馮林(北京航空航天大學教授)

細胞生物學、生物製造以及再生醫療等領域中，細胞組織級的精密操作顯得極為重要，比如克隆、體外受精、人工誘導多能幹細胞生長成型等。傳統的細胞操縱方法大多採用體積龐大的微操作機械臂，其精度低、可重複性低、價格昂貴、效率低下。因此為了解決這一幾十年不變的陳舊技術，我們設計開發出了新型磁控微型機器人，套用於單細胞操作。其具有精度高、控制簡單、可重複性高等優勢。該微型機器人由磁性材料加工而成，封裝於微流控晶片中，通過利用外界磁場的自動化控制，可以有效避免外界環境對細胞的侵染，並極大的提高了操作控制精度。
創新點
1. 提出零摩擦非接觸微空間驅動新方法，發表在機器人頂級雜誌（IJRR，JAP）
2. 實現細胞級非接觸多自由度精密控制，發表在晶片上實驗室（Lab chip）
3. 實現了細胞級微手術操作，發表在生物微流體、微機械（APL, Biomicrofluidics, Micromachines）
近年來參與了日本文部科學省多項重大課題研究，並在國際機器人及微納米學會獲得多個獎項。目前在微納米系統及機械領域發表論文40餘篇，其中於2016年2月在機器人領域最高級別的國際機器人研究雜誌(International Journal Of Robotics Research)上發表了關於磁控晶片機器人的創新性研究成果。
___·參與課題·_______________________________________________________________
主持或參加的主要科研項目（按時間順序倒排）
北航青年拔尖人才
ZG226S188D
細胞手術級機器人研究
2018.1-2022.1
100萬
在研
主持
橫向
KH54144501
新型醫用膠囊機器人
2018.1-2018.12
10萬
在研
主持
橫向
KH54154201
智慧型廚房系統
2018.1-2018.12
20萬
在研
主持
北京市自然基金
KZ72000801
針對細胞級微納米機器人系統研究
2017.10-2020.6
28萬
在研
主持
科技委
17-163-12-ZT-004-005-01
仿生懸停平台器件研究及演示驗證
2017.7-2018.6
750萬
在研
參與
科技委
17-163-12-ZT-003-045-01
仿生智慧型變色光子晶體納驅動
2017.8-2019.7
100萬
在研
主持
北京航空航天大學人才啟動經費
ZG216S1751
卓越百人科研啟動經費
2016.10-2017.12
50萬
在研
主持
北京航空航天大學青年科學家團隊
ZG216S17F1
仿生多級結構多場效應創新團隊
2017.8-2018.7
100萬
在研
參與
基礎研究文部科學省
20246044
Challenge of On-chip Precise Enucleation of Oocyte Using 3D 6DOF Manipulation
2013.4-2015.3
4,030,000日元
已結題
參與
基礎研究文部科學省
23106002
Autonomous induction monitoring and cell measurement by ultra-high-speed operation
2013.4-2014.3
122,720,000日元
已結題
參與
Nagoya University
3027160582
GCOE High Speed Enucleation of Oocyte Using Magnetically Actuated Microrobot on a Chip
2013.4-2014.3
1,000,000日元
已結題
主持
基礎研究科技振興會
25000351
Automatic oocyte enucleation manipulation
2011.4-2013.3
2,000,000日元
已結題
主持
基礎研究文部科學省
25630090
Evaluation and dynamic measurement of biomembrane transporter using on-chip
2008.4-2010.3
49,790,000日元
已結題
參與
___·學術期刊·_______________________________________________________________
[1] Lin Feng, P. Di, and F. Arai, “High-precision motion of magnetic microrobot with ultrasonic levitation for 3-D rotation of single oocyte,” IJRR (International Journal of Robotics Research), Feb. 23, 2016, doi: 10.1177/0278364916631414.
[2] Y. Yamanishi, Lin Feng, and F. Arai, “On-demand Production of Emulsion Droplets Over a Wide Range of Sizes,” Adv. Robot., vol. 24, no. 14, pp. 2005–2018, Jan. 2010.
[3] M. Hagiwara, T. Kawahara, Y. Yamanishi, T. Masuda, Lin Feng, and F. Arai, “On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations.,” Lab Chip, vol. 11, no. 12, pp. 2049–2054, 2011.
[4] Lin Feng, T. Kawahara, Y. Yamanishi, M. Hagiwara, K. Kosuge, and F. Arai, “Size Controlled and On-Demand Production of Droplets by Magnetically Driven Microtool,” J. Robot. Mechatronics, vol. 24, no. 1, pp. 133–140, 2012.
[5] Lin Feng, M. Hagiwara, A. Ichikawa, and F. Arai, “On-Chip Enucleation of Bovine Oocytes using Microrobot-Assisted Flow-Speed Control,” Micromachines, vol. 4, no. 2, pp. 272–285, 2013.
[6] Lin Feng, Y. Sun, C. Ohsumi, and F. Arai, “Accurate dispensing system for single oocytes using air ejection,” Biomicrofluidics, vol. 7, no. 5, p. 054113, Oct. 2013.
[7] Lin Feng., Zhang S, Jiang Y, et al. Microrobot with passive diamagnetic levitation for microparticle manipulations[J]. Journal of Applied Physics, 2017, 122(24):243901.
[8] Lin Feng., Liang, S., Zhou, X., Yang, J., Jiang, Y., & Zhang, D., et al. (2017). On-chip microfluid induced by oscillation of microrobot for noncontact cell transportation. Applied Physics Letters, 111(20), 203703.
[9] Jiang Y, Wang R, Lin Feng*, et al. Mechanochromic response of the barbules in peacock tail feather[J]. Optical Materials, 2018, 75: 74-78.
[10] Lin Feng., Wu, X., Jiang, Y., & Zhang, D., et al. (2018). Manipulating Microrobots Using Balanced Magnetic and Buoyancy Forces. Micromachines, 2018, 9(2), 50.
[11] Yonggang Jiang, Rui Wang, Lin Feng*, Jian Li, Zhonglie An, Deyuan Zhang, Tunable alumina 2D photonic-crystal structures via biomineralization of peacock tail feathers, Optical Materials 2018 78, 490-494
[12] Yonggang Jiang, Longlong Gong, Xiaohe Hu, Yong Zhao, Huawei Chen, Lin Feng *, Aligned P(VDF-TrFE) Nanofibers for Enhanced Piezoelectric Directional Strain Sensing, Polymers, 2018, 281126
[13] Yao, G., Lin Feng., Zhang, D., & Jiang, X. (2018). Morphology and mechanical properties of vibratory organs in the leaf-cutting ant ( atta cephalotes ). Journal of Bionic Engineering, 15(4), 722-730.
[14] Gong, De, Jun Cai, Nuoer Celi, Lin Feng, Yonggang Jiang, and Deyuan Zhang. "Bio-inspired magnetic helical microswimmers made of nickel-plated Spirulina with enhanced propulsion velocity." Journal of Magnetism and Magnetic Materials 468 (2018): 148-154.
[15] Jiang, Yonggang, Mengyang Liu, Xing Yan, Takahito Ono, Lin Feng, Jun Cai, and Deyuan Zhang. "Flexible Force Sensors: Electrical Breakdown‐Induced Tunable Piezoresistivity in Graphene/Polyimide Nanocomposites for Flexible Force Sensor Applications (Adv. Mater. Technol. 8/2018)." Advanced Materials Technologies 3, no. 8 (2018): 1870031.
[16] Lin Feng, Zhou Q, Song B, Feng Y, Cai J, Jiang Y, Zhang D. Cell Injection Millirobot Development and Evaluation in Microfluidic Chip. Micromachines. 2018; 9(11):590.
[17] Lin Feng, Song B, Zhang D, Jiang Y, Arai F. On-Chip Tunable Cell Rotation Using Acoustically Oscillating Asymmetrical Microstructures. Micromachines. 2018; 9(11):596.
[18] Development of a Tactile and Slip Sensor with a Biomimetic Structure-enhanced Sensing Mechanism，Yonggang Jiang, Zhiqiang Ma, Bonan Cao, Longlong Gong, Lin Feng*, Deyuan Zhang, Journal of Bionic Engineering, 2018, accepted
[19] Wang, X., Cai, J., Sun, L., Zhang, S., Gong, D., Li, X., ... & Zhang, D. (2019). Facile Fabrication of Magnetic Microrobots Based on Spirulina Templates for Targeted Delivery and Synergistic Chemo-Photothermal Therapy. ACS applied materials & interfaces, 11(5), 4745-4756.
[20] Chen, Yuanyuan, Yanmin Feng, John Gregory Deveaux, Mohamed Ahmed Masoud, Felix Sunata Chandra, Huawei Chen, Deyuan Zhang, and Lin Feng*. "Biomineralization Forming Process and Bio-inspired Nanomaterials for Biomedical Application: A Review." Minerals 9, no. 2 (2019): 68.
[21] Hu, X., Yan, X., Gong, L., Wang, F., Xu, Y., Lin Feng, ... & Jiang, Y. (2019). Improved Piezoelectric Sensing Performance of P (VDF-TrFE) Nanofibers by Utilizing BTO Nanoparticles and Penetrated Electrodes. ACS applied materials & interfaces.
[22] Gong, D., Cai, J., Celi, N., Liu, C., Zhang, W., Lin Feng, & Zhang, D. (2019). Controlled propulsion of wheel-shape flaky microswimmers under rotating magnetic fields. Applied Physics Letters, 114(12), 123701.
[23] Jiang, Y., Shen, D., Liu, M., Ma, Z., Zhao, P., Lin Feng*, & Zhang, D. (2019). Fabrication of graphene/polyimide nanocomposite-based hair-like airflow sensor via direct inkjet printing and electrical breakdown. Smart Materials and Structures.
國際會議
[1] Lin Feng, Y. Yamanishi, and F. Arai, “On-demand generation of droplet in size over a wide range by microfluidic control,” in 2009 International Symposium on Micro-Nano Mechatronics and Human Science, 2009, pp. 139–144.
[2] Y. Yamanishi, Lin Feng, and F. Arai, “On-demand and Size-controlled Production of emulsion droplets by magnetically driven microtool,” Robot. Autom. (ICRA), 2010 IEEE Int. Conf., pp. 4094–4099, 2010.
[3] Lin Feng, T. Kawahara, Y. Yamanishi, M. Hagiwara, and F. Arai, “On-chip production of droplets with on-demand and size control,” in International Conference on Advanced Mechatronics, 2010, pp. 367–372.
[4] M. Hagiwara, T. Shiori, M. Niimi, T. Kawahara, Y. Yamanishi, Lin Feng, and F. Arai, “On-chip Particle Sorting into Multiple Channels by Magnetically Driven Microtools,” in International Conference on Advanced Mechatronics, 2010, pp. 373–378.
[5] M. Hagiwara, T. Kawahara, Lin Feng, Y. Yamanishi, and F. Arai, “High Precision Magnetically Driven Microtools with Ultrasonic Vibration for Enucleation of Oocytes,” in International Symposium on Micro-Nano Mechatronics and Human Science, 2010, pp. 47–52.
[6] M. Hagiwara, T. Kawahara, Lin Feng, Y. Yamanishi, and F. Arai, “On-chip dual-arm microrobot driven by permanent magnets for high speed cell enucleation,” 2011 IEEE 24th Int. Conf. Micro Electro Mech. Syst., pp. 189–192, 2011.
[7] H. Uvet, Lin Feng, S. Ohashi, M. Hagiwara, T. Kawahara, Y. Yamanishi, and F. Arai, “On-Chip Single Particle Loading and Dispensing,” in International Conference on Robotics and Automation, 2011, pp. 3151–3156.
[8] M. Hagiwara, T. Kawahara, Lin Feng, Y. Yamanishi, and F. Arai, “High performance magnetically driven microtools with ultrasonic vibration for biomedical innovations,” 2011 IEEE Int. Conf. Robot. Autom., pp. 3453–3454, 2011.
[9] M. Hagiwara, T. Kawahara, Lin Feng, Y. Yamanishi, and F. Arai, “On-chip Enucleation of Oocyte by Magnetically Driven Microtools with Ultrasonic Vibration,” in International Conference on Robotics and Automation, 2011, pp. 2680–2685.
[10] T. Kawahara, T. Hirano, Lin Feng, H. Uvet, M. Hagiwara, Y. Yamanishi, F. Arai, and F. Lin, “High-speed single cell dispensing system,” in Micro-NanoMechatronics and Human Science (MHS), 2011 International Symposium on, 2011, pp. 472–474.
[11] Lin Feng, U. Huseyin, T. Kawahara, M. Hagiwara, Y. Yamanishi, and F. Arai, “On-Chip High-Speed and On-Demand Single Microbeads Loading,” in International Symposium On Micro-Nano Mechatronics and Human Science, 2011, pp. 472–474.
[12] Lin Feng, M. Hagiwara, H. Uvet, Y. Yamanish, T. Kawahara, K. Kosuge, and F. Arai, “High-speed delivery of microbeads in microchannel using magnetically driven microtool,” 2011 16th Int. Solid-State Sensors, Actuators Microsystems Conf., pp. 1312–1315, 2011.
[13] Lin Feng, M. Hagiwara, A. Ichikawa, and F. Arai, “Continuous Enucleation of Bovine Oocyte by Microrobot with Local Flow Distribution Control,” in International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 2012, pp. 944–949.
[14] Lin Feng, M. Hagiwara, A. Ichikawa, T. Kawahara, and F. Arai, “Smooth Enucleation of Bovine Oocyte by Microrobot with Local Flow Speed Control in Microchannel,” in International Conference on Intelligent Robots and Systems, 2012, pp. 944–949.
[15] Lin Feng, M. Hagiwara, A. Ichikawa, and F. Arai, “On-chip continuous enucleation by hydraulic force control using magnetically actuated microrobot,” in International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2012, pp. 1270–1273.
[16] Lin Feng, M. Hagiwara, Y. Sun, A. Ichikawa, and F. Arai, “High-speed Production and Dispensing of Enucleated Oocyte by Microrobot on a Chip,” in International Symposium On Micro-Nano Mechatronics and Human Science, 2012, pp. 111–115.
[17] Lin Feng, U. Ningga, F. Arai, “Rotation of single bovine oocyte by micro-robot on a chip”, Proceedings of the 6th International Symposium on Microchemistry and Microsystems (ISMM), 2014, pp. 256-257.
[18] Lin Feng, B. Turan, U. Ningga, F. Arai, “Three dimensional rotation of bovine oocyte by using magnetically driven on-chip robot”. In Intelligent Robots and Systems (IROS 2014), 2014 pp. 4668-4673.
[19] Turan, Bilal ，Sakuma, Shinya，Arai, Fumihito，Lin Fengin, Automation of an on-chip cell mechanical characterization system for stiffness evaluation，MHS，Nagoya，2015.11.02-2015.11.06
[20] Lin Feng, Manipulation of Oocytes by Magnetically Driven Microrobot on a Chip, ICMNM2017, Wuhan, August 25, 0ral 50.
[21] Lin Feng, Microgripper for 3D-micromanipulation Felix S. Chandra Beihang University, China P24
[22] Lin Feng, Microrobot for 3D-Manipulating Cells on a Chip Xiaocong Wu Beihang University, China
[23] Lin Feng, The Design of High Precision Rotating Magnetic Field for the Orderly Arrangement of Flaky Particles Yuguo Dai, Beihang University, China
[24] Lin Feng, Cell injection Microrobot Development and Evaluation in Microfluidic Chip
[25] Lin Feng, Newly Established Three Dimensional Magnetically Controlling System
[26] Mousa, A., Feng, L., Dai, Y., & Tovmachenko, O. (2018, August). Self-Driving 3-legged Crawling Prototype Capsule Robot with Orientation Controlled by External Magnetic Field. In 2018 WRC Symposium on Advanced Robotics and Automation (WRC SARA) (pp. 243-248). IEEE.
日本國內
[1] Lin Feng, Y．Yamanishi, T．Kawahara, M．Hagiwara, K．Kosuge, and F．Arai, “Robot-on-a-chip Part 1: On-chip Generation of Droplets and Size Control,” in 日本機械學會ロボティクス・メカトロニクス講演會, 2010, pp. 1P1–U04.
[2] 萩原將也, 川原知洋, 馮林, 山西陽子, and 新井史人, “雙腕マイクロアームの高精度な非接觸操作,” in 第22回化學とマイクロ・ナノシステム研究會, 2010, p. P.26.
[3] 萩原將也, 川原知洋, 馮林, 山西陽子, and 新井史人, “マイクロ流體チップ內で超高速動作する雙腕マイクロロボットによる細胞操作・切斷,” in 第28回日本ロボット學會學術講演會, 2010, pp. 2M2–7.
[4] Lin Feng, Y．Yamanishi, T．Kawahara, M．Hagiwara, K．Kosuge, and F．Arai, “Generation of Droplet with Feedback Control on a Chip,” in 第22回化學とマイクロ・ナノシステム研究會, 2010, p. P.25.
[5] Lin Feng, Y．Yamanishi, T．Kawahara, M．Hagiwara, K．Kosuge, and F．Arai, “On-chip Size-controllable Droplet Generation,” in 第11回計測自動制御學會システムインテグレーション部門講演會, 2011, pp. 3I2–3.
[6] Lin Feng, Y．Yamanishi, T．Kawahara, M．Hagiwara, K．Kosuge, and F．Arai, “On-chip Smooth Enucleation by Hydraulic Force Control Using Magnetically Driven Microtool,” in ロボティクス・メカトロニクス講演會, 2012, pp. 1P1–U04.
[7] 平野　達彥, 川原　知洋, ウベット　フセイン, 馮林, 新井　史人, “ローディング機構を有する単一細胞分注システム” in第12回計測自動制御學會システムインテグレーション部門講演會, 2012, pp. 1P1–U04

◆學術與社會服務

1. IEEE美國電子電氣工程師學會高級會員
2. 中國機械工程學會生物製造工程分會組織委員會：副主任委員
3. 醫工交叉高精尖中心雙聘研究員
4. 中國機械學會高級會員
5. 中國微米納米技術學會高級會員
6. 中國生物醫學工程學會高級會員
7. 中國細胞生物學會高級會員
8. ICRA, (IEEE Robotics and Automation Society's flagship conference) 機器人及自動化頂級會議特約審稿人。
9. IROS 2016, (IEEE/RSJ International Conference on Intelligent Robots and Systems) 機器人及自動化頂級會議特約審稿人。
10. 期刊特約審稿人
<Nanoscale> Q1 IF 7.394
<IEEE Transaction on Robotics Research> Q1 IF 2.6
<Sensors and Actuators B> Q1 IF 4.8
<Sensors and Materials> Q4 IF 0.489
<Journal of Magnetics> Q4 IF 0.421
11. 2009-11美國電氣電子工程師學會IEEE International Symposium on Micro-Nano Mechatronics and Human Science 2009 (MHS 2009), Best Paper Award (最佳論文獎).
12. 2010-05 美國電氣電子工程師學會IEEE International Conference on Advanced Mechatronics 2010 (ICAM 2010), Young Fellow Prize (優秀年輕學者).
13. 2011-05 美國電氣電子工程師學會IEEE Robotics and Automation Society, IEEE International Conference on Robotics and Automation 2011 (ICRA 2011), Best Video Award (最佳視頻獎) .
14. 2011-11美國電氣電子工程師學會IEEE International Symposium on Micro-Nano Mechatronics and Human Science 2011 (MHS 2011), Best Paper Award (最佳論文獎).
15. 2016-10 北京航空航天大學卓越百人
16. 2017 ICMNM 國際微納米機械會議邀請報告
17. 2018 Material Science 國際生物材料科學大會特邀報告
18. 2017 20th International Conference on Emerging Materials and Nanotechnology, 大會邀請報告

馮林(北京航空航天大學教授)

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