高學娟博士, 副研究員，碩士生導師。2003年於河南醫科大學臨床醫學系獲得本科學位，2003年至2009年在華南師範大學雷射生命教育部重點實驗室碩博連讀，2009年任職於暨南大學生命科學技術學院，生命與健康工程研究院生物化學與分子生物學系。
研究方向主要圍繞功能蛋白質在惡性腫瘤發生髮展中的生物學功能和作用機制、抗癌藥物的作用機理。相關研究結果已經在《Sci. Rep.》、《J. Cell. Physiol.》、《Apoposis》、《J. Biomed. Sci.》、《Cell Cycle》、《Int. J. Cancer》、《J. Cell. Biochem.》、《Biochem. Cell Biol.》、《J. Mol. Biol.》等國際一流刊物上發表SCI收錄論文30餘篇，其中11篇為第一作者，4篇為通訊作者。應邀為«Lasers Med. Sci.»、«J. X-RAY Sci. Technol. »、«中國臨床藥理學與治療學»期刊審稿。主持國家自然科學基金青年項目1項、廣東省自然科學基金項目1項、廣州市科技計畫1項、暨南大學創新與培育基金3項，作為第二負責人參與國家自然科學基金多項，以及廣東省自然科學基金多項。
基本介紹
- 中文名：高學娟
- 國籍：中國
- 畢業院校：華南師範大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：功能蛋白質在惡性腫瘤發生髮展中的生物學功能和作用機制
- 職務：碩士生導師
- 職稱：副研究員
人物經歷,學習經歷,工作經歷,研究方向,學術成果,主要論文,承擔課題,
人物經歷
學習經歷
2003-2009：華南師範大學，碩博連讀，細胞生物學
1998-2003：河南醫科大學，學士學位，臨床醫學
工作經歷
2009-至今，暨南大學生物化學與分子生物學系（生命與健康工程研究院），副研究員
研究方向
研究方向主要圍繞功能蛋白質在惡性腫瘤發生髮展中的生物學功能和作用機制、抗癌藥物的作用機理。
學術成果
主要論文
1.第一作者論文
（1）Xuejuan Gao., Junxia Feng., Yujiao He., Fengmei Xu., Xiaoqin Fan., Wensi Huang., Haiting Xiong., Qiuyu Liu., Wanting Liu., Xiaohui Liu., Xuesong Sun., Qing-Yu He., QihaoZhang*., Langxia Liu*, hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells, Sci. Rep, 2016, 6:22999.
（3）Xuejuan Gao., Songsong Dan., Yingying Xie., Huanhuan Qin., Donge Tang., Xiaohui Liu., Qing-Yu He., Langxia Liu*,14-3-3ζ reduces DNA damage by interacting with and stabilizing proliferating cell nuclear antigen,J Cell Biochem,2015,116(1):158-169. doi: 10.1002/jcb.24955
（4）Cuihua Wang., Xuejuan Gao., Shengyou Liao., Junxia Feng., Bin Luo., Langxia Liu*, Transcriptome analysis of human breast cancer cell lines MCF-7 andMDA-MB-435 by RNA-Seq, Molecular Biology, 2015, 49(2):244-252.
（5）Xuejuan Gao., Yujiao He., Ling-Mei Gao., Junxia Feng., Yingying Xie., Xiaohui Liu., Langxia Liu*,Ser9-phosphorylated GSK3β induced by 14-3-3ζ actively antagonizes cell apoptosis in a NF-κB dependent manner,Biochem Cell Biol,2014, 92(5):349-56.doi: 10.1139/bcb-2014-0065.
（6）Xuejuan Gao.,JunxiaFeng.,Sen Zhu.,Xiaohui Liu.,Isabelle Tardieux., Langxia Liu*, Protein Phosphatase 2C of Toxoplasma Gondii Interactswith Human SSRP1 and Negatively Regulates Cell Apoptosis,Biomed Environ Sci,2014, 27(11):883-93.doi: 10.3967/bes2014.130.
（7）MiaojuanChen., Xuejuan Gao.,LinaXu.,TengfeiLiu.,Xiaohui Liu.,Langxia Liu*, Ezrin is required for epithelial-mesenchymal transition induced by TGF-β1 inA549 cells,Int J Oncol,2014,45(4):1515-22. doi: 10.3892/ijo.2014.2554.
（8）Xuejuan Gao., Jian-Ying Wang., Ling-Mei Gao., Xing-Feng Yin., Langxia Liu*, Identification and analysis ofglycogen synthase kinase 3beta1 interactome, Cell Biol Int, 2013, 37(8):768-779
（9）Xuejuan Gao., Da Xing*.，Lei Liu.，Yonghong Tang, H-Ras and PI3K are required for the formation of circular dorsal ruffles induced by low power laser irradiation. Journal of Cellular Physiology, 2009, 219: 535–543
（10）Xuejuan Gao., Da Xing*, Molecular mechanisms of cell proliferation induced by low power laser irradiation. Journal of Biomedical Science, 2009, 16:4, doi:10.1186/1423-0127-16-4
（11）Xuejuan Gao., Da Xing*., Yihui Pei., Fang Wang, Dynamic activation of H-Ras induced by low power laser irradiation in living cells, Proc SPIE. 2007, 6534, 65341D-1-8 (EI indexed).
（12）Xuejuan Gao., Tongsheng Chen., Da Xing*., Fang Wang., Yihui Pei., Xunbin Wei, Single Cell Analysis of PKC Activation During Proliferation and Apoptosis Induced by Laser Irradiation. Journal of Cellular Physiology, 2006, 206:441–448
（13）Xuejuan Gao., Da Xing*., Tongsheng Chen, Dynamic interaction between14-3-3zeta and Bax during TNF-alpha-induced apoptosis in living cells, Proc. SPIE, 2006, 6047, 6047371-6 (EI indexed).
（14）Xuejuan Gao., Fang Wang., Da Xing*, Molecular Imaging of Low-Power Laser Irradiation Induced Cell Proliferation, Proc SPIE,2006,6087, 60870N-1-12 (EI indexed).
（15）Xuejuan Gao., Tongsheng Chen., Da Xing*., and Fang Wang, Imaging of Protein Kinase C Activation by FRET During Proliferation Induced by Low-Energy Laser Irradiation in Living Cells, Proc SPIE,2005, 5630, 593-598 (EI indexed).
2.通訊作者論文
（1）Zeng QZ, Liu WT, Lu JL, Liu XH, Zhang YF, Liu LX*,Gao XJ*.YWHAZ Binds to TRIM21 but Is Not Involved in TRIM21-stimulated Osteosarcoma Cell Proliferation. Biomed Environ Sci. 2018 Mar;31(3):186-196. doi: 10.3967/bes2018.024.
（2）Huang WS, Xu FM, Zeng QZ, Xiaohui Liu,Xuejuan Gao *, Langxia Liu *, ERK1/2-mediated Cytoplasmic Accumulation of hnRNPK Antagonizes TRAIL-induced Apoptosis through Upregulation of XIAP in H1299 Cells.Biomed Environ Sci.2017, 30(7):473-481.
（3）Xiaoqin Fan., Jinmei Wei., Haiting Xiong., Xiaohui Liu., Serge Benichou*.,Xuejuan Gao*., Langxia Liu*,A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction, Int J Oncol,2015, 47(4): 1485-1493.
3.參與論文
（1）Li Z, Liu X, Ma J, Zhang T, Gao X, Liu L.hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells. Int J Oncol. 2018 Nov;53(5):2200-2212. doi: 10.3892/ijo.2018.4517.
（2）Liang GH, Liu N, He MT, Yang J, Liang ZJ, Xuejuan Gao, Rahhal AH, He QY, Zhang HT, Zha ZG,Transcriptional regulation of Runx2 by HSP90 controls osteosarcoma apoptosis via the AKT/GSK-3β/β-catenin signaling. J. Cell. Biochem., 2017, doi: 10.1002/jcb.26260.
（3）Zhang HT, Yang J, Liang GH, Xuejuan Gao, Sang Y, Gui T, Liang ZJ, Tam MS, Zha ZG,Andrographolide Induces Cell Cycle Arrest and Apoptosis of Chondrosarcoma by Targeting TCF-1/SOX9 Axis. J. Cell. Biochem., 2017, 118:4575-4586.
（4）Jia HL, Liu CW, Zhang L, Xu WJ, Xuejuan Gao, Bai J, Xu YF, Xu MG, Zhang G,Sets of serum exosomal microRNAs as candidate diagnostic biomarkers for Kawasaki disease. Sci. Rep., 2017, 7:44706.
（5）Xiaoqin Fan., Haiting Xiong., Jinmei Wei.,Xuejuan Gao., Yuan Feng., Xiaohui Liu., Gong Zhang., Qing-Yu He*., Jiake Xu*., Langxia Liu*, Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation, Sci Rep,2015, 5: 17732.
（6）Miaojuan Chen., Tengfei Liu., Lina Xu.,Xuejuan Gao., Xiaohui Liu., Cuihua Wang., Qing-Yu He., Gong Zhang., Langxia Liu*,Direct interaction of 14-3-3ζ with ezrin promotes cell migration by regulating the formation of membrane ruffle,J Mol Biol,2014,426(18):3118-33. doi: 10.1016/j.jmb.2014.06.021.
（7）Shengnan Wu., Da Xng*,Xuejuan Gao., Wei R Chen, High fluence low-power laser irradiation induces mitochondrial permeability transition mediated by reactive oxygen species, J Cell Physiol, 2009, 218(3): 603-611
（8）Lingling Zhang., Da Xing*.,Xuejuan Gao., Shengnan Wu, Low-Power Laser Irradiation Promotes Cell Proliferation by Activating PI3K/Akt Pathway. J Cell Physiol, 2009, 219(3): 553–562
（9）Juntao Zhang., Da Xing.,*Xuejuan Gao, Low-Power Laser Irradiation Activates Src Tyrosine Kinase Through Reactive Oxygen Species-Mediated Signaling Pathway, J Cell Physiol, 2008, 217: 518–528
（10）Lei Liu., Da Xing*., WR Chen., Tongsheng Chen, Yihui Pei,Xuejuan Gao, Calpain-mediated pathway dominates cisplatin-induced apoptosis in human lung adenocarcinoma cells as determined by real-time single cell analysis, Intern J Cancer, 2008, 122(10): 2210-2222.
（11）Juntao Zhang.,Xuejuan Gao., Da Xing*,Dynamic activation of Src induced by low-power laser irradiation in living cells mediated by reactive oxygen species,Proc SPIE, 2008, 6826, U123-U131 (EI indexed).
（12）Yihui Pei., Da Xing*.,Xuejuan Gao., Lei Liu., Tongsheng Chen, Real-time Monitoring Full length Bid Interacting with Bax during TNF-alpha-induced Apoptosis. Apoptosis, 2007, 12:1681–1690
（13）Lan Zhang., Da Xing*., Lei Liu.,Xuejuan Gao., Miaojuan Chen, TNF alpha Induces Apoptosis Through JNK/Bax-Dependent Pathway in Differentiated, but Not Naïve PC12 Cells, Cell Cycle, 2007, 6: 1479-1486
承擔課題
1.廣東省自然科學基金項目,2018A030313544,TRIM21通過調控自噬抑制骨肉瘤細胞分化的分子機制,2018/5/1-2021/4/30,10萬，主持
2.廣州市科技計畫項目科學（技術）研究專項一般項目，201707010263，hnRNPK調節α-tubulin乙醯化與Hippo通路交叉對話進而調控腫瘤增殖的分子機制研究，2017/5/1-2020/4/30，20萬，主持
3.暨南大學創新與培育基金躍升計畫項目，21615407，GSK3β與hnRNPK的相互作用參與調節TRAIL誘導的腫瘤細胞凋亡，2015/1/1—2016/12/31，12萬，主持
4.國家自然科學基金面上項目，31271607，重金屬鎘暴露影響子代睪丸Leydig細胞發育的線粒體相關機制研究，2013/01-2016/12，75萬，已結題，參加
5.國家自然科學基金青年項目,21310037，GSK3β調控腫瘤細胞凋亡分子機制的研究，2011/01-2013/12，21萬元，已結題，主持
