馬永敏，男，博士，台州學院醫藥化工與材料工程學院，博士生導師。
基本介紹
教育經歷,工作經歷,研究方向,代表論文及專利,
教育經歷
2002/8 - 2005/11，倫敦國王學院，藥學，博士，導師：Robert C Hider
1998/9 - 2001/6，浙江大學，化學，碩士，導師：張永敏
工作經歷
2018/12-至今，台州學院，醫藥化工與材料工程學院，教授
2013/8 - 2018/11，浙江中醫藥大學，藥學院，研究員
2008/1 - 2013/4，倫敦國王學院，藥物研究所，研究員
2006/1 - 2007/12，倫敦國王學院，藥物研究所，助理研究員
研究方向
設計和合成小分子的3-羥基-吡啶-4-酮類化合物如含氟、含糖的3-羥基-吡啶-4-酮用於治療神經退化性疾病，用螢光探針來檢測細胞內游離鐵（labile iron）和血漿里非轉運鐵蛋白結合鐵（Non-Transferrin Bound Iron， NTBI）的含量。
代表論文及專利
1. Zhou, Y.-J.; Kong, X.-L.; Li, J.-P.; Ma, Y.; Hider, R. C.; Zhou, T. Novel 3-hydroxypyridin-4-one hexadentate ligand-based polymeric iron chelator: synthesis, characterization and antimicrobial evaluation. Medchemcomm 2015, 6, 1620-1625.
2. Chen, Y.-L.; Chen, J.; Ma, Y.*; Hider, R. C. The Synthesis of 5-Functional 3-Hydroxypyridin-4-ones and Their Impact on the Chelating Properties of the Ligands. Chemistry Letters 2015, 44, 515-517.
3. Ma, Y.; Kong, X.; Abbate, V.; Hider, R. C. Synthesis and characterization of novel iron-specific bicyclic fluorescent probes. Sensors and Actuators B-Chemical 2015, 213, 12-19.
4.Ma, Y.; Zhou, T.; Hider, R. C. pFe(3+) determination of multidentate ligands by a fluorescence assay. Analyst 2015, 140, 3603-3606.
5. Tao, X.; Ma, Y.; Chen, J.; Zhao, H. Design, Synthesis and Biological Evaluation of Caudatin and its Ester Derivatives as Novel Antitumor Agents. Natural Product Communications 2015, 10, 571-574.
6. Ma Y*, Hider RC. Novel synthetic approach to fluoro- and amido-disubstituted 3-hydroxypyridin-4-ones. J Fluorine Chem. 2015, 173, 29-34 .
7. Ma Y, Abbate V, Hider RC. Iron-sensitive fluorescent probes: monitoring intracellular iron pools. Metallomics. 2015, 7, 212-222.
8. Ma MT, Meszaros LK, Paterson BM, Berry DJ, Cooper MS, Ma Y, Hider RC, Blower PJ. Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with Zr: comparison with desferrioxamine-B. Dalton Trans, 2015, 44, 4884-4900.
9. Ma Y, Kong X, Chen YL, Hider RC. Synthesis and characterizations of pyridazine-based iron chelators. Dalton Trans. 2014, 43, 17120-17128.
10. Ma Y, Podinovskaia M, Evans PJ, Emma G, Schaible UE, Porter J, Hider RC. A novel method for non-transferrin-bound iron quantification by chelatable fluorescent beads based on flow cytometry. Biochem J. 2014, 463, 351-362.
11. Ma, Y., Luo, W., Quinn, P.J., Liu, Z. and Hider, R.C. Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors.J Med Chem, 2004,47, 6349-6362.
12.Ma, Y., Roy, S., Kong, X., Chen, Y., Liu, D., & Hider, R. C. Design and synthesis of fluorinated iron chelators for metabolic study and brain uptake.J Med Chem, 2004,55, 2185-2195.
13.Ballinger, J. R.; Berry, D. J.; Blower, P. J.; Ma, Y. M. Conjugates and Their Uses in Molecular Imaging. Patent WO2012063028.
14. Hider, R. C.; Ma, Y.M. Podinovskaia, M; Schaible, U. E. Compounds Patent WO2011135361.
15. Hider, R. C.; Ma, Y. M. The fluorinated pyridine-4-ones. Patents WO2009103950.
