantao, Shen Shun, Jiang Xinguo, He Qin, Zhu Jianhua*, Gao Huile*. Fluorescent carbonaceous nanospheres as biological probe for noninvasive brain imaging. J Colloid Interf Sci, 2014, 436: 227-233.(IF=3.368)
16. Qian Jun, Chen Jiantao, Ruan Shaobo, Shen Shun, He Qin, Jiang Xinguo, Zhu Jianhua*, Gao Huile*. Preparation and biological evaluation of photoluminescent carbonaceous nanospheres. J Colloid Interf Sci, 2014, 429: 77-82. (IF=3.368)
15. Ruan Shaobo, Zhu Biyue, Zhang Huajin, Chen Jiantao, Shen Shun, Qian Jun, He Qin, Gao Huile*. A simple one-step method for preparation of fluorescent carbon nanospheres and the potential application in cell organelles imaging. J Colloid Interf Sci, 2014,422: 25-29. (IF=3.368)
14. Gao Huile, Yang Zhi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Internalization and subcellular fate of aptamer and peptide dual-functioned nanoparticles. J Drug Target, 2014, 22(5): 450-459. (IF=2.741)
13. Zhang Li, Zhang Shuang, Ruan Shaobo, Zhang Qianyu, He Qin, Gao Huile*. Lapatinib incorporated lipoprotein-like nanoparticles: preparation and breast cancer targeting mechanism. Acta Pharmacol Sin, 2014,35(6): 846-852.(IF=2.912)
2013 and before
12. Gao Huile, Yang Zhi, Zhang Shuang, Cao Shijie, Pang Zhiqing, Yang Xiao, Jiang Xinguo*. Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth. J Control Release, 2013, 172(3):921-928.(IF=7.261)
11. Gao Huile, Cao Shijie, Chen Chen, Cao Shilei, Yang Zhi, Xi Zhangjie, Pan Shuaiqi, Zhang Qizhi, Jiang Xinguo*. Incorporation of lapatinib into lipoprotein-like nanoparticles with enhanced water solubility and anti-breast cancer effect. Nanomedicine (Lond), 2013, 8(9): 1429-1442.(IF=5.824)
10. Gao Huile, Yang Zhi, Zhang Shuang, Cao Shijie, Pang Zhiqing*, Jiang Xinguo*. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Sci Rep, 2013, 3: 2534. (IF=5.078)
9. Gao Huile, Hu Yue, Xiong Yang, Zhang Shuang, Yang Jiarong, Yu Lian*, Jiang Xinguo*. Glioma targeting and anti-glioma effect of interleukin 13 peptide and RGD peptide dual functionalized nanoparticles. Curr Pharm Biotechnol, 2013, 14: 1118-1126.(IF=2.511)
8. Gao Huile, Chen Chen, Xi Zhangjie, Chen Jun, Zhang Qizhi, Cao Shlei, Jiang Xinguo*. In Vivo Behavior and Safety of Lapatinib-Incorporated Lipid Nanoparticles. Curr Pharm Biotechnol, 2013, 14: 1062-1071.(IF=2.511)
7. Gao Huile, Qian Jun, Cao Shijie, Yang Zhi, Pang Zhiqing, Pan Shuaiqi, Fan Li, Xi Zhangjie, Jiang Xinguo, Zhang Qizhi*. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials, 2012, 33(20):5115-5123.(IF=7.604) ESI高被引論文
6. Gao Huile, Qian Jun, Yang Zhi, Pang Zhiqing, Xi Zhangjie, Cao Shijie, Wang Yuchen, Pan Shuaiqi, Zhang Shuang, Wang Wei, Jiang Xinguo, Zhang Qizhi*. Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(epsilon-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials, 2012, 33(26): 6264-6272.(IF=7.604)
5. Gao Huile, Yang Zhi, Cao Shijie, Xi Zhangjie, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Behavior and anti-glioma effect of lapatinib-incorporated lipoprotein-like nanoparticles. Nanotechnology, 2012,23(43):435101.(IF=3.842)
4. Gao Huile, Pang Zhiqing, Pan Shuaiqi, Cao Shijie, Yang Zhi, Chen Chen, Jiang Xinguo*. Anti glioma effect and safety of docetaxel-loaded nanoemulsion.Arch Pharm Res, 2012,35(2):333-341. (IF=1.538)
3. Gao Huile, Pan Shuaiqi, Yang Zhi, Cao Shijie, Chen Chen, Jiang Xinguo, Pang Zhiqing*, Hu Yu*. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein.Biomaterials, 2011, 32(33): 8669-8675.(IF=7.404)
2. Gao Huile, Pang Zhiqing, Lu Wei, Pan Shuaiqi, Jiang Xinguo*. Encapsulation of cationic peptides into polymersomes through in situ gelatinization. J Microencapsul, 2011, 28(6): 465-471. (IF=1.553)
1. Gao Huile, Pang Zhiqing, Fan Li, Hu Kaili, Wu Bingxian, Jiang Xinguo*. Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations. Acta Pharmacol Sin, 2010,31(2): 237-243.(IF=1.953)
綜述和書的章節
20. Qin Lin, Gao Huile*. The application of nitric oxide delivery in nanoparticle-based tumor targeting drug delivery and treatment. Asian J Pharm Sci, 2019, online. (IF=4.56)
19. Gao Huile, GaoXiaoling, Edited. Brain Targeted Drug delivery system. Academic Press, 2018.9.28, Singapore. ISBN：978-0-12-814001-7
18. Xiao Wei, Gao Huile*. The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system. Int J Pharm, 2018, 552(1-2): 328-339.(IF=3.862)
17. Gao Huile*. Editorial (Thematic Issue: Novel Nanoparticles for Tumor Targeting Drug Delivery). Curr Drug Metab, 2018, 19(9): 722. (IF=2.659)
16. Shevtsov Maxim#*, Zhou Yang#, Khachatryan William, Multhoff Gabriele, Gao Huile*. Recent advances in gold nanoformulations for cancer diagnosis and therapy.Curr Drug Metab, 2018, 19(9): 768-780. (IF=2.659)
15. Xiong Jingyuan, Gao Huile*. Matrix metalloproteases responsive nanomaterials for tumor targeting diagnosis and treatment. J Microencapsul, 2017, 34(5): 440-453. (IF=1.543)
14. Yang Shu,Gao Huile*. Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy.Pharmacol Res, 2017, 126: 97-108. (IF=4.480)
13. 高會樂, 蔣新國*. 新型藥物遞釋系統的研究進展. 藥學學報（Acta Pharmaceutica Sinica）, 2017, 52(2): 181-188.
12. Gao Huile*. Perspectives on dual targeting delivery systems for brain tumors.Journal of Neuroimmune Pharmacology, 2017, 12(1): 6-16.(IF=3.896) ESI高被引論文
11. Gao Huile*. Editorial (Thematic Issue: Nanoparticles for Brain and Tumor Targeting Delivery). Curr Drug Metab, 2016, 17(8): 730. (IF=2.659)
10. Gao Huile*. Shaping tumor microenvironment for improving nanoparticles delivery. Curr Drug Metab, 2016, 17(8): 731-736. (IF=2.659)
9. Gao Huile*. Progress and perspectives on targeting nanoparticles for brain drug delivery. Acta Pharmaceutica Sinica B, 2016, 6(4): 268-286.
8. Jiang Xinguo,Gao Huile, Edited. Neurotoxicity of Nanomaterials and Nanomedicine. Elsevier Inc, 2016.9.28, Singapore.
7. 高會樂, 蔣新國*.腫瘤靶向遞藥新策略的研究進展. 藥學學報（Acta Pharmaceutica Sinica）, 2016, 51(2): 272-280.
6. Gao Huile. Nanoparticles for brain targeting drug delivery. In Hari Singh Nalwa, Encyclopedia of nanoscience and nanotechnology, American Scientific Publishers, 2016, Valencia, chapter 9, 1-21.
5. Gao Huile, Jiang Xinguo. Brain delivery using nanotechnology. In Di Li and Edward H. Kerns. Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects, John Wiley & Sons, Inc, 2015, New York, chapter 24, 521-534.
4. Gao Huile, Zhang Qianyu, Yu Zhiqiang, He Qin*. Cell-penetrating peptide-based intelligent liposomal systems for enhanced drug delivery. Curr Pharm Biotechnol, 2014, 15(3):210-219.(IF=2.511)
3. Gao Huile, He Qin*. The interaction of nanoparticles with plasma proteins and the consequent influence on nanoparticles behavior. Expert Opin Drug Deliv, 2014,11(3): 409-420.(IF=4.84)
2. Gao Huile, Jiang Xinguo*. Progress on the diagnosis and evaluation of brain tumors. Cancer Imaging, 2013, 13(4): 466-481. (IF=1.592)
1. Gao Huile, Pang Zhiqing, Jiang Xinguo*. Targeted delivery of nano-therapeutics for major disorders of the central nervous system. Pharm Res, 2013, 30: 2485-2498.(IF=3.952)
